• Natural Product Sciences
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• 제24권3호
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• pp.155-158
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• 2018

A new flavonol derivative, meliglabrin (1) along with three known flavonols, ternatin (2), meliternatin (3), and 5,4'-dihydroxy-3,7,3'-trimethoxyflavon (4) were isolated from the leaves of Melicope glabra (Blume) T.G. Hartley. Their structures were determined using extensive spectroscopic methods, including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1 - 4 were evaluated for their cytotoxicity against murine leukemia P-388 cells, compound 4 showed moderate activity.

• Natural Product Sciences
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• 제8권3호
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• pp.77-82
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• 2002

An investigation of the methanolic extract of Maesa lanceolata leaves has led to the isolation of four novel flavonol glycosides characterised as myricetin 3-0-2', 3', 4'-triacetylxylopyranoside (1), quercetin $3-O-{\beta}-3'$, $6'-diacetylglucopyranosyl-(1{\longrightarrow}4)-{\alpha}-2'$, 3'-diacetylrhamnopyranoside (2), myricetin $3-O-xylopyranosyl-(1{\to}3)-{\alpha}-rhamnopyranoside$ (3) and quercetin $3-O-{\beta}-ga1actopyranosyl-(1{\to}4)-{\alpha}-rhamnopyranoside-7-O-{\beta}-galactopyranoside$ (4). Also isolated from the same extract were known flavonols; quercetin (5), myricetin (6), quercetin 3-O-xylopyranoside (7), quercetin $3-O-{\alpha}-rhamnopyranoside$ (8), myricetin $3-O-{\alpha}-rhamnopyranoside$ (9), myricetin $3-O-{\beta}-galactopyranoside$ (10) and quercetin 3-O-rutinoside (11).

• 셀메드
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• 제5권4호
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• pp.24.1-24.7
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• 2015

Bahunia racemosa family, Caesalpiniaceae, is one of the precious resources of the earth. It has played a significant role in human civilization since ancient times. It is tall sized tree growing throughout India, Ceylon, China, and Timor. The different part of this plant contains β-sitosterol and β-amyrin, flavonols (kaempferol and quercetin) and two coumarins (scopoletin and scopolin), tannins etc. Various part of this plant has great pharmacological potential with a great utility and usage as folklore medicine as analgesic, antipyretic, anti-inflammatory, antispasmodic and antimicrobial activity. This review mainly focus on the exclusive review work on the traditional, phytochemical and pharmacological activities of this plant.

• Archives of Pharmacal Research
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• 제17권4호
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• pp.236-239
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• 1994

The suppressive activity of isoflavonoids against lymphocyte proliferation in vitro was examined. Isoflabvonoid derivatives tested were isflavones isolated from Pueraia radix and synthesized 7-O-substituted biochanin A derivatives. The certain isoflavones such as biochanin A and 2-carbethoxybiochainin A were found to possess the suppressive activity against concanavaline A (Con A)-induced lymphocyte proliferation from mouse spleen. Against mixed lymphocyte culture reaction, biochanin A, 2-carbethoxybiochainin A, daidzein, formononetin, genistein and 7-O-isopropylbiochaninl A showed the suppressive activity at $10^{-5}$ M. However, all isoflavones tested did not show the suppressive activity against lymphocyte proliferation induced by B-cell mitogen, lipopolysaccharide (LPS). In general, isoflavones were revealed to be less active than flavones/flavonols.

• 한국식물생명공학회:학술대회논문집
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• 한국식물생명공학회 2005년도 추계학술대회 및 한일 식물생명공학 심포지엄
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• pp.3-8
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• 2005

Torenia hybridacv. Summerwave Blue and Violet mainly produce delphinidin. Down regulation of their flavonoid 3'-hydroxylase and flavonoid 3',5'-hydroxylase (F3'5'H) genes and over expression of rose or pelargonium dihydroflavonol 4-reductase (DFR) cDNA yielded pelargonidin-based bright pink flowers. Nierembergia cv. Fairybells lack pink color as they produced only delphinidin and flavonols. Pelargonidin-based pink flowers were achieved by down regulation of F3'5'H and flavonol synthase genes and over expressing rose DFR cDNA. Introduction of petunia F3'5'H and DFR cDNAs into white carnations deficient in DFR activity produced violet carnations, which arc now commercialized in the USA, Canada, Australia, Europe and Japan. Introduction of pansy F3'5'H and iris DFR cDNAs and down regulation of rose DFR gene produced rose flowers which accumulates delphinidin imparting novel violet color.

• Biomolecules & Therapeutics
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• 제14권1호
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• pp.36-39
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• 2006

Some flavones/flavonols were previously found to inhibit collagenase. To establish a therapeutic potential for skin inflammation, twenty-three synthetic flavone derivatives were examined for their inhibitory potential against collagenase from Clostridium histolyticum. From the results, it was found that most of them having various hydroxyl, methoxyl, methylsulfuryl and/or chloro substitution(s) on A- and B-rings were not efficient collagenase inhibitors. Among the synthetic flavones tested, only two synthetic derivatives, 3',4'-dihydroxyflavone and 5-hydroxy-4'-methoxyflavone, weakly inhibited bacterial collagenase (13-29% inhibition at 50-100 ${\mu}M$).

• Bulletin of the Korean Chemical Society
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• 제29권2호
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• pp.507-510
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• 2008

• Natural Product Sciences
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• 제4권4호
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• pp.215-220
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• 1998

A new flavonol $3,5-di-O-KSO_3$:kaempferol 7,4'-dimethyl ether $3,5-O-KSO_3$, was isolated and identified from the flowers of Tamarix amplexicaulis. The known compounds quercetin $3-mono-O-KSO_3$, kaempferol 4'-methyl ether $3-mono-O-KSO_3$, kaempferol 7,4'-dimethyl ether $3-O-KSO_3$, quercetin 7,4'-dimethyl ether $3-mono-O-KSO_3$, kaempferol 3-O-glucuronide and quercetin 3-O-glucuronide were also separated and identified. Structures were established by conventional methods, including electrophoretic analysis, and confirmed by negative FAB-MS, $^1H-\;and\;^{13}C-NMR$.

• Journal of Applied Biological Chemistry
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• 제65권3호
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• pp.129-142
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• 2022

새싹인삼은 잎부터 뿌리까지 섭취가 가능하며 스마트 팜 또는 식물공장에서 재배 시 계절에 영향을 받지 않으며 농약을 사용하지 않아도 되는 이점이 있다. 본 연구에서는 새싹인삼의 최적 재배 시기를 확인하고 영양성분과 항산화 활성을 비교 분석하였다. 생육 시기에 따른 지방산과 무기질 함량은 큰 차이를 보이지 않았다. 총 아미노산 함량은 45일까지 약간 감소하였고 이후에는 증가하였으며 생육 65일 arginine 함량은 3309.11 mg/100 g으로 가장 높게 확인되었다. 총 ginsenoside 함량은 생육기간 동안 큰 변화가 없었다(25일 29.83 mg/g→45일 32.77 mg/g→65일 26.02 mg/g). Ginsenoside Rg2 (0.62 mg/g), Re (8.69 mg/g), Rb1 (4.75 mg/g) 및 Rd (3.47 mg/g)의 함량은 생육기간 중 45일에 가장 높았다. Phenolic acids와 flavonols 함량은 생육 45일 (338.6 및 1277.14 ㎍/g)까지 증가 후 65일까지 감소하였다. Phenolic acids와 flavonols의 주요 화합물은 각각 benzoic acid (99.03-142.33 ㎍/g)와 epigallocatechin (416.03-554.64 ㎍/g)로 확인되었다. DPPH (44.27%), ABTS (75.16%)와 hydroxyl (63.29%) 라디칼 소거활성 및 FRAP 환원력(1.573 OD_573nm) 또한 총 phenolics 및 총 flavonolids 함량과 마찬가지로 생육 45일에 가장 높은 활성을 보였다.

• 한국산림과학회지
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• 제90권3호
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• pp.266-276
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• 2001

물들메나무(F. chiisanensis Nakai)의 분류학적 실체를 규명하기 위해 국내에 자생하는 4종(種)(쇠물푸레나무, 물푸레나무, 물들메나무, 들메나무)과 근연종으로 판단되는 중국, 일본의 F. platypofa Oliv.의 형태 및 flavonoids분석을 실시하였다. 물들메나무는 화서가 전년지(前年技)에 달리며 꽃잎이 없고 꽃받침이 존재하며, 나아(裸芽)(naked bud)를 가져 화서가 당년지(들에나무제외)에 달리거나 인아(鱗芽)(scaled bud)를 가지는 다른 3종(種)과 뚜렷이 구분되었다. 한편, flavonoids성분에서는 다른 3종(種)에서 flavonols와 C-glycosylflavone, flavanone 성분이 존재한 반면(물푸레나무형) 물들메나무에서는 3종류의 flavonoids 이외의 flavones성분이 확인(물들메나무형)되어 뚜렷한 종의 특성을 보였다. 따라서 물들메나무는 전북 내장산, 덕유산, 충청북도 민주지산, 전라남도 지리산, 백운산 등 전라남북도에 국한하여 분포하는 우리나라 특산종으로서 기존의 들메나무와 물푸레나무의 자연 교잡종이라는 주장보다는 독립종으로 처리하는 것이 타당하다. 특히, 형태적 특정에 의해 물들메나무는 들메나무아속(亞屬)(subgen. Fraxinus) 물들메나무절(節)(sect. Melioides)에 속하지만 중국과 일본의 물들메나무절(節)의 F. platypoda Oliv.는 인아(scaled bud)를 가지며 사과의 날개가 꽃받침까지 내려오며 화학적으로는 물푸레나무형이 확인되어 물들메나무와는 근연관계가 없고 오히려 북미대륙에 분포하는 동일 절(section)의 4종이 물들메나무에 더 가까운 것으로 생각된다.