• 약학회지
• /
• 제44권3호
• /
• pp.245-250
• /
• 2000

Because nonsteroidal anti-inflammatory drugs are reported to cause fluid retention and hypertension by inhibition of prostaglandin synthesis, the effects of piroxicam on pharmacodynamics and pharmacokinetics of nifedipine were studied in male spontaneously hypertensive rats. They received nifedipine (0.5 mg/kg) alone or combined with piroxicam (5 mg/kg) intravenously. Plasma levels norepinephrine, an index of sympathetic stimulation, were measured prior to each treatment and 5 min after drug administration. Changes in blood pressure were examined serially and blood samples for analysis of nifedipine were also taken for 6 hr following drug administration. Plasma nifedipine concentration were assayed by HPLC and pharmacokinetic parameters were calculated. Blood pressure was reduced (p<0.01), but plasma norepinephrine level was increased (p<0.05) by nifedipine administration. Anti-hypertensive effect of nifedipine was potentiated (p<0.05) by piroxicam coadministration, but effect of nifedipine on plasma norepinephrine level was not affected. In case of rats received nifedipine and piroxicam, plasma nifedipine concentrations were higher (p<0.05) than those from rats received nifedipine alone at 2,3,4,5 and 6 hours following drug administration. The area under the plasma concentration vs. time curve was increased (p<0.05), while the elimination rate constant was decreased (p<0.01) by piroxicam coadministration. No significant differences were observed in the plasma clearance, apparent volume of distribution and elimination half-life. Thus, piroxicam not only potentiated antihypertensive effect of nifedipine, but also altered nifedipine pharmacokinetics in the rats. It is concluded that the potentiation of nifedipine antihypertensive effect might correlate with the increment of its plasma concentration by piroxicam coadministration.

• 사상체질의학회지
• /
• 제19권2호
• /
• pp.73-81
• /
• 2007

1. Objectives This study was to investigate correlation between the diagnosis of Sasang Constitutional Medicine(SCM) and the differentiation of syndromes according to the state of Qi, Blood, Body Fluid, Phlegm retention and the five viscera in storke inpatients. 2. Methods Stroke inpatients were investigated through questionaire of differentiation of syndromes and QSCC2. The results were analyzed statistically by one-way ANOVA on SPSS 12. 3. Results and Conclusions 1) Soeumin had a high grade on Qi-insufficiency than other consititutions. 2) Soyangin had a low grade on Qi-insufficiency, spleen disease than other consititutions. 3) There were not significant results in the investigation item of the sweating, constipation, diarrhea, anorexia, abdominal pain among the constitutions.

• 한국물환경학회지
• /
• 제22권1호
• /
• pp.30-36
• /
• 2006

This study was carried out to evaluate the performance of Modified Ludzsck Etinger (MLE) process with waste oyster shell media in aerobic tank. Influent flow was 36 L/d and the order of reactor was anoxic, aerobic and sedimentation tank and unit hydraulic retention time was 2 hr, 6 hr and 4 hr, respectively. Sludge recycling rate in sedimentation tank and internal recycling rate were 100%. Media fill rate in aerobic tank was 5%, 10% and 17% and fluid MLSS concentration in aerobic tank was 3000~4000 mg/L. Average TCOD removal rate was 91~93%, TBOD 92~96%, SS 95~96% and when media fill rate was 10% or more, in organic compound removal it could satisfy with wastewater discharge standard. Average total nitrogen removal rate was 70~76% and average total phosphorous removal rate was 58~65%. With media fill rate increasing, total phosphorous average removal rate also increased. For it was that released calcium ion from waste oyster shell reacted with soluble phosphorous. From these experiment results, the MLE process using waste oyster shell as media is a practical method for advanced sewage treatment in rural area.

• 대한한의진단학회지
• /
• 제17권3호
• /
• pp.203-214
• /
• 2013

Objectives Yusanghan(類傷寒) means disease which chills and fever manifest like Cold damage(傷寒) but not Cold damage. However, study on Yussanghan is insignificant. The purpose of this study is to examine the origin and development process of Yusanghan. Methods: 1. Terms and disease related with Yusanghan was collected from books covering Cold damage of all time and analyzed. 2. The transition history was researched by analyzing collected terms. 3. Total appearance frequency of all time by collected disease was researched. Results: Yusanghan was appeared in Hwalinseo(活人書), which Ju Geong(朱肱) of the Song Dynasty wrote, for the first time and the definition and type were established. For the types of those, there are four diseases such as Phlegm-Fluid Retention(痰飮), Food Accumulation(食積), Vexation of Deficiency Type(虛煩), Beriberi(脚氣). Since then, the theory about Yusanghan had developed and the number of types had also increased until the Myung Dynasty. Conclusions: In early days, External Contraction Diseases(外感病) was not included in Yusanghan, but since the late Myung Dynasty, there were a lot of doctors who included External Contraction Diseases in Yusanghan, not in Cold damage. There are Summerheat Stroke, Wind-Dampness(風濕), and Warm Disease(溫病) etc. for included External Contraction Diseases. Because of this, the number of types of Yusanhan had significantly increased.

• 한국임상수의학회지
• /
• 제34권2호
• /
• pp.90-93
• /
• 2017

A nine-month-old intact female Maltese dog (body weight: 1.5 kg) presented with frequent syncopal episodes (1-2/day), exercise intolerance, and dyspnea. Cardiomegaly with marked dilation of right and left atria along with ascites was indicated on radiography. Tricuspid regurgitant jets (4.36 m/s), pulmonary regurgitant jets (3.4 m/s), left-to-right shunting flow at the ductus arteriosus, and an atrial septal defect were observed on echocardiography. A bubble study with agitated saline found right-to-left shunting at the interatrial septum. Based on diagnostic studies, the dog was diagnosed with right-to-left atrial septum defect (ASD) compounded with patent ductus arteriosus (PDA). The treatment was directed to reduce the pulmonary hypertension, improve cardiac performance, and lower fluid retention. Despite medical treatment for 2 months, the dog died of sudden cardiac arrest. Herein, we describe a very rare case of right-to-left ASD compounded with PDA.

• Journal of Medicine and Life Science
• /
• 제16권1호
• /
• pp.17-22
• /
• 2019

Epstein-Barr virus(EBV) infection is common and usually asymptomatic in young infants and children. However, EBV infections in transplant recipients and other immunosuppressed patients can be fatal. EBV-related neurological complications in immunocompetent adults are extremely rare and self-limited. Acute disseminated encephalomyelitis(ADEM) may also follow EBV infection; ADEM is characterized by abrupt onset and rapid progression. We report an immunocompetent adult patient who developed diffuse meningoencephalitis with ADEM-like features caused by EBV infection. A 35-year-old Vietnamese woman was admitted presenting with urinary retention, altered mental status, and paraplegia. PCR of the patient's cerebrospinal fluid showed positive results for EBV. Brain and spine magnetic resonance imaging showed ADEM-like features. She was treated with acyclovir, steroid, and immunoglobulins. We report the case of an immunocompetent adult Vietnamese woman who presented with rapidly progressive diffuse meningoencephalitis associated with EBV infection and was treated with antivirals, corticosteroids, and immunoglobulins.

• Nuclear Engineering and Technology
• /
• 제54권4호
• /
• pp.1343-1354
• /
• 2022

Experiments were performed to measure the critical heat flux (CHF) on a vertical surface abutting a coarse packed bed of spherical particles. This geometry is representative of a CANDU reactor calandria tubesheet facing the end shield cavity during the in-vessel retention (IVR) phase of a severe accident. Deionized light water was used as the working fluid. Low carbon steel shielding balls with diameters ranging from 6.4 to 12.7 mm were used, allowing for the development of an empirical correlation of CHF as a function of shielding ball diameter. Previously published data is used to develop a more comprehensive empirical correlation accounting for the impacts of both shielding ball diameter and heating surface height. Tests using borosilicate shielding balls demonstrated that the dependence of CHF on shielding ball thermal conductivity is insignificant. The deposition of iron oxide particles transported from shielding balls to the heating surface is verified to increase CHF non-trivially. The results presented in this paper improve the state of the knowledge base permitting quantitative prediction of CHF in the CANDU end shield, refining our ability to assess the feasibility of IVR. The findings clarify the mechanisms governing CHF in this scenario, permitting identification of potential future research directions.

• Nuclear Engineering and Technology
• /
• 제54권1호
• /
• pp.72-83
• /
• 2022

This paper presents a numerical investigation of two-phase natural circulation flows established when external reactor vessel cooling is applied to a severe accident of the APR1400 reactor for the in-vessel retention of the core melt. The coolability limit due to external reactor vessel cooling is associated with the natural circulation flow rate around the lower head of the reactor vessel. For an elaborate prediction of the natural circulation flow rate using a thermal-hydraulic system code, MARS-KS1.5, a three-dimensional computational fluid dynamics (CFD) simulation is conducted to estimate the flow rate and pressure distribution of a liquid-state coolant at the brink of significant void generation. The CFD calculation results are used to determine the loss coefficient at major flow junctions, where substantial pressure losses are expected, in the nodalization scheme of the MARS-KS code such that the single-phase flow rate is the same as that predicted via CFD simulations. Subsequently, the MARS-KS analysis is performed for the two-phase natural circulation regime, and the transient behavior of the main thermal-hydraulic variables is investigated.

• Imaging Science in Dentistry
• /
• 제52권3호
• /
• pp.327-332
• /
• 2022

Mucocele of the paranasal sinuses is a benign, slow-growing, expansile lesion. Maxillary sinus mucoceles are usually associated with painless bulging of the cheek; however, orbital expansion is rarely observed. Maxillary sinus mucoceles can be classified as primary or secondary according to their etiology. An impediment to sinus ostium ventilation is thought to be the cause of primary mucocele, while sequestering of residual mucosa after surgery in the wound and long-term retention of tissue fluid have been suggested to lead to the formation of secondary mucocele. This report presents 2 cases of primary and secondary mucoceles, with a focus on radiographic features. As primary and superiorly positioned secondary maxillary sinus mucoceles are uncommon and their close proximity to the orbit predisposes the patient to significant morbidity, the authors expect that this report will contribute to a better understanding and diagnosis of maxillary sinus mucocele involving the orbit.

• 동의생리병리학회지
• /
• 제24권5호
• /
• pp.727-736
• /
• 2010

This study is about researching mechanistic pattern identification of disease for DongEuiBoGam NaeGyungPyen by analysing with pattern identification of modern Traditional Korean medical patholgy as more logical, systematic and standardized theory. Disease pattern mechanisms of uterine, urine and excrements parts of DongEuiBoGam NaeGyun gPyen in NaeGyungPyen of DongEuiBoGam are these. Menstrual irregularities in DongEuiBoGam can be classified flui d-humor depletion, blood deficiency, qi deficiency, qi stagnation, qi stagnation complicated by heat, blood stasis, blood deficiency complicated by heat, syndrome of heat entering blood chamber, syndrome of cold entering blood chamber. The disease pattern of abdominal pain after menstruation in DongEuiBoGam is blood deficiency complicated by heat, and a dysmenorrhea represents blood stasis with heat, fluid-humor deficiency. Advanced menstruation represent dual heat of the qi and blood, delayed menstruation is blood deficiency. The disease pattern of inhibited urination in DongEuiBoGam can be classified deficiency heat pattern of kidney yin deficiency(yin deficiency with effulgent fire), kidney qi deficiency, yin deficiency with yang hyperactivity, fluid-humor depletion, spleen-stomach dual deficiency, and excess he at pattern of bladder excess heat. The disease pattern of urinary incontinence in DongEuiBoGam can be classified deficiency pattern of kidney-bladder qi deficiency, consumptive disease, lung qi deficiency, kidney yin deficiency(yin deficiency with effulgent fire), kidney yang deficiency and excess pattern of lower energizer blood amassment, bladder excess heat. And most of them are deficiency from deficiency-excess Pattern Identification. The disease pattern of diarrhea in DongEuiBoGam can be classified deficiency pattern of qi deficiency, qi fall, spleen yang deficiency, kidney yang deficiency and so on and excess pattern of wind-cold-summerheat-dampness-fire, phlegm-fluid retention, dietary irregularities, qi movement stagnation. And most of them are deficiency from deficiency-excess Pattern Identification. Like these, this study identify pattern of disease in DongEuiBoGam by mechanism of disease theory.