• Journal of Environmental Impact Assessment
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• v.27 no.6
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• pp.548-561
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• 2018

The objectives of this study were to construct a three-dimensional (3D) hydrodynamic and water quality model (EFDC) for the river reach between the Daecheong dam and the Sejong weir, which are directly affected by Gap and Miho streams located in the middle of the Geum River, and to evaluate the trophic status and water quality improvement effect according to the flow control and pollutant load reduction scenarios. The EFDC model was calibrated with the field data including waterlevel, temperature and water quality collected from September, 2012 to April, 2013. The model showed a good agreement with the field data and adequately replicated the spatial and temporal variations of water surface elevation, temperature and water quality. Especially, it was confirmed that spatial distributions of nutrients and algae biomass have wide variation of transverse direction. Also, from the analysis of algal growth limiting factor, it was found that phosphorous loadings from Gap and Miho streams to Sejong weir induce eutrophication and algal bloom. The scenario of pollutant load reduction from Gap and Miho streams showed a significant effect on the improvement of water quality; 4.7~18.2% for Chl-a, 5.4~21.9% for TP at Cheongwon-1 site, and 4.2~ 17.3% for Chl-a and 4.7~19.4% for TP at Yeongi site. In addition, the eutrophication index value, identifying the tropic status of the river, was improved. Meanwhile, flow control of Daecheong Dam and Sejong weir showed little effect on the improvement of water quality; 1.5~2.4% for Chl-a, 2.5~ 3.8% for TP at Cheongwon-1 site, and 1.2~2.1% for Chl-a and 0.9~1.5% for TP at Yeongi site. Therefore, improvement of the water quality in Gap and Miho streams is essential and a prerequirement to meet the target water quality level of the study area.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.42 no.6
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• pp.815-824
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• 2022

Among the main facilities of the power plant, the circulating water used for cooling the power generation system is supplied through the Circulation Water Intake Basin (CWIB). The vortexes of various types generated in the Pump Sump (PS) of CWIB adversely affect the Circulation Water Pump (CWP) and pipelines. In particular, the free surface vortex accompanied by air intake brings about vibration, noise, cavitation etc. and these are the causes of degradation of CWP performance, damage to pipelines. Then power generation is interrupted by the causes. Therefore, it is necessary to investigate the hydraulic characteristics of CWIB through the hydraulic model experiment and apply an appropriate Anti Vortex Device (AVD) that can control the vortex to enable smooth operation of the power plant. In general, free surface vortex is controlled by Curtain Wall (CW) and the submerged vortex is by the anti vortex device of the curtain wall. The detailed specifications are described in the American National Standard for Pump Intake Design. In this study, the circulating water intake part of the Tripoli West 4×350 MW power plant in Libya was targeted, the actual operating conditions were applied, and the vortex reduction effect of the anti vortex device generated in the suction tank among the circulating water intake part was analyzed through a hydraulic model experiment. In addition, a floor splitter was basically applied to control the submerged vortex, and a new type of column curtain wall was additionally applied to control the vortex generated on the free surface to confirm the effect. As a result of analyzing the hydraulic characteristics by additionally applying the newly developed Column Curtain Wall (CCW) to the existing curtain wall, we have found that the vortex was controlled by forming a uniform flow. In addition, the vortex angle generated in the circulating water pump pipeline was 5° or less, which is the design standard of ANSI/HI 9.8, confirming the stability of the flow.

• Journal of Life Science
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• v.21 no.10
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• pp.1494-1499
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• 2011

${\beta}$-lapachone, a quinone of lapachol extracted from the bark of the lapacho tree, has been found to induce apoptosis in various human cancer cells. In the present study, we investigated further possible mechanisms by which ${\beta}$-lapachone exerts its pro-apoptotic action in cultured human lung cancer A549 cells. ${\beta}$-lapachone treatment resulted in inhibition of growth and induction of apoptosis in a concentration-dependent manner, as determined by MTT assay and flow cytometry analysis. The induction of apoptosis by ${\beta}$-lapachone was associated with up-regulation of the expression of p53 and p21 in both transcriptional and translational levels, and the phosphorylation of p53. In addition, ${\beta}$-lapachone activated caspase-3 and -9, and induced degradation of caspase-3 target proteins such as poly (ADP-ribose) polymerase (PARP) and ${\beta}$-catenin. Furthermore, ${\beta}$-lapachone treatment caused a progressive decrease in the expression levels of cyclooxygenase (COX)-2 without significant changes in the levels of COX-1, which was correlated with a decrease in prostaglandin E2 synthesis. Taken together, these results indicated that ${\beta}$-lapachone may have therapeutic potential in human lung cancer treatment.

• Journal of Korea Water Resources Association
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• v.44 no.10
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• pp.777-786
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• 2011

In the previous researches for storm sewer design, the flow path, pipe diameter and pipe slope were determined to minimize the construction cost. But in the sewer networks, the flows can be changed according to flow path. The current optimal sewer layout models have been focussed on satisfying the design inflow for sewer designs, whereas the models did not consider the occurrences of urban inundation from excessive rainfall events. However, in this research, the sewer networks are determined considering the superposition effect to reduce the inundation risk by controlling and distributing the inflows in sewer pipes. Then, urban inundation can be reduced for excessive rainfall events. An Optimal Sewer Layout Model (OSLM) was developed to control and distribute the inflows in sewer networks and reduce urban inundation. The OSLM uses GA (Genetic Algorithm) to solve the optimal problem for sewer network design and SWMM (Storm Water Management Model) to hydraulic analysis. This model was applied to Hagye basin with 44 ha. As the applied results, in the optimal sewer network, the peak outflow at outlet was reduced to 7.1% for the design rainfall event with 30 minutes rainfall duration versus that of current sewer network, and the inundation occurrence was reduced to 24.2% for the rainfall event with 20 years frequency and 1 hour duration.

• Journal of the Korean Association of Geographic Information Studies
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• v.13 no.4
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• pp.157-169
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• 2010

In this study, the applicability of SRTM(The Shuttle Radar Topography Mission) DEM(Digital Elevation Model) which is one of the remotely sensed shuttle's radar digital elevation was tested for use as the input data in a grid-based rainfall-runoff model. The SRTM DEM and digital topographic map derived DEM(TOPO DEM) were building with 500m spatial resolution for the Chungju-Dam watershed which located in the middle east of South Korea, and stream-burning method was applied to delineate the proper flow direction for model application. Similar topographical characteristics were shown as a result of comparing elevation, flow-direction, hydrological slope, number of watershed cell, and profile between SRTM DEM and TOPO DEM. Two DEMs were tested by using a grid-based rainfall-runoff model named KIMSTORM with 6 storm events. The results also showed no significant differences in average values of relative error for both peak runoff(0.91 %) and total runoff volume(0.29 %). The results showed that the SRTM DEM has applicability like TOPO DEM for use in a grid-based rainfall-runoff modeling.

• Tuberculosis and Respiratory Diseases
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• v.56 no.5
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• pp.450-464
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• 2004

Background : The FHIT (fragile histidine triad) gene is a frequent target of deletions associated with abnormal RNA and protein expression in lung cancer. Previous studies have shown FHIT gene transfer into lung cancer cell line lacking FHIT protein expression resulted in inhibition of tumor cell growth attributable to the induction of apoptosis and reversion of tumorigenecity. However, the mechanism of the tumor suppressor activity of the FHIT gene and the cellular pathways associated with its function are not completely understood. Methods : To gain insight into the biological function of FHIT, we compared the NCI-H358 cell line with its stable FHIT transfectants after treatment with cisplatin or paclitaxel. We investigated the effects of FHIT gene expression on cell proliferation, apoptosis, and activation of caspase system and Bcl-2 family. The induction of apoptosis was evaluated by using DAPI staining and flow cytometry. Activation of caspases and Bcl-2 members was evaluated by Western blot analysis. Results : A significantly increased cell death was observed in FHIT transfectants after cisplatin or paclitaxel treatment and this was attributable to the induction of apoptosis. Remarkable changes in caspases and Bcl-2 family were observed in the transfected cells as compared with the control cells after treatment with paclitaxel. Activation of caspase-3 and caspase-7 was markedly increased in cells expressing FHIT. Expression level of Bcl-2 and Bcl-xL protein was significantly decreased and that of Bax and Bad protein was significantly increased in the transfected cells. Conclusion : FHIT gene delivery into lung cancer cells results in enhanced apoptosis induced by treatment with cisplatin or paclitaxel. The data suggest that apoptosis in FHIT-expressing cells could be related to activation of caspase pathway and Bcl-2 family.

• Journal of Korean Society of Forest Science
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• v.103 no.3
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• pp.383-391
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• 2014

Long-term changes in the hydrological characteristics of a small forest watershed were examined using a master baseflow recession curve and the measured rainfall-runoff data from the experimental forest watershed in the measured years 2003-2011. The results of the study showed that the recession coefficient of direct runoff was lower than that of baseflow. In small forested watershed, the direct flow was lower than that of large scale watershed, flow due to its shorter period of occurrence. And baseflow was similar to large scale watershed's. A regression equation $y=0.7528e^{-0.022x}$($R^2=0.8938$, range 0.3~0.8 mm) was obtained using the master baseflow recession curve for the study period and the recession coefficient was calculated as K = 0.978. Changes between master baseflow recession curve and runoff showed great association and relevance such as increasing runoff was associated with the gentle slope of master baseflow recession curve and decreasing runoff was associated with the slope of master baseflow recession curve contrary. In the later years of the study period, the slope of the master baseflow recession curve appreciably became more gentle due to increases in baseflow. This suggests that the forested experimental watershed exhibit improved structural functioning of normal flood control and reduced occurrence of water shortage problems.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.39 no.9
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• pp.751-759
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• 2015

In this study, we investigate the Characteristics of the flowfields of a circular cylinder having a small triangular prism at the upstream side. We measure the fluid force on the circular cylinder and obtain a visualization of the flow fields using particle image velocimetry (PIV). The experimental parameters employed were the width ratios (H/B = 0.2~0.6) of the triangular prisms to the circular cylinder's diameter, and the gap ratios (G/B = 0~3) between the circular cylinder and the triangular prism. We observed that the drag reduction rate and Strouhal number of the circular cylinder increased and then decreased with G/B in the case of the same H/B. The drag reduction rate increased with H/B in the case of the same G/B. In the case where the circular cylinder had a small triangular prism, the stagnation regions were represented in the upstream and downstream sides of the circular cylinder.

• Tunnel and Underground Space
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• v.22 no.3
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• pp.173-180
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• 2012

In this study, diagonal ventilation circuits that are advantageous in air flow direction control were studied. Based on the results of the study, it could be seen that air volumes in diagonal ventilation circuits could also be calculated using numerical formulas or programs if the air volumes and air flow directions to be infused into diagonal branches are determined in advance as with other serial/parallel circuits. To apply the results, design plans for high level radioactive waste repositories applied with diagonal ventilation circuits and parallel ventilation circuits. To compared the each design plans and obtain expected operation results, ventilation network simulations were conducted through the Ventsim program which is a ventilation networking program. Based on the results, in the case of diagonal repositories that was expected to cause great increases in resistance, fan pressure was 1570 pa, total flux was 84 $m^3/s$, fan efficiency was 76.4%, fan power consumption was 181.2 kW and annual fan operating costs were 178,710,838 and thus maximum around 8% differences were shown in pressure and flux values and a difference of around 1.5% was shown in terms of operating costs.

• Journal of Soil and Groundwater Environment
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• v.13 no.6
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• pp.93-102
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• 2008

Experimental studies were conducted to characterize the synthesized nanoscale zero-valent iron (NZVI) which is resistant to oxidation in the atmospheric environment. XRD, XPS, and TEM analyses revealed that the oxidation-resistant NZVI particles formed under various controlled air contact conditions (4, 8 and 12 mL/min) have shells with ${\sim}$5 nm thickness. The shells consist of magnetite (${Fe_3}{O_4}$) and maghemite (${\gamma}-{Fe_2}{O_3}$), predominantly. No substantial differences were found in the shell components and thickness among NZVI particles formed under the various air flow rates. On the other hand, shell was not detected in the TEM image of rapidly oxidized NZVI particles. NZVI particles synthesized under the various air flow rates showed similar TCE degradation performances ($k_{obs}$= 0.111, 0.102, and 0.086 $hr^{-1}$), which are equivalent to approximately 80% of those obtained by the fresh NZVI particles. TCE degradation efficiencies of the NZVI particles(fresh, controlled air contact and rapidly oxidized) were improved after equilibrating with water for one day, indicating that depassivation of the shells occurred. The performances of NZVI particles decreased to 90% and 50% of those of the fresh NZVI particles, when they were equilibrated with the atmosphere for a week and two months, respectively. The NZVI particles synthesized under the controlled air contact would have advantages over traditional NZVI particles in terms of practical application into the site, because of their inertness toward atmospheric oxygen.