• Genomics & Informatics
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• v.2 no.3
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• pp.142-146
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• 2004

Biological data and analysis tools are accumulated in distributed databases and web servers. For this reason, biologists who want to find information from the web should be aware of the various kinds of resources where it is located and how it is retrieved. Integrating the data from heterogeneous biological resources will enable biologists to discover new knowledge across the specific domain boundaries from sequences to expression, structure, and pathway. And inevitably biological databases contain noisy data. Therefore, consensus among databases will confirm the reliability of its contents. We have developed WeSAT that integrates distributed and heterogeneous biological databases and analysis tools, providing through Web Services protocols. In WeSAT, biologists are retrieved specific entries in SWISS-PROT/EMBL, PDB, and KEGG, which have annotated information about sequence, structure, and pathway. And further analysis is carried by integrated services for example homology search and multiple alignments. WeSAT makes it possible to retrieve real time updated data and analysis from the scattered databases in a single platform through Web Services.

• The KIPS Transactions:PartA
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• v.18A no.3
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• pp.109-114
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• 2011

We describe a technique for automatically proving compiler optimizations sound, meaning that their transformations are always semantics-preserving. As is well known, IR (Intermediate Representation) optimization is an important step in a compiler backend. But unfortunately, it is difficult to detect and debug the IR optimization errors for compiler developers. So, we introduce a C level error check system for detecting the correctness of these IR transformation techniques. In our system, we first create an IR-to-C converter to translate IR to C code before and after each compiler optimization phase, respectively, since our technique is based on the Memory Comparison-based Clone(MeCC) detector which is a tool of detecting semantic equivalency in C level. MeCC accepts only C codes as its input and it uses a path-sensitive semantic-based static analyzer to estimate the memory states at exit point of each procedure, and compares memory states to determine whether the procedures are equal or not. But MeCC cannot guarantee two semantic-equivalency codes always have 100% similarity or two codes with different semantics does not get the result of 100% similarity. To increase the reliability of the results, we describe a technique which comprises how to generate C codes in IR-to-C transformation phase and how to send the optimization information to MeCC to avoid the occurrence of these unexpected problems. Our methodology is illustrated by three familiar optimizations, dead code elimination, instruction scheduling and common sub-expression elimination and our experimental results show that the C level error check system is highly reliable.

• Korean Journal of Psychosomatic Medicine
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• v.12 no.2
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• pp.122-134
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• 2004

Objective : The purpose of this study was to develop the Anger Response Scale(ARS), and then to use the scale in clinical practice. Methods First, a preliminary survey was conducted for 123 healthy adults to obtain 16 response items. Second, a preliminary questionnaire was completed by 258 healthy subjects. Third, a comparison was made regarding anger responses among 189 patients(59 with anxiety disorder, 72 with depressive disorder and 58 with somatoform disorder) and 258 healthy subjects. Results : Factor analysis yielded 4 subscales : aggression, irritability, avoidance and anger suppression. Reliability was computed by administering the ARS to 53 healthy subjects during a 2-week interval. Test-retest reliability for 4 subscales and the total score was significantly high, ranging between .53-.71. Cronbach's ${\alpha}$ for 4 subscales ranged between .62-.72, and .76 for the total score. Convergent validity was computed by correlating the 4 subscales and the total score with the total score of Aggression Questionnaire, State-Trait Anger Expression Inventory, anger and aggression subscale of Stress Response Inventory and hostility subscale of Symptom Checklist-90-Revised. The disorder group was significantly higher than normal group in scores of the avoidance and anger suppression subacale. The depressive disorder and somatoform disorder groups scored significantly higher on the avoidance subscale than the normal group. Conclusion : These results indicate that the ARS is highly reliable and valid. In addition, avoidance response is likely to be a characteristic anger response of the depressive disorder and somatoform disorder groups.

• Science of Emotion and Sensibility
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• v.20 no.1
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• pp.95-104
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• 2017

This study aims to develop a reliable and valid Geriatric Reaction Inventory-Simplified Form (GRI-SF). Reaction inventory for measuring anger (Evans & Stangelang, 1971) is an assessment tool in a view of stimuli for measuring the level of anger invoked from the anger-triggered experiences. Yet, the inventory, comprised of 76 items, is sometimes incapable of finishing up the lengthy questionnaire. In the sense, a simplified form of RI is necessary for those lacks cognitive ability such as stroke patients or the elderly. In study 1, a full version of Reaction Inventory was given for the elder who are above 60, and ten items out of 76 was selected to form GRI-SF based on the psychometric theory. In study 2, the reliability and validity of GRI-SF was tested by another sample group of elderly with some additional examinations. The reliability was good with Cronbach's alpha of 0.79. Based on the fact that GRI-SF measures the personal trait anger, GRI-SF should not be only strong correlation with the scores of trait anger strongly, but be less correlated with scores representing other aspects of anger. As a result, GRI-SF score showed strong correlations with trait anger among other sub-categories of State-Trait Expression Inventory (STAXI), and was less correlated with anger-out score which reflects behavioral aspect of anger. Moreover, it is less correlated (r=.41) with hostility representing attitudinal or cognitive aspects of anger. Consequently, GRI-SF, constructed by this research, is verified to be a reliable and valid tool for anger measurement.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.21 no.5
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• pp.197-217
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• 2022

As automated vehicle(AV) accidents continue to occur, the importance of safety verification to ensure the safety and reliability of automated driving system(ADS) is being emphasized. In order to encure safety and reliability, it is necessary to define an operational design domain(ODD) of the ADS and verify the safety of the ADS while evaluating its ability to respond in situations outside of the ODD. To this, international associations such as SAE, BSI, NHTSA, ISO, etc. stipulate ODD standards. However, in Korea, there is no standard for the ODD, so automated vehicles's ODD expression method and safety verification and evaluation are not properly conducted. Therefore, this study analyzed overseas ODD standards and selected suitable ODD for safety verification and evaluation, and presented evaluation elements for ADS safety verification and evaluation. In particular, evaluation elements were selected by analyzing the evaluation environment of the automated driving experimental city (K-City) that supports the development of ADS technology.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.3
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• pp.408-417
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• 2017

The objective of this study is to examine the structural relations between physical self-efficacy, depression, and ego-integrity among the elderly (60 years and older) currently participating in leisure sports. In addition, since the variables affecting ego integrity are presented in a multidimensional manner, it is very important to examine the cause and effect of the variables from an integrated perspective. To achieve this objective, 427 senior citizens attending the leisure sports program of a seniors center were assigned as the research subjects. For the structural equation modeling performed in the study, confirmatory factor analysis and reliability analysis were conducted for each variable, and direct, indirect, and total effects were estimated. The model fit is based on TLI, CFI, and RMSEA, and both the fit of the measurement model and the fit of the research model satisfy the criterion. The results of the analysis are as follows. First, in the results of verifying the validity and reliability of the questionnaire, all the variables of physical self-efficacy, depression, and ego-integrity were suitable. Second, the perceived physical ability had positive effects on depression, current life satisfaction, wise life, and attitude toward life, whereas the physical self-expression confidence had positive effects on current life satisfaction and attitude toward life, but negative effects on acceptance of the past life. Lastly, depression had negative effects on current life satisfaction. The results showed that the elderly identified the integrated relationship of physical self - efficacy, depression, and self-integration.

• Journal of Microbiology and Biotechnology
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• v.14 no.6
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• pp.1239-1248
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• 2004

The methylotrophic yeast Hansenula polymorpha has been extensively studied as a model organism for methanol metabolism and peroxisome biogenesis. Recently, this yeast has also attracted attention as a promising host organism for recombinant protein production. Here, we describe the fabrication and evaluation of a DNA chip spotted with 382 open reading frames (ORFs) of H. polymorpha. Each ORF was PCR-amplified using gene-specific primer sets, of which the forward primers had 5'-aminolink. The PCR products were printed in duplicate onto the aldehyde-coated slide glasses to link only the coding strands to the surface of the slide via covalent coupling between amine and aldehyde groups. With the partial genome DNA chip, we compared efficiency of direct and indirect cDNA target labeling methods, and found that the indirect method, using fluorescent-labeled dendrimers, generated a higher hybridization signal-to-noise ratio than the direct method, using cDNA targets labeled by incorporation of fluorescence-labeled nucIeotides during reverse transcription. In addition, to assess the quality of this DNA chip, we analyzed the expression profiles of H. polymorpha cells grown on different carbon sources, such as glucose and methanol, and also those of cells treated with the superoxide­generating drug, menadione. The profiles obtained showed a high-level induction of a set of ORFs involved in methanol metabolism and oxidative stress response in the presence of methanol and menadione, respectively. The results demonstrate the sensitivity and reliability of our arrays to analyze global gene expression changes of H. polymorpha under defined environmental conditions.

• Asia pacific journal of information systems
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• v.18 no.4
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• pp.83-103
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• 2008

In the new web based learning environment which has recently emerged, a variety of new learning objectives and teaching methods suited to this learning environment have been adopted. Recently, web based project-based learning methods have received a great deal of attention from those wishing to improve learning performance. The objective of this study is to identify the impact of characteristics of communication media and instruction behavior on collaborative interaction and project performance through web based group projects. The characteristics of communication media were divided into richness, flexibility, and ease of use, and the characteristics of instruction behavior were divided into support and expression, which are independent variables. Collaborative interaction as a mediate variable, was divided into information sharing and negotiation. Project performance was the dependent variable. To verify the proposed research model empirically, an experiment was conducted in which learners participated in on-line and off-line courses with group projects. The group project was conducted virtual product development(VPD), and designed a web-site about the VPD. At the end of the project, a survey was conducted. Of the 270 students, 239 responded. The students were assigned to groups of 3 or 4 members, and represented different genders and levels of computer competence. The reliability, validity, and correlation of research variables were analyzed using SPSS 14.0, and the measurement model and the structural goodness-of-fit of the research model were verified through SEM analysis using Lisrel 8.54. We found important results as follows; First, richness and ease of use has positive impacts on each of sharing information and negotiation. This suggests that richness and ease of use are useful in sharing information which is related to the task and agreeing in opinions among group members. However, flexibility has not positive impacts on sharing information and negotiation. This implies that there is no great difference in performance of PC and information literacy of user. Second, support and expression of instructor have positive impacts on sharing information and negotiation. This indicates that instructors play an important role in encouraging learners to participate in the project and communicating with them, sharing information related to the project, making a resonable decision and finally leading them to improve a project performance. Third, collaborative interaction has a positive impact on project performance. This result shows that if the ability to share information and negotiate among students was improved then a project performance would be improved as well. Recently, in the state of revitalized web based learning, it is opportune that web-based group project is practically conducted, and the impact of characteristics of communication media and characteristics of instruction behavior on sharing information, negotiating among group members and improving a project performance is verified. On the basis of these results, we propose that forms of learning, such as web based project, could be one of solution which is to enforce interaction among learners, and ultimately improve learning performance. Moreover web-based group project is able to make up for a weakness which makes it difficult to make interpersonal relations or friendship among learners in computer mediated communication or web based learning.

• Journal of Korean Medicine Rehabilitation
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• v.21 no.2
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• pp.159-170
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• 2011

Objectives : We have studied to know analgesic effects of the combination of Aconitum Cilliare Tuber with honey in the models of peripheral neuropathic pain. Methods : Neuropathic pain model was made by ligating left 5th lumbar spinal nerve. After 3 days, combination of Aconitum Ciliare Tuber and honey extract was administrated each alternate day. Administration was divided three groups, that is NP-OA1(0.06 mg/ml), NP-OA2(0.24 mg/ml), and NO-OA3(0.96 mg/ml). After that, we examined the withdrawl response of neuropathic rats legs by von Frey filament and acetone stimulation. And also we examined c-Fos, glutamic oxaloacetic transaminase(GOT), glutamate-pyruvate transaminase(GPT) and change of weight. Results : Mechanical allodynia in NP-OA1 groups were significantly decreased compared with the control group. Cold allodynia in all experimental groups were no significant differences with the control group. c-Fos protein expression on the central grey, all experimental groups were lower than that of control groups. But, there were no statistically significant differences. Change of weight in all experimental groups were significantly increased compare with the control group. In blood serum GOT in NP-OA1, NP-OA2 groups were significantly decreased compare with the control group. In blood serum GPT in all experimental groups were no significant difference with the control group. Conclusions : We had noticed that the combination of Aconitum Ciliare Tuber and honey decreased mechanical allodynia in the model of neuropathic pain compared with the control group and it has not efficacy in elevation of GOT, GPT and weight loss etc., the element of which becomes damage to liver. This study can be proposed that Aconitum Ciliare with Honey may be applicable to neuropathic pain in clinic. But it is reliability not that cold allodynia and c-Fos expression have effectively to control pain. Therefore we have to follow up about that.

• Korea Science and Art Forum
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• v.29
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• pp.279-292
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• 2017

This study was started by recognizing that visual storytelling(VST) is an important factor that determines the success of the work. The goal of this study is to analyze the VST study approaching from the narrative and visual dimension by analyzing the conflict intensity and VST factor. Therefore, in this paper, we analyzed the conflicts of the theater animation(4) that succeeded in the worldwide success and attempted the VST interpretation by approaching it technically. The results and contents of the study are as follows. Firstly, based on the narrative theory of Sung bong-Sun and Robert McKee, we classified the conflict scenes and found the kinds of conflicts. In addition, based on the 5B model, a total of 108 conflict shots were extracted. Secondly, through expert experiment, we found the conflict intensity of conflict shots. Thirdly, the visual elements of fifteen significant conflicts were extracted from internal and super individual conflicts. Fourth, as a result of the experiment, it was confirmed that the reliability of the visual elements in the inner and super personal conflicts was in the range of 100-83.33%, and the frequency of usage was found to be widely distributed in 5.88-70.59% and 5-70%. This means that the VST expression, which relied on the sense of the artist, can be engineered. Finally, I expect that it will be the basis of the development of the VST Tool which can predict the conflict expression of the work in the animation pre - production stage successfully.