• IMMUNE NETWORK
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• v.16 no.4
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• pp.201-210
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• 2016

Allergic inflammation requires the orchestration of altered gene expression in the target tissue and in the infiltrating immune cells. The transcription factor STAT6 is critical in activating cytokine gene expression and cytokine signaling both in the immune cells and in target tissue cells including airway epithelia, keratinocytes and esophageal epithelial cells. STAT6 is activated by the cytokines IL-4 and IL-13 to mediate the pathogenesis of allergic disorders such as asthma, atopic dermatitis, food allergy and eosinophilic esophagitis (EoE). In this review, we summarize the role of STAT6 in allergic diseases, its interaction with the co-factor PARP14 and the molecular mechanisms by which STAT6 and PARP14 regulate gene transcription.

• The Journal of Engineering Geology
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• v.18 no.4
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• pp.439-446
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• 2008

We have developed a method to evaluate pumping rates from a system of pumping-well family. For a given system actual pumping rates depend on pump characteristics and the sum of the static head and the dynamic head. The static head is the elevation difference between the natural groundwater level and the outlet of the pipeline that connects all the wells. Major components of the dynamic head are groundwater drawdown in the well and pipeline head loss. The dynamic head and the pump characteristics depend on the pumping rates. Actual pumping rates are determined at the intersections of the system total-head curves and the pump characteristic curves. The Newton-Raphson's method is used to solve the nonlinear simultaneous equations. The method is applied to a hypothetical well family. Impacts of various design and operational parameters on the pumping rates are analyzed.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.835-840
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• 2012

아프리카는 현재 극심한 식수난에 시달리며 국민들의 건강과 경제활동에 위협을 받고 있다. 에티오피아 역시 이러한 어려움에 처한 국가 중 하나이다. 우리나라는 2006년 이후 현재 아프리카의 식수개발을 확대하고 있는데, 본 연구에서는 이를 뒷받침하고자 에티오피아 내 식수개발원조 동향이 분석하고 이에 따른 우리나라 식수개발사업의 지원 방안을 모색하였다. 에티오피아 농촌지역에서는 현재 대규모 관정 사업보다 저비용 소규모 단위 수준에서의 기술을 사용한 물의 자급(Self Supply)에 대한 지원이 필요하고, 구체적인 사례는 가족우물(Family wells)이다. 또한 이러한 물 자급 방안 지원 시에는 수질에 대한 고려가 함께 필요하다.

• Animal Systematics, Evolution and Diversity
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• v.30 no.3
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• pp.183-190
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• 2014

The four species of the family Dendrophylliidae are newly recorded in Korea: Balanophyllia (Balanophyllia) cumingii Milne Edwards and Haime, 1848, Balanophyllia (Balanophyllia) vanderhorsti Cairns, 2001, Cladopsammia eguchii (Wells, 1982), and Cladopsammia gracilis (Milne Edwards and Haime, 1848). The two genera of Balanophyllia and Cladopsammia, to which the four species belong, are newly recorded in Korea. They were collected from the subtidal zones in Jeju-do Island, Korea by SCUBA diving from 1987 to 2012. This study aims to identify the four dendrophyllid species based on external and internal morphological characters including growth form, size, budding, and color of colonies, shape and size of corallites, columella, theca, and septa. Balanophyllia (Balanophyllia) cumingii is distinguished by its solitary growth form, small and low subturbinate corallite with enlarged calice, and expanded basal part, exsert first and second septa, and Pourtal$\acute{e}$s plan. Balanophyllia (Balanophyllia) vanderhorsti is characterized by its quasi-colonial growth form, subturbinate corallites with compressed calice, thick theca, and Pourtal$\acute{e}$s plan. Cladopsammia eguchii is characterized by its phaceloid growth form of compressed corallites basally united with common coenosteum, flat spongy columella, thick theca, and Pourtal$\acute{e}$s plan. Cladopsammia gracilis is distinguished by its phaceloid growth form of corallites basally united with common coenosteum, and pronounced Pourtal$\acute{e}$s plan forming flower patterns.

• Korean Journal of Family Social Work
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• no.58
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• pp.67-96
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• 2017

The purpose of this study is to examine psychological difficulties that elderly women experience in each divorce decision making stage and they are shown by counselling cases made with elderly women who got divorced in their early stage of elderly life. For this purpose, total 18 counseling cases were collected from November 2012 to March 2013 and a qualitative analysis was made accordingly. The result of this study was made by analyzing meaningful subjects emerged in individual testimonies during a counseling process and it shows that the decision to divorce goes through stages such as , , , , , and . In addition, psychological difficulties experienced in a divorce decision process appear to be, , , , , , and . It is meaningful that this study provides counseling strategies for psychosocial support of the elderly women who go through difficulties in their divorce decision making process.

• Molecules and Cells
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• v.43 no.3
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• pp.286-297
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• 2020

Mammalian patatin-like phospholipase domain containing proteins (PNPLAs) play critical roles in triglyceride hydrolysis, phospholipids metabolism, and lipid droplet (LD) homeostasis. PNPLA7 is a lysophosphatidylcholine hydrolase anchored on the endoplasmic reticulum which associates with LDs through its catalytic region (PNPLA7-C) in response to increased cyclic nucleotide levels. However, the interaction of PNPLA7 with LDs through its catalytic region is unknown. Herein, we demonstrate that PNPLA7-C localizes to the mature LDs ex vivo and also colocalizes with pre-existing LDs. Localization of PNPLA7-C with LDs induces LDs clustering via non-enzymatic intermolecular associations, while PNPLA7 alone does not induce LD clustering. Residues 742-1016 contains four putative transmembrane domains which act as a LD targeting motif and are required for the localization of PNPLA7-C to LDs. Furthermore, the N-terminal flanking region of the LD targeting motif, residues 681-741, contributes to the LD targeting, whereas the C-terminal flanking region (1169-1326) has an anti-LD targeting effect. Interestingly, the LD targeting motif does not exhibit lysophosphatidylcholine hydrolase activity even though it associates with LDs phospholipid membranes. These findings characterize the specific functional domains of PNPLA7 mediating subcellular positioning and interactions with LDs, as wells as providing critical insights into the structure of this evolutionarily conserved phospholipid-metabolizing enzyme family.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.38 no.4
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• pp.527-535
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• 2018

Agricultural activities of western Jeju island has suffered from saltwater intrusion seasonally. Objectives of this study are to prove the occurrence of saltwater intrusion in the coastal aquifer and to consider a management plan using MODFLOW-family code SEAWAT model. Model results show that the saltwater-freshwater interface intrudes inland only a few meters and that upconing phenomenon is rather the cause of the severe disaster of the agricultural water contamination. This study selected Gosan area as a representative site to estimate optimal groundwater development regulation against upconing by seasonal pumping for agriculture. The suggested optimal groundwater development estimation method considers the groundwater levels of representative monitoring wells for regulatory alarms.