• Biomolecules & Therapeutics
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• v.28 no.4
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• pp.302-310
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• 2020

Botulinum toxins are neurotoxic modular proteins composed of a heavy chain and a light chain connected by a disulfide bond and are produced by Clostridium botulinum. Although lethally toxic, botulinum toxin in low doses is clinically effective in numerous medical conditions, including muscle spasticity, strabismus, hyperactive urinary bladder, excessive sweating, and migraine. Globally, several companies are now producing products containing botulinum toxin for medical and cosmetic purposes, including the reduction of facial wrinkles. To test the efficacy and toxicity of botulinum toxin, animal tests have been solely and widely used, resulting in the inevitable sacrifice of hundreds of animals. Hence, alternative methods are urgently required to replace animals in botulinum toxin testing. Here, the various alternative methods developed to test the toxicity and efficacy of botulinum toxins have been briefly reviewed and future perspectives have been detailed.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.42 no.1
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• pp.55-59
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• 2016

The two main forms of myositis ossificans are congenital and acquired. Either form is rare in the head and neck region. The acquired form is often due to trauma, with bullying as a fairly common cause. This report of myositis ossificans of the platysma in an 11-year-old female patient emphasizes the need for a high index of suspicion in unexplainable facial swellings in children and the benefit of modern investigative modalities in their management.

• The Journal of the Korean dental association
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• v.58 no.2
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• pp.114-122
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• 2020

Aesthetic facial profile is mainly determined by cultural background. In some countries, prominent mandibular angle is considered as characteristics, whereas it is considered as unattractive in East Asian countries. Therefore, reduction surgery for prominent mandibular angle is one of the popular cosmetic surgery in theses countries. The anatomical component of the mandibular angle consists of masseter muscle and the angular part of the mandibular ramus. Thus, the mandibular angle reduction can be performed by myotomy or bone reduction or both.

• Proceedings of the Korea Information Processing Society Conference
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• 2002.04a
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• pp.265-268
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• 2002

얼굴은 성별, 나이, 인종에 따라 다양한 특징을 가지고 있어서 개개인을 구별하기가 쉽고 내적인 상태를 쉽게 볼 수 있는 중요한 도구로 여겨지고 있다. 본 논문은 얼굴표정 애니메이션을 위한 효과적인 방법으로 실제얼굴의 피부조직 얼굴 근육 등 해부학적 구조에 기반한 근육기반모델링을 이용하는 방법을 소개하고자 한다. 제안하는 시스템의 구성은 얼굴 와이어프레임 구성과 폴리곤 메쉬분할 단계, 얼굴에 필요한 근육을 적용시키는 단계, 근육의 움직임에 따른 얼굴 표정생성단계로 이루어진다. 와이어프레임 구성과 폴리곤 메쉬 분할 단계에서는 얼굴모델을 Water[1]가 제안한 얼굴을 기반으로 하였고, 하나의 폴리곤 메쉬를 4등분으로 분할하여 부드러운 3D 얼굴모델을 보여준다. 다음 단계는 얼굴 표정생성에 필요한 근육을 30 개로 만들어 실제로 표정을 지을 때 많이 쓰는 부위에 적용시킨다. 그 다음으로 표정생성단계는 FACS 에서 제안한 Action Unit 을 조합하고 얼굴표정에 따라 필요한 근육의 강도를 조절하여 더 자연스럽고 실제감 있는 얼굴표정 애니메이션을 보여준다.

• Proceedings of the Korea Information Processing Society Conference
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• 2002.11a
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• pp.801-804
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• 2002

뇌기능 연구 수단으로 널리 사용되고 있는 뇌파의 시각적 분석 및 정량적 분석시 오차를 증가시키는 원인이 되어 왔던 잡파(artifact)를 제거 대상이 아닌 제어 신호로써 활용한다. 본 연구에서는 다양한 잡파 중 뇌파 측정시 가장 잘 포함되고, 시각적으로 쉽게 구별이 가능한 안면근(facial muscle) 신호를 이용한다. 측정된 뇌파에 파워스펙트럼(power spectrum)을 적응하여 뇌파를 분석하고, Backpropagation 알고리즘을 이용하여 전 처리된 뇌파를 인식하는 2 채널 실시간 인식(recognition) 및 분류(classification) 시스템을 구현한다. 이와 같이 구현된 시스템을 이용하여 5 방향(상, 하, 좌, 우, 정지) 제어를 실시함으로써 뇌-컴퓨터간 통신을 통한 방향제어 시스템을 구현하였다.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 1999.11a
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• pp.368-372
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• 1999

새롭게 표준화된 멀티미디어 동영상 파일 포맷인 MPEG-4에는 자연영상과 소리뿐만 아니라 합성된 그래픽과 소리를 포함하고 있다. 특히 화상회의나 가상환경의 아바타를 구성하기 위한 모델링과 에니메이션을 위한 FDP, FAP에 대한 표준안을 포함하고 있다. 본 논문은 MPEG-4에서 정의한 FDP와 FAP를 이용하여 화상회의나 가상환경의 아바타로 자연스럽고 현실감 있게 사용할 수 있는 얼굴 모델 생성을 위해서 보다 정교한 일반모델을 사용하고, 이에 근육 모델을 사용하여 보다 정밀한 표정 생성을 위해서 임의의 위치에 근육을 생성 할 수 있도록 근육 편집기를 작성하여, 표정 에니메이션을 수행할 수 있도록 에니메이션 편집 프로그램을 구현하였다.

• Archives of Craniofacial Surgery
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• v.20 no.5
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• pp.310-313
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• 2019

Post-traumatic hematoma formation is a common complication of contusion. If the hematoma is large enough to aspirate or drain, it can be treated quickly and appropriately. However, if the hematoma is small or concealed by local swelling, it may be overlooked and left untreated. In most cases, a hematoma will resolve following conservative treatment; however, associated infection or muscle fibrosis can occur. Herein, we present the case of a patient with a chin deformity caused by a post-traumatic hematoma. The deformity was treated using botulinum toxin and triamcinolone acetonide injections as minimally invasive treatments. The course of treatment was good.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.46 no.6
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• pp.428-434
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• 2020

Orbital floor blowout fractures can result in a variety of signs and symptoms depending on the severity of the bone defect. Large defects often result in enophthalmos and restriction of ocular movement; yet the timing of surgery can be delayed up to two weeks with good functional outcomes. In contrast, an orbital trapdoor defect with entrapment of the inferior rectus muscle usually elicits pain with marked restriction of the upward gaze and activation of the oculocardiac reflex without significant dystopia or enophthalmos. When autonomic cardiac derangement is diagnosed along with an orbital floor fracture, it has been suggested that the fracture should be treated immediately. Otherwise, it will result in continued hemodynamic instability and muscular injury and may require a second surgery. This article reports the management of an unusual presentation of a trapdoor blowout orbital floor fracture surgery with oculocardiac response in an adult, with emphasis on its pathophysiology, management, and differential diagnosis.

• Journal of Oral Medicine and Pain
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• v.35 no.2
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• pp.155-163
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• 2010

Dermatomyositis (DM) is an idiopathic inflammatory connective tissue disorder and a systemic autonomic immune disease which shows a progressive muscle weakness and characteristic rash. It is identified by a characteristic rash accompanying, or more often preceding muscle weakness. Pathognomonic skin lesions are a blue-purple discoloration on the upper eyelids with edema (heliotropic rash), a flat red rash on the face and upper trunk, and erythema of the knuckles with a raised violaceous scaly eruption (Gottron's papule). The myopathy represents inflammatory and degenerative changes primarily affecting proximal muscles. DM often involves GI tract and respiratory system with as risk of 15-25% internal malignancy. It's managed with sun protection since muscle weakness as well as a rash could be aggravated by sun exposure. Systemic corticosteroid is an initial therapy and other immunosuppressive agent has been used as alternatives. Facial muscles are unaffected and masticatory muscles are rarely affected in DM. We present trismus close to muscle contracture in a patient with DM. Therefore, it needs continuous mouth-opening exercise to prevent progressive muscle contracture and to ensure normal mouth opening.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.34 no.3
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• pp.180-185
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• 2012

Purpose: An accurate preoperative analysis of the patient is essential in orthognathic surgery in order to acquire superior results. In profile, the location of the chin's position may change according to the neck's inclination. This may ultimately affect the amount of surgical movement. During acquisition of cephalometric radiographs, or in supine position, there is a discrepancy in the neck's inclination. This means that there are also various discrepancies between the actual profile and the various preoperative profile images. In the clinical situation, the decision in performing genioplasty usually lies in the analysis of the patient's profile on the operating table at the final stages of orthognathic surgery. This study aims to analyze the different preoperative profile images and to compare their discrepancies. Methods: Fifty eight patients undergoing orthognathic surgery were chosen. These patients were divided into three groups according to angle's classification of malocclusion, as class I, II or III. The right profile of these patients in centric occlusion was taken in natural head position (NHP). This was set as the 'actual profile image.' Another right profile image was taken on the operating table after insertion of the nasotracheal intubation and with muscle relaxants in effect. This was also taken in centric occlusion. The angle (denoted 'A') between the soft tissue glabella-pognion and the true vertical plane was found in the above-mentioned profile images and in the cephalometric radiographs. The differences of these values were analyzed. Results: There were differences in Angle 'A' in all of the preoperative images. These values were however, not statistically significant. Conclusion: In order to gain an esthetic profile during orthognathic surgery, the NHP is shown to be the most reliable position. Images reproducing such head positions should be used in the treatment planning process.