• Molecules and Cells
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• 제45권12호
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• pp.963-975
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• 2022

Exogenous polyamines are able to induce life span and improve glucose homeostasis and insulin sensitivity. However, the effects of exogenous polyamines on adipocyte differentiation and which polyamine transporters mediate them have not been elucidated yet. Here, we identified for the first time that exogenous polyamines can clearly stimulate adipocyte differentiation through polyamine transporters, solute carrier family 3 member A2 (SLC3A2) and SLC7A1. Exogenous polyamines markedly promote 3T3-L1 adipocyte differentiation by increasing the intracellular lipid accumulation and the expression of both adipogenic and lipogenic genes in a concentration-dependent manner. In particular, exogenous putrescine mainly regulates adipocyte differentiation in the early and intermediate stages. Moreover, we have assessed the expression of polyamine transporter genes in 3T3-L1 preadipocytes and adipocytes. Interestingly, the putrescine-induced adipocyte differentiation was found to be significantly suppressed in response to a treatment with a polyamine transporter inhibitor (AMXT-1501). Furthermore, knockdown experiments using siRNA that specifically targeted SLC3A2 or SLC7A2, revealed that both SLC3A2 and SLC7A2 act as important transporters in the cellular importing of exogenous putrescine. Thus, the exogenous putrescine entering the adipocytes via cellular transporters is involved in adipogenesis through a modulation of both the mitotic clonal expansion and the expression of master transcription factors. Taken together, these results suggest that exogenous polyamines (such as putrescine) entering the adipocytes through polyamine transporters, can stimulate adipogenesis.

• 한국건설관리학회논문집
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• 제22권2호
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• pp.3-11
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• 2021

미얀마는 아시아 국가 중 개발 가치가 높은 미개발 국가이다. 이에 미국을 비롯한 다양한 국가에서 시장 진출을 고려하고 있는 상황이다. 이러한 측면에서 부동산 개발 프로젝트의 수요는 외국인들의 유입 증가와 미얀마 경제성장에 따라 증가할 것으로 예측된다. 하지만 미얀마는 국가적 리스크를 포함해 해외 진출기업의 측면에서 위험도가 높은 국가이다. 이에 본 연구에서는 미얀마에 관한 자료분석을 실시해 리스크 유발요인을 추출한 후 전문가(법률, 금융, 기술, 현지 전문가) 심층인터뷰를 실시하였다. 이를 통해 106가지 리스크 요인을 추출하였으며, 친화도법을 활용해 3차에 걸친 그룹핑 작업을 실시하여 최종 리스크 분류 체계를 구축하였다. 그리고 AHP 기법을 활용해 각 요인별 상대적 중요도를 분석하여 제시하였다. 그 결과 해당 국가 관련 리스크, 자금 관련 리스크, 분양 관련 리스크의 중요도가 높게 나타났다. 본 연구결과는 미얀마 부동산 개발형사업의 진출기업에게 리스크관리 기준을 제공할 것으로 기대된다.

• Journal of Hospice and Palliative Care
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• 제10권3호
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• pp.120-127
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• 2007

Bereavement is the state of loss resulting from death. Grief is the emotional response associated with loss, intense and acute sorrow resulting from loss. Complicated grief represent a pathological outcome involving social, physical, emotional, cognitive, spiritual morbidity. The common psychiatric disorders associated complicated grief or abnormal grief responses include clinical depression, anxiety disorders, alcohol abuse or other substance abuse, and dependence, psychotic disorders, and post-traumatic stress disorder (PTSD). Grief tasks involve a series of stage or phases following an important loss that gradually permit adjustment and recovery. Three phases of grief involve phase 1 (walking the edges), phase 2 (entering the depths), and phase 3 (reconnecting the world). For intervention to be effective they need to be individually tailored to abnormal grief reaction or unresolved grief reaction. Clear understandings of complicated grief, abnormal responses, factors increasing risk after bereavement will often enable us to prevent psychiatric disorders in bereaved patients.

• 대한간호학회지
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• 제31권6호
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• pp.988-997
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• 2001

This study aimed at uncovering the experience of adaptation of the new nursing staff in hospital setting. Methods: For this study, 15 new graduate nurses participated. The data was collected through the in-dept interviews and analysed in terms of Strauss and Corbin′s grounded theory methodology. Results: The core category was identified with "entering orbit". The new graduate nurses, who experienced the taeoom because of their unskilled professions, tried to enter orbit by overcoming difficult situations through reducing stress, maintaining good interpersonal relationship, grasping, compensating, persisting, and introspecting. Noticeably, in the process of adaptation, negative image of nursing, conflict of interpersonal relationship and the educational program for the new nursing staff had effect on the intervening factors. Finally, this study confirmed that the processes of new nurses′ adaptation are confusing, confrontating, becoming a member and settling in hospital setting. Conclusion: Therefore, the educational programs reflecting new nursing staffs′ experiences should be developed.

• 한국산업융합학회 논문집
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• 제19권3호
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• pp.144-153
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• 2016

In this research performed on a pneumatic actuator, the air flow entering and exiting the cylinder, and the motion and deformation characteristics of the piston during operation of the actuator, were predicted. This was carried out by utilizing an FSI(Fluid-Structural Interaction) analysis technique that incorporates principles in computational fluid dynamics and structural stress analysis, and potential performance degradation factors were examined. Analysis results indicated that performance improvements could be made through design modifications. These include adding an inlet and outlet on the upper and lower sections of the cylinder in the conventional model, and increasing the number of sites for piston guide bars from three to four.

• 한국간호교육학회지
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• 제20권4호
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• pp.569-576
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• 2014

Purpose: This study investigates the factors affecting spirituality in nursing students. Method: A total of 247 nursing students participated in the study. Data were analyzed by frequencies, t-tests, ANOVA, Pearson correlation coefficients and multiple stepwise regression via SPSS WIN 18.0. Results: The mean scores for hope, gratitude, and spirituality were above-average. However, there were significant mean differences in spirituality according to religion, religious activity, voluntary service, satisfaction with the nursing field, and motivation for entering a college of nursing. Spirituality positively correlated with hope and gratitude. Significant predictors of spirituality included hope, gratitude, voluntary service and religious activity. The regression model explained 51.3% of perceived spirituality. Conclusion: To improve spirituality among nursing students, nursing educators should develop educational intervention programs to promote hope and gratitude, and support participation in voluntary service and religious activity.

• 셀메드
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• 제13권10호
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• pp.13.1-13.4
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• 2023

This paper presents the possibility of entering the global health food market as well as Korean market due to the expected effects such as satisfying the health-oriented desire of modern people and preventing diseases in advance by analyzing the consumers' reactionsto Jincho Civet Musk Dan(Jin), which uses Civet Musk, which has recently been in the limelight as a raw material for health foods, as its main ingredient and factors that can affect the demand for health food due to the aging of the population and the spread of well-being culture based on the characteristics and efficacy of each raw material.

• 한국치위생학회지
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• 제11권6호
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• pp.993-1003
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• 2011

Objectives : This study is designed to identify the need for an efficient infection control plan in the curriculum of Dept. of Dental Hygiene and encourage dental hygienists to be more attentive to infection control by analyzing their personal protective measures, hand-washing frequency and other factors relating to infection control. Methods : A survey was conducted of 471 dental hygienists in general hospitals, dental clinics and dental hospitals in City of Busan and Gyeongsangnam-do from December 20, 2009 to February 21, 2010. Results : 1. Among those who worked for more than 11 years, personal protection (3.79) and hand-washing frequency (3.90) factors were rated high (p<0.05). 2. When surveyed by workplace, personal protection was high in general hospitals (3.75) while hand-washing frequency was high in dental clinics (3.74). 3. Among those who received infection control education more than three times, personal protection (4.07) and hand-washing frequency (3.80) were high (p<0.05). 4. Personal protection-related factors were general hospital workers, necessity of infection control education and awareness on infectious disease (p<0.05), while factors associated with hand-washing frequency were number of patients per day, whether or not infection control-related class is given at school, necessity of infection control education and awareness on infectious disease (p<0.05). Conclusions : To enhance awareness of infection control, it may be necessary to addan infection control-related class to the school curriculum and provide the necessity of conducting continuous and systematic infection control education through newly entering staff training and education of dental practitioners.

• 대한간호학회지
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• 제41권1호
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• pp.119-128
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• 2011

Purpose: This study was done to determine the risk factors for recurrent fallers (2+falls) compared to single fallers. Methods: Participants were 104 community-dwelling people 65 yr of age or older. The data were collected from June 1, 2008 to June 30, 2009 using the Residential Assessment Instrument-Home Care. Results: Over the past 90 days, 55.7% of the 104 participants fell once, and 44.2% experienced recurrent falls (2+falls). In comparison of recurrent fallers with single fallers, there were significant differences in scores on the following factors: gender ($X^2$=4.22, p=.040), age ($X^2$=5.74, p=.017), educational level ($X^2$=5.22, p=.022), living arrangements ($X^2$=35.02, p<.001), cardiovascular diseases ($X^2$=17.10, p<.001), hypertension ($X^2$=4.43, p=.035), diabetes mellitus ($X^2$=4.44, p=.035), glaucoma ($X^2$=13.95, p<.001), Minimal Data Set (MDS)-Pain (t=-2.56, p=.012), fear of falling ($X^2$=4.08, p=.034), reduced vision (t=-3.06, p=.003), MDS-activity of daily living (t=3.46, p=.001), MDS-Instrumental Activities of daily living (t=3.24, p=.002), cognition (MDS-Cognition Performance Scale) (t=3.40, p=.001), and 'difficulties entering and leaving the house' ($X^2$=4.53, p=.033). Conclusion: It is important to assess the risk factors for recurrent falls and develop differentiated strategies that will help prevent recurrent falls. Additionally, utilizing a standardized tool, such as RAI-HC, would help health professionals assess multi-variate fall risk factors to facilitate comparisons of different community care settings.

• 디지털융복합연구
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• 제20권5호
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• pp.661-669
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• 2022

본 연구는 종합병원, 요양병원, 한방병원 이용자의 선택요인과 고객만족, 재이용의도에 미치는 영향을 비교 분석하였다. 본 연구는 2019년 11월 1일부터 2020년 4월 30일까지 4개 종합병원, 6개 요양병원, 3개 한방병원을 대상으로 설문조사를 실시하였다. 종합병원, 요양병원, 한방병원은 인적 요인, 효율성 요인이 고객만족에 양(+)의 영향력이 있었다. 요양병원은 소득이 높을수록 고객만족도가 높았으며, 효율적 요인이 재이용의도에 양(+)의 영향력이 있었다. 한방병원은 대외이미지 요인이 고객만족과 재이용의도에 중요한 요인이었다. 이러한 연구결과를 바탕으로 경쟁 시대에 접어든 병원들이 고객만족도와 재이용의도를 높이고 효율적 경영을 위한 유용한 자료가 될 것을 기대된다.