• Journal of Chest Surgery
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• v.13 no.3
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• pp.219-228
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• 1980

The heart block and bradyarrhythmia with or without Stokes-Adams attacks are serious, usually terminal events and the immediate mortality is very high. Stimulation with an artificial pacemaker is now an accepted form of treatment in cases of Stokes-Adams syndrome in which medication in unable to produce any lasting improvement. Permanent pacemaker therapy is indicated in these circumstances. The purpose of this report is to describe the successful use of pacemaker in 3 cases of Stokes-Adams syndromes and a case of sinoatrial block with bradyarrhythmia at the Department of Thoracic and Cardiovascular Surgery, Kyungpook National University School of Medicine. Electrode catheter was passed through the right external jugular vein and attached to the endocardial surface of the right ventricle. In case 1, fixed type generator was used at first and for the case 2, 3, 4, and case 1 at second, demand type generators were used. The bipolar electrode catheters were used for the three cases and unipolar electrode catheter for case 4. The results of immediate and late period were satisfactory.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.1836-1840
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• 2003

This paper, we propose a new phase-locked loop (PLL) system with the controllable output phase, independent from the output frequency, and lock-up time. This PLL system has a dual control loop is described, the inner loop greatly improved VCO characteristic such as faster speed response as well as higher operation bandwidth, to minimize the effect of the VCO noise and the power supply variation and also get better linearity of VCO output. The main loop is the heart of this PLL which greatly improved the output frequency instability due to the external high frequency noise coupling to the input reference frequency also the main loop can control the output phase, independent from the output frequency, and reduce the lock-up time of the step frequency response. The experimental results confirm the validity of the proposed strategy.

• Journal of Integrative Natural Science
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• v.10 no.4
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• pp.202-208
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• 2017

Xanthine Oxidase is an enzyme, which oxidizes hypoxanthine to xanthine, and xanthine to uric acid. It is widely distributed throughout various organs including the liver, gut, lungs, kidney, heart, brain and plasma. It is involved in gout pathogenesis. Hence, in the present study, Hologram based Quantitative Structure Activity Relationship Study was performed on a series of Xanthine Oxidase antagonist named 2-(indol-5-yl) thiazole derivatives. The best HQSAR model was obtained using Atoms, Bonds, Connection, Hydrogen, Chirality and Donor Acceptor as fragment distinction parameter using hologram length 71 and 4 components with fragment size of minimum 2 and maximum 5. Significant cross-validated correlation coefficient ($q^2$= 0.563) and non cross-validated correlation coefficients ($r^2$= 0.967) were obtained. The model was then used to evaluate the six external test compounds and its $r^2{_{pred}}$ was found to be 0.798. Contribution map show that presence of propyl ring in indole thiazole makes big contributions for improving the biological activities of the compounds. We hope that our HQSAR model and analysis will be helpful for future design of xanthine oxidase antagonists.

• Journal of Integrative Natural Science
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• v.10 no.4
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• pp.192-196
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• 2017

Xanthine Oxidase is an enzyme, which oxidizes hypoxanthine to xanthine, and xanthine to uric acid. It is widely distributed throughout various organs including the liver, gut, lungs, kidney, heart, brain and plasma. It is involved in gout pathogenesis. Hence, in the present study, topomer based Comparative Molecular Field Analysis (topomer CoMFA) was performed on a series of Xanthine oxidase antagonist named 2-(indol-5-yl) thiazole derivatives. The best topomer CoMFA model was obtained with significant cross-validated correlation coefficient ($q^2$ = 0.572) and non cross-validated correlation coefficients ($r^2$ = 0.937). The model was evaluated with six external test compounds and its $r^2{_{pred}}$ was found to be 0.553. The steric and electrostatic contribution map show that presence of bulky and electropositive group in indole thiazole ring is necessary for improving the biological activities of the compounds. The generated topomer CoMFA model could be helpful for future design of novel and structurally related xanthine oxidase antagonists.

• Proceedings of the Materials Research Society of Korea Conference
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• 2011.05a
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• pp.10.1-10.1
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• 2011

Energy harvesting technologies converting external sources (such as thermal energy, vibration and mechanical energy from the nature sources of wind, waves or animal movements) into electrical energy is recently a highly demanding issue in the materials science community for making sustainable green environments. In particular, fabrication of usable nanogenerator attract the attention of many researchers because it can scavenge even the biomechanical energy inside the human body (such as heart beat, blood flow, muscle stretching, or eye blinking) by converging harvesting technology with implantable bio-devices. Herein, we describe procedure suitable for generating and printing a lead-free microstructured $BaTiO_3$ thin film nanogenerator on plastic substrates to overcome limitations appeared in conventional flexible ferroelectric devices. Flexible $BaTiO_3$ thin film nanogenerator was fabricated and the piezoelectric properties and mechanically stability of ferroelectric devices were characterized. From the results, we demonstrate the highly efficient and stable performance of $BaTiO_3$ thin film nanogenerator and the integration of bio-eco-compatible ferroelectric materials may enable innovative opportunities for artificial skin and energy harvesting system.

• Journal of Oriental Neuropsychiatry
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• v.13 no.2
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• pp.1-10
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• 2002

Dreams are experiences of life that is recognized to have taken place in .the mind while asleep. The phenomenon of dreams is occured by external stimuli such as somatic factor and emotion-arousing pre-sleep stimuli. The contents of dreams reflect the dreamer's unique psychic situation, we can view them from category of Yin and Yang and the Five Elements(陰陽五行). Also dreams are characterized by an objectivity that provides whatever in necessary for psychic balance, regardless of the ego's wishes. Hence dreams are objective sources of psychotherapy. The doctor must not treat patient by the doctor's subject mind. The Orient has taken the idea that human beings have the divine center in the heart, so dreams in the psychotherapy of the oriental medicine are more valuable as representation of inner world. The images of dream are classified as the deficiency and excessiveness of Yin-Ki and Yang-Ki of the internal organs, an property and source of stimulus. Dream applies to diagnose the disease of internal organs and to decide to the method of medical treatment.

• Journal of Veterinary Clinics
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• v.1 no.1
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• pp.49-52
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• 1984

Ponies were administered at the level of 0.1mg per kg of body weight of acetylpromazine malate through the jugular vein. Sedative effect, clinical signs such as body temperature, and changes of red blood cell counts and serum glucose concentration were investigated. Sedation was induced 5 to 6 minutes after injection of acepromazine and sedative effect was lasted for 30 to 40 minutes. Responsive reactions, however, to external stimuli were remained. Change of body temperature was not observed and heart beat was increased at the stage of induction and respiratory rate was decreased during the sedative period. Red blood cell count was considerably decreased during sedation, and concentration of serum glucose showed a tendency to increase gradually from the induction.

• Proceedings of the Korean Biophysical Society Conference
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• 1996.07a
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• pp.5-5
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• 1996

In sino-atrial node cells which act as the normal pacemaker of the heart, K conductance in resting state is minimal due to the absence of inward rectifier K channels K conductance only increases when the membrane is depolarized by the activation of the delayed rectifier K current I$\_$k/. In the present study, we investigated the gating mechanism of$\_$k/ using the whole cell patch clamp technique in isolated single sinoatrial cells of the rabbit. (omitted)

• Korean Journal of Veterinary Research
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• v.60 no.2
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• pp.89-92
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• 2020

A 5-year-old dog was evaluated for a lethargy and respiratory distress. Radiograph revealed cardiomegaly with pleural effusion, and the dog died during a thoracocentesis. At necropsy, the descending aorta and pulmonary trunk were dilated and in close contact, but there was no external evidence of a patent ductus arteriosus (PDA). When the descending aorta was opened however, an ostium opening into the pulmonary trunk was evident. Histopathological investigation revealed that the intramural PDA resembled vascular tissue with a structure and architecture. The diagnosis was an intramural PDA, an extremely rarely reported type of PDA in the dog.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.12 no.1
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• pp.295-312
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• 1999

A literature study on the nasal stuffiness, the results are as follows. 1. The pathogenic factors nasal stuffiness are wind-cold, cold, fire-heat, heart & lung disease, deficiency of lung-energy and spleen & stomach disease caused by internal damage. 2. The method on the external treatment of nasal stuffiness are obstructive method, blowing method and pouring method, obstructive method used many. 3. The method on the internal treatment of nasal stuffiness are diaphoretic therapy, clearing away heat & toxic materials and warming the lung & invigorating the spleen. 4. You-taek-tong-gue-tang is used in nasal stuffness. 5. Herba Asari, Radix Angelicae Dahuricae, Flos Magnaliae, Fructus Xanthii, Rhizama Acori Graminei, Herba Menthae, Zanthoxyli Fructus and Spina Gleditsiae are used in nasal stuffness.