• BMB Reports
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• 제56권9호
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• pp.508-513
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• 2023

The phytochemical quercetin has gained attention for its anti-inflammatory and anti-tumorigenic properties in various types of cancer. Tumorigenesis involves the aberrant regulation of kinase/phosphatase, highlighting the importance of maintaining homeostasis. Dual Specificity Phosphatase (DUSP) plays a crucial role in controlling the phosphorylation of ERK. The current study aimed to clone the DUSP5 promoter, and investigate its transcriptional activity in the presence of quercetin. The results revealed that quercetin-induced DUSP5 expression is associated with the serum response factor (SRF) binding site located in the DUSP5 promoter. The deletion of this site abolished the luciferase activity induced by quercetin, indicating its vital role in quercetin-induced DUSP5 expression. SRF protein is a transcription factor that potentially contributes to quercetin-induced DUSP5 expression at the transcriptional level. Additionally, quercetin enhanced SRF binding activity without changing its expression. These findings provide evidence of how quercetin affects anti-cancer activity in colorectal tumorigenesis by inducing SRF transcription factor activity, thereby increasing DUSP5 expression at the transcriptional level. This study highlights the importance of investigating the molecular mechanisms underlying the anti-cancer properties of quercetin, and suggests its potential use in cancer therapy.

• 조명전기설비학회논문지
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• 제22권5호
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• pp.80-85
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• 2008

계약전력 산정 방법에서 적용되는 계약전력 환산율은 전력용변압기의 용량을 산정하는데 매우 중요한 기준이다. 본 연구에서는 AMR(자동검침시스템) 시스템에 의해 일반용 고객을 대상으로 각 수용가의 계약전력과 최근 5년 동안의 최대전력을 조사하였다. 조사된 자료의 전체 특징과 중심적인 경향을 알아보기 위해서 평균값 등의 특징파라메터를 분석하였고, 회귀분석을 통한 선형적인 방법과 비선형적인 방법으로 그 경향을 분석하였다. 따라서 일반용 고객의 계약전력 결정에 필요한 계약전력환산율의 특성과 변압기최대이용률이 60[%] 이상인 고객을 중심으로 분석한 회귀분석 모형과의 특성을 비교한 결과 유사한 특성을 나타냄을 확인하였다.

• 한국세라믹학회지
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• 제34권7호
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• pp.747-757
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• 1997

ZSM-5 zeolite composite membranes have been synthesized from a silica sol solution containing TPABr as an organic template by the dip-coating and the pressurized-coating hydrothermal treatment techniques. The CO2 separation efficiency of synthesized composite membranes was also investigated. The permeation mechanism of CO2 through ZSM-5 membranses was the surface diffusion, and that of N2, O2, and He gases was Knudsen diffusion or activated diffusion depending on the synthetic method of membranes and the measurement temperature. The CO2/N2 separation factor of the membrane prepared by the dip-coating hydrothermal treatment was 2.5 at about 12$0^{\circ}C$, while the ZSM-5 composite membrane synthesized by the pressurized-coating hydrothermal treatment technique showed the CO2/N2 separation factor of 9.0 at room temperature higher than that ever reported in the literature.

• 대한간호학회지
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• 제43권5호
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• pp.587-594
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• 2013

Purpose: The purpose of this study is to provide researchers with a simplified approach to undertaking exploratory factor analysis for the assessment of construct validity. Methods: All articles published in 2010, 2011, and 2012 in Journal of Korean Academy of Nursing were reviewed and other relevant books and articles were chosen for the review. Results: In this paper, the following were discussed: preliminary analysis process of exploratory factor analysis to examine the sample size, distribution of measured variables, correlation coefficient, and results of KMO measure and Bartlett's test of sphericity. In addition, other areas to be considered in using factor analysis are discussed, including determination of the number of factors, the choice of rotation method or extraction method of the factor structure, and the interpretation of the factor loadings and explained variance. Conclusion: Content validity is the degree to which elements of an assessment instrument are relevant to and representative of the targeted construct for a particular assessment purpose. This measurement is difficult and challenging and takes a lot of time. Factor analysis is considered one of the strongest approaches to establishing construct validity and is the most commonly used method for establishing construct validity measured by an instrument.

• Computers and Concrete
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• 제8권5호
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• pp.583-595
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• 2011

This paper studied the cement efficiency factor (k factor) of high calcium Class F fly ash. This k factor represents a unit of fly ash with efficiency equivalent to k unit of cement. The high calcium Class F fly ash was used to replace cement in concrete. The modified Bolomey's law with linear relationship was used for the analysis of the result of compressive strength, cement to water ratio (c/w) and fly ash to water ratio (f/w) by using the multi-linear regression to determine the k factor and other constants in the equations. The results of analysis were compared with the results from other researcher and showed that the k factor of high calcium Class F fly ash depends on the fineness of fly ash, replacement level and curing age. While the amount of CaO content in Class F fly ash not evident. Furthermore, necessary criteria and variables for the determination of the k factor including the use of the k factor in concrete mix design containing fly ash were proposed.

• Tribology and Lubricants
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• 제21권5호
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• pp.221-226
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• 2005

A new calibration method for exact measurement of friction force in atomic force microscope (AFM) is presented. A new conversion factor involves a contact factor affected by tip, cantilever and contact stiffness. Especially the effect of contact stiffness on the conversion factor between lateral force and lateral signal is considered. Conventional conversion factor and a new modified conversion factor were experimentally compared. Results showed that a new calibration method could minimize the effect of normal load on friction force and improve the conventional method. A new method could be applied to the specimens with different physical properties.

• International Journal of Computer Science & Network Security
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• 제21권5호
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• pp.211-216
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• 2021

This study intended to test the structure of the latent factor of a subjective happiness scale and the stability of invariance across groups of students' classifications (gender and students' status). In the large, non-clinical sample (619), students completed the subjective happiness scale. The (CFA) confirmatory factor analysis was used to investigate the factor-structure of the measure, and multiple-group confirmatory factor analysis (MGCFA) model was used to test the stability of invariance across groups of students classifications. The findings of the CFA indicated support for the original one-factor model. Additional analyses of the MGCFA method support the measurement (configural, metric and strong) invariant and practical invariant components of this model. There was an invariant across gender. There was partially invariant across groups of students' statuses. The scale exists in both groups to assess the same concepts of (single and married), excluding Items 3 and 4. Given that this study is the first investigation for the structure of the subjective happiness scale.

• 한국의류학회지
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• 제34권6호
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• pp.982-996
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• 2010

This study classified the body shapes of Korean obese women and investigated the differences of each body shape, using 2004 Size Korea data. For selecting the obesity sample, 7 obesity judgment indices were chosen through previous clothing-related studies. A total of 636 females defined as "obese" by 5 out of 7 indices were selected as subjects and 54 body measurements and obesity judgment indices were used in this study. Firstly, mean, standard deviation, minimum, and maximum values of each measurement and item were obtained from the descriptive analysis of 53 measurements. According to the descriptive analysis, all measurements and obesity judgment indices of the subjects demonstrated a serious obesity level shown by BMI 27.11, R$\ddot{o}$hrer index 1.76, Vervaeck index 104.77, Relative weight 133.00, WHR 0.90, and waist circumference 86.71cm. In addition, the measurements and indices showed considerable differences between minimum and maximum values. Significant differences were identified in all measurements and items at a significant level, p=.001. Each distribution of body types according to age, stature, bust, and waist circumference groups was provided in this study. Secondly, factor analyses were conducted using 38 measurement items to extract the body characteristics of obese women. Factor 1 was "circumference measurements & obesity judgment indices," Factor 2 was "heights & arm-related lengths," and Factor 3 was "size and ratio of waist circumference & hip circumference." Factor 4 was "lengths in upper body," Factor 5 was "back width in upper body," Factor 6 was "side neck point to bust & bust circumference," Factor 7 was "length in lower body & arm circumferences" and Factor 8 was "neck base circumference & front width in upper body." These 8 factors explained 76.54% of the total variance. Finally, 5 body types were selected in the cluster analysis. Type 1 (with big back widths & arm circumferences) was 15.5% of the entire subjects, Type 2 (the shortest and fattest, with big upper body) was 18.8%, Type 3 (with big breast) was 27.8%, Type 4 (the tallest and longest in arm lengths, with the smallest arm circumferences and lengths in torso) was 22.5%, and Type 5 (with big hips compared to waist circumferences, smaller height and upper body) was 15.5%. Fundamental differences were identified in all measurements and items at the significant level of p=.001. In addition, each distribution of body type according to age, height, bust, and waist circumference groups was provided in this study.

• Nuclear Engineering and Technology
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• 제55권12호
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• pp.4426-4430
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• 2023

In this article, Exposure Buildup Factor(EBF) and the Energy Absorption Buildup Factor(EABF) have been determined for blood, brain, and muscle using the Monte Carlo method which is represented by MCNP5 codes and compared with geometric progression(G-P) fitting method which is represented by Phy-X/PSD online platform. The novelty of the present work is used an energy source of less than 0.1 MeV to determine buildup factors using MCNP5 and using Phy-X/PSD for some human tissues. thus, the energy range used in this case study was 0.06-3 MeV for penetration depths covered 0.5-3 MFP. Results of MCNP5 and Phy-X/PSD are validated against reference values of water that were reported at ANS-6.4.3. present results of EABFs and EBFs for the previously mentioned human tissues appeared good agreement between MCNP5 in comparison with Phy-X/PSD, whereas, the maximum average relative deviation did not exceed 2.37%. results of our article can be used in different medical applications, such as brachytherapy, radiotherapy, and diagnostics.

• 생명과학회지
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• 제13권4호
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• pp.463-472
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• 2003

제5인자와 지질막 phosphatidylserine과의 상호작용은 prothrombinase 복합체의 활성을 조절하는데 중요하다. 본 연구에서 제5인자의 지질 결합부위에 위치한 Trp2063과 Trp2064를 동시에 돌연변이 시킨 재조합 제5인자를 과발현 시키고 정제하였다. 돌연변이된 제5인자는 1-10%의 phosphatidylserine을 포함하는 지질막에서 아주낮은 활성을 보였다. surface plasmon resonance에 의해서 지질막과의 결합을 측정한 결과 돌연변이된 제5인자가 본래의 제5인자보다 고정된 지질막에의 결합이 현저하게 떨어지는 것을 관찰하였다. 제5인자가 phosphatidylserine을 포함하는 지질막에 높은 친화력으로 결합하기 위해서는 Trp2063과 Trp2064가 필수적이고 이러한 상호작용은 생리적인 phosphatidylserine 농도를 포함하는 지질막 위에서 prothrombinase 복합체의 형성에 필요하다는 결론을 내렸다.