• Journal of the Korean Statistical Society
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• 제36권1호
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• pp.77-91
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• 2007

This paper considers development of noninformative priors for the familial data when the families have equal number of offspring. Several noninformative priors including the widely used Jeffreys' prior as well as the different reference priors are derived. Also, a simultaneously-marginally-probability-matching prior is considered and probability matching priors are derived when the parameter of interest is inter- or intra-class correlation coefficient. The simulation study implemented by Gibbs sampler shows that two-group reference prior is slightly edge over the others in terms of coverage probability.

• Communications for Statistical Applications and Methods
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• 제12권2호
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• pp.395-411
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• 2005

In this paper, we develop the Jeffreys' prior, reference prior and the the probability matching priors for the difference of intraclass correlation coefficients in familial data. e prove the sufficient condition for propriety of posterior distributions. Using marginal posterior distributions under those noninformative priors, we compare posterior quantiles and frequentist coverage probability.

• Journal of Korean Neurosurgical Society
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• 제53권1호
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• pp.1-5
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• 2013

Objective : The purpose of this study was to evaluate the characteristics and surgical outcomes of familial hemifacial spasm (HFS) and to discuss the role of genetic susceptibility. Methods : Between 2001 and 2011, 20 familial HFS patients with ten different pedigrees visited our hospital. The data from comprehensive evaluation of these patients, including clinical, radiological and electrophysiological data and surgical outcomes were reviewed to characterize familial HFS and to compare the characteristics between familial HFS and sporadic HFS. Results : According to the family tree, the inheritance pattern was difficult to define clearly using these data. Radiologic findings suggested that the vertebral artery (VA) was a more frequent offender in familial HFS than in sporadic cases (35.0% vs. 10.0%, p<0.001). Chi-square test showed that there were no correlation between VA tortuosity and underlying morbidity such as diabetes or hypertension (p=0.391). Eighteen out of 19 patients who underwent microvascular decompression showed no residual spasm. Other features of familial HFS overlap with sporadic cases. These findings suggest that certain genetic susceptibilities rather than hypertension or diabetes may influence vascular tortuosity and HFS development. Conclusion : In this study, familial HFS seems not so different from sporadic cases. Authors thought familial HFS could have heterogeneous etiology. Further study of familial HFS including clinical, anatomic, genetic, and molecular information may help identify a gene or trait that can provide insight into the mechanisms of sporadic and familial HFS.

• 한국통계학회:학술대회논문집
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• 한국통계학회 2005년도 춘계 학술발표회 논문집
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• pp.53-57
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• 2005

In this paper, we develp the group ordering referecne priors for the differecne of the intraclass correlation coefficient in familial data. Using marginal posterior distributions under those priors, we compare frequentist coverage probabilities.

• Child Health Nursing Research
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• 제10권3호
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• pp.300-310
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• 2004

Purpose: To compare normal weight children with obese children in terms of family factors, eating habits, and sociocognitive factors. Method: This study compared 217 obese children with 231 normal standard weight children of 4th-6th graders from 7 elementary schools in Kangwon province. The study also surveyed 817 their parents using questionnaires in which familial factors, eating habits, and sociocognitive factors such as dietary self-efficacy, locus of control and self-esteem were included. Result: Obese children had more obese family members, more family members with chronic metabolic disease, and lower breast-feeding rate than normal weight group. Dietary self-efficacy was positively correlated with eating habits and locus of control while no correlation was found with obesity index.. Self-esteem was negatively correlate with obesity index. Both the parents and the childrens eating habits showed significant positive correlation to the obesity index. Conclusion: These results implied familial factors, eating habits, and sociocognitive factors influenced childhood obesity. Thus, further research targeting to positive attitude toward familial dietary practices combined with significant sociocognitive factors, may lead to prevention and effective management of childhood obesity.

• Genomics & Informatics
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• 제7권2호
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• pp.107-110
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• 2009

In Sasang constitutional medicine, both disease susceptibility and drug response are considered to be related to the characteristics of an individual's physiology and psychology: a theory which is central to traditional Korean medicine. Based on such observable characteristics, Sasang constitutional medicine classifies people into four constitutional types. Genetic studies of Sasang constitution would help reveal the inheritance patterns and models of the typological traits and, moreover, help with traditional medical diagnosis and treatment. To investigate the heritable aspect of Sasang constitution, we collected various pedigrees from South Korea. The study population has 101 pedigrees composed of 593 individuals. The determination of the Sasang constitution type of each individual was performed by doctors who diagnose the Sasang constitutional type of individuals as part of their professional practice. We calculated estimates of familial correlation and heritability. Parent-Offspring pairs showed the strongest familial correlation of Sasang constitutional type, with the correlation values of 0.21 and 0.28, followed by sibling pairs with the value ranging between 0.14 and 0.25. From the heritability analysis conducted with the Variance-Component method, the heritability of TE (Tae-Eum) type, SY (So-Yang) type, and SE (So-Eum) type were 55%, 41%, and 47%, respectively. This pattern of heritability was consistent with different set of analyses, which suggest the robustness of our result. Our result clearly shows that the Sasang constitution type is heritable, and further genetic analysis based on our result will shed light on the biological mechanism of Sasang constitution.

• 여성건강간호학회지
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• 제26권1호
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• pp.84-92
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• 2020

Purpose: The objective of this study was to identify the factors influencing maternal identity in pregnant women. Methods: Using a descriptive research design, a cross-sectional survey was conducted. In total, 127 pregnant women were recruited from a tertiary hospital in Korea from January to April 2019. Measurements included maternal identity, stress, depression, spousal and familial support, and demographic and obstetric characteristics. Data were analyzed by descriptive statistics, the independent t-test, one-way ANOVA, Pearson correlation coefficients, and stepwise multiple regression using SPSS version 25.0. Results: The mean score for maternal identity was 131.15 out of 160, and the mean scores for stress, depression, and spousal and familial support were 14.59 (out of 40), 6.82 (out of 30), and 109.04 (out of 132), respectively. Stress (r=-.38, p<.001), depression (r=-.37, p<.001), and spousal and familial support (r=.37, p<.001) were significantly correlated with maternal identity. In multiple regression analysis, stress (β=-0.27, p=.005) and spousal and familial support (β=0.23, p=.014) were found to be significant factors influencing maternal identity in pregnant women (F=14.19, p<.001). Conclusion: It is necessary to develop effective strategies to mitigate stress and to encourage spousal and familial support in pregnant women. Such strategies could further enable pregnant women to enhance their maternal identity.

• 대한핵의학회지
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• 제23권1호
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• pp.1-6
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• 1989

The occurrence of thyroid disorders is connected with iodine deficiency, defective synthesis or releasing of thyroid hormone and endemicity. Genetic factors are known as a single gene defects, interaction of multiple genes with environmental factors, as well as chromosomal aberrations. Diofnosis thyroid disorders is enforced by I-131 uptake test, thyroid scanning with I-131 or Tc-99 m and serum radioimmunoassays of T3, T4, free T4 and TSH. They were largely classified as hypothyroidism, hyperthyroidism, simple goiter and normal. The pedigree of 58 families was drawn by propositus, and then the correlation between thyroid disorders and TSH levels was analyzed. The results are as follows: 1) The offsprings and their mothers of 15 families were hypothyroidism, THS level was 5 folds for offsprings and 4 folds for mothers in comparison with control group. 2) 13 families were hyperthyyroidism in siblings but their mothers were normal in thyroid function, TSH level of the siblings was lower than control group. 3) Though the offsprings and their mothers of 10 families were similar to TSH level of control group, they are all simple goiter, familial thyroid disorders, in other thyroid function test. The familial thyroid disorders suggested that these transmitted from mothers to offsprings with X-linked dominant or autosomal dominant inheritance.

• 대한간호학회지
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• 제32권2호
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• pp.231-242
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• 2002

The purpose of this study was to identify the rate of suicidal attempts, investigate difference of rate of suicidal attempts between students and delinquents, and examine correlation between personality, family dynamics, environment, and suicidal attempts among Korean adolescents. Method: Data were collected through questionnaire surveys. Internal consistencies for this questionnaire ranged from 0.63 to 0.88. The subject used in this study consisted of 922(delinquent : 367, student : 555), using the proportional stratified random sampling method. Statistical methods employed were Chi-square and t-test. Results: \circled1 The rate of suicidal attempts were 10.8%, and the highest peak age of suicidal attempt was 17-18 year old (16.9%). \circled2 Delinquents(19.6%) showed a higher rate of suicidal attempts than students (5.1%). Among the students, girls (43.3%) showed a higher rate of suicidal attempt than boys (19.1%). Whereas, boys (80.9%) showed a higher rate of suicidal attempt than girls (56.7%) among delinquents. \circled3 Those who attempt suicide have more familial problem such as incest, psychosis, depression, attempted suicide, committed suicide, and alcoholism in their family. They also have more dysfunctional family dynamics, environment, and maladaptive personalities than non-attempters. Conclusions: Suicide and suicidal behaviors are multifaceted events. For suicide prevention, independent assessments of variables such as familial problems, personality, family dynamics, and environment must be considered.

• 육아정책연구
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• 제12권3호
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• pp.55-76
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• 2018

본 연구는 2012년 전국 규모로 실시된 5차 한국아동패널의 자료를 활용하여 만 4세 유아의 개인적 특성요인(기질), 가족특성변인(모 취업여부), 생활시간변인(육아지원기관 이용시간, 기관에서의 낮잠시간, 전자매체 사용시간)이 유아의 야간수면시간에 어떠한 영향을 미치는지와 가장 높은 설명력을 가지는 변인이 무엇인지 살펴보고자 하였다. 그 결과, 유아의 개인적 특성변인, 가족특성변인, 생활시간변인이 야간수면시간과 부적 상관관계가 있는 것으로 나타났다. 상대적 설명력은 생활시간변인, 가족특성변인 순으로 높았으며 개인적 특성변인은 유의하지 않았다. 이에 따라 유아가 가정에서 충분한 야간수면을 취할 수 있도록 부모는 적절한 생활환경을 제공해 주어야하며 자녀의 양육을 지원하기 위해 가정과 기관의 연계 강화, 부모의 근무시간 유연제 등의 제도 확산과 시행의 필요성이 제기된다.