• Title, Summary, Keyword: fine needle aspiration biopsy

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Fine Needle Aspiration Cytology of Atypical Proliferative Lesion of the Breast (유방의 비정형 증식성 병변의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Song, Kun-Chang;Lee, Kwang-Gil
    • The Korean Journal of Cytopathology
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    • v.5 no.1
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    • pp.52-56
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    • 1994
  • We experienced a case of fine-needle aspiration (FNA) cytology of breast which showed atypical proliferative lesion. It was very difficult to differentiate this case from malignancy, because of hypercellular smear and many clusters composed of large, atypical ductal cells. However, it showed other features favoring benignancy, such as tendency of cellular cohesiveness, only slightly increased nucleus/cytoplasm ratio and most importantly presence of myoepithelial cells. It's histologic diagnosis was intraductal hyperplasia with atypia. This case indicates that all atypical breast FNA specimen should lead to the suggestion of surgical biopsy for avoiding over- or under-diagnosis.

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Malignant Phyolldes Tumor of the Breast Metastatic to the Lung - A Case Report of Fine Needle Aspiration Cytologic Features - (폐로 전이한 유방의 악성 엽상종양 - 세침흡인 세포학적 소견의 1례 보고 -)

  • Yim, Hyun-Ee;Lee, Kwang-Gil
    • The Korean Journal of Cytopathology
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    • v.4 no.2
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    • pp.160-165
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    • 1993
  • Phyllodes tumor of the breast, especially malignant, is a rare tumor which has characteristic cytologic features. We recently experienced a case of fine needle aspiration cytology of malignant phyllodes tumor of the breast metastatic to the lung. The aspirate showed cellular smear with biphasic population of epithelial and stromal cells. Many individual large cells with round hyperchromatic nuclei were found in the necrotic background and stromal cell atypia was also present. Chondrosarcomatous fragments were also seen in cytologic specimens.

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Fine Needle Aspiration Cytology on Solitary Fibrous Tumors of the Pleura (흉막의 고립성 섬유성 종양의 세침 흡인 세포학적 검색)

  • Keum, Joo-Seob;Lee, Jung-Dal
    • The Korean Journal of Cytopathology
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    • v.2 no.2
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    • pp.134-141
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    • 1991
  • Localized or solitary fibrous tumor (SFT) of the pleura has been classified as a type of mesothelioma, arising from the submesothelial connective tissue cells. The preoperative diagnosis of the tumor at the cytologic or histologic level is very important for the proper handling of the lesion. This preoperative diagnosis is now possible by means of the advance in the transthoracic fine needle aspiration biopsy (FNA) techniques and in the very experience of the cytopathologists. We describe FNA cytologic feature of two cases of SFT arising from the pleura. Cytologic, histologic, immunohistochemical, and electron microscopic characteristics of pleural SFT are discussed. The tumor cells of SFT are spindle or oval in shape with a variable amount of cytoplasm. They are arranged in irregular trabeculae intimately associated with capillaries. A unique cytologic feature observed in this tumor is that thick, eosinophilic, amorphous collagen bundles are scattered between tumor cells.

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Fine Needle Aspiration Cytology of Hepatoblastoma -Report of Two Cases- (간아세포종의 세침흡인 세포학적 소견 -2예 증례보고-)

  • Park, Young-Nyun;Lee, Kwang-Gil;Park, Chan-Il
    • The Korean Journal of Cytopathology
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    • v.1 no.1
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    • pp.98-102
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    • 1990
  • Hepatoblastoma (HB) is a rare embryonic malignant tumor of the liver. Most morphological studies on HB have limited to the histological characteristics and only 3 cases of HB have been described in the cytology literature. We present 2 cases of HB occurring in children aged 1 year and 3 years, respectively. The distinctive cytologic features of fine needle aspiration of HB were clusters of tumor cells showing acinar and trabecular pattern, smaller tumor cells with a high nuclear-cytopalsmic ratio and hyperchromatic nuclei having prominent nucleoli, and the presence of extramedullary hematopoiesis and osteoid material. These features were also found in the cell block and the biopsy specimen, and appeared very useful in the differentiation of HB from hepatocellular carcinoma.

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Fine Needle Aspiration Cytology of Pulmonary Hamartoma - A Report of Two Cases - (폐 과오종의 세침흡인 세포학적 소견 - 2예 보고 -)

  • Kim, Jean-A;Kim, Young-Sill;Lee, An-Hi;Shim, Sang-In;Kim, Byung-Kee;Kim, Kyoung-Mee
    • The Korean Journal of Cytopathology
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    • v.11 no.1
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    • pp.31-34
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    • 2000
  • Pulmonary hamartoma is an uncommon benign tumor consisting of a mixture of loose fibromyxoid tissue, cartilage, fat, and cleft-like spaces lined by cuboidal or ciliated epithelium. Cytologically, the presence of a mesenchymal component is essential for the diagnosis of pulmonary hamartoma. We report the fine needle aspiration cytologic findings of two cases of pulmonary hamartoma. Case 1 was a 71-year-old woman with a mass, measuring $1.8{\times}1.5cm$ in the upper lobe of the right lung. Case 2 was a 51-year-old woman with a mass, measuring $2.3{\times}2.0cm$ in the lower lobe of the right lung. Fine needle aspiration cytology of both pulmonary masses revealed several sheets of loose fibromyxoid tissue fragments with focal cartilaginous differentiation and a few clusters of bland cuboidal epithelial cells on the bloody background. The diagnosis was histologically confirmed by needle biopsy.

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Fine Needle Aspiration Cytology of Metastatic Prostatic Adenocarcinoma, Pseudohyperplastic Variant (전이된 가성증식성 전립선 샘암종의 세침흡인 세포소견 -1예 보고-)

  • Kwon, Young-Mee;Park, Won-Seo;Lee, Geon-Kook;Hong, Eun-Kyung
    • The Korean Journal of Cytopathology
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    • v.19 no.2
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    • pp.183-187
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    • 2008
  • Pseudohyperplastic prostatic adenocarcinoma is a rare histologic variant of prostatic adenocarcinoma that resembles benign nodular hyperplasia. Immunohistochemistry can verify the absence of basal cells, but it is frequently admixed with conventional adenocarcinoma. Because fine needle aspiration cytology is rarely performed in primary prostatic adenocarcinoma, the cytology of the pseudohyperplastic variant has not been described. We experienced a case of metastatic pseudohyperplastic adenocarcinoma in a pulmonary nodule of 75-year-old man. The cytologic smear was mostly composed of large, flat sheets with elongated branching papillae in a clean background. The sheets showed a well-defined honeycomb appearance of tall columnar, regularly arranged monotonous cells with little cytologic atypia. In subsequent prostatic biopsy, pseudohyperplastic variants were identified together with conventional adenocarcinoma of Gleason's grade 3 and 4. The cytologic features of pulmonary nodules were identical to those of pseudohyperplastic components of prostatic adenocarcinoma.

Fine Needle Aspiration Cytology of Amyloid Goiter - A Case Report - (아밀로이드 갑상선종대의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Chae, Seoung-Wan;Nam, Eun-Sook;Kim, Duck-Hwan;Shin, Hyung-Sik;Sohn, Jin-Hee
    • The Korean Journal of Cytopathology
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    • v.11 no.2
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    • pp.109-114
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    • 2000
  • Amyloid golfer is a rare disease entity that is defined as a symptomatic mass or clinically detectable thyroid enlargement because of amyloid deposition. We present a case of amyloid golfer diagnosed in the fine needle aspiration cytology(FNAC) in a 73-year-old Korean woman presented with nephrotic syndrome and thyroid enlargement. The thyroid function was in normal range. Thyroid scan showed a nodule, $4{\time}2cm$ in the right lobe with underlying diffuse golfer. Aspirates revealed benign looking follicular cells and scattered eosinophilic material. The sections of the cell block showed nodular deposit of eosinophilic hyalinized material in the interfollicular area. It showed apple-green birefringence under polarization with Congo red stain. The renal biopsy also exhibited deposition of eosinophilic materials in the glomeruli and interstitial vascular wall, which were confirmed as amyloidosis. This material was morphologically distinct from the colloid.

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Fine Needle Aspiration Cytology of Subacute Necrotizing Lymphadenitis - Three Cases Report - (아급성 괴사성 림프절염 - 세침흡인 세포검사로 진단된 3예 보고 -)

  • Cho, Soo-Yeon;Cho, Min-Sun;Kim, Sung-Sook;Koo, Hye-Soo;Han, Woon-Sub;Chung, Sung-Min
    • The Korean Journal of Cytopathology
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    • v.5 no.1
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    • pp.23-27
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    • 1994
  • Three cases of subacute necrotizing lymphadenitis diagnosed by fine needle aspiration (FNA) of enlarged lymph nodes are reported. The FNA smears contained randomly activated lymphoid cells, necrotic debris and histiocytes. The same patterns were found in subsequently examined excised lymph nodes from these cases. The differential diagnosis of this entity is discussed and the value of preparing FNA cell blocks and accompanying AFB stain with culture is emphasized. FNA may be able to provide a diagnosis in case of this benign disease, therefore avoiding a more traumatic excisional biopsy.

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Percutaneous Fine Needle Aspiration Cytology of Malignancies of the Pancreas (췌장암의 경피성 세침 흡인 세포학적 검색)

  • Lee, Jung-Dal;Lyu, Keun-Shin;Ko, Jin-Seok;Lee, Chul-Yong
    • The Korean Journal of Cytopathology
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    • v.3 no.2
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    • pp.37-51
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    • 1992
  • The fine needle aspiration (FNA) cytology findings in 19 cases of primary neoplasia of the pancreas are reported. The aspirates were obtained under ultrasound guidance in 16 cases and under direct vision intraoperatively in three cases. These cases represented 79% of 24 diagnoses in a series of 30 pancreatic FNAs. Of these 30 cases no cytologic diagnoses were made in six cases (20%) because of insufficient or inadequate samples The cytologic diagnoses were confirmed by histologic examination following resection or biopsy of the tumors. The diagnoses included 9 duct ceil adenocarcinomas, 1 mucinous adenocarcinoma, 2 mucinous cystadenocarcinomas, 1 acinar cell carcinoma, 1 papillary cystic tumor 3 islet ceil tumors, 1 neuroendocrine carcinoma and 1 leiomyosarcoma. The cytologic features of the neoplasia were detailed and the differential diagnosis was discussed. The important criteria for the cytodiagnosis of pancreatic tumors were reviewed. This review leads us to think that nonoperative (percutaneous) cytologic approaches to the diagnosis of pancreatic tumor are advantageous for the management of patients, and that correct cytologic diagnosis with pancreatic FNAs can easily be made, if adequate samples are obtained.

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Touch Imprint and Fine Needle Aspiration Cytology of Giant Cell Tumor of Tendon Sheath - A Case Report - (건초거대세포종의 압착도말 및 세포흡인 세포소견 - 1예 보고 -)

  • Lee, Jong-Im
    • The Korean Journal of Cytopathology
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    • v.19 no.1
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    • pp.57-64
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    • 2008
  • Giant cell tumor of the tendon sheath (GCTTS) is a slowly growing, benign soft tissue tumor. The tumors occur predominantly on the hands and feet. Although the clinical and histopathologic features are well-defined, only a few reports have described the cytologic appearance of this entity. A 26-year-old woman presented with a gradually developing circumscribed soft tissue mass near the proximal phalanx of her left little finger for one year. Imprint and fine needle aspiration (FNA) smears were obtained from the excisional biopsy specimen. The imprint smears were composed of predominantly singly dispersed bland mononuclear cells and several giant cells. The mononuclear cells were polygonal to round, and they showed a histiocyte-like appearance. Osteoclast-type multinucleated giant cells of various sizes were randomly scattered throughout the smears, and these cells contained 3 to 50 nuclei. Nuclear atypia and pleomorphism were absent in both the single and giant cells. Loose aggregates of hemosiderin-laden macrophages and binuclear stromal cells were also seen. The cytologic features of the FNA smears were similar with those of the imprint, Additionally, the FNA smears contained several clumps of densely collagenous stromal tissue that were seldom noted in previously reported cytologic material. The cytologic features were well-correlated with the concurrent histologic findings and the diagnosis of GCTTS was made. When the clinical and radiologic datas are integrated, the diagnosis of GCTTS can be strongly suggested, based on the pre-operative cytologic specimen.