• Journal of the Korean Society of Radiology
• /
• v.82 no.6
• /
• pp.1524-1533
• /
• 2021

Purpose To investigate the incidence of tuberculosis (TB) in healthcare workers (HCWs) with positive interferon-gamma release assay (IGRA) results based on chest X-ray (CXR) and CT findings and determine the role of imaging in the diagnosis of TB. Materials and Methods Among 1976 hospital personnel screened for TB using IGRA, IGRApositive subjects were retrospectively investigated. Clustered nodular and/or linear streaky opacities in the upper lung zone were considered positive on CXR. The CT findings were classified as active, indeterminate, inactive, or normal. The active or indeterminate class was considered CT-positive. Results IGRA was positive in 255 subjects (12.9%). CXR and CT were performed in 249 (99.2%) and 113 subjects (45.0%), respectively. CXR- and CT-positive findings were found in 7 of 249 (2.8%) and 9 of 113 (8.0%) patients, respectively. Among the nine CT-positive subjects, active and indeterminate TB findings were found in 6 (5.3%) and 3 (2.7%) patients, respectively. Microbiological tests, including acid-fast bacilli staining, culture, and polymerase chain reaction for TB, were negative in all nine CT-positive subjects. Empirical anti-TB medications were administered to 9 CT-positive subjects, and 3 of these nine subjects were CXR-negative for pulmonary TB.

• Polymer(Korea)
• /
• v.26 no.3
• /
• pp.326-334
• /
• 2002

The purpose of this work was the producing of a biodegradable poly($\varepsilon$-caprolactone) (PCL) microcapsule and the analyzing of form and features for the manufacturing conditions which could be observed in a prospective drug delivery systems (DDS) through drug release. The effects of different stirring rates, stirring times and concentrations of emulsifier for the diameter and form of the microcapsules were observed using image analyzer (IA) and scanning electron microscopy (SEM). As a result, the microcapsules were made in wrinkle and spherical forms with a mean particle size of 40~300$\pm$20 $mu extrm{m}$. PCL microcapsules containing drugs were confirmed using FT-IR spectra. The role of interfacial adhesion between PCL and drug was determined by contact angle measurements. The drug release test of PCL microcapsules was characterized by UV/vis. spectra. It was found that the drug release rate of the microcapsules prepared with high concentration emulsifier was significantly fast.

• Journal of the Korean Society of Safety
• /
• v.32 no.5
• /
• pp.20-24
• /
• 2017

In this study, we have performed the Cone Calorimeter test in accordance with ISO 5660-1 to check the combustion characteristics of building flooring materials. The fire risk of these materials were evaluated by construction code, KFI criteria and standards of flame retardant performance. When samples exposed to external heat flux, all samples consumed a lot of Oxygen for a long time. So heat release from sample burning continued so long. And also all samples produced so much smoke. Even though a few samples were satisfied with only peak heat release rate criteria, all 8 samples were not satisfied with criteria of peak heat release rate and total heat released together. The results of 5 min total heat released were $15.9MJ/m^2{\sim}5.9MJ/m^2$. It menas the results are more than 2~6 times higher than the criteria. The results of 10 min total heat released were $30.1MJ/m^2{\sim}100.8MJ/m^2$. It means the results are more than 3~12 times higher than the criteria. 6 of 8 samples were not satisfied with Dm.corr.(corrected maximum smoke density) criteria. The building flooring materials which we used for this test ignited very fast and the burning continued so long. It means these samples are susceptible to fire.

• Korean Journal of Applied Biomechanics
• /
• v.17 no.4
• /
• pp.65-71
• /
• 2007

The purpose of this study was to investigate variability of kinematic factors affecting the record in women's javelin throwing. For this study, 8 female-javelin thrower participated in this experiment. The three digital video cameras (Sony, 120x) were used to record motions. Kwon3D 2.1 was used to process data and they were analyzed with Excell for factors. The sampling rate of a camera was 60Hz and shutter speed of a camera was 1/1000sec. The coordinate data were filtered using a fourth-order Butterworth low pass filtering with an estimated optimum cut-off frequency of 6Hz. The results were as follows: 1. From cross step to landing of delivery, the average velocities of CoM of non-dominant athletes were greater than dominant athletes and those of CoM of non-dominant athletes less than dominant athletes, but at release dominant athletes had a lower average velocity and a variability than non-dominant athletes. 2. From cross step to landing of delivery, the average throwing velocities and variabilities of a javelin of dominant athletes were greater than dominant athletes, but at release, dominant athletes had a higher velocity than dominant athletes and had a equal variability. 3. At every events, a forward or backward angles and variabilities of non-dominant athletes were greater than dominant athletes. 4. From cross step to landing of delivery, dominant athletes' elbow average angles were greater than non-dominant athletes and the variabilities of latter less than non-dominant athletes, but at release dominant athletes' variabilities were smaller than non-dominant athletes. 5. At landing of delivery, dominant athletes' knee average angles and variabilities of a supporting foot were a greater than non-dominant athletes, and at release, dominant athletes' knee average angles was a greater but variabilities less than non-dominant athletes. In conclusion, the dominant threw javelins fast while having stable postures and the range of elbow's angle large.

• Polymer(Korea)
• /
• v.28 no.4
• /
• pp.328-334
• /
• 2004

A series of methoxy poly(ethylene glycol) (MPEG)-poly(L-lactide-co-glycolide) (PLGA) diblock copolymers were synthesized by ring-opening polymerization of L-lactide and glycolide with carbitol (134 g/mole) or different molecular weights of MPEG (550, 2000, and 5000 g/mole) as an initiator in presence of Sn(Oct)$_2$. The properties of diblock copolymers were characterized by using $^1$H-NMR, GPC, and XRD. After uniform mixing of block copolymers and 1% albumin bovine-fluorescein isothiocyanate(FITC-BSA) with a freeze miller, the wafers loaded FITC-BSA were fabricated by using a mold with a dimensions of 3 mm${\times}$1mm diameter. The release profiles of FITC-BSA and the pH changes of wafer were examined using pH 7.4 PBS for 30 days at 37$^{\circ}C$. The release profiles of albumin showed fast initial burst as the molecular weights of MPEG increased. As a result of this study, the release behavior of BSA was controlled with introducing MPEG in the block copolymers.

• Fire Science and Engineering
• /
• v.17 no.3
• /
• pp.1-6
• /
• 2003

In this study, it reviewed about evacuation performance of a specified Office Building. assessment tools is FAST 3.1.7 (Estimation of Flash Over, Estimation of Layer Height Down Flow Time), SIMULEX 32-bit (Estimation of Evacuation Time), JASMINE 3.25d. (Smoke Flow Assessment of a specified time) Result from Fire Scenario # 1, Flash Over is not generated in Compartment. Evacuation Time is estimated 25.2 sec by SIMULEX 32-bit. layer height until this time (25.2 sec) was estimated 2.4 m by FAST 3.1.7. After ignition until this time (25.2 sec), smoke was not release to the a corridor. In consequence, We concluded that people in building are completing the safe evacuation without the damage of smoke. Result from Fire Scenario # 1, Flash Over generated 6 min 33.2 sec in Compartment. Evacuation Time is estimated 1 min 25.5 sec by SIMULEX 32-bit. layer height down flow time is 1 min 40.8 sec by FAST 3.1.7 and 5 min 23 sec by theoretical calculation. Also, total building evacuation time was estimated 2 min 26.6 sec. After ignition until this time (2 min 26.6 sec), smoke released to the a corridor but it amount was few little. Therefore, generated smoke in compartment not effected to the people in buildings.

• Nuclear Engineering and Technology
• /
• v.56 no.4
• /
• pp.1204-1212
• /
• 2024

To accurately calculate the heating distribution of the fast reactor, a neutron-photon library in MATXS format named Knight-B7.1-1968n × 94γ was processed based on the ENDF/B-VII.1 library for ultrafine groups. The neutron cross-section processing code MGGC2.0 was used to generate few-group neutron cross sections in ISOTXS format. Additionally, the self-developed photon cross-section processing code NGAMMA was utilized to generate photon libraries for neutron-photon coupled heating calculations, including photo-atom cross sections for the ISOTXS format, prompt photon production cross sections, and kinetic energy release in materials (KERMA) factors for neutrons and photons, and the self-shielding effect from the capture and fission cross sections of neutron to photon have been taken into account when the photon source generated by neutron is calculated. The interface code GSORCAL was developed to generate the photon source distribution and interface with the DIF3D code to calculate the neutron-photon coupling heating distribution of the fast reactor core. The neutron-photon coupled heating calculation route was verified using the ZPPR-9 benchmark and the RBEC-M benchmark, and the results of the coupled heating calculations were analyzed in comparison with those obtained from the Monte Carlo code MCNP. The calculations show that the library was accurately processed, and the results of the fast reactor neutron-photon coupled heating calculations agree well with those obtained from MCNP.

• YAKHAK HOEJI
• /
• v.41 no.1
• /
• pp.60-73
• /
• 1997

In order to design a 24 hr sustained release preparation of sulindac for oral administration, fast release pellet (FR), slow release pellet (SR) and two combined formulation (1 : 1 and 1 : 2) were prepared. The pharmacokinetic effect of such preparations has been evaluated using rabbits as a suitable in vivo model, and tested in man. Dose determination was carried out using curve fitting according to RSTPJP II program. In bioavailability test using rabbit, AUCs of sulindac in a few designed formulations were similar to each other. $C_{max}$- of RF and SR were 1.8 times and 1.2 times higher, respectively, compared to that of combined formulation (FR:SR=1:1). While plasma concentration of FR and SR decreased rapidly, that of combined formulation (FR:SR 1:1) lasted at the level close to $C_{max}$ for 24 hrs. Plasma concentration of sulfide form from the combined pellet(FR:SR=1:1) lasted for 24 hrs, and its AUC value was 1.4-fold, 2.7-fold. and 1.2-fold greater than FR pellet, SR pellet and combined pellet (FR:SR 1 : 2). Thus, the combined pellet of 1:1 ratio was found to be the most effective for oral sustained release formulation. Bioavailability test in human showed that AUC of sulfide from TSRP (1 : 1) was approximately 1.5 times greater than total AUC of Immbaron$^{\circledR}$ administered twice in a day. While $T_{max}$ of sulfide from lmmbaron$^{\circledR}$ was 4.33 +/- 1.37 hr (lst administration) and 3.33 ${pm}$ 0.82 hr (2nd administration), respectively, that of sulfide from TSRP increased to 7.17 ${pm}$ 2.86 hr. Plasma concentration of sulfide from TSRP was sustained at more, than 1.0 ${\mu}g{\cdot}$hr/ml until 24 hrs after one dose administration. In addition, TSRP may decrease local adverse reaction in the stomach, since plasma concentration of sulfide from the combined pellet was low within 2hrs in the stomach. In conclusion, it is suggested that TSRP formulation may be effective for oral 24 hr sustained release formulation of sulindac dosing 300 ~ 350mg once a day.

• Polymer(Korea)
• /
• v.32 no.3
• /
• pp.199-205
• /
• 2008

In this study, we fabricated poly (lactide-co-glycolide) (PLGA) scaffold modified with small intestinal submucosa (SIS) as a drug delivery matrix of bioactive molecules. SIS derived from the submucosa layer of porcine intestine has been widely used as biomaterial because of low immune response. PLGA scaffold was prepared by the method of solvent casting/salt leaching. Novel composite scaffolds of SIS/PLGA were manufactured by simple immersion method of PLGA scaffold in SIS solution under vacuum. SEM observation shows that PLGA and SIS/PLGA scaffolds have interconnective and open pores. Especially, SIS/PLGA scaffold showed that micro-sponge of SIS with interconnected pore structures were formed in the pores of PLGA scaffold. In order to assay release profile of proteins, we manufactured FITC conjugated BSA loaded PLGA and SIS/PLGA scaffold. And the release amount was identified by fluorescence intensity using the fluorescence spectrophotometer. The initial burst of BSA containing SIS/PLGA scaffolds was lower than that of PLGA scaffolds resulting in constant release. And release of BSA in SIS/PLGA scaffold was fast and incremental because of the increased content of BSA. In conclusion, we confirmed that penetrated SIS solution prevented the initial burst of BSA and PLGA modified with SIS scaffold is useful as protein carriers with controlled release pattern.

• Animal cells and systems
• /
• v.8 no.4
• /
• pp.307-312
• /
• 2004

Fast kinetics of transient pH changes and difference spectrum formation have been investigated following mixing of ADP/ATP with partially purified plasma membrane PM-ATPase of the pathogenic yeast Candida albicans in the presence of five nutrients: glucose, glutamic acid, proline, lysine, and arginine and two analogs of glucose: 2-deoxy D-glucose and xylose. Average $H^+$- absorption to release ratio, indicative of population of ATPase undergoing complete hydrolytic cycle, was found to be 0.27 for control. This ratio varied between 0.25 (proline) to 0.36 (arginine) for all other compounds tested, except for glucose. In the presence of glucose, $H^+$- absorption to release ratio was exceptionally high (0.92). While no UV difference spectrum was observed with ADP, mixing of ATP with ATPase led to a large conformational change. Exposure to different nutrients restricted the magnitude of the conformational change; the analogs of glucose were found to be ineffective. This suppression was maximal in the case of glucose (80%); with other nutrients, the magnitude of suppression ranged from 40-50%. Rate of $H^+$- absorption, which is indicative of E~P complex dissociation, showed positive correlation with suppression of conformational change only in the case of glucose and no other nutrient/analog. Mode of interaction of glucose with plasma membrane $H^+$-ATPase thus appears to be strikingly distinct compared to that of other nutrients/analogs tested. The results obtained lead us to propose a model for explaining glucose stimulation of plasma membrane $H^+$-ATPase activity.