• 대한의용생체공학회:의공학회지
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• 제35권5호
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• pp.151-159
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• 2014

Computed tomography (CT) is one of the most widely used medical imaging modality. However, substantial x-ray dose exposed to the human subject during the CT scan is a great concern. Region-of-interest (ROI) CT is considered to be a possible solution for its potential to reduce the x-ray dose to the human subject. In most of ROI-CT scans, the ROI is set to a circular shape whose diameter is often considerably smaller than the full field-of-view (FOV). However, an arbitrarily shaped ROI is very desirable to reduce the x-ray dose more than the circularly shaped ROI can do. We propose a new method to make a non-circular convex-shaped ROI along with the image reconstruction method. To make a ROI with an arbitrary convex shape, dynamic collimations are necessary to minimize the x-ray dose at each angle of view. In addition to the dynamic collimation, we get the ROI projection data with slightly lower sampling rate in the view direction to further reduce the x-ray dose. We reconstruct images from the ROI projection data in the compressed sensing (CS) framework assisted by the exterior projection data acquired from the pilot scan to set the ROI. To validate the proposed method, we used the experimental micro-CT projection data after truncating them to simulate the dynamic collimation. The reconstructed ROI images showed little errors as compared to the images reconstructed from the full-FOV scan data as well as little artifacts inside the ROI. We expect the proposed method can significantly reduce the x-ray dose in CT scans if the dynamic collimation is realized in real CT machines.

• 한국방재안전학회논문집
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• 제12권2호
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• pp.65-72
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• 2019

한국은 국토의 64%이상이 산지로 구성되어 있어 산지재해에 취약한 지형적 특성을 가진다. 연구대상지역인 태백산국립공원 당골유역은 탐방로 대부분이 급경사지와 인접해 있어 집중호우 시 산사태와 토석류에 취약한 지역이다. 본 연구에서는 결정론적 분석방법인 사면안정성 모델을 이용하여 사면재해 발생예측 가능성을 검토하였다. 모델의 매개변수는 정밀토양도의 토양분류에 따라 토질의 단위중량, 유효점착력, 흙의 내부마찰각, 유효토심, 지표경사 등을 이용하였고 1 m격자의 DEM을 바탕으로 사면안정성 평가를 실시하였다. 사면안정성평가 분석결과 지하수/ 유효토심과의 비가 1.0에 가까워질수록 위험지역이 높게 나타났으며, 국립공원 하류지역의 민가와 상업시설 상당수가 위험에 노출된 것으로 나타났다.

• IMMUNE NETWORK
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• 제23권3호
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• pp.23.1-23.17
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• 2023

Inflammation is a series of host defense processes in response to microbial infection and tissue injury. Inflammatory processes frequently cause extracellular acidification in the inflamed region through increased glycolysis and lactate secretion. Therefore, the immune cells infiltrating the inflamed region encounter an acidic microenvironment. Extracellular acidosis can modulate the innate immune response of macrophages; however, its role for inflammasome signaling still remains elusive. In the present study, we demonstrated that macrophages exposed to an acidic microenvironment exhibited enhanced caspase-1 processing and IL-1β secretion compared with those under physiological pH. Moreover, exposure to an acidic pH increased the ability of macrophages to assemble the NLR family pyrin domain containing 3 (NLRP3) inflammasome in response to an NLRP3 agonist. This acidosis-mediated augmentation of NLRP3 inflammasome activation occurred in bone marrow-derived macrophages but not in bone marrow-derived neutrophils. Notably, exposure to an acidic environment caused a reduction in the intracellular pH of macrophages but not neutrophils. Concordantly, macrophages, but not neutrophils, exhibited NLRP3 agonist-mediated translocation of chloride intracellular channel protein 1 (CLIC1) into their plasma membranes under an acidic microenvironment. Collectively, our results demonstrate that extracellular acidosis during inflammation can increase the sensitivity of NLRP3 inflammasome formation and activation in a CLIC1-dependent manner. Thus, CLIC1 may be a potential therapeutic target for NLRP3 inflammasome-mediated pathological conditions.

• 대한치과보철학회지
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• 제50권4호
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• pp.249-257
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• 2012

연구 목적: 본 연구는 광주지역 주민의 나이에 따른 미소형태를 분석하고 설문조사를 통해 심미적인 미소형태를 분석하여 전치부의 보철 수복에 도움을 주고자 하였다. 연구 재료 및 방법: 20대(평균연령 27.2세)와 50, 60대(평균연령 55.6세)의 정상 교합자를 각각 33명(남자 15명, 여자 18명), 20명 (남자 7명, 여자 13명)을 대상으로 하였고, 안정위 시와 미소 시 얼굴정면 사진을 촬영하여 미소 시 입술 형태, 입술의 변화와 치아와의 관계를 계측, 분석하였다. 그 후, 전남대학교 치의학전문대학원 1학년(67명), 4학년(47명)을 대상으로 아름다운 미소에 대한 설문조사를 실시하였다. 결과: 미소 시 상순과 치아와의 관계는 두 그룹 모두 average smile이 가장 많았으며, smile line ratio는 청년층에서 1.09, 장년층에서 0.90으로 나타나 거의 평행한 관계를 보였다. 미소 시 buccal corridor ratio가 커질수록 노출되는 치아 수는 적어지는 역상관관계를 보였다. 미소 시 노출되는 치아는 청년층에서 제2소구치까지 보이는 경우가 63.64%로 제일 많았고, 장년층에서는 제1소구치까지 보이는 경우가 35%로 가장 많았다. 미소 시 상순 하연의 수직적 길이 변화와 상악 중절치 노출 임상치관 길이 사이에는 서로 역상관관계가 보였으며, 하순 상연의 길이 변화와 상악 중절치 노출 임상치관 길이 사이에는 아무런 상관관계가 나타나지 않았다. 결론: 심미성에 관하여는 High smile line과, 미소 시 상악 제1소구치까지 보이는 경우가 제일 심미성이 높았으며, 전남대학교 치의학전문대학원 1학년의 경우, 얼굴전체 사진과 입술만 나타난 사진에서 뽑은 아름다운 미소 사진이 달랐으며, 4학년의 경우에는 일치하였다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2011년도 정기총회 및 추계학술대회 논문집
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• pp.966-970
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• 2011

The thermo-mechanical interaction between brake block and wheel tread during braking has been found to cause thermal crack on the wheel tread. Due to thermal expansion of the rim material, the thermal cracks will protrude from the wheel tread and be more exposed to wear during the wheel/block contact than the rest of the tread surface. The wheel rim is in residual compression stress when is new. After service running, the region in the tread has reversed to tension. This condition can lead to the formation and growth of thermal cracks in the rim which can ultimately lead to premature failure of wheel. In the present paper, the thermal cracks of railway wheel, one of severe damages on the wheel tread, were evaluated to understand the safety of railway wheel in running condition. The residual stresses for damaged wheel which are applied to tread brake are investigated. Mainly X-ray diffusion method is used. Under the condition of concurrent loading of continuous rolling contact with rails and cyclic frictional heat from brake blocks, the reduction of residual stress is found to correlate well with the thermal crack initiation.

• 대한전자공학회논문지SP
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• 제47권3호
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• pp.70-80
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• 2010

본 논문에서는 치과용 의료시스템(Dental PACS)에서 필요한 시계열 분석(Subtraction Radiography) 방법에 기반 하여 기존의 연구에서 갖지 못했던 영상정렬의 자동화 방안과 미세변화 검출 방안을 제안한다. 제안된 방법은 기존의 단일 템플릿 방식의 문제점을 해결하기 위해 인공치아 및 자연치아의 기하학적 형태 정보를 이용하여 각 치아에 대한 관심영역을 획득하고 획득된 관심영역을 기준으로 지식 기반(knowlege-based)의 다중 템플릿(multi-template) 방식의 정합을 통해 치아 주위에서 발생되는 미세변화를 빠르고 정확하게 검출할 수 있다. 실험결과 제안된 방법은 신속하고 정확하게 치아 주위의 미세변화에 대한 검출이 가능하였고, 보다 객관적이고 정량적인 결과를 제시할 수 있음을 보여주었다.

• Current Photovoltaic Research
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• 제6권2호
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• pp.39-42
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• 2018

When the PV module is illuminated in a high temperature region, solar cells are also exposed to the high temperature external environment. The operating temperature of the solar cell inside the module is increased, which causes the power drops. Various efforts have been made to reduce the operating temperature and compensate the power of solar cells according to the outdoor temperature such as installing of a cooling system. Researches have been also reported to lower the operating temperature of solar cells by improving the heat dissipation properties of the backsheet. In this study, we conducted a test to measure the internal temperature of each module components and the external temperature when the light was irradiated according to the surrounding temperature. Backsheets with different thermal conductivities were compared in the test. Finally, in order to explain the temperature difference between the solar cell and the outside of the module, we proposed an evaluation method of the heat transfer characteristics of photovoltaic modules with different backsheet.

• 열처리공학회지
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• 제33권3호
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• pp.129-134
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• 2020

Due to excellent properties such as high specific strength and low density, application of magnesium alloys have been rapidly increased. However, magnesium alloy has a serious problem that is easily oxidized when exposed to high-temperature. For this reason, magnesium alloys have been generally used for SF6 gas such as protective cover gas in casting and melting, but it has been reported that this gas has a serious influence on global warming. Therefore, many researchers have been studied to improve the oxidation resistance of magnesium alloy. It was reported that addition of Be, Ca and CaO in magnesium alloy can improve the oxidation properties. In this study, the possibility of improving the oxidation resistance by adding CaO extracted from oyster shells was investigated. Oyster shells were completely decomposed into CaO and CO₂ by annealing. With the addition of CaO, a coexistence region of MgO + CaO was formed in the oxide layer and its thickness was also reduced.

• 대한의생명과학회지
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• 제18권2호
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• pp.160-164
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• 2012

The baculovirus/insect cell expression system is of great value for the large-scale production of normal and mutant mammalian passive glucose-transport proteins heterologously for structural and functional studies. In most mammalian cells that express HepG2, this transporter isoform is predominantly located at the cell surface. However, it had been reported that heterologous expression of other membrane proteins using the baculovirus system induced highly vacuolated cytoplasmic membranes. Therefore, how a cell responds to the synthesis of large amounts of a glycoprotein could be an interesting area for investigation. In order to examine the subcellular location of the human HepG2 transport proteins when expressed in insect cells, immunofluorescence studies were carried out. Insect cells were infected with the recombinant baculovirus AcNPVHIS-GT or with wild-type virus at a MOI of 5, or were not exposed to viral infection. A high level of fluorescence displayed in cells infected with the recombinant virus indicated that transporters are expressed abundantly and present on the surface of infected Sf21 cells. The evidence for the specificity of the immunostaining was strengthened by the negative results shown in the negative controls. Distribution of the transporter protein expressed in insect cells was further revealed by making a series of optical sections through an AcNPVHIS-GT-infected cell using a confocal microscope, which permits optical sectioning of cell sample. These sections displayed intense cytoplasmic immunofluorecence surrounding the region occupied by the enlarged nucleus, indicating that the expressed protein was present not only at the cell surface but also throughout the cytoplasmic membranous structures.

• Journal of Trauma and Injury
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• 제33권1호
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• pp.48-52
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• 2020

Composite skull defects in patients with severe head injuries are very challenging to manage. The dilemma when deciding whether to perform a definitive reconstruction is how long to wait for physiological recovery before an intervention complicates the situation. The inability of such patients to tolerate prolonged anesthetic exposure is a driving factor for performing the minimal intervention necessary to facilitate recovery. Herein, we present a case involving the successful immediate reconstructive treatment of a severely head-injured adolescent with a composite scalp defect secondary to trauma. A 14-year-old boy sustained a severe head injury from a motor vehicle accident with a composite scalp defect in the right fronto-parietal region. The frontal lobe was exposed, and the right eye was crushed and devitalized. The patient was deeply unconscious for 3 days, without any significant improvements before reconstructive surgery was proposed due to fear of possible meningitis resulting from the exposure of brain structures. We successfully managed the patient with a fronto-parieto-occipital flap, after which the patient promptly recovered consciousness.