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Studies on the Stability of Multivitamin Solutions (종합비타민 액제의 안정성에 대한 연구)

  • Park, Hong-Koo
    • Applied Biological Chemistry
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    • v.43 no.1
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    • pp.39-45
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    • 2000
  • The stability of vitamin A, $B_1,\;B_2,\;B_6$, C in aqueous multivitamin solutions was carried out by means of estimation of reaction velocity and the results are described in this paper. The stability of vitamin A, $B_1$ and C due to thermal degradation method in aqueous multivitamin solutions was evaluated at 40, 50, 60 and $70^{\circ}C$ up to 40 days. The shelf-lives of vitamin A, B₁ and C in this preparation, calculated using the Arrhenius equation, were 1493, 449 and 639 days at $25^{\circ}C$ respectively. Examination was made on the effect of initial concentration of vitamin $B_2$$(C_0)$ on light fading of vitamin $B_2$ in aqueous multivitamin solutions and it was found that the fading progressed according to the following formula : $-{\frac {dc}{dt}}=K_c\;{\frac C{C_0}}$ where Kc is apparent light-fading rate constant relate to $C_0$. Photodecomposition of vitamin $B_6$ in aqueous multivitamin solutions was apparently first order kinetics and was stable in polyethylene>brown color>glass container to sunlight. Photodecomposition of vitamin $B_6$ in four seasons also investigated.

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Estimation and validation of the genetic coefficient of cv. Superior for the DSSAT-CSM (DSSAT 작물모형을 위한 수미품종의 품종모수의 결정과 기후변화에서의 활용)

  • Bak, Gyeryeong;Lee, Gyejun;Lee, Eunkyeong
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.20 no.2
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    • pp.166-174
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    • 2018
  • Potato(Solanum tuberosum L.) is one of the major food crop in the world following rice, wheat, and maize. It is thus important to project yield predict of potato under climate change conditions for assessment of food security. A crop growth modelling is widely used to simulate crop growth condition and total yield of various crops under a given climate condition. The decision support system for agrotechnology transfer (DSSAT) cropping system model, which was developed by U.S. which package integrating several models of 27 different crops, have been used to project crop yield for the impact assessment of climate change on crop production. In this study, we simulated potato yield using RCP 8.5 climate change scenario data, as inputs to the DSSAT model in five regions of Korea. The genetic coefficients of potato cultivar for 'superior', which is one of the most widely cultivated potato variety in Korea were determined. The GenCalc program, which is a submodule of the DSSAT package, was used to determine the genetic coefficients for the superior cultivar. The values of genetic coefficients were validated using results of 39 experiments performed over seven years in five regions. As a case study, the potato yield was projected that total yields of potato across five regions would increase by 26% in 2050s but decrease by 17% in 2090s, compared with 2010s. These results suggested that the needs for cultivation and irrigation technologies would be considerably large for planning and implementation of climate change adaptation for potato production in Korea.

A Study on Design of Vacuum Silo for Batch Treatment System for Dredged Soil (준설토 일괄처리시스템을 위한 진공사이로 설계에 관한 연구)

  • Kim, Yong-Seok;Yang, Hae-Rim;Kim, Hac-Sun;Jeoung, Chan-Se;Yang, Soon-Yong
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.36 no.5
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    • pp.571-577
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    • 2012
  • In this study, a small movable batch treatment system for dredging soil deposited in a rain water tube is proposed; further, a vacuum silo sorting separation device with a vacuum silo, first-stage sorting separator, and conveyor is designed. The vacuum silo sorting separation device also consists of a storage tank, transferring screw, vacuum gate, screen bar, screen bar cleaner, and vacuum discharging device. In view of the fact that the flow of drawn air in the storage tank is a major factor influencing the sorting separation performance, the optimum shape of the tank is determined by CFD flow analysis. In addition, by using CAE structure analysis, the safety of a storage tank made of boards is examined. The specifications of the vacuum silo sorting separation device are determined by conducting mechanical and dynamic simulations of the driving mechanism of the vacuum silo sorting separation device through 3D-CAD modeling. Following this study, we will design a drum-screen-type second sorter, a decanter-type dehydration device, and waste water tank and pump as a secondary device. Further, on the basis of this design, we will construct a prototype model and carry out a field test.

An Experimental Study of Effect on ECV 304 Cells, Platelet Rich Plasma and Rats treated with L-NAME by Boonsimgieum extract (분심기음(分心氣飮)이 고혈압 백서와 인간유래 혈관내피세포주(ECV 304)에 미치는 영향에 대한 연구)

  • Jeon, Yeon-Yi;Park, Chang-Gook;Lee, So-Yeon;Yoon, Hyeon-Deok;Shin, Wo-Cheol;Park, Chi-Sang
    • The Journal of Internal Korean Medicine
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    • v.26 no.1
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    • pp.182-198
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    • 2005
  • Object : This study was designed to research whether the protection and inhibitory effects of cardiovascular diseases in L-NAME induced rat or ECV 304 cell lines through the Cell morphological pattern, Tunel assay, LDH activity, heart rate, blood pressure and immunohistochemistric analysis by Boonsimgieum water extract Methods : Nitric oxide(NO) play an important role in normal and pathophysiological cells including as a messenger molecule, neurotransmitter, microbiocidal agent, or dilator of blood vessels and artheriosclerosis, hypertension, myocardial infarction, respectively. Endothelial cell products can modulate the magnitude of a response to a vasoconstrictor, as evinced by the greater constriction after endothelium removal or NO synthesis blockade. To investigate that Boonsimgieum in the potential contribution of the levels of nitric oxide generated by endothelial nitric oxide synthase (eNOS) and the mechanisms of protection against NG-nitro-L-arginine methyl ester (L-NAME), human ECV 304 cells, which normally do not express eNOS, were expressed by L-NAME. L-NAME stimulated rat or cells were found to be resistant to injury and delayed death following the Boonsimgieum. Inhibition of nitric oxide synthesis abolished the protective effect against L-NAME, thrombin and collagen exposure. Interestingly, such effects have been observed during stimulation with agents such as phenylephrine and KCl on L-NAME mediate rats, were damaged by the NOS inhibitor L-NAME. Result : As the result of this study, In group, the anti-apoptosis and necrosis in the cardiovascular system have a potential capacity for prevented, protected and treating the diseases of cardiovascular system, against the necrosis of rat and ECV 304 cells with Caspase 3 and calpain expression by L-NAME is promoted. Conclusion : these results demonstrate neuroprotective and memory enhancing effects of ZIBU, suggesting its beneficial actions for the treatment of AD.

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The Effects of Injinchunggantang on Interferon Signaling Pathway of HepG2 Cells (인진청간탕(茵蔯淸肝湯)이 HepG2 cell의 인터페론 신호전달계에 미치는 영향)

  • Yi, Jong-Hoon;Kim, Young-Chul;Lee, Jang-Hoon;Woo, Hong-Jung
    • The Journal of Internal Korean Medicine
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    • v.26 no.1
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    • pp.74-92
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    • 2005
  • Objectives/Methods : To analyze the effect of Injinchunggantang(IJCGT) to Interferon-${\alpha}/{\beta}$ signal transmission system in HepG2 cells, HepG2 Cell were treated with IJCGT. Also, revelation of MxA, 2'5'-OAS mRNA leaded by Interferon-${\alpha}/{\beta}$ and revelation and activation of Jak1, TYK1, and STAT 1, all main signal transmission factors, were analyzed. Results : The analysis resulted in the following 1. With interferon ${\alpha}/{\beta}$ there was no affect cell propagation of Hep G2 cells. With IJCGT alone, cell propagation of HepG2 was promoted, and cell propagation control function was recovered. 2. With interferon ${\alpha}/{\beta}$ cell death was unaffected. With IJCGT apoptosis of HepG2 cell was restrained, and the cell's reaction to interferon was unaffected. 3. With interferon ${\alpha}/{\beta}$ treatment mRNA revelation of MxA and 2'5'-OAS was induced. When HepG2 cells were injected with IJCGT without interferon ${\alpha}/{\beta}$ treatment, mRNA revelation of MxA and 2'5'-OAS increased in proportion to the treatment density. With pre-treatment of IJCGT, leaded with interferon ${\alpha}/{\beta}$, promoted revelation of MxA, 2'5' -OAS mRNA. 4. Though mRNA revelation of lakl, TYK1 and STAT1 was unaffected with IJCGT, activation of STAT1 was promoted with an increase of phosphorylation of STAT1 protein. With pre-treatment of IJCGT, Jak1, TYK2, STAT1 phosphorylation, leaded with interferon, strengthened. 5. TNF-a, IL-1b and LPS present, revelation of MxA and 2'5'-OAS mRNA leaded by interferon was restrained when HepG2 cells were treated with IJCGT, and the interferon signal transmission system restraint action leaded by inflammatory cytokines was moderated. Conclusion : These results support a role for IJGCT in promotion of anti-virus action through maintainance of the liver's sensibility toward interferon. A clinical study of an interferon treated patient treated also with IJGCT is needed to determine its efficacy.

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UCN-Tree: A Unified Index for Moving Objects in Constrained Networks (UCN-트리: 제한된 망 구조 내의 이동체를 위한 통합 색인)

  • Cheon, Jong-Hyeon;Jeong, Myeong-Ho;Jang, Yong-Il;Oh, Young-Hwan;Bae, Hae-Young
    • Journal of Korea Spatial Information System Society
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    • v.8 no.1 s.16
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    • pp.37-57
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    • 2006
  • To support Location Based Services, the technology to store and search locations information of moving objects effectively was needed. And the study about indexes to manage these moving objects effectively has been done. As these indexes for moving objects was not considered for the objects which are moving along constrained networks such as road and railroad, indexes for the moving objects based on constrained networks was proposed. But these kinds of indexes have two problems as following. First, as the indexes for the moving objects based on constrained networks is divided according to time domain, when the places of moving objects from the present to the past are needed, the problem to search past indexes as well as present indexes occurs. Second, in this case, we should construct both present indexes and past indexes, so we have no other choice but to spend space cost and reconstruction cost additionally. This paper proposes A Unified Index for Moving Objects in Constrained Networks to solve these kinds of problems. As this proposed indexes support both present location and past location of moving objects, it can solve the current problems such as when we search present and past location of moving objects, we need a separate processing procedure. And as it consolidated the common parts of current location indexes and past location indexes, we can use less space cost and reconstruction cost than when we maintain indexes separately.

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Geochronology and Petrogenetic processes of the so-called Hongjesa granite in the Seogpo-Deogku Area (석포(石浦)-덕구간(德邱間)에 분포(分布)하는 소위(所謂) 홍제사화강암(洪濟寺花崗岩)의 지질연대(地質年代)와 생성과정(生成過程)에 대(對)한 硏究(연구))

  • Kim, Yong Jun;Lee, Dai Sung
    • Economic and Environmental Geology
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    • v.16 no.3
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    • pp.163-221
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    • 1983
  • Main aspects of this study are to clarify geochronology and petrogenetic processes of the so-called Hongjesa granite, which is a member of various intrusive rocks exposed in the northeastern part of the Ryongnam Massif, one of the Precambrian basements of South Korea. In this study, the Hongjesa grainte is divided into four rock units based on the geologic age, mineralogical and chemical constituents, and texture: the Precambrian Hongjesa granite gneiss (Hongjesa granite Proper) and leucogranite gneiss, the Paleozoic gnessic two mica granite, and the Jurassic muscovite granite. The Hongjesa granite gneiss is identified by its grayish color, slight foliation, and porphyroblastic texture. The leucogranite gneiss is distinct by its light gray color, sand medium to coarse grained texture. The gneissic two mica granite is distinguished from others by its strong foliation, containing gray-colored feldspar phenocrysts with biotite and muscovite in varying amounts. The muscovite granite occurs as a small stock containing feldspar phenocrysts along margin of the stock. These granitic rocks vary widely in composition, reflecting the facts that they partly include highly metamorphosed xenolith and schlierens as relics of magmatic and anatectic processes. In particular, grayish porphyroblasts of microcline perthite is characteristic of the Hongjesa granite gneiss, whereas epidote and garnet occur in both the Hongjesa granite gneiss and leucogranite gneiss. These minerals are considered to be formed by potassic metasomatism and contamination of highly metamorphosed rocks deeply buried under the level of the Hongjesa granite emplacement. The individual synchronous granitic rocks plotted on Harker diagram show mostly similar trends to the Daly's values. The plots of the Hongjesa granite gneiss and gneissic two mica granite concentrate near the end part of the calc-alkalic rock series on the AMF diagrams, whereas those of the leucogranite gneiss and muscovite granite indicate the trend of the Skaergaard pluton. These granitic rocks plotted on a Q-Ab-Or diagram (petrogeny's residua system) fall well outside the trough of the system. This can be attributed to the potassic matasomatism of these rocks. On the ACF diagram, these rocks appear to be dominantly I-type prevailing over S-type. The K-Ar ages, obtained from a total of 7 samples of the leucogranite gneiss, gneissic two mica granite, muscovite granite, porphyritic alkali granite, and rhyolitic rock, in addition to the Rb/Sr ages of the Hongjesa granite gneiss by previous workers, permit the rock units to be arranged in the following chronological order: The middle Proterozoic Hongjesa granite gneiss (1714-1825 m.y.), the upper proterozoic leucogranite gneiss (875-880 m. y.), the middle Paleozoic gneissic two mica granite (384 m. y.) the upper Jurassic muscovite granite (147 m. y.), the Eocene alkali granite (52 m. y.), and the Eocene rhyolitic rock (45 m. y.). From the facts and data mentioned above, it is concluded that the so-called Hongjesa granite is not a single granitic mass but is further subdivided into the four rock units. The Hongjesa granite gneis, leucogranite gneiss, and gneissic two mica granite are postulated to be either magmatic or parautochtonous, intrusive, and the later muscovite granite is to be magmatic in origion.

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Transforming an Entity-Relationship Model into a Temporal Object Oriented Model Based on Object Versioning (객체 버전화를 중심으로 시간지원 개체-관계 모델의 시간지원 객체 지향 모델로 변환)

  • 이홍로
    • Journal of Internet Computing and Services
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    • v.2 no.2
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    • pp.71-93
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    • 2001
  • Commonly to design a database system. a conceptual database has to be designed and then it is transformed into a logical database schema prior to building a target database system. This paper proposes a method which transforms a Temporal Entity-Relationship Model(TERM) into a Temporal Object-Oriented Model(TOOM) to build an efficient database schema. I formalize the time concept in view of object versioning and specify the constraints required during transformation procedure. The proposed transformation method contributes to getting the logical temporal data from the conceptual temporal events Without any loss of semantics, Compared to other approaches of supporting various properties, this approach is more general and efficient because it is the semantically seamless transformation method by using the orthogonality of types of objects, semantics of relationships and constraints over roles.

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A Study on a Model for University Library in the Future (미래형 대학도서관 모형개발 연구)

  • Han Sang-Wan;Kim Tae-Soo;Kim Suk-Young;Kim Sung-Hyuk;Moon Sung-Been
    • Journal of the Korean Society for Library and Information Science
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    • v.29
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    • pp.63-139
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    • 1995
  • At this point, the universities preparing the 21st century, require a great reform in various ways, especially a renovation of the function of the university library that can provide intellectual and information ability in information society is raised as an imminent task. Information technology, particularly the advanced technology in networking, have already constructed networks for university libraries using the information super-highway and it has enabled formation seekers to get the retrieved results transferred to their personal computers in a second. On the other hand, university libraries playing the most important role as an information center are still not corresponding effectively with the information age since it is tied down to the previous system, policy and tradition. The duty of university library is to distribute the accumulated, processed and stored academic information promptly and accurately to professors, researchers and students who are in need, and thereby to enhance their research capability, However, the present university libraries do not seem to be functioning smoothly due to the lack of an effective administrating system, budget, facilities, and human resources, Accordingly, our university libraries are in urgent need to be of a new and futuristic form appropriate for the 21st century. They must be able to cope with the growth of users' expectation in the future. This study examined several university libraries in the America, the structures of which have been reorganized, and also looked into the network(NACSIS) for the college and research libraries in Japan. In particular, the study focused on the following aspects : 1) changing role of university library, 2) new criteria for evaluating university libraries, 3) urgent need of a network for college and research libraries, 4) administrative support for the university libraries, and 5) case studies of the university libraries in the foreign countries. Finally, this study suggests a model for our university library in the 21st century.

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COMPARATIVE STUDY OF DIGITAL AND CONVENTIONAL RADIOGRAPHY FOR THE DIAGNOSTIC ABILITY OF ARTIFICIAL PROXIMAL SURFACE CARIES (디지털방사선사진과 구내방사선사진의 인접면 인공우식진단능에 관한 비교연구)

  • Cho, Young-Gon;Park, Si-Seung
    • Restorative Dentistry and Endodontics
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    • v.27 no.2
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    • pp.113-121
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    • 2002
  • Conventional intraoral radiography continues to be the most widely used image modality for the diagnosis of dental caries. But, conventional intraoral radiography has several shortcomings, including the difficulty of exposing and processing intraoral film of consistently acceptable quality. In addition, radiographic retaking that was the result of processing errors, may result in increased discomfort and radiation dose to the patient. Recently, various digital radiographies substitute for conventional intraoral radiography to overcome these disadvantages. The advantages of digital radiography are numerous. One of advantages Is the elimination of processing errors. In addition, the radiation dose for digital system is approximately 20% to 25% of that required for conventional intraoral radiography Another potential advantage of digital imaging is the ability to perform image quality enhancements such as contrast and density modulation, which may increase diagnostic accuracy. The purpose of this study was to compare the diagnostic ability of artificial proximal defects to conventional intraoral radiography, direct digital image(CDX2000HQ$^{\circledR}$) and indirect digital image(Digora$^{\circledR}$). Artificial defects were made in proximal surfaces of 60 extracted human molars using #1/2, #1, #2 round bur. Five dentists assessed proximal defects on conventional intraoral radiography, direct digital image(CDX2000HQ$^{\circledR}$) and indirect digital image(Digora$^{\circledR}$). ROC(Receiver Operating Characteristic) analysis and Two-way ANOVA test were used for the evaluation of detectability, and following results were acquired. 1. The mean ROC area of conventional intraoral radiography, direct digital image(CDX2000HQ$^{\circledR}$) and indirect digital Image(Digora$^{\circledR}$) were 0.6766, 0.7538, 0.6791(Grade I), 0.7176, 0.7594, 0.7361(Grade II), and 0.7449, 0.7608, 0.7414(Grade III), respectively. 2. Diagnostic ability of direct digital image was higher than other image modalities. But, there was no statistically significant difference among other imaging modalities for Grade I, II, III lesion(p>0.05). In conclusion, when direct and indirect digital system are comparable with conventional intraoral radiography. these systems may be considered an alternative of conventional intraoral radiography for the diagnosis of proximal surface caries.