• 한방재활의학과학회지
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• 제26권2호
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• pp.1-12
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• 2016

Objectives The purpose of this study was to evaluate anti-obesity effect of Galgeuntang (gegentang) and elucidate the effect of it on gene expression related to obesity. Methods The experiments were performed with the use of Diet-Induced Obese mice. They were grouped NC (normal control), HFD (high fat diet control), GGT (Galgeun-tang (gegentang), 700 mg/kg), ORL (Orlistat, 10 mg/kg). GGT was orally administered for 12 weeks. Body weight was measured every week. Real-time PCR was performed to investigate the effect of GGT on gene expression in liver tissue. Results GGT group and ORL group were reduced in body weight compared with HFD. HFD increased $PPAR{\gamma}$, SREBP-1, Leptin, aP2, FATP1, FAS gene expression compared with NC. GGT increased FATP1 gene expression. But GGT reduced $PPAR{\gamma}$ & FAS gene expression in liver tissue of diet-induced obese mice compared with HFD. Conclusions These results suggest that GGT is supposed to have a certain impact on the treatment of obesity. But more study is needed in the future.

• Asian-Australasian Journal of Animal Sciences
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• 제28권1호
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• pp.127-134
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• 2015

Castration induces the accumulation of body fat and deposition of intramuscular fat in Korean cattle, resulting in improved beef quality. However, little is known about the metabolic adaptations in the liver following castration. To understand changes in lipid metabolism following castration, hepatic expression levels of lipid metabolism genes were compared between Korean bulls and steers. Steers had higher (p<0.001) hepatic lipids contents and higher (p<0.01) mRNA levels of lipogenic acetyl-CoA carboxylase. This differential gene expression may, in part, contribute to increased hepatic lipid content following the castration of bulls. However, we found no differences in the hepatic expression levels of genes related to triglyceride synthesis (mitochondrial glycerol-3-phosphate acyltransferase, diacylglycerol O-acyltransferase 1 and 2) and fatty acid (FA) oxidation (carnitine palmitoyltransferase 1A, C-4 to C-12 straight chain acyl-CoA dehydrogenase, very long chain acyl-CoA dehydrogenase) between bulls and steers. No differences in gene expression for very-low-density lipoprotein (VLDL) secretion, including apolipoprotein B mRNA and microsomal triglyceride transfer protein (MTTP) protein, were observed in the liver although MTTP mRNA levels were higher in steers compared to bulls. In conclusion, FA synthesis may contribute to increased hepatic lipid deposition in steers following castration. However, hepatic lipid metabolism, including triglyceride synthesis, FA oxidation, and VLDL secretion, was not significantly altered by castration. Our results suggest that hepatic lipid metabolism does not significantly contribute to increased body fat deposition in steers following castration.

• 대한한방부인과학회지
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• 제31권2호
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• pp.49-67
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• 2018

Objectives: This study was conducted to assess the effects of Hwanggimacmundong-tang extract (HM) on obese rats with estrogen deficiency. Methods: The experiments were performed with ovariectomized rats as estrogen-deficient obesity model. Rats were grouped NC (Normal Control Group; sham operation group), OC (Obesity Control Group; estrogen-deficient group), HML (20 mg/kg/day), HMH (100 mg/kg/day). HM was administered orally for six weeks. Body weights and serum lipid level were measured, and real-time PCR was performed to estimate the effect of HM on gene expression in liver. Results: HM decreased the total cholesterol and triglyceride in serum. And HM increased leptin, CPT1 gene expression in liver tissue of obese rats with estrogen deficiency. However HM decreased $PPAR{\gamma}$, $PGC-1{\alpha}$, HMGCR, CYP8B1, LPL, ACAT1, ACAT2, ApoB, ACOX gene expression in liver tissue of obese rats with estrogen deficiency. Conclusions: It is concluded that HM reduced total cholesterol and triglyceride in serum, and regulate gene expression related to lipid metabolism. These results indicate Hwanggimacmundong-tang that might have potential for treatment of obesity and complications during the menopause caused by estrogen-deficiency.

• 복식문화연구
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• 제16권6호
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• pp.1142-1155
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• 2008

The purpose of this study is to analyze the effects of playful aspects through the research into characteristics and playful expressional tendency that are expressed in the contemporary fashion illustration. This study covered from 1995, the beginning point of play trend spreading, to 2006 and the fashion magazines, illustrator's collections, and about 1800 pieces of work which have been revealed on the internet web site were collected. At the next stage, 443 pieces of work were selected by researcher for a questionnaire. As a result of the questionnaire, ultimately frequency was more than n=5, so it examined playful expression characteristics, the methods and the effects of the modern fashion illustration based on 335 pieces of work(75.6% of total sample) which were selected by the majority of expert group. It showed the biggest part of playful expression tendency in the modern fashion illustration was 'simplification', and second one was 'exaggeration'. 'Immature expression' and 'fantastic expression' which are included in kidult expression were next. Hopefully, this study would be helpful for creative expression of the fashion illustration which is fit for spreading play trend in modern society.

• 패션비즈니스
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• 제14권4호
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• pp.23-40
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• 2010

The purpose of this study is to explore the aesthetic characteristics of outerization phenomenon of contemporary fashion. Outerization, transforming underwear as outerwear, is one of the most dominant and widespread fashion trends in the dawning of new millenium. Fashion always exists for living body and tributes to express idealized beauty of human body and aesthetics of the era. If so, exploring the formative expressions and aesthetic characteristics of outerization would be an meaningful guideline to deduce changed relationship between fashion and body of the 21st century. The methodology of this study is to research of fashion collections such as Paris, Milan and New York which were held the first decade of new millenium, from 2000 Spring/Summer to 2009 Spring/Summer. The styles expressing outerization were selected and assorted based on the main formative expression. Then the aesthetic characteristics were classified. The way of expression of outerization is categorized into 4 parts ; Transition, Exposure, Transparency, and Deconstruction. Aesthetic Characters of outerization is classified 4 assortments as well ; Eroticism, Fun with parody and kitch, cyber culture, Gender politics, and Power fetish. Eroticism is the most clearly identified one. Coming out of underwear imply naked body itself, so it has erotic appeal. Fun is the second character. A pleasant sensation from the outerization of undergarments maximizes a disposition of play from parody, kitch, and cyber culture. The third is Gender Politics and it introspects how the society consumes woman body in history and modern times. Power Fetish, the last one, speaks for the female body with changed vision for femininity underneath the sphere of influence of feminism and post modernism, then emphasizes the subjectivity and independence of woman. From the research above, this study will help to understand the overwhelming outerization phenomenon and contribute to expansion of the horizon of the study of fashion aesthetics. It will serve fashion creative source through various outerization cases as well.

• 한국의상디자인학회지
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• 제6권3호
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• pp.123-138
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• 2004

The objective of this study is to review the expressive effect of fashion illustrations and to enlarge its expressive range by analysing the correlations between fashion illustrations and surrealistic expressive characteristics. The results are as follows. The surrealistic expressive methods of fashion illustration such as depaysement and automatism have been used by many foreign and domestic fashion illustrators. I think that these methods reinforce the subjective aspect of expressive effects and enlarge the transmitting function of fashion message. The elements of expression are divided into color, texture, shape/form and space. Subjective colors rather than natural colors are used for the surrealistic expressive effect of color in fashion illustrations, and illusion of space is expressed by the change of brightness. The surrealistic expressive effect in fashion illustrations distorted the experience of factual texture and disturbed the visual texture. The use of tactile texture presented strange effects perspectively. The objects of shape in fashion illustrations were mainly human body. The form of human body presents reconstituted and reinterpreted figure by transformation or distortion according to the intention of the artist rather than realistic and physical form. In fashion illustration, the transformation of the human body itself whose body parts get separated, superposition of exterior material and human body, and the distortion of human body by the change are done. Space is where background and shapes are inter-penetrated because they are ambiguous and untransparent, and where all are in disorder and unbalance. The method of projection uses distance perspective, multiple perspective and amplified perspective representation, and forms a psychological space feeling. And I think the use of surrealistic expressive methods are very useful for the subjective sensitiveness and the transmission of a fashion message, and presents a possibility to develop a new expressive method.

• 한국실내디자인학회논문집
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• 제16권6호
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• pp.77-85
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• 2007

The space where one's body lives is not only a space as the simple environment that is built with the physical factors, but also a space experienced by a movement accompanied by the concept of body perception including mental activities. In this study, the importance of the body is recognized and the meaning of the space of body perception including mental activities is understood. In this manner, the spatial unfolding phase and expression features are to be investigated through a standard of "What do they change?" by grasping those as a flexible space that changes spatial recognition. The following results have been drawn in this study; First, the application of the flexible concept in the space can give rise to the activities of an experiencing person in terms of being the object of spatial experience and appreciation. Also, the application changes a slightly static concept into a relative and dynamic space by introducing the movement. Second, the establishment of a space by a human's movement is accompanied by all perceptions and enables to perceive the space shape, the space itself and mutual communication between the spaces. Third, the expression of the human's movement in the fixed form of space lies in the extension of the fused spacial area with an observer beyond the physical spatial limitation. As human body intervenes in space, the meaning of the space has become more abundant and diverse and the space will be presented as the arena for sensitive and flexible communication as a responsive space that corresponds.

• BMB Reports
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• 제51권5호
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• pp.211-218
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• 2018

Chromatin is an intelligent building block that can express either external or internal needs through structural changes. To date, three methods to change chromatin structure and regulate gene expression have been well-documented: histone modification, histone exchange, and ATP-dependent chromatin remodeling. Recently, a growing body of literature has suggested that histone tail cleavage is related to various cellular processes including stem cell differentiation, osteoclast differentiation, granulocyte differentiation, mammary gland differentiation, viral infection, aging, and yeast sporulation. Although the underlying mechanisms suggesting how histone cleavage affects gene expression in view of chromatin structure are only beginning to be understood, it is clear that this process is a novel transcriptional epigenetic mechanism involving chromatin dynamics. In this review, we describe the functional properties of the known histone tail cleavage with its proteolytic enzymes, discuss how histone cleavage impacts gene expression, and present future directions for this area of study.

• Asian-Australasian Journal of Animal Sciences
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• 제22권2호
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• pp.232-237
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• 2009

The expression of SGLT-1 mRNA has been reported in the small intestine of mammals and the rectum of chickens. However, the expression and functional significance of SGLT-1 in bovine rectum is not known. In this study, we studied the effects of fasting and grazing on SGLT-1 gene expression in biopsy epithelial tissue of bovine rectum. In Japanese Black beef cattle, i) SGLT-1 gene expression was measured by quantitative real-time PCR in the biopsy rectal epithelia samples obtained through an endoscope, ii) SGLT-1 gene expression in the rectal epithelial tissues increased at 48 and 72 h after fasting correlating with a decrease in body weight. iii) SGLT-1 gene expression decreased after one month from the start of grazing (May to June) and then stabilized until the end of the grazing period (June to October) in the rectal epithelial tissues of grazing cattle. In conclusion, it is clear that SGLT-1 gene expression in the rectal epithelial tissue is increased by a restricted dietary condition.

• 한국콘텐츠학회논문지
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• 제9권2호
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• pp.173-180
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• 2009

최근 신체는 미의 범주에서 점차 확대되어 환경에 의해 변형되는 유기적인 매체로 바뀌어가고 있다. 이러한 신체는 디지털 테크놀로지 기술 발달의 의해 변형되고 왜곡되어 더 현실감 있게 재현되고 있다. 이렇게 과장된 신체의 이미지에서 관객들은 그로테스크한 느낌을 받게 된다. 영국 감독 크리스 커닝햄은 그로테스크 신체를 주제로 영상작업을 시도하고 있다. 본 논문에서는 그의 작품의 디지털 미디어를 통한 카니발적, 언캐니적 그로테스크 신체 표현 방식의 단계와 그로테스크 신체 이미지의 궁극적인 목표에 관해 접근 하였다.