• Journal of Chest Surgery
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• v.57 no.2
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• pp.225-229
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• 2024

Venovenous (VV) extracorporeal membrane oxygenation (ECMO) is a lifesaving technique for patients experiencing respiratory failure. When VV ECMO fails to provide adequate support despite optimal settings, alternative strategies may be employed. One option is to add another venous cannula to increase venous drainage, while another is to insert an additional arterial return cannula to assist cardiac function. Alternatively, a separate ECMO circuit can be implemented to function in parallel with the existing circuit. We present a case in which the parallel ECMO method was used in a 63-year-old man with respiratory failure due to coronavirus disease 2019, combined with cardiac dysfunction. We installed an additional venoarterial ECMO circuit alongside the existing VV ECMO circuit and successfully weaned the patient from both types of ECMO. In this report, we share our experience and discuss this method.

• Molecules and Cells
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• v.46 no.11
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• pp.655-663
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• 2023

Autophagy dysfunction is associated with human diseases and conditions including neurodegenerative diseases, metabolic issues, and chronic infections. Additionally, the decline in autophagic activity contributes to tissue and organ dysfunction and aging-related diseases. Several factors, such as down-regulation of autophagy components and activators, oxidative damage, microinflammation, and impaired autophagy flux, are linked to autophagy decline. An autophagy flux impairment (AFI) has been implicated in neurological disorders and in certain other pathological conditions. Here, to enhance our understanding of AFI, we conducted a comprehensive literature review of findings derived from two well-studied cellular stress models: glucose deprivation and replicative senescence. Glucose deprivation is a condition in which cells heavily rely on oxidative phosphorylation for ATP generation. Autophagy is activated, but its flux is hindered at the autolysis step, primarily due to an impairment of lysosomal acidity. Cells undergoing replicative senescence also experience AFI, which is also known to be caused by lysosomal acidity failure. Both glucose deprivation and replicative senescence elevate levels of reactive oxygen species (ROS), affecting lysosomal acidification. Mitochondrial alterations play a crucial role in elevating ROS generation and reducing lysosomal acidity, highlighting their association with autophagy dysfunction and disease conditions. This paper delves into the underlying molecular and cellular pathways of AFI in glucose-deprived cells, providing insights into potential strategies for managing AFI that is driven by lysosomal acidity failure. Furthermore, the investigation on the roles of mitochondrial dysfunction sheds light on the potential effectiveness of modulating mitochondrial function to overcome AFI, offering new possibilities for therapeutic interventions.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.10
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• pp.4762-4767
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• 2012

The AF track circuit that detecting train position and transmitting various train control data for DTG to the train on-board is composed of single operation system. If a failure occurs on this system, the driver should be operate the train by manually until the system is restored, because the system cannot control switch machines and signals by automatically. In this process the human error affects to the train delay, collision, derailment and critical safety accident. Therefore, this document has analyzed the effects that each failure mode influences on system and train, and quantified the failure valuation point and class. Basis on this quantified analysis result, MTBF increased and MTTR decreased and failure number also decreased by adopting the independent installation of power supply, the replacement of defected capacitors, the installation of resister cooling system and the improvement of maintenance methods. And the failure factors of AF track circuits were decreased by conducting the preventive maintenance which is a quantitative way of maintenance system by experience.

• KIISE Transactions on Computing Practices
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• v.23 no.1
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• pp.1-12
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• 2017

Preventive maintenance is required for best performance of facilities in large scale industry. Ultimately, the efficiency of production is maximized by preventing the failure of facilities in advance. Typically, regular maintenance is conducted manually; however, it is hard to prevent repeated failures. Also, since measures to prevent failure depend on proactive problem-solving by the facility expert, they have limitations when the expert is absent or diagnosis error is made by an unskilled expert. Alarm system is used to aid manual facility diagnosis and early detection. However, it is not efficient in practice, since it is designed to simply collect information and is activated even with small problems. In this study, we designed and developed an automated preventive maintenance system based on expert's experience in detecting failure, determining the cause, and predicting future system failure. We also discussed the system structure designed to reuse the expert's knowledge and its applications.

• Corrosion Science and Technology
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• v.3 no.5
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• pp.216-221
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• 2004

The operating experience showed that the fatigue is one of the major piping failure mechanisms in nuclear power plants (NPPs). The pressure and/or temperature loading transients, the vibration, and the mechanical cyclic loading during the plant operation may induce the fatigue failure in the nuclear piping. Recently, many fatigue piping failure occurred at the socket weld area have been widely reported. Many failure cases showed that the gap requirement between the pipe and fitting in the socket weld was not satisfied though the ASME Code Sec. III requires 1/16 inch gap in the socket weld. The ASME Code OM also limits the vibration level of the piping system, but some failure cases showed the limitation was not satisfied during the plant operation. In this paper, the fatigue behavior of the socket weld in the nuclear piping was estimated by using the three dimensional finite element method. The results are as follows. (1) The socket weld is susceptible to the vibration if the vibration levels exceed the requirement in the ASME Code OM. (2) The effect of the pressure or temperature transient load on the socket weld in NPPs is not significant because of the very low frequency of the transient during the plant lifetime operation. (3) 'No gap' is very risky to the socket weld integrity for the specific systems having the vibration condition to exceed the requirement in the ASME OM Code and/or the transient loading condition. (4) The reduction of the weld leg size from $1.09*t_1$ to $0.75*t_1$ can affect severely on the socket weld integrity.

• Korean Medical Education Review
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• v.16 no.2
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• pp.88-91
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• 2014

Medical students often need high levels of specialized institutional and personal support to recover from a burnout experience and to prevent student failure. This study aimed to present approaches to supporting medical students who had experienced burnout using case studies. The study subjects were 45 burnout cases who had been supported by the student support system and committee in one medical school. The factors associated with burnout include poor social network: the lack of belongingness, immature sense of identity, poor mental health, a lack of intrinsic motivation and aptitude, or a major personal crisis. We summarized some tips according to the factors associated with burnout. These tips should provide guidance to organizations and individual support providers to encourage the best quality support for medical students with burnout experiences.

• Wind and Structures
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• v.14 no.4
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• pp.321-335
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• 2011

The vulnerability of roofing components of contemporary houses built in cyclonic regions of Australia is assessed for increasing wind speeds. The wind loads and the component strengths are treated as random variables with their probability distributions derived from available data, testing, structural analysis and experience. Design details including types of structural components of houses are obtained from surveying houses and analyzing engineering drawings. Wind load statistics on different areas of the roof are obtained by wind tunnel model studies and compared with Australian/New Zealand Standard, AS/NZS 1170.2. Reliability methods are used for calculating the vulnerability of roofing components independently over the roof. Cladding and batten fixings near the windward gable edge are found to experience larger negative pressures than prescribed in AS/NZS 1170.2, and are most vulnerable to failure.

• Journal of Trauma and Injury
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• v.25 no.4
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• pp.261-266
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• 2012

Purpose: Traumatic pancreatic injury is not common in abdominal trauma injury. However, the morbidity and the mortality rates of patients with pancreatic injury, which are related with difficulties of initial assessment, establishment of diagnosis, and treatment are relatively high. The aim of this study is to review our institution's experience and suggest a diagnosis and therapeutic algorithm for use in cases involving traumatic pancreatic injury. Methods: Eighteen(18) patients with blunt pancreatic injury from January, 2004 to October 2012 were included in this study. We analyzed treatment and diagnosis method, other organ injury, treatment interval, hospital stay and complications retrospectively. Results: Nine patients were treated with conservative medication and another nine patients were treated surgically. Complications occurred in nine patients, and one patient died due to intraventricular hemorrhage and subdural hemorrhage with multiple organ failure. Delayed surgery was performed in three cases. The early and delayed surgery groups showed difference in hospital stay and intensive care unit stay. Delayed surgery was associated with a longer hospital stay (p=0.007) than immediate surgery. Conclusion: In blunt pancreatic trauma, proper early diagnosis and prompt treatment are recommended necessity. Based on this review of our experience, we also suggest the adoption of our institution's algorithm for cases involving traumatic pancreatic injury.

• Knee surgery & related research
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• v.30 no.4
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• pp.303-310
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• 2018

Purpose: The purpose of this study was to investigate whether surgical experience could improve surgical competency in medial open wedge high tibial osteotomy (MOWHTO). Materials and Methods: One hundred consecutive cases of MOWHTO were performed with preoperative planning using the Miniaci method. Surgical errors were defined as under- or overcorrection, excessive posterior slope change, or the presence of a lateral hinge fracture. Each of these treatment failures was separately evaluated using the cumulative summation test for learning curve (LC-CUSUM). Results: The LC-CUSUM showed competency in prevention of undercorrection, excessive posterior slope change, and lateral hinge fracture after 27, 47, and 42 procedures, respectively. However, the LC-CUSUM did not signal achievement of competency in prevention of overcorrection after 100 procedures. Furthermore, the failure rate for overcorrection showed an increasing tendency as surgical experience increased. Conclusions: Surgical experience may improve the surgeon's competency in prevention of undercorrection, excessive posterior slope change, and lateral hinge fracture. However, it may not help reduce the incidence of overcorrection even after performance of 100 cases of MOWHTO over a period of 6 years.

• Convergence Security Journal
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• v.21 no.2
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• pp.81-88
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• 2021

Officers and noncommissioned officers are the leaders of the military. Every year, more than 5,000 first-time officers are commissioned and perform their duties in various parts of the country. There is a conflict between officers and noncommissioned officers over the efficiency of experience. First-time officers are experiencing experience and a loss of authority from older noncommissioned officers and a failure to obey orders. Noncommissioned officers have complaints about first-time officers who want to direct only by class.Conflicts between officers and noncommissioned officers have existed in the past, but some first-time officers were resolved when they gained experience. Recently, the chief executives protested against the Chief of Staff's words and actions. I would like to study the cause of conflict between officers and noncommissioned officers and suggest solutions.