• The Journal of Korean Academy of Prosthodontics
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• v.39 no.6
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• pp.659-681
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• 2001

Platelet-rich plasma(PRP) has been known to increase the rate and degree of bone formation by virtue of growth factors in concentrated platelets. Although its great healing effect on bone defect or pre-implantation site preparation in conjunction with bone substitute has been reported, the effect associated with implant is unknown. The purpose of this study was to investigate the effect of PRP on rapid osseointegration of endosseous dental implants in the rabbit tibiae. Twenty two adult female New Zealand white rabbits, weighing approximately 2.7-3.3kg, were used for this study. Twelve of the 22 animals were used for histomorphometric analysis and ten of the 22 were for removal torque test. Each animal received two implants in each tibia (two treated with PRP and two as control) and was given fluorochrome intramuscularly. For histomorphometric analysis, rabbits were divided into four groups according to the healing period. At 1 week, 2 weeks, 4 weeks and 8 weeks postoperatively, each three animals were sacrificed serially and the amount and rate of bone formation around dental implant were examined on the undecalcified sections under fluorescent microscope, polarized microscope and light microscope connected to a personal computer equipped with image analysis system. For removal torque test, rabbits were divided into two groups and removal torque tests were performed at 4 weeks, 10 weeks after implant placement. In total, 88 screw shaped, commercially pure titanium implants (Neoplant, Neobiotech, Seoul, Korea) were used in this study. Labeling pattern reflected differences of two groups in bone formation rate at each period. Histomorphometrically, PRP group showed significantly higher bone volume within threads compared to control group at 2 weeks ($70.30{\pm}4.96%$ vs. $50.68{\pm}6.33%$; P < .01) and 4 weeks ($82.59{\pm}5.94%$ vs. $72.94{\pm}4.57%$; P < .05 ). PRP group at 1, 2 and 4 weeks revealed similar degree of bone volume formation comparable to control group at 2, 4 and 8 weeks, respectively. On the other hand, while PRP group showed higher bone-implant contact ($47.37{\pm}8.09%$) than control group ($33.16{\pm}13.47%$) at 2 weeks, there were no significant differences between PRP group and control group for any experimental period. Removal torque values also showed no significant differences between PRP group and control group at any experimental period (P > .05). These findings imply that PRP could induce rapid, more bone formation around implant during early healing period and get faster secondary stability for reducing healing period, though it has not induced bone maturation enough to resist functional loading.

• Journal of Powder Materials
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• v.5 no.4
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• pp.250-257
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• 1998

The synthesis of titanium silicides ($Ti_3Si$, $TiSi_2$, $Ti_5Si_4$, $Ti_5Si_3$ and TiSi) by mechanical alloying has been investigated. Rapid, self-propagating high-temperature synthesis (SHS) reactions were observed to produce the last three phases during room-temperature high-energy ball milling of elemental powders. Such reactions appeared to be ignited by mechanical impact in an intimate, fine powder mixture formed after a critical milling period. During the high-energy ball milling, the repeated impact at contact points leads to a local concentration of energy which may ignite a self-propagating reaction. From in-situ thermal analysis, each critical milling period for the formation of $Ti_5Si_4$, $Ti_5Si_3$ and TiSi was observed to be 22, 35.5 and 53.5 min, respectively. $Ti_3Si$ and $TiSi_2$, however, have not been produced even till the milling period of 360 min due to lack of the homogeneity of the powder mixtures. The formation of titanium silicides by mechanical alloying and the relevant reaction rates appeared to depend upon the critical milling period, the homogeneity of the powder mixtures, and the heat of formation of the products involved.

• Journal of Powder Materials
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• v.6 no.2
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• pp.145-151
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• 1999

Nickel silicides ($Ni_5$Si$_2$, Ni$_2$Si and NiSi) have been synthesized by mechanical alloying (MA) of Ni-27.9at.9at%Si, Ni-33.3at% and Ni-50.0at% powder mixtures, respectively. From in situ thermal analysis, eash citical milling period for the formation of the three phases was observed to be 40.2, 34.9 and 57.5 min, at which there was a rapid increase in temperature. This indicates that rapid, self-propagating high-temperature synthesis (SHS) reactions were observed to produce the three phases during room-temperature high-energy ball milling of elemental powders. Each Ni silicide, Ni and Si, however, coexisted for an extended milling time even after the critical milling period. The powders mechanically alloyed after the critical period showed the rapid increase in microhardness. The Hv values were found to be higher than 1000kgf/mm$^2$. The formation of nickel silicides by mechanical alloying and the relevant reaction rates appeared to be influenced by the critical milling period and the heat of formation of the products involved ($Ni_5$Si$_2$$\rightarrow$-43.1kJ/mol.at., Ni$_2$Si$\rightarrow$-47.6kJ/mol.at., NiSi$\rightarrow$-42.4kJ/mol.at).

• The Plant Pathology Journal
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• v.39 no.2
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• pp.220-227
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• 2023

Rose crown gall caused by Agrobacterium tumefaciens is a major disease that damages the production of cutroses in Korea. The effective prevention methods for this disease include the use of resistant varieties. This study was conducted to evaluate the resistance of 58 Korean cultivars and six foreign cultivars to crown gall disease with nodal explants in vitro. Among 180 A. tumefaciens strains, pathogenic strain RC12 was selected as an inoculant strain. The strain RC12 was identified based on characteristics of some selective media, pathogenicity test, and polymerase chain reaction analysis. Forty rose cultivars formed tumors on explants inoculated with A. tumefaciens RC12. However, 24 cultivars, including 22 Korean cultivars and 2 foreign cultivars, showed resistance to A. tumefaciens RC12 without forming any tumors. Six cultivars with tumor formation rates of over 30% formed initial tumors within 23 days after inoculation. Six cultivars with low tumor formation rates of around 5% formed initial tumors after 28 days of inoculation. It was found that gall formation rate was highly correlated with the initial gall formation period. Thus, the relationship between the period of gall formation and the rate of gall formation could be useful for assessing resistance to crown gall disease. In vitro inoculation methods could be used to evaluate resistance of cut-rose cultivars to crown gall diseases.

• Journal of Embryo Transfer
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• v.23 no.4
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• pp.245-250
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• 2008

This study was designed to investigate the effect of essential amino acids (EAA) and/or non-essential amino acids (NEAA) on the development of parthenogenetic and somatic cell nuclear transfer (SCNT) porcine embryos in vitro. To evaluate the timing of amino acids supplementation, activated oocytes were cultured in NCSU23-PVA with EAA, NEAA or NEAA+EAA (AAs) during specific periods as below: EAA, NEAA or AAs were supplemented during Day 0 to 6 (whole culture period: ALL), Day 2 to Day 6 (post-maternal embryonic transition period: POST-MET), Day 5 to Day 6 (post-compaction period: POST-CMP), Day 0 to Day 2 (pre-maternal embryonic transition period: PRE-MET), or Day 0 to Day 4 (post-compaction period: PRE-CMP). Supplementation of NEAA decreased cleavage rates in PRE-MET and PRE-CMP and also decreased blastocyst rates in POST-CMP. On the other hand, EAA significantly enhanced blastocyst formation rate in POST-MET and no detrimental effect on embryonic development in other groups. Interestingly, NEAA and EAA had synergistic effect when they were supplemented to the medium during whole culture period. Supplementation of AAs also enhanced SCNT porcine embryo development whereas BSA-free medium without AAs could not supported blastocyst formation of SCNT embryos. In conclusion, existence of EAA and NEAA in defined culture medium variously influences the development of parthenogenetic and SCNT porcine embryos, and their positive effect are only occurred when both EAA and NEAA are supplemented to the medium during whole culture period. Additionally, AAs supplementation enhances the blastocyst formation of SCNT porcine embryos when they are cultured in the defined condition.

• Tribology and Lubricants
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• v.26 no.5
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• pp.297-302
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• 2010

This study is focused on the resin layer formation of UV imprinting process by changing imprinting pressure and period. The mold shape is made for the process of window open over the pattern transfer area and the imprinting period is assigned as the time just before the UV light curing. The residual layer is measured by changing the imprinting period and pressure magnitude, and the measured data of residual layer provides useful information for the design of the process conditions of imprinting processes.

• Journal of Science and Technology Studies
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• v.2 no.1 s.3
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• pp.63-83
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• 2002

This article examines the historical and general characteristics of science and technology policy in Korea. Historical characteristics are analyzed through formation period, growth period, and transition period. Korea institutional sis for the promotion of science and technology was made from the initial stage of industrialization. As national R&D programs were launched, technological activities in the private sector were rapidly increased from the 1980s. Korea pursued new directions of science and technology policy with the formation of related laws and Plans from the late 1990s. General characteristics are analyzed by the concept of 'policy regime'. The prime policy goal of science and technology policy in Korea has been related to industrial development so far. In the policy means, input element has been increased focusing on the external aspects. Bureaucratic policy culture has dominated other cultures including economic culture, academic culture, and civic culture.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.1
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• pp.94-100
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• 2002

The effects of periodic fuel supply on the nonpremixed flame stability and soot formation were experimentally studied. A solenoid valve was used to control the period of fuel supply. The laser induced incandescence technique was used to visualize cool: volume fraction profile. The flame base shape was changed significantly by the fuel supply period and partially by the fuel flowrates. The portion of bluish flame near the flame base became larger as the period increased. When the period was long, two flames coexisted within one period. It seemed that the characteristic of flame stability were repeated with 4.68m change of fuel supply line length. The soot mass measurements and soot volume fraction measurements revealed that the maximum suppression of soot by the perioic fuel supply was approximately 75% , which occurred when the occurred when the fuel supply period was relatively long.

• The Mathematical Education
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• v.34 no.1
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• pp.17-63
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• 1995

The exploration of Mathematics-learningmodel on the basis of Cognitive development The purpose of this paper is to sequenctialize Mathematics-learning contents, and to explore teaching-learning model for mathematics, with on the basis of the theory of cognitive development and the period of condservation formation for children. The Specific topics are as follows: (1) Systemizing those theories of cognitive development which are related to Mathematics - learning for children. (2) Organizing a sequence of Mathematics - learning, on the basis of experimental research for the period of conservation formation for children. (3) Comparing the effects of 4 types of teaching - learning model, on the basis of inference activity and operational learning principle. $\circled1$ Induction-operation(IO) $\circled2$ Induction-explanation(IE) $\circled3$ Deduction-operation(DO) $\circled4$ Deduction-explanation(DE) The results of the subjects are as follows: (1) Cognitive development theory and Mathe-matics education. $\circled1$ Congnitive development can be achieved by constant space and Mathematics know-ledge is obtained by the interaction of experience and reason. $\circled2$ The stages of congnitive development for children form a hierarchical system, its function has a continuity and acts orderly. Therefore we need to apply cognitive development for children to teach mathematics systematically and orderly. (2) Sequence of mathematical concepts. $\circled1$ The learning effect of mathematical concepts occurs when this coincides with the period of conservation formation for children. $\circled2$ Mathematics Curriculum of Elementary Schools in Korea matches with the experimental research about the period of Piaget's conservation formation. (3) Exploration of a teaching-learning model for mathematics. $\circled1$ Mathematics learning is to be centered on learning by experience such as observation, operation, experiment and actual measurement. $\circled2$ Mathematical learning has better results in from inductional inference rather than deductional inference, and from operational inference rather than explanatory inference.

• Ocean and Polar Research
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• v.26 no.1
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• pp.1-10
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• 2004

Ice cliff retreat and sea-ice formation around King Sejong Station in King George Island were analysed and compared with air temperature change. Analysis of 33-year (1969-2001) air temperature records at Bellingshausen Station has revealed regional atmospheric warming, and the increasing rate of air temperature Is equivalent to a warming of $1^{\circ}C$ for 27-year period. Here we present time-series of observations for the areal extent of the ice cliff and ice sheet, showing that they have retreated dramatically in the past 45 years (1956-2001). Retreat of 1,050 m in length of the ice clifr has changed the Marian Cove into a low rectangular form of 4 km in length and 1 to 1.3km in width. The retreat rates have since increased from 6 m/yr of the Primary investigated Period to 54 and 81m/yr in the recent years. Exceptionally, the ice cliff had been advanced of 21m in length for a year between 1987 and 1988 of cold winters. Ice sheet in King George Island also shows a similar decrease, and the decreasing extent is much larger at the southern part of the Main Cove, relatively more exposed to the sun, than at the northern part. Comparing sea-ice formation in winter with air temperature data shows a pattern starting to freeze below $-5^{\circ}C$ and to thaw over $-3^{\circ}C$. It is conclusively estimated that the patterns and magnitudes of ice cliff retreat and sea-ice formation are consistent with fluctuations of the air temperature, and that the recent rapid retreat of ice cliff and less formation of sea-ice are caused especially by the warming trends in autumn accompanied with expansion of summer thawing period.