• Journal of the Korean Society of Clothing and Textiles
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• v.34 no.3
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• pp.540-552
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• 2010

This research forms preliminary data for the coordination of environmental color planning in industry through a color analysis of work clothes and the work environment. A digital camera was used to study the work environment of two major shipbuilding companies located in Geoje city and Goseong county. The picture data was analyzed as G (ground: environment) and F (figure: clothes), and analyzed hue, value, and the chroma value through a Muncell conversion 9.0.6 from the color cluster, number of pixel, and RGB value. The results are as follows: First, GY, Y color were mostly used in the shipbuilding environment and work clothes. The color value was used in a relatively wide range but very low chroma (0-3), dark grayish, grayish tone dominated both fields. Second, the use of limited colors cannot be secured for safety in attention of the shipbuilding field. Third, unclear and vogue colors lessened the optical tiredness of workers that helped in the prevention of industrial accidents. Color combination and color selection should be considered for a secure safety color coordination between work clothes and the work environment when it comes to complicated color principles.

• BMB Reports
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• v.36 no.1
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• pp.128-137
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• 2003

Matrix metalloproteinases (MMPs), zinc dependent proteolytic enzymes, cleave extracellular matrix (ECM: collagen, laminin, firbronectin, etc) as well as non-matrix substrates (growth factors, cell surface receptors, etc). The deregulation of MMPs is involved in many diseases, such as tumor metastasis, rheumatoid arthritis, and periodontal disease. Metastasis is the major cause of death among cancer patients. In this review, we will focus on the roles of MMPs in tumor metastasis. The process of metastasis involves a cascade of linked, sequential steps that involve multiple host-tumor interactions. Specifically, MMPs are involved in many steps of tumor metastasis. These include tumor invasion, migration, host immune escape, extravasation, angiogenesis, and tumor growth. Therefore, without MMPs, the tumor cell cannot perform successful metastasis. The activities of MMPs are tightly regulated at the gene transcription levels, zymogen activation by proteolysis, and inhibition of active forms by endogenous inhibitors, tissue inhibitor of metalloproteinase (TIMP), and RECK. The detailed regulations of MMPs are described in this review.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6485-6488
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• 2014

Research over the years has progressively and sequentially provided near complete resolution of regulators of the DNA repair pathways which are so important for cancer prevention. Ataxia-telangiectasia mutated kinase (ATM), a high-molecular-weight PI3K-family kinase has emerged as a master regulator of DNA damage signaling and extensive cross-talk between ATM and downstream proteins forms an interlaced signaling network. There is rapidly growing scientific evidence emphasizing newly emerging paradigms in ATM biology. In this review, we provide latest information regarding how oxidative stress induced activation of ATM can be utilized as a therapeutic target in different cancer cell lines and in xenografted mice. Moreover, crosstalk between autophagy and ATM is also discussed with focus on how autophagy inhibition induces apoptosis in cancer cells.

• Journal of the Korean Wood Science and Technology
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• v.46 no.4
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• pp.415-422
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• 2018

Terpenoids have a wide range of biological functions and have extensive applications in the pharmaceutical, cosmetic, and flavoring industry. The white-rot fungus, Polyporus brumalis, is able to synthesize terpenoids via terpene synthase, which catalyzes an important step that forms a large variety of sesquiterpene products from farnesyl pyrophosphate (FPP). To improve the production of sesquiterpenes, the terpene synthase gene was isolated from Polyporus brumalis and was heterologously transformed into a Pichia pastoris strain. The open reading frame of the isolated gene (approximately 1.2 kb) was inserted into Pichia pastoris to obtain a recombinant enzyme. Five transformants were obtained and the expression of terpene synthase was analyzed at the transcript level by reverse transcription PCR (polymerase chain reaction) and at the protein level by SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis). Expression of the terpene synthase gene product was elevated in the transformants and as expected the molecular weight of the protein was approximately 45 kDa. These recombinant enzymes have potential practical applications and future studies should focus on their functional characterization.

• Journal of architectural history
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• v.5 no.2 s.10
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• pp.83-95
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• 1996

Computerized visual database construction of architectural precedents has just begun in some research institutes in the world. In Korea the first visual database has shown its testl version by S architectural design firm in september 1996. In this article the author discusses the historical contexts and the recent computerization cases, the traits, the uses and the limits of architectural visual database system of precedents. The forms and contents of data fields in two cases are compared with a focus on the description of architectural traits of each data entry. Compared to the KIA format, the S database has better performance for architectural design reference because it collects more pictures and drawings and larger texts for the field of architectural chracteristics. But this latter also is constrained by its capacity of memory and so lacks the reciprocity of the DOORS in the Graduate School of Design, Harvard University. A visual database system which has more flexible allocation of memory and respondent with the users is yet to be prepared. But this system also should be maintained by some experts in architectural history, theory and criticism, because their knowledge is essential for selection of precedents and revision of the data description. A full-fledged electronic visual database in architecture will not only save much effort for the architect, but also will change the architects' design behavior. Nevertheless this does not mean the automatic promotion of architects' creativity.

• Journal of Korea Society of Digital Industry and Information Management
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• v.11 no.1
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• pp.69-78
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• 2015

Internet of Things(IoT) is electronic devices and household appliances use wireless sensor network in environment of high speed wireless network and LTE mobile service. The combination of the development of Internet and wireless network led to development of new forms of service such as electronic devices and household appliances can connect to the Internet through various sensors and online servers such as a Home Network. Even though Internet of Things is useful, there are problems in Internet of Things. In environment of Internet of Things, information leakage could happens by illegal eavesdropping and spoofing. Also illegal devices of wireless communication interference can cause interfere in Internet of things service, physical damage and denial of service by modulation of data and sensor. In this thesis, it will analyze security threats and security vulnerability in environment of mobile services and smart household appliances, then it will suggest plan. To solve security issues, it is important that IT and RFID sensor related companies realize importance of security environment rather than focus on making profit. It is important to develop the standardized security model that applies to the Internet of Things by security-related packages, standard certification system and strong encrypted authentication.

• Environmental Analysis Health and Toxicology
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• v.19 no.1
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• pp.1-24
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• 2004

Since dioxins became a serious concern in Korea, a significant number of investigations have been conducted to address diverse issues related to dioxins. However, the results have not been organized for ready access and use. The principal purposes of the work were to ⅰ) provide an archive of dioxin researches in Korea and ⅱ) give an overview of dioxin contamination. The focus of this work was placed on the contamination levels and characteristics concerning the waste incinerators emissions, environmental media, and biological samples(fishes/shellfishes, foods, and human body). Principal component analysis was conducted to identify common and/or unique features and the important variables associated with the congener patterns. From a comprehensive search of academic journals, research and monitoring project reports, dissertations, and periodicals of other forms, a total of 115 counts were found that met the purposes of this study. The contamination levels of various samples were summarized and compared to those reported in foreign literatures. The congener patterns varied largely with environmental media and distinguished particularly by OCDD, 1,2,3,4,6,7,8-HpCDF, and OCDF for the samples within the same media. The proximity to emission sources differentiated the congener patterns in air and soil samples by the fraction of OCDD.

• YAKHAK HOEJI
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• v.52 no.2
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• pp.151-159
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• 2008

Consultation program for pharmaceutical development is a new system in which pharmaceutical companies meet and discuss scientific and/or regulatory issues with drug regulatory authority in the research process and before submitting new drug applications. This program helps pharmaceutical companies reduce uncertainties in the research and development and increase the possibilities of getting drug marketing approval. Developed countries such as US, EU, and Japan have implemented various forms of pre-submission meetings or consultation programs since the mid-1990s. The rapid development of technology in pharmaceutical R&D increases the importance of communication between drug development companies and drug regulatory authority in Korea, too. In designing the consultation program, it is desirable to focus on the stages of clinical trials which take the longest period of time and the biggest amount of money in the pharmaceutical R&D process. We suggested that results or recommendations by drug regulatory authorities in pre-submission meetings or consultations be formally documented and considered in review process. Explicit scientific reasons are required for changing the results from consultations.

• Journal of information and communication convergence engineering
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• v.9 no.1
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• pp.100-104
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• 2011

In software system development, an application interface is the main communication platform between human developers and applications. Interaction in any software application requires human's mental and physical activities. Although software systems have increased drastically in diverse sectors and many forms to quench human's needs and satisfactions, human always concern about the ease in usability of the software application so that it can be easily understood and navigated. Since many software developers still focus on the quantity of contents instead of the quality of the interface from the user's point of view, it is important to address human factors need in the early stage of the design and to continue addressing them during the entire stages of the software design for the persistent support of usability. In this paper, we propose the Modified Prototype Model (MPM), which helps the software designers and developers to design user-friendly software systems with easy-to-navigate interfaces by uncovering human factors in a convenient way. Moreover, we propose methods that assist to identify more human factors regarding software design. In this paper, we also study the implications of the proposed model and the proposed methods.

• BMB Reports
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• v.49 no.1
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• pp.11-17
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• 2016

The gastrointestinal tract forms the largest surface in our body with constantly being exposed to various antigens, which provides unique microenvironment for the immune system in the intestine. Accordingly, the gut epithelium harbors the most T lymphocytes in the body as intraepithelial lymphocytes (IELs), which are phenotypically and functionally heterogeneous populations, distinct from the conventional mature T cells in the periphery. IELs arise either from pre-committed thymic precursors (natural IELs) or from conventional CD4 or CD8αβ T cells in response to peripheral antigens (induced IELs), both of which commonly express CD8α homodimers (CD8αα). Although lineage commitment to either conventional CD4 T helper (Th) or cytotoxic CD8αβ T cells as well as their respective co-receptor expression are mutually exclusive and irreversible process, CD4 T cells can be redirected to the CD8 IELs with high cytolytic activity upon migration to the gut epithelium. Recent reports show that master transcription factors for CD4 and CD8 T cells, ThPOK (Th-inducing BTB/POZ-Kruppel-like factor) and Runx3 (Runt related transcription factor 3), respectively, are the key regulators for re-programming of CD4 T cells to CD8 lineage in the intestinal epithelium. This review will focus on the unique differentiation process of IELs, particularly lineage re-commitment of CD4 IELs. [BMB Reports 2016; 49(1): 11-17]