• International Journal of Computer Science & Network Security
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• v.22 no.5
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• pp.335-341
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• 2022

This article is devoted to the study of the process of formation of the digital generation in a distance learning environment. With the introduction of quarantine due to the spread of COVID-19, opponents of digital technologies were forced to turn to relevant resources, while supporters identified new opportunities for the development of didactics and education in general. The irreversibility of the former educational reality became apparent and only the scale of the vision of potential change by interested and disinterested groups differed. Using a comprehensive approach, the authors consider the issues related to the direct and indirect impact of distance learning on children and young people born after the beginning of the XXI century. The article reveals the prerequisites and implications of distance education for the interaction of participants in the educational process. IC technologies during the educational process in the primary grades, in addition to identifying the student's learning deficit, should provide the transmission of non-verbal signals, which are important for children of this age. At the same time in the secondary school IR-technologies are designed to replace frontal learning during the assimilation of knowledge and at the same time not to worsen the quality of the educational process. Formation of students in the HEI takes place in the political science format, constant discussion of problem situations, so the task of introducing IC technology in this process is the accurate transfer of the content of the discussions. Individualization and autonomization of the educational process, its dependence on the results of the choice of educational content, and the use of pedagogical management tools change the philosophy of education for children and youth. The authors conclude that the formation of a digital generation, characterized by an increased level of digital literacy of children and youth, the possession of a certain level of digital capacity requires the use of strategies aimed at optimizing the learning process in a digital educational environment.

• Korean Journal of Acupuncture
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• v.29 no.2
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• pp.271-289
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• 2012

Objectives : Ganoderma lucidum(Ganoderma or lingzhi, 靈芝) is a well-known oriental medical mushroom containing many bioactive compounds. The possible mechanisms involved in its effects on cancer cells remain to be elucidated. In the present study, the anti-proliferative and apoptotic activities of the G. lucidum ethanol extract(GEE), in AGS human gastric cancer cells were investigated. Methods : It was found that exposure of AGS cells to GEE resulted in the growth inhibition in a dose and time dependent manner as measured by trypan blue count and MTT assay. The anti-proliferative effect of GEE treatment in AGS cells was associated with morphological changes and formation of apoptotic bodies, and the flow cytometry analysis confirmed that GEE treatment increased the populations of apoptotic-sub G1 phase. Growth inhibition and apoptosis of AGS cells by GEE were connected with a concentration and time-dependent up-regulation of tumour necrosis factor-related apoptosis-inducing ligand(TRAIL) expression. Results : The levels of XIAP and survivin expression, members of IAP family proteins, were gradually down-regulated by GEE treatment. However other members of IAP family proteins such as cIAP-1 and cIAP-2 remained unchanged in GEE-treated AGS cells. GEE treatment also induced the proteolytic activation of caspase-3, caspase-8 and caspase-9 and a concomitant degradation of poly(ADP-ribose) polymerase(PARP) protein, a caspase-3 substrate protein. Additionally, GEE-induced apoptosis was associated with the inhibition of Akt activation in a concentration and time-dependent manner, and pre-treatment with LY294002, a phosphoinositide 3-kinase(PI3K)/Akt inhibitor, significantly increased GEE-induced growth inhibition and apoptosis. Conclusions : Therefore, G. lucidum has a strong potential as a therapeutic agent for preventing cancers such as gastric cancer cells.

• Journal of architectural history
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• v.2 no.1 s.3
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• pp.9-24
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• 1993

The objective of this study is to describe more positively and concretely the entity of traditional village through the quantitative and scientific analysis process using positive data. Dan-Gye, a traditional village in San-Cheong, has been populated since more than 500 years ago because of its ideal conditions for settlement. In this study, the fluctuations on the numbers of households in Dan-Gye were analyzed from the first settlement era to the present, and the transformations of housing sites and roads since 1913 were also analyzed. The results are as follows. 1) The village Dan-Gye has a history of more than 500 years, and the first inhabitants were the Ryus. As time went by, the Ryus' power became weak gradually, but the powers of the Kwons and the Parks who had flowed later into this village became prosperous to make up a prominent family village in the late period of Cho-Sun dynasty. Such powers had reached the peak in the early period of Japanese occupation, and although the powers became weak gradually after that time, those two families have overwhelmed other families in population and possession of large houses until now. But as the confucianism in every-day life fell off and the inhabitants moved to cities, the existence of a family community became meaningless. 2) The Kwons and the Parks have possessed the large parts of the village's housing sites. As time went by, the sites have been divided and fields have been changed to housing sites for the increasing families, and such division and change have been made chiefly on perimeter areas. 3) The characteristics of the road in Dan-Gye where traditional roads existed began to be destroyed by Japanese construction of new roads, and such destruction has continued due to the bank construction after a flood and the road constructions after 1970s.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.38 no.10
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• pp.853-858
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• 2014

We propose a fabrication method for polydiacetylene (PDA)-embedded hydrogel microfibers on a microfluidic chip. These fibers can be applied to the detection of cyclodextrines (CDs), which are a family of sugar and aluminum ions. PDA, a family of conjugated polymers, has unique characteristics when used for a sensor, because it undergoes a blue-to-red color transition and nonfluorescence-to-fluorescence transition in response to environmental stimulation. PDAs have different sensing characteristics depending on the head group of PCDA. By taking advantage of ionic crosslinking-induced hydrogel formation and the 3D hydrodynamic focusing effect on a microfluidic chip, PCDA-EDEA-derived diacetylene (DA) monomer-embedded microfibers were successfully fabricated. UV irradiation of the fibers afforded blue-colored PDA, and the resulting blue PDA fibers underwent a phase transition to red and emitted red fluorescence upon exposure to CDs and aluminum ions. Their fluorescence intensity varied depending on the CDs and aluminum ion concentrations. This phase transition was also observed when the fibers were dried.

• Toxicological Research
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• v.19 no.2
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• pp.91-98
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• 2003

Alkylating agents form alkylated base adducts in the DNA and cause DNA lesions leading to cell killing. In this study, we investigated the mechanism of apoptosis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in PC-3 and DU145 human prostate carcinoma cell lines. MNNG treatment resulted in the inhibition of cell proliferation in a concentration-dependent manner to a similar extent in both cell lines. This anti-proliferative effect of PC-3 and DU145 cells by MNNG was associated with morphological changed such as membrane shrinking, cell rounding up and formation of apoptotic bodies. MNNG treatment also induced a proteolytic cleavage of specific target proteins such as poly(ADP-ribose) polymerase (PARP) and $\beta$-catenin proteins in DU145 cells but in PC-3 cells. Furthermore, we observed an increase of proapoptotic protein Bax family expression and a decrease of antiapoptotic protein Bcl-2 family by MNNG treatment in a concentration-dependent manner MNNG also induced a proteolytic activation of caspase-3 and -9, which is believed to play a central role in the apoptotic signaling pathway.

• Microbiology and Biotechnology Letters
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• v.33 no.1
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• pp.9-15
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• 2005

Chitin deacetylase (CDA; EC 3.5.1.41) catalyzes the hydrolysis of N-acetamide bonds of chitin, converting it to chitosan. Chitosan has several applications in areas such as biomedicine, food ingredients, cosmetics, pharmaceuticals, and agriculture. In this paper, occurrence, assay and purification protocols, enzymatic characteristics, substrate specificity, and mode of action of microbial CDAs have been described. Several lines of evidence have substantiated the biological roles involved in cell wall formation and plant-pathogen interactions for fungal CDAs. The gene structure of CDAs has been compared with other family 4 carbohydrate esterases which deacetylate a wide variety of acetylated poly/oligo-saccharides. The use of CDAs for the conversion of chitin to chitosan, in contrast to the presently used chemical procedure, offers the possibility of a controlled, non-degradable process, resulting in the production of well-defined chitosan oligomers and polymers. Insect pathogen that can secrete high levels of chitin-metab­olizing enzymes including CDA can be a possible alternative for new pest management tools.

• International Journal of Human Ecology
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• v.8 no.1
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• pp.53-66
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• 2007

The purpose of the study is to microscopically re-clarify the reality of renovation and conflicts that females faced within their families since the modernization period. The research method is the literature review. Families have been considered based on the formation of individual spaces for housing by husband and wife. The study will analyze changes in daily lives and housing consciousness to understand how such housing areas are transforming. The results of the study are as follows. From the perspective of symbolic interaction, in a traditional society, Korean females have been experiencing alienation and isolation in private areas in their daily lives due to family centrism and male chauvinism. Since industrialization, the female's role as the major consumer has been emphasized. Also, in terms of housing space, the symbol of family interaction was influenced more by utility, rationality, and equality than spatial hierarchy. From the perspective of the dailiness of phenomenological traditions, the modern girl's housing consciousness, which appeared during modernization under colonial rule, is considered as revolutionary from traditional society. Soon after in industrialized society, females appeared as leaders of 'sweet home'. They also became the main body to create the space for living by giving meaning to the interior of housing. Considering dailiness from the Marxist perspective, under the colonial social system, females became the subject of colonization through education, socialization, and the labor market. The modern public system presents the female as 'a wise mom and good wife' or laborer causing the colonization of her life. After industrialization, the socialization of housing and prioritization of spending caused the daily lives of females to become colonized by the consumption market.

• The Journal of the Convergence on Culture Technology
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• v.2 no.4
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• pp.45-48
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• 2016

Prenatal and postnatal management is very important as the health of pregnant woman is directly related to the health of fetus. Therefore, there is a need for systematic management of prevent potential problems regarding the health of mother and fetus. The health of pregnant woman and fetus is the responsibility regarding health management of family and childcare, which influence the health and welfare of not only just woman but also the entire family. So the health management of pregnant woman and infant is a significant problem that must be socially taken into account. This thesis studied how to provide correct prenatal education method and attachement formation method before and after the birth using mobile application. The application provides writing childcare diary, fetus diary, introduce to correct prenatal education, postnatal education method, information of expected due date and emergency contact to manage both mother and fetus at the same time.

• Journal of Korean Public Health Nursing
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• v.17 no.1
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• pp.96-112
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• 2003

The purpose of this study was to determine how often toddlers and preschoolers in kindergartens have accidents and what factors affect the accident rate. The study population consisted of 150 children who were attending at nursery schools and 150 children who were attending at kindergartens. The data was collected from ten nursery schools and five kindergartens from five districts in Daegu. The questionnaires were distributed to teachers of participating nursery schools and kindergartens to be completed using nursing care records in the institutions and by interviewing children's parents about all of the accidents happened in a previous year. Data were collected during the period of August 1 through 31, 2002. The results of the study are as follow: 1. Among 300 children, 282 had 506 accidental injuries during the study period. 2. The month, the day and the time with the highest accident rate were April. Monday, and between 2 and 4 o'clock in the afternoon, respectively. 3. Locations where the injury took place most included nursery schools or kindergartens, around the homes of the children, and inside the home. 4. Most accidents were occurred due to lack of carefulness of the children, and the most prevalent forms of injury was abrasions. 5. Most frequently injured part of the body was legs of the children. 6. Most injuries were healed within three days and required first aid measures to disinfect the wound. Mostly, these were performed by family members at home. Some children go to the hospital to suture the open wound. Most frequent type of complication was scar formation and the cost of the treatment ranged from 9,000 to 30,000 won. 7. Children's age. sex, birth order. personality. type of family composition. type of residency. father's occupation, father's age, and mother's age were significantly related to the frequency of injury among children. Children who were in nursery schools and kindergartens need their assessment for accident involving condition according to seasons, time. place. This study provided a very useful and important data to prepare accident prevention education program and accident prevention strategies, and to develop Injury Surveillance System.

• Journal of architectural history
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• v.14 no.1 s.41
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• pp.123-134
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• 2005

This study is focused on a space for man in upper classes house that is one of appeared characteristics as Korea, China and Japan imported Confucianism become common cultural base in these countries. Because a space for man in these countries has the same nature represented as a typical space in a upper classes house, and this space is differentiated by regional features, a way of thinking, a way of life and social structure as well, these characteristics are compared one another. Import of Confucianism influenced formation of a upper classes house and the spaces of the house are divided by generation, sexuality and classes. A space for man become a center of the house as well as a space for reception in accordance with patriarchism because this space stands for hierarchy of the house. A space for man of each country, Korea, China and Japan, has differences; that is, Chinese Jeongbang is used as a space for family as well as for guests; Korean Sarangchae is for only men and used as a reception space; Japanese Zasiki is used just for reception. These differences among countries are caused by owner's class, a civil officer or a military officer, and this class differentiated the characteristics of reception for guest. Even though the these countries take the space for man for meeting, Chinese is for family, Korean is for ancestors and Japanese is for guests.