• BMB Reports
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• v.46 no.2
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• pp.73-79
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• 2013

Polycystic kidney disease (PKD) is a common hereditary disorder which is characterized by fluid-filled cysts in the kidney. Mutation in either PKD1, encoding polycystin-1 (PC1), or PKD2, encoding polycystin-2 (PC2), are causative genes of PKD. Recent studies indicate that renal cilia, known as mechanosensors, detecting flow stimulation through renal tubules, have a critical function in maintaining homeostasis of renal epithelial cells. Because most proteins related to PKD are localized to renal cilia or have a function in ciliogenesis. PC1/PC2 heterodimer is localized to the cilia, playing a role in calcium channels. Also, disruptions of ciliary proteins, except for PC1 and PC2, could be involved in the induction of polycystic kidney disease. Based on these findings, various PKD mice models were produced to understand the roles of primary cilia defects in renal cyst formation. In this review, we will describe the general role of cilia in renal epithelial cells, and the relationship between ciliary defects and PKD. We also discuss mouse models of PKD related to ciliary defects based on recent studies.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.31 no.3
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• pp.1-7
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• 2003

In the study, aeroelastic behaviors and aerodynamic performances of flexible airfoil in low Reynolds number environment are evaluated. To facilitate the present study, flexible airfoil in modeled through attaching massless membrane in portion of the upper CLARK-Y airfoil surface, which is often proposed low Reynolds number airfoil. The behavior of membrane in governed by aerodynamic forces and membrane equilibrium equation. Nondimensional parameter deducted by nondimensionalizing the membrane equilibrium equation, which represents the interaction between fluid and membrane has a great influence on membrane aeroelastic behavior. Changing the starting point of the membrane is conducted on aerodynamic performances. As a result, the value of nondimensional parameter should almost linearly increase according to moving the starting point of the membrane surface toward the trailing edge.

• Journal of the Korean Society of Tobacco Science
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• v.27 no.2
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• pp.163-170
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• 2005

A theoretical model for predicting the capability curve of cellulose acetate filter is derived. The pressure drop is expressed as a function of the filter dimensions, the tow fiber characteristics, the filter weight, the fluid flow rate, and a filter fiber factor. Where, the filter fiber factor is affected by the distribution of the tow fibers within the filter, the relative orientations of the tow fibers, and their cross-sectional shapes. The minimum and maximum fraction of solids in capability curves determined from experimental data. Also, the filter fiber factor is expressed as a function of the filter length, tow fiber length, and tow fiber diameter. Capability curves predicted by the suggested model in this work correspond well with capability curves by experimental data.

• International Journal of Aeronautical and Space Sciences
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• v.2 no.2
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• pp.65-72
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• 2001

This paper demonstrates an explicit-implicit, finite element analysis for linear as well as nonlinear hygrothermal stress problems. Additional features, such as moisture diffusion equation, crack element and virtual crack extension(VCE) method for evaluating J-integral are implemented in this program. The Linear Elastic Fracture Mechanics(LEFM) Theory is employed to estimate the crack driving force under the transient condition for an existing crack. Pores in materials are assumed to be saturated with moisture in the liquid form at the room temperature, which may vaporize as the temperature increases. The vaporization effects on the crack driving force are also studied. The ideal gas equation is employed to estimate the thermodynamic pressure due to vaporization at each time step after solving basic nodal values. A set of field equations governing the time dependent response of porous media are derived from balance laws based on the mixture theory. Darcy's law is assumed for the fluid flow through the porous media. Perzyna's viscoplastic model incorporating the Von-Mises yield criterion are implemented. The Green-Naghdi stress rate is used for the invariant of stress tensor under superposed rigid body motion. Isotropic elements are used for the spatial discretization and an iterative scheme based on the full Newton-Raphson method is used for solving the nonlinear governing equations.

• 유체기계공업학회:학술대회논문집
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• 2004.12a
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• pp.208-216
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• 2004

The waterhammer occured when the pumps are started or stopped for the operation or tripped due to the power failure, the hydraulic transients occur as a result of the sudden change in velocity. The field tests of the waterhammer were carried out for PanGyo booster pumping station. The PanGyo pumuing station was installed booster pump of 6 sets and in-line pump of 2 sets. The main surge suppression device was equipped with the pump control valve and the surge relief valve as auxiliary. However, the pump control valve had not early controlled in the planned closing mode, and the slamming occurred to the valve of which abruptly closed during the large reverse flow. Because the pressure wave caused by the pump failure was superposed on the slam surge, the upsurge increased so extremely that the shaft of the valve was damaged. After the addition surge suppression device was equipped with air chamber. Further more in-line pump is needed surge suppression device that the pumping station acquired the safety and reliability for the pressure surge.

• Special Issue of the Society of Naval Architects of Korea
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• 2005.06a
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• pp.22-30
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• 2005

Sloshing loads, produced by the violent liquid free-surface motions inside the cargo tank have become an important design parameter in ship building industry since there have been demands for the increased sizes of the cargo containment system of LNG carriers. In this study, sloshing impact pressure acting on the shell of the spherical cargo tank of an LNG carrier as well as dynamic pressure and flow behavior around the pump tower located at the center of the tank have been calculated. Comparative numerical sloshing simulations for a spherical LNG tank using 2-D LR.FLUIDS which is based on the finite difference method and 3-D MSC.DYTRAN which is capable of calculating nonlinear fluid-structure interaction have been carried out. A method of calculating sloshing-induced dynamic loads and the subsequent structural strength analysis for pump tower of a spherical LNG carrier using MSC. DYTRAN and MSC.NASTRAN have been presented.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.24 no.3
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• pp.247-255
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• 2012

Numerical calculations are carried out for the natural convection in a square enclosure with two hot cylinders induced by temperature difference between a cold outer rectangular cylinder and two hot circular cylinders. A two-dimensional solution for unsteady natural convection is obtained, using the immersed boundary method (IBM) to model two inner circular cylinders based on finite volume method, for different Rayleigh numbers varying over the range of $10^3$ to $10^5$. The study goes further to investigate the effect of the location of two cylinders on the heat transfer and fluid flow. The location of inner circular cylinders is changed vertically along the center-line of square enclosure. The changes of heat transfer quantities have been presented.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.28 no.7
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• pp.879-886
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• 2004

A numerical optimization has been carried out to determine the shape of the three-dimensional channel with oblique ribs attached on both walls to enhance turbulent heat transfer. The response surface based optimization is used as an optimization technique with Reynolds-averaged Navier-Stokes analysis of fluid flow and heat transfer. Shear stress transport (SST) turbulence model is used as a turbulence closure. Numerical results fur heat transfer rate show good agreements with experimental data. four dimensionless variables such as, rib pitch-to-rib height ratio, rib height-to-channel height ratio, streamwise rib distance on opposite wall to rib pitch ratio, and the attack angle of the rib are chosen as design variables. The objective function is defined as a linear combination of heat-transfer and friction-loss related coefficients with a weighting factor. D-optimal method is used to determine the training points as a means of design of experiment. Sensitivity of the objective parameters to each design variable has been analyzed. And, optimal values of the design variables have been obtained in a range of the weighting factor.

• Journal of Hydrogen and New Energy
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• v.30 no.6
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• pp.585-592
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• 2019

In this study, a flashing boiling phenomenon of pressurized water jet was numerically studied and validated against an experimental data in the literatures. The volume of fluid (VOF) technique was used to consider two-phase behavior of water, while the homogeneous relaxation model (HRM) model was used to provide the velocity of phase change. During the flashing boiling through a nozzle, a mach disk was observed near nozzle exit because of pressure drop resulting from two-phase under-expansion. The flashing jet structure, local distributions of temperature/vapor volume fraction/velocity, and position of the mach disk were examined as nozzle inlet temperature changed.

• The Journal of the Korea institute of electronic communication sciences
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• v.10 no.2
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• pp.261-266
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• 2015

Power system for renewable energy is composed of module, transform DC power into AC power inverter, control power flow and device for a charge of the grid-connected. Power system for renewable energy produce the most DC power, when this system is much insolation in summer and daytime. But if the certain temperature rises above, the essential grid-connected power inverter is take a nose dive. There, in this paper, we propose an improved reduction of heating system. In addition, selection of the most serious heat region and through analysis of temperature characteristics according to location and distance derive the optimal model.