• 한국응용과학기술학회지
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• 제32권3호
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• pp.536-545
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• 2015

This study aimed to investigate the effect of various emulsifiers on the formation of nanoemulsions and their stability properties. MCT (medium chain triglyceride) nanoemulsions were prepared (10 wt% oil, 10 wt% emulsifiers, 20 mM bis-tris, pH 7) with emulsifier such as Tween 20 (Polyoxyethylene(20) sorbitan monolaurate), Almax 3800 (Sorbitan monooleate), soy lecithin, and SSL (sodium stearoyl lactylate) and changes in fat globule size with respect to storage period and stability properties by Turbiscan were investigated. In case of control nanoemulsion with 10 wt% Tween 20, the initial fat globule size was 89.0 nm and 113.4 nm after 28 day of storage and this large increase (ca. 24 nm) was thought to be caused by Ostwald ripening. When Tween 20 was partially replaced with Almax 3800, lecithin and SSL in nanoemulsions, their physicochemical properties (i.e., fat globule size and stability) were changed accordingly. In general, the intial fat globule size was decreased with increasing the concentration of the emulsifiers and the stability against Ostwald ripening increased. The most stable nanoemulsions against Ostwald ripening could be prepared with emulsifiers of Tween 20 and Almax 3800 or lecithin in the ratio of 6:4 (wt%), which was verified with Ostwald ripening rate (${\omega}$). In addition, the emulsion stability by Turbiscan was observed to be consistent with results of changes in fat globule size with storage period.

• Journal of Nutrition and Health
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• 제39권8호
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• pp.733-741
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• 2006

The study was conducted to investigate the effects of dietary calcium and soy isoflavone on body fat and lipid metabolism in high fat-induced obesity. Four week old female C57/BL6J mice, known as a good model of diet-induced obesity, were fed low Ca and high fat diet for 6 weeks. After induced obesity, mice were divided into six groups according to diets varying calcium contents (0.1 or 1.5%) and genistein contents (0 or 500 or 1,000 ppm). Body weight, fat pad (perirenal fat and parameterial fat), adipocyte size, serum total lipid and total cholesterol were significantly decreased by both high Ca intake and genistein supplementation. However, the effect of genistein supplementation showed in low Ca-fed groups. Serum LDL-cholesterol and TG were significantly decreased by high Ca intake and genistein supplementation, respectively. In liver, lipogenic enzymes (fatty acid synthase and malic enzyme) activity and TG were significantly decreased by both high Ca intake and genistein supplementation. This inhibitory effect of genistein on lipogenic enzymes showed in low Ca-fed groups. But liver total cholesterol and total lipid were significantly decreased by high Ca intake and genistein supplementation, respectively. Fecal excretion of total lipid, total cholesterol and TG were significantly increased by high Ca intake, not by genistein supplementation. In conclusion, high calcium intake and genistein supplement may be beneficial for suppression of obesity through direct anti-adipogenesis by decreasing fat weight and size and indirect anti-lipo-genesis by inhibiting lipogenic enzymes activity and improving lipid profile.

• Journal of information and communication convergence engineering
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• 제21권2호
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• pp.110-116
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• 2023

Recently, as various examples of machine learning have been applied in the healthcare field, deep learning technology has been applied to various tasks, such as electrocardiogram examination and body composition analysis using wearable devices such as smart watches. To utilize deep learning, securing data is the most important procedure, where human intervention, such as data classification, is required. In this study, we propose a model that uses a clustering algorithm, namely, the K-means clustering, to label body fat according to gender and age considering body size aspects, such as chest circumference and waist circumference, and classifies body fat into five groups from high risk to low risk using a convolutional neural network (CNN). As a result of model validation, accuracy, precision, and recall results of more than 95% were obtained. Thus, rational decision making can be made in the field of healthcare or obesity analysis using the proposed method.

• 한국가금학회지
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• 제19권2호
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• pp.57-64
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• 1992

한국법과 육계의 지방세포에 대한 세포학적 비교를 하였던 바 정의 지방세포의 직경은 평균 25~45$\mu$으로서 비교적 같은 체중의 육계의 40~55$\mu$에 비하여 월등히 적었으며 세표용적은 육계의 48~101pl에 비하여 불과 10~75pl로 지방 저장능력이 아주 낮은 것으로 확인되었으며 따라서 극히 소량의 복부 지방층은 지방세포의 작은 직경에 기인하는 것으로 사료된다.

• Journal of Gastric Cancer
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• 제15권1호
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• pp.39-45
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• 2015

Purpose: Recent studies have revealed recurrent alterations in the cell adhesion gene FAT4, a candidate tumor suppressor gene, in cancer. FAT atypical cadherin 4 (FAT4) is a transmembrane receptor involved in the Hippo signaling pathway, which is involved in the control of organ size. Here, we investigated the loss of FAT4 expression and its association with clinicopathological risk factors in gastric cancer. Materials and Methods: We assessed the expression of FAT4 by using immunohistochemistry on three tissue microarrays containing samples from 136 gastric cancer cases, radically resected in the Soonchunhyang University Cheonan Hospital between July 2006 and June 2008. Cytoplasmic immunoexpression of FAT4 was semi-quantitatively scored using the H-score system. An H-score of ${\geq}10$ was considered positive for FAT4 expression. Results: Variable cytoplasmic expressions of FAT4 were observed in gastric cancers, with 33 cases (24.3%) showing loss of expression (H-score <10). Loss of FAT4 expression was associated with an increased rate of perineural invasion (H-score <10 vs. ${\geq}10$, 36.4% vs. 16.5%, P=0.015), high pathologic T stage (P=0.015), high tumor-node-metastasis stage (P=0.017), and reduced disease-free survival time (H-score <10 vs. ${\geq}10$, mean survival $62.7{\pm}7.3$ months vs. $79.1{\pm}3.1$ months, P=0.025). However, no association was found between the loss of FAT4 expression and tumor size, gross type, histologic subtype, Lauren classification, lymphovascular invasion, or overall survival. Conclusions: Loss of FAT4 expression appears to be associated with invasiveness in gastric cancer.

• 한국식품과학회지
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• 제28권4호
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• pp.668-672
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• 1996

10% 지방육은, 풍미, 단단함을 제외하고는 대체로 좋지 않은 것으로 나타났고 10% 지방에 재고미 5%를 첨가한 육은 풍미, 입자 크기, 단단함, 전반적 적성은 좋게, 다즙성, 연도는 재고미의 첨가량이 더 많은 육과 30% 지방육에 비해 낮은 것으로 나타났다. 10% 지방에 10% 또는 20%의 재고미가 첨가된 육은 다즙성, 연도, 입자 크기, 전반적 적성은 좋게, 풍미, 단단함 등은 낮게 나타났으며 30% 지방육은 풍미, 다즙성, 연도, 단단함은 좋게, 입자 크기, 전반적 적성은 좋지 않게 나타났다. 결론적으로 재고미를 다량(20%) 혼입하는 것은 전반적 적성을 감소시켰지만 5% 혹은 10% 수준의 재고미를 혼합하는 것은 재고미의 적절한 소비를 꾀하면서 열량 감소, 지방 제거시 잃기 쉬운 육의 풍미, 다즙성, 전반적 적성의 유지 등 좋은 효과를 얻을 수 있었다. 관능 검사 결과 10% 지방에 5%와 10%의 재고미가 첨가된 우육이 좋은 평가를 받은 것은 근래 지방 섭취량을 줄이고자 하는 추세에 맞추어 큰 호응이 있을 것으로 기대된다.

• 한국축산식품학회지
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• 제40권5호
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• pp.734-745
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• 2020

Commercially sterilized ultra high temperature (UHT) milk was manufactured at different homogenization pressures (20, 25, and 30 MPa), and changes in fat particle size, mechanical stress-induced fat aggregation, plasmin activity, and lipid oxidation were monitored during ambient storage of the UHT milk for up to 16 wk. The particle sizes of milk fat globules were significantly decreased as homogenization pressure increased from 20 to 30 MPa (p<0.05). The presence of mechanical stress-induced fat aggregates in milk produced at 20 MPa was significantly higher than for UHT milk produced at either 25 or 30 MPa. This difference was maintained all throughout the storage. There were no significant differences in plasmin activity, trichloroacetic acid (12%, w/v) soluble peptides, and the extent of lipid oxidation. Based on these results, an increase of homogenization pressure from 20 (the typical homogenization pressure employed in the Korea dairy industry) to 25-30 MPa significantly decreased mechanical stress-induced fat aggregation without affecting susceptibility to lipid oxidation during storage.

• 한국식품영양과학회지
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• 제36권4호
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• pp.419-423
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• 2007

본 연구에서는 천연소재 혼합물이 혈중 지질 함량 및 부고환 지방세포의 크기에 미치는 영향을 측정하였다. 그 결과 혈액 중 총 콜레스테롤과 LDL 콜레스테롤은 천연소재 섭취에 의한 유의적인 감소 효과가 나타나지 않았지만, 중성지방은 정상식이군에서 감소하였고 HDL 콜레스테롤은 정 상식이군에서 증가하였다. 부고환 지방조직은 고지방식이 섭취에 의해 지방세포 크기가 유의적으로 증가되었으나 천연소재 섭취로 인하여 유의적으로 감소하였다. 이는 천연소재섭취에 의해 체지방 축적이 억제되어 지방세포의 hypertrophy를 억제했기 때문으로 사료된다.

• Nutritional Sciences
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• 제5권3호
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• pp.117-122
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• 2002

This study was designed to observe the effect of conjugated linoleic acid (CLA) supplementation on body fatness, fat cell sizes and leptin levels in male Sprague Dawley rats. Following weaning, forty rats were divided into 4 groups beef tallow (BT), fish oil (FO). beef tallow with CLA supplementation (BTC), and fish oil with CLA supplementation (FOC) group. For four weeks, all rats were fed experimental diets containing 12％ of total dietary fat (w/w) with or without 1％ CLA. After 4 weeks, the animals were sacrificed; the total carcass fat, plasma leptin levels, epididymal fat pad weights and fat cell sizes in adipose tissue were measured. CLA supplementation did not significantly affect the rat's body weights, total body fat, epididymal fat pad weights, and fat cell sizes. CLA also did not have a significant effect on plasma leptin levels. These results suggest that CLA supplement was not an effective way to reduce the body weights of male Sprague Dawley rats.

• 한국동물위생학회지
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• 제17권3호
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• pp.198-207
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• 1994

4, 919 Samples of the slaughtered cattle(female) were investigated the abattoir in southern Kangwon to reveal the incidence rates of abdominal fat necrosis from June to December 1993. The results obtained were summarized as follows ; 1. The incidence rate of abdominal fat necrosis investigated from 4, 919 samples was 4.39%. 2. It revealed that the incidence rate of abdominal fat necrosis increased gradually with the advance in the age, 2.5% in below 5 years, 6.0% in 6 years, 7.2% in 7 years, 8.5% in 7 years, 8.9% in older than 9 years and that incidence rate of the sites of lesion, pericolonic fat 84.7%, perirectumic fat 48.6%, perirenal fat 37.9%. mesenteric fat 24.0%, others 7.8%. 3. The size of necrotic fat were $2{\times}3cm{\sim}10{\sim}18{\times}15{\sim}25cm$ in average and color was yellowish white or milk white.