• Journal of Chest Surgery
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• v.18 no.4
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• pp.537-541
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• 1985

Recently, we met a 12 year old female patient who suffered from bacterial endocarditis and pericarditis which were complicated by patent ductus arteriosus. She was admitted to our hospital because of dyspnea, fever, headache, and generalized ache for 10 days. The initial diagnosis was bacterial endocarditis and pericarditis complicated by patent ductus arteriosus and congestive heart failure. At first, we tried to treat the patient medically with digitalis, diuretics, and massive antibiotics. On echocardiography large amount of pericardial fluid was accumulated mainly right anterior aspect and also noted a large vegetation at pulmonary valve area. With vigorous medical treatment including repeated pericardiocentesis, the patient showed no improvement. So we decided to perform pericardiectomy for elimination of the most probable septic focus. On operation, we encountered an unpredicted event, the pericardium was thickened, distended, and its surface showed pulsating which meant connecting to systemic circulation. We decided to close the operative wound and reoperate her under cardiopulmonary bypass later. On the next day, we operated her under cardiopulmonary bypass later. On the next day we operated her under cardiopulmonary bypass. The operative findings were ruptured main pulmonary artery about 1.5cm in diameter on its ventral portion, the blood from the ruptured main pulmonary artery was filled up the localized pericardial sac due to previous pericarditis. Through the ruptured main pulmonary artery, we also found 0.5cm diametered patent ductus arteriosus. With the aid of partial cardiopulmonary bypass and inserting 24F ballooned Foley catheter at aorta, pericardiectomy was performed first. After completion of the pericardiectomy, total cardiopulmonary bypass was established. With minimum pump flow [0.3L/min/m2] the PDA was closed with two Teflon-felted 4-0 Prolene interrupted sutures. The ruptured main pulmonary artery was also closed using thickened pericardium with three Teflon-felted 4-0 Prolene interrupted sutures. The operation was successful and postoperative course was uneventful. She was discharged on the 16th POD. We report this case as a very rare secondary complication of bacterial endocarditis complicated by patent ductus arteriosus.

• Journal of Ship and Ocean Technology
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• v.12 no.3
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• pp.36-54
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• 2008

A jet stream applied tangential to a curved surface in fluid increases lift force by strengthening circulation around the surface and this phenomenon is known as the Coanda effect. Many experimental and numerical studies have been performed on the Coanda effect and the results found to be useful in various fields of aerodynamics. Recently, preliminary studies on Coanda control surface are in progress to look for practical application in marine hydrodynamics since various control surfaces are used to control behaviors of ships and offshore structures. In the present study, the performance of a Coanda control surface with different geometries of the jet injection nozzle was surveyed to assess applicability to ship rudders. A numerical simulation was carried out to study flow characteristics around a section of a horn type rudder subjected to a tangential jet stream. The RANS equations, discretized by a cell-centered finite volume method were used for this computation after verification by comparing to the experimental data available. Special attentions have been given to the sensitivity of the lift performance of a Coanda rudder to the location of the slit (outlet) and intake of the gap between the horn and rudder surface at the various angles of attack. It is found that the location of the water intake is important in enhancing the lift because the gap functions as a conduit of nozzle generating a jet sheet on the rudder surface.

• Steel and Composite Structures
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• v.31 no.6
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• pp.575-589
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• 2019

The main focus of this study is to numerically investigate the influence of strong earthquake and tsunami-induced wave impact on the response and behavior of a cable-stayed steel bridge with large caisson foundations, by assuming that the earthquake and the tsunami come from the same fault motion. For this purpose, a series of numerical simulations were carried out. First of all, the tsunami-induced flow speed, direction and tsunami height were determined by conducting a two-dimensional (2D) tsunami propagation analysis in a large area, and then these parameters obtained from tsunami propagation analysis were employed in a detailed three-dimensional (3D) fluid analysis to obtain tsunami-induced wave impact force. Furthermore, a fiber model, which is commonly used in the seismic analysis of steel bridge structures, was adopted considering material and geometric nonlinearity. The residual stresses induced by the earthquake were applied into the numerical model during the following finite element analysis as the initial stress state, in which the acquired tsunami forces were input to a whole bridge system. Based on the analytical results, it can be seen that the foundation sliding was not observed although the caisson foundation came floating slightly, and the damage arising during the earthquake did not expand when the tsunami-induced wave impact is applied to the steel bridge. It is concluded that the influence of tsunami-induced wave force is relatively small for such steel bridge with large caisson foundations. Besides, a numerical procedure is proposed for quantitatively estimating the accumulative damage induced by the earthquake and the tsunami in the whole bridge system with large caisson foundations.

• Journal of Energy Engineering
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• v.27 no.4
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• pp.70-79
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• 2018

A heat pump system using the thermal effluent from the Jeju thermal power plant of KOMIPO was constructed with the capacity of 300 RT to supply cool or hot water to greenhouse facilities located 3 km from the power station. The way of transporting heat from the thermal effluent to greenhouses at a long distance was optimized, and a monitoring system to measure the water temperature and detect a leakage in a pipe conduit was also installed. This paper presents the system configuration of the constructed heat pump system for air conditioning and heating of greenhouse facilities in Jeju, and the characteristics of major components deployed in the system. The preoperational tests of the heat pump system were conducted during the summer season in 2018 for evaluation of its cooling performance. The operational stability and cooling performance of the heat pump system were confirmed by investigating the measured fluid temperature and flow rate, and COP of the heat pump in a cooling mode.

• Wind and Structures
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• v.16 no.1
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• pp.1-23
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• 2013

The wind-induced transient response of internal pressure following the creation of a sudden dominant opening during the occurrence of high external pressure, in low-rise residential and industrial buildings was numerically investigated. The values of the ill-defined parameters namely the flow contraction coefficient, loss coefficient and the effective slug length were calibrated by matching the analytical response with the computational fluid dynamics predictions. The effect of a sudden i.e., "instantaneously created" windward opening in the Texas Technical University (TTU) test building envelope was studied for two different envelope flexibility-leakage combinations namely: (1) a quasi-statically flexible and non-porous envelope and (2) a quasi-statically flexible and porous envelope. The responses forced by creating the openings at different time leads/lags with respect to the occurrence of the peak external pressure showed that for cases where the openings are created in close temporal proximity to the peak pressure, the transient overshoot values of internal pressure could be higher than the peak values of internal pressure in the pre-sequent or subsequent resonant response. In addition, the influence of time taken for opening creation on the level of overshoot was also investigated for the TTU building for the two different envelope characteristics. Non-dimensional overshoot factors are presented for a variety of cavity volume-opening area combinations for (1) buildings with rigid/quasi-statically flexible non-porous envelope, and (2) buildings with rigid/quasi-statically flexible and porous envelope (representing most low rise residential and industrial buildings). While the factors appear slightly on the high side due to conservative assumptions made in the analysis, a careful consideration regarding the implication of the timing and magnitude of such overshoots during strong gusts, in relation to the steady state internal pressure response in cyclonic regions, is warranted.

• Particle and aerosol research
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• v.10 no.2
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• pp.83-91
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• 2014

Since airborne bacteria have been known to aggravate indoor air quality, studies on reducing bacteria particles increase recently. In this study, a chamber(0.8m x 0.8m x 1.56m) system was built in order to simulate real conditions for reducing airborne bacteria, and evaluated by a simple aerosol reduction test. A method utilizing CFD(Computational Fluid Dynamics) simulation was used to detect the horizontal cross-sectional area which represents particle distribution in the chamber. Then an air-cleaner with HEPA filter and Carbon Fiber Ionizer was located on that area for aerosol reduction test. The CFD result found the area was located at 0.2m height from the bottom of the chamber, and the test showed aerosol reduction efficiencies using measurements of number concentration and CFU(colony forming unit) per each case. At the measurement of number concentration, the reduction efficiency of air-cleaner with filter and ionizer(Case 3) was about 90% after 4 minutes from the stop of the bacteria injection, and that with only filter(Case 2) was about 90% after 8 minutes from the beginning. Lastly, that without filter and ionizer(Case 1) was about 30% after 10 minutes. At the measurement of CFU, it shows similar results but it is related to viability of bio-aerosol.

• 제어로봇시스템학회:학술대회논문집
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• 2004.08a
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• pp.243-247
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• 2004

The dynamometers which had made in a long time ago could not control the input/output quantity of water minutely and was sensitive to a noise since it was controlled by an analog control method. Therefore, a fully digital controlled system was urgently required to be robust against various noises. In this paper, the new system which can control the amount of circulated water in dynamometer was developed. This system is consisted of an industrial digital type controller and a servo motor. The industrial PLC was used as a main controller for the developed system, and the actuator and servo motor were used to control the inlet and outlet valve independently. The torque signal of load cell was fed back to the main controller to regulate the diesel engines load. Generally, an input/output valve position of the old dynamometer was fixed with a proper situation for an engine output test and the torque was changed according to the time interval. However, the torque value for the dynamometer could not be constantly kept because of the variation of the input water flow and fluid characteristic. Therefore, the automatic control of an inlet and outlet valve should be performed to keep the constant torque. So, the PID control method was applied to solve this problem. Also, the development of a web-based remote control system was described in this paper. This software will give us the convenience of operation, the more efficient operations, and the reduced operator workload for operation of the dynamometer. The application results of the system have been verified at actual diesel engine field.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.6973-6979
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• 2015

Background: Ovarian cancer is the third most common cause of cancer in Indian women. Despite an initial 70-80% response rate, most patients relapse within 1-2 years and develop chemoresistance. Hence, identification or repositioning of drugs to resensitise ovarian cancer cells to existing chemotherapy is needed. Traditionally immortalized cell lines have been used in research, but these may contain genetic aberrations and chromosomal abnormalities serving as poor indicators of normal cell phenotype and progression of early-stage disease. The use of primary cells, maintained for only short periods of time in vitro, may serve as the best representative for studying in vivo conditions of the tissues from which they are derived. In this study we have attempted to evaluate the effect of metformin (an antidiabetic drug) in primary ovarian cancer cells because of its promising effect in other solid tumours. Materials and Methods: Primary cultures of epithelial ovarian cancer cells established from ascitic fluid of untreated ovarian cancer patients were used. The cells were treated with metformin at doses standardized by MTT assay and its ability to induce apoptosis was studied. The cells were analysed for apoptosis and apoptosis related proteins by flow cytometry and western blotting respectively. Results: Metformin induced apoptosis in ovarian cancer cells, provoking cell cycle arrest in the G0/G1 and S phase. It induced apoptosis in ovarian cancer cells by, down-regulating Bcl-2 and up-regulating Bax expression. Conclusions: Metformin was able to induce apoptosis in primary ovarian cancer cells by modulating the expression of Bcl-2 family proteins. These data are relevant to ongoing translational research efforts exploring the chemotherapeutic potential of metformin.

• Journal of Hydrogen and New Energy
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• v.31 no.4
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• pp.387-394
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• 2020

A parametric study of a 2.5 kW class propeller type micro hydraulic turbine was performed. In order to analyze the internal flow characteristics in the hydraulic turbine, three dimensional Reynolds-averaged Navier-Stokes equations with shear stress transport turbulence model were used and the hexahedral grid system was used to construct computational domain. To secure the reliability of the numerical analysis, the grid dependency test was performed using the grid convergence index method based on the Richardson extrapolation, and the grid dependency was removed when about 1.7 million nodes were used. For the parametric study, the axial distance at shroud span (L) between the inlet guide vane and the runner, and the inlet and outlet blade angles (β₁, β₂) of the runner were selected as the geometric parameters. The inlet and outlet angles of the runner were defined in the 3 spans from the hub to tip, and a total of 7 geometric parameters were investigated. It was confirmed that the outlet angles of the runner had the most sensitive effect on the power and efficiency of the micro hydraulic turbine.

• Journal of Advanced Marine Engineering and Technology
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• v.41 no.1
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• pp.36-43
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• 2017

The results of a numerical study on the performance of a propeller operating near a free surface are presented in this paper. The simulations are verified through comparison with experimental data, which was performed in a circulating water channel. The propeller performance as a function of the submerged depth was investigated. The effect of the propeller advance ratio on the wave patterns, flow structures around propeller, and thrust and torque of the propeller was also studied. Air ventilation was not observed for low advance coefficients. However, the simulations showed that wave pattern was strongly related to the tip vortex strength and inflow velocity. When air ventilation does not occur, the deduction of propeller thrust and torque increase for high advance coefficients.