• Title/Summary/Keyword: fine particle size

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Effect of Particle Size of HPMC on Dissolution Rate of Venlafaxine HCl and Carbamazepine Sustained Release Tablet (HPMC의 입도에 따른 염산벤라팍신 및 카바마제핀 서방성 정제의 용출 특성)

  • Cha, Jae-Uk;Cha, Ja-Hyun;Hong, Jun-Kee;Lee, Sung-Wan;Ko, Won-Hwa;Beak, Hyun-Ho
    • Polymer(Korea)
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    • v.36 no.3
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    • pp.332-337
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    • 2012
  • The primary objective of this work is to find the properties of sustained release dissolution pattern depending on solubility of drugs, so venlafaxine HCl and carbamazepine tablets were made by using polymer wich various particle size. Hydroxy propyl methyl cellulose (HPMC) has been utilized in this study as an excipient that is one of the most widely used polymers for an oral sustained release formulation, and drug release pattern was strongly influenced by swelling rate depending on particle size of HPMC. Scanning electron microscope (SEM) was employed to investigate the surface of tablets with various HPMC particle size, and differential scanning calorimeter (DSC) was employed to investigate the crystallization of drugs in tablets. The release model equation was applied to analyze the main mechanism of drug release pattern. The results demonstrate that drug release pattern is controlled by the drug solubility and HPMC particle size.

Theoretical Study on Magnetic Field Application for Fine Particle Capture

  • Huang, Shan;Park, Haewoo;Jo, Youngmin
    • Particle and aerosol research
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    • v.10 no.2
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    • pp.45-51
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    • 2014
  • Fine particle capture is facing a challenge since traditional filtration which relies on the combination of impaction, interception, diffusion has a limited efficiency for fine particle capture particularly in size from 0.1 to $0.5{\mu}m$. This paper reviewed the collection efficiency of above mechanisms, as well as magnetic mechanisms for ferromagnetic particles, and mainly studied the influencing factors of magnetic filtration. Filtration velocity, magnetic field intensity and fiber size were found to be the most important parameters for magnetic filtration.

Computer Simulation for Microstructure Development in Porous Sintered Compacts (다공질 소결체의 조직형성에 관한 컴퓨터 시뮬레이션)

  • Shin, Soon-Ki;Matsubara, Hideaki
    • Journal of the Korean Ceramic Society
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    • v.43 no.4 s.287
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    • pp.213-219
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    • 2006
  • A Monte Carlo simulation based on Potts model in a three dimensional lattice was studied to analyze and design microstructures in porous sintered compacts such as porosity, pore size, grain (particle) size and contiguity of grains. The effect of surface energy of particles and the content of additional fine particles to coarse particles on microstructure development were examined to obtain fundamentals for material design in porous materials. It has been found that the larger surface energy enhances sintering (necking) of particles and increases contiguity and surface energy does not change pore size and grain size. The addition of fine particles also enhances sintering of particles and increases contiguity, but it has an effect on increment of pore size and grain size. Such a simulation technique can give us important information or wisdom for design of porous materials, e.g., material system with high surface energy and fine particle audition are available for higher strength and larger porosity in porous sintered compacts with applications in an automobile.

Analysis of Characteristics and Removal Efficiency of Road-deposited Sediment on Highway by Road Sweeping According to Particle Size Distribution (고속도로 노면퇴적물의 특성 및 도로청소에 의한 입도별 제거효율 분석)

  • Kang, Heeman;Kim, Hwang Hee;Jeon, Ji-Hong
    • Journal of Korean Society on Water Environment
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    • v.37 no.4
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    • pp.286-295
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    • 2021
  • The removal efficiency of road-deposited sediment (SDR) by road sweeping was analyzed by performing particle size analysis before and after road sweeping at four highways during May to December 2019. The SDR accounted for the largest proportion in the range of 250 to 850 ㎛ and the degree of its proportion had an effect on the particle size distribution curve. The particle size distribution of the collected sediments showed a similar distribution at all sites. Below 75 ㎛, the removal efficiency of SDR showed a constant value around 40%, but above 75 ㎛, it increased as the particle size increased. The removal efficiency was 82-90% (average 86%) for gravel, 66-93% (average 79%) for coarse sand, 35-92% (average 64%) for fine sand, 29-69% (average 44%) for very fine sand, 19-58% (average 40%) for silt loading, 10-59% (average 40%) for TSP, 13-57% (average 40%) for PM10, and 15-61% (average 38%) for PM2.5. SDR removal efficiency showed an average of 69% for the four highways. It was found that if the amount of SDR was less than 100 g/m2, it was affected by the road surface condition and had a large regional deviation. As such, the amount of SDR and the removal efficiency increased. The fine particles, which have relatively low removal efficiency, contained a large amount of pollutants, which is an important factor in water and air pollution. Therefore, various measures to improve the removal efficiency of fine particles in SDR by road sweeping are needed.

An Analysis of Characteristics of Particulate Matter Exhausted from Diesel Locomotive Engines (디젤기관차 엔진에서 배출되는 입자의 특성분석)

  • 박덕신;김태오;김동술
    • Journal of Korean Society for Atmospheric Environment
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    • v.19 no.2
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    • pp.133-143
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    • 2003
  • Numerous evidence have been reported that fine particulate matters can play an important role in threatening human health. Recently concerns on fine particle pollution from various engines may require re-examination of particulate emission standards. The particles emitted by most diesel engines are mainly divided into their size ranges such as Dp< 50 nm and 50 nm< Dp< 1,000 nm. In this work, the number concentration and the size distribution of fine particles emitted from an exhaust manifold of a railroad diesel engine were measured under load test conditions using a scanning mobility particle sizer (SMPS). The fine particles observed were within the range of 7 to 304 nm under different load conditions with two different dilution ratios. The fine particles exhibited unique patterns showing bimodal shapes in size distribution.

The Examination of Strength Properties of Mortar with Variation of Fine Particle Size Distribution of Oyster Shell (굴 패각의 잔골재 입도분포 변화에 따른 모르타르의 강도특성)

  • Choi, In-Kwon;Hong, Sang-Hun;Jung, Ui-In;Kim, Bong-Joo
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2017.11a
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    • pp.43-44
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    • 2017
  • In this study, mortar strength was measured by grinding oyster shell and changing the particle size distribution. For the experiment, the oyster shells were processed to a fine aggregate size of 10mm or less. In this experiment, seven particle size distribution conditions were selected and tested. Because oyster shells are different in density from sand, their volume ratios were calculated and converted to mass ratios of 1: 3. The strength test was carried out one day after the steam curing.

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EFFECTS OF AP PARTICLE SIZE IN COMPOSITE PROPELLANT COMBUSTION

  • Lee, S. T.;S. W. Hong;K. H. Yoo
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • 1993.10a
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    • pp.4-11
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    • 1993
  • Composite propellant combustion is studied experimentally with systematic variation of particle sizes and mix ratios of coarse and fine APs. Considering the different modes of oxidizer-fuel flames in heterogeneous systems, the complex flame model is described to identify what combustion mechanisms are important under what conditions. The effects of AP particle size, ratio of coarse to fine AP, and pressure on burning rates are discussed in terms of qualitative theory of flame microstructure.

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Monthly Variation in the Salmonella Mutagenicity by Suspended Particulate according to Particle Size in Seoul City (서울시 대기중 부유분진의 입도별 돌연변이원성의 월변화)

  • Jang, Jae-Yeon;Kim, Bak-Kwang;Jo, Seong- Joon;Chung, Yong
    • YAKHAK HOEJI
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    • v.32 no.5
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    • pp.362-369
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    • 1988
  • Monthly variation of mutagenicity by airborne particulate were studied according to particle size of the particulate. Airborne particulates were collected in Shinchon of Seoul which is commocial and traffic area in 1986. And those were separately collected into two parts such as fine particle (less than $2.5{\mu}m$ aerodynamic diameter) and coarse particle (greater than $2.5{\mu}m$). Extractable organic matters(EOM) were extracted and mutagenicity of the EOM was tested in Salmonella thyphimurium TA 98 by Ames method. While the concentration of coarse particle did not show the seasonal variation, that of fine particle showed great seasonal variation. The contents and mutagenicity of EOM in fine particles were higher than those of coarse particles. So fine particles were expected to contribute to the 90% of mutagenicity in atmosphere by suspended particulates. The content of EOM and mutagenicity by suspended particulates in atmosphere were highest in January all the year around and also higher as much as 6 and 30 times than in July, respectively.

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Facile Synthesis of Highly Dispersed Ultra-fine ZrC Powders by Carbothermal Reduction Method Using Nanosized ZrO2 and Nanosized Graphite Powder Mixtures (나노크기의 ZrO2와 Graphite 분말 혼합체의 열탄소환원법에 의한 고분산 초미립 ZrC 분말의 합성)

  • Lee, Wha-Jun;Ryu, Sung-Soo
    • Journal of Powder Materials
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    • v.20 no.2
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    • pp.100-106
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    • 2013
  • Ultra-fine zirconium carbide (ZrC) powder with nano-sized primary particles was synthesized by the carbothermal reduction method by using nano-sized $ZrO_2$ and nano-sized graphite powders mixture. The synthesized ZrC powder was well dispersed after simple milling process. After heat-treatment at $1500^{\circ}C$ for 2 h under vacuum, ultra-fine ZrC powder agglomerates (average size, $4.2{\mu}m$) were facilely obtained with rounded particle shape and particle size of ~200 nm. Ultra-fine ZrC powder with an average particle size of 316 nm was obtained after ball milling process in a planetary mill for 30 minutes from the agglomerated ZrC powder.

Development of $CIEL^{*}a^{*}b^{*}$-CMYK color conversion system by Neural Network (신경망에 의한 $CIEL^{*}a^{*}b^{*}$-CMYK 색변환 시스템 개발)

  • 김종필
    • Journal of the Korean Graphic Arts Communication Society
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    • v.16 no.1
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    • pp.81-93
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    • 1998
  • For the purpose of preparation of monodispersed spherical zinc oxide fine particles, and experimental research on the preparation of zinc oxide particles from zinc salts solutions by high temperature precipitation reaction was performed. Zinc oxide particles were precipitated from all the precipitation solutions tested if the precipitation temperature was higher than 60$^{\circ}$C. As the precipitation temperature increased until 80$^{\circ}$C, the average particle diameter of zinc oxide particles decreased and the narrower particle size distribution were obtained. Spherical zinc oxide fine particles with relativeyl narrow particle size distribution were precipitated from the ZnSo4 solutions with NaOH as precipitant. Final pH of precipitation solution had an effect on the amount of zinc oxide precipitated, but had no effect on the their particle size or size distribution.

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