• The Korean Journal of Medicine
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• v.99 no.3
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• pp.149-157
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• 2024

Background/Aims: Carbapenems are recommended for treating bacteremia caused by extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae (ESBL-E). However, this has resulted in a significant rise in the utilization of carbapenems in cases of ESBL-E infection. We evaluated the clinical outcomes of patients with ESBL-E bacteremia treated with non-carbapenem antimicrobials. Methods: We conducted a retrospective case-control study of a cohort of patients with documented ESBL-E bacteremia from January 2021 to December 2021. The patients were divided into two groups according to whether they received non-carbapenem or carbapenem therapy. The rates of treatment failure, 30-day mortality and microbiologic failure, and the durations of hospitalization and of antimicrobial therapy were compared between the two groups. Antimicrobial susceptibility testing and phenotypic identification of ESBL-E were performed using the Vitek 2 system. Results: Of 118 patients with ESBL-E bacteremia, 54 received non-carbapenem drugs (non-carbapenem group [NCG]) and 64 received carbapenems (carbapenem group [CG]). Treatment failure at 30 days occurred in 16.7% of the patients in the NCG and in 18.8% in the CG (p = 0.65). The 30-day mortality rate was 14.8% in the NCG and 17.2% in the CG (p = 0.63). Extra-urinary tract infection and prior antimicrobial therapy within 30 days were risk factors for treatment failure in patients with ESBL-E bacteremia. The clinical outcomes did not differ significantly between the two groups, challenging the prevailing preference for carbapenems in the treatment of ESBL-E bacteremia. Conclusions: Non-carbapenem antimicrobials such as piperacillin/tazobactam are recommended for patients with mild ESBL-E bacteremia in South Korea.

• Earthquakes and Structures
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• v.7 no.2
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• pp.179-199
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• 2014

The steel tube-reinforced concrete (ST-RC) composite column is a novel type of composite column, consisting of a steel tube embedded in reinforced concrete. The objective of this paper is to investigate the effect of cumulative damage on the seismic behavior of ST-RC columns through experimental testing. Six large-scale ST-RC column specimens were subjected to high axial forces and cyclic lateral loading. The specimens included two groups, where Group I had a higher amount of transverse reinforcement than Group II. The test results indicate that all specimens failed in a flexural mode, characterized by buckling and yielding of longitudinal rebars, failure of transverse rebars, compressive crushing of concrete, and steel tube buckling at the base of the columns. The number of loading cycles was found to have minimal effect on the strength capacity of the specimens. The number of loading cycles had limited effect on the deformation capacity for the Group I specimens, while an obvious effect on the deformation capacity for the Group II specimens was observed. The Group I specimen showed significantly larger deformation and energy dissipation capacities than the corresponding Group II specimen, for the case where the lateral cyclic loads were repeated ten cycles at each drift level. The ultimate displacement of the Group I specimen was 25% larger than that of the Group II counterpart, and the cumulative energy dissipated by the former was 2.8 times that of the latter. Based on the test results, recommendations are made for the amount of transverse reinforcement required in seismic design of ST-RC columns for ensuring adequate deformation capacity.

• Journal of Korean Neurosurgical Society
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• v.57 no.4
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• pp.229-234
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• 2015

Objective : Pedicle screw fixation for spine arthrodesis is a useful procedure for the treatment of spinal disorders. However, instrument failure often occurs, and pedicle screw loosening is the initial step of a range of complications. The authors recently used a modified transpedicular polymethylmethacrylate (PMMA) screw augmentation technique to overcome pedicle screw loosening. Here, they report on the laboratory testing of pedicle screws inserted using this modified technique. Methods : To evaluate pullout strengths three cadaveric spinal columns were used. Three pedicle screw insertion methods were utilized to compare pullout strength; the three methods used were; control (C), traditional transpedicular PMMA augmentation technique (T), and the modified transpedicular augmentation technique (M). After control screws had been pulled out, loosening with instrument was made. Screw augmentations were executed and screw pullout strength was rechecked. Results : Pedicle screws augmented using the modified technique for pedicle screw loosening had higher pullout strengths than the control ($1106.2{\pm}458.0N$ vs. $741.2{\pm}269.5N$; p=0.001). Traditional transpedicular augmentation achieved a mean pullout strength similar to that of the control group ($657.5{\pm}172.3N$ vs. $724.5{\pm}234.4N$; p=0.537). The modified technique had higher strength than the traditional PMMA augmentation technique ($1070.8{\pm}358.6N$ vs. $652.2{\pm}185.5N$; p=0.023). Conclusion : The modified PMMA transpedicular screw augmentation technique is a straightforward, effective surgical procedure for treating pedicle screw loosening, and exhibits greater pullout strength than traditional PMMA transpedicular augmentation. However, long-term clinical evaluation is required.

• Smart Structures and Systems
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• v.12 no.1
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• pp.55-71
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• 2013

Structural health monitoring (SHM) is vital for detecting the onset of damage and for preventing catastrophic failure of civil infrastructure systems. In particular, piezoelectric transducers have the ability to excite and actively interrogate structures (e.g., using surface waves) while measuring their response for sensing and damage detection. In fact, piezoelectric transducers such as lead zirconate titanate (PZT) and poly(vinylidene fluoride) (PVDF) have been used for various laboratory/field tests and possess significant advantages as compared to visual inspection and vibration-based methods, to name a few. However, PZTs are inherently brittle, and PVDF films do not possess high piezoelectricity, thereby limiting each of these devices to certain specific applications. The objective of this study is to design, characterize, and validate piezoelectric nanocomposites consisting of zinc oxide (ZnO) nanoparticles assembled in a PVDF copolymer matrix for sensing and SHM applications. These films provide greater mechanical flexibility as compared to PZTs, yet possess enhanced piezoelectricity as compared to pristine PVDF copolymers. This study started with spin coating dispersed ZnO- and PVDF-TrFE-based solutions to fabricate the piezoelectric nanocomposites. The concentration of ZnO nanoparticles was varied from 0 to 20 wt.% (in 5 % increments) to determine their influence on bulk film piezoelectricity. Second, their electric polarization responses were obtained for quantifying thin film remnant polarization, which is directly correlated to piezoelectricity. Based on these results, the films were poled (at 50 $MV-m^{-1}$) to permanently align their electrical domains and to enhance their bulk film piezoelectricity. Then, a series of hammer impact tests were conducted, and the voltage generated by poled ZnO-based thin films was compared to commercially poled PVDF copolymer thin films. The hammer impact tests showed comparable results between the prototype and commercial samples, and increasing ZnO content provided enhanced piezoelectric performance. Lastly, the films were further validated for sensing using different energy levels of hammer impact, different distances between the impact locations and the film electrodes, and cantilever free vibration testing for dynamic strain sensing.

• Steel and Composite Structures
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• v.37 no.3
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• pp.307-321
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• 2020

The slim-floor solution provides an efficient alternative to the classic slab-over-beam configuration due to architectural and structural benefits. Two deficiencies can be identified in the current state-of-art: (i) the technique is limited to nonseismic applications and (ii) the lack of information on moment-resisting slim-floor beam-to-column joints. In the seismic design of framed structures, continuous beam-to-column joints are required for plastic hinges to form at the ends of the beams. The present paper proposes a slim-floor technical solution capable of expanding the current application of slim-floor joints to seismic-resistant composite construction. The proposed solution relies on a moment-resisting connection with a thick end-plate and large-diameter bolts, which are used to fulfill the required strength and stiffness characteristics of continuous connections, while maintaining a reduced height of the configuration. Considering the proposed novel solution and the variety of parameters that could affect the behavior of the joint, experimental and numerical validations are compulsory. Consequently, the current paper presents the experimental and numerical investigation of two slim-floor beam-to-column joint assemblies. The results are discussed in terms of moment-rotation curves, available rotational capacity and failure modes. The study focuses on developing reliable slim-floor beam joints that are applicable to steel building frame structures located in seismic regions.

• Geomechanics and Engineering
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• v.23 no.3
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• pp.227-244
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• 2020

Earthen structures have an excellent bioclimatic performance, but they are vulnerable against earthquakes. In order to investigate the edification process and costs, a full-scale rammed soil house was constructed in 2004. In 2016-2019, it was studied its seismic damage, durability and degradation process. During 2004-2016, the house presented a relatively good seismic performance (M_w=5.6-6.4). The damaged cover contributed in the fast deterioration of walls. In 2018 it was observed a partial collapse of one wall due to recent seismicity (M_w=5.6-6.1). The 15-year-old samples presented a reduced compressive strength (0.040 MPa) and a minimum moisture (1.38%). It is estimated that the existing house has approximately a remaining 20% of compressive strength with a degradation of about 5.4% (0.0109 MPa) per year (considering a time frame of 15 years) if compared to the new soil samples (0.2028 MPa, 3.52% of moisture). This correlation between moisture and compressive strength degradation was compared with the study of new soil samples at the same construction site and compared against the extracted samples from the 15-year-old house. At 7-14-days, the specimens presented a similar compressive strength as the degraded ones, but different moisture. Conversely, the 60-days specimens shown almost five times more strength as the existing samples for a similar moisture. It was observed in new rammed soil that the lower the water content, the higher the compressive/shear strength.

• IMMUNE NETWORK
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• v.4 no.3
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• pp.131-142
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• 2004

In recent years, adjuvants have received much attention because of the development of purified subunit and synthetic vaccines which are poor immunogens and require adjuvants to evoke the immune response. Therefore, immunologic adjuvants have been developed and testing for most of this century. During the last years much progress has been made on development, isolation and chemical synthesis of alternative adjuvants such as derivatives of muramyl dipeptide, monophosphoryl lipid A, liposomes, QS-21, MF-59 and immunostimulating complexes (ISCOMS). Biodegradable polymer microspheres are being evaluated for targeting antigens on mucosal surfaces and for controlled release of vaccines with an aim to reduce the number of doses required for primary immunization. The most common adjuvants for human use today are aluminum hydroxide and aluminum phosphate. Calcium phosphate and oil emulsions have been also used in human vaccination. The biggest issue with the use of adjuvants for human vaccines is the toxicity and adverse side effects of most of the adjuvant formulations. Other problems with the development of adjuvants include restricted adjuvanticity of certain formulations to a few antigens, use of aluminum adjuvants as reference adjuvant preparations under suboptimal conditions, non-availability of reliable animal models, use of non-standard assays and biological differences between animal models and humans leading to the failure of promising formulations to show adjuvanticity in clinical trials. The availability of hundreds of different adjuvants has prompted a need for identifying rational standards for selection of adjuvant formulations based on safety and sound immunological principles for human vaccines. The aim of the present review is to put the recent findings into a broader perspective to facilitate the application of these adjuvants in general and experimental vaccinology.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.32 no.3
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• pp.30-36
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• 2004

As fiber reinforced composite materials are widely used in aircraft, space structures and robot arms, the study on the non-destructive testing methods of the composite materials has become an important research area for improving their reliability and safety. In this paper, the AE signal analyzer with the resonance circuit to extract the specified frequency of the acoustic emission signal were designed and fabricated. The noise levels of the fabricated AE signal analyzer by the disturbance such as impact or mechanical vibration had a very small value comparable to those of the conventional AE signal analyzer. Also, the fabricated AE signal analyzer was proved to have about the same crack detection capabilities with the conventional AE signal analyzer under the static and dynamic tensile tests of the composite materials.

• The Journal of Korean Academy of Prosthodontics
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• v.38 no.5
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• pp.640-649
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• 2000

In the restoration of endodontically treated teeth, carbon fiber post was recently introduced. The purpose of this in vitro study was to investigate the fracture strength of teeth restored with a pre-fabricated carbon fiber post in comparison with teeth restored with a prefabricated titanium post & custom cast gold post after cyclic loading in the different environment. A total of 30 recently extracted human central incisors of similar dimension with crowns removed were used. All teeth were placed into acrylic blocks and every steps for post and core fabrication were made accord-ing to manufacture's instruction. The post length and core dimensions were standardizd. All teeth were divided into 6 groups: 1) carbon fiber post / atmosphere, 2) titanium post / atmosphere, 3) gold post / atmosphere, 4) carbon fiber post / wet, 5) titanium post / wet, 6) gold post / wet. Carbon fiber post and titanium post were cemented in place using resin cement and cores were fabricated with Ti-Core. Custom cast gold post was made from Duralay pattern resin and cemented using resin cement, too. All specimens were thermocycled 10,000 times. After 50,000 cyclic loading, failure strength was measured using Instron testing machine. Kruskal-Wallis test followed by Mann-Whitney test was used to compare the mean fracture strength. Results were as follows : 1. All specimens showed lower fracture strength in wet environment after cyclic loading than in atmosphere condition, but did not reveal a significant difference. 2. There was no significant difference between carbon fiber post specimen and titanium post specimen in the same environment. 3. Gold cast post specimen showed significant different greater fracture strength than those of others in the same environment. 4. Carbon fiber post specimen showed no root fracture.

• Journal of Hydrogen and New Energy
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• v.31 no.3
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• pp.284-292
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• 2020

In this study, hydrogen charging was conducted for API X70 steel by the electro-chemical hydrogen charging method. Right after hydrogen was diffused from the specimen surface to the inside of the X70, the small punch tests and hydrogen concentration analysis was conducted within 5 minutes. Hydrogen was analyzed by melting the whole specimen and detect the gas after melting. Mechanical properties were measured by the small punch (SP) testing. Fracture surface and specimen surface were observed using scanning electron microscope. Three tests were repeated for study sensitivity of the SP test results under a same charging condition. It was observed that the variation of the maximum load, SP displacement at failure, hydrogen concentration as the charging period was not much in the case of X70 as the other steel such as Inconel. It can be argued that X70 base metal may have high hydrogen damage resistance and hydrogen diffusion in the base metal would not cause much embrittlement. Limitations of the SP test with 0.5 mm thickness for hydrogen damage test for X70 were discussed.