• Journal of Ginseng Research
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• 제35권1호
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• pp.111-123
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• 2011

To investigate the effects of repeated immobilization-stress challenge on the the hypothalamic-pituitary-adrenal axis, the genomic transcriptome in the adrenal cortex of immobilization-stressed mouse was analyzed by using a cDNA microarray. Mice were subjected to immobilization stress for 2 h per day for 5 consecutive d. With a 4.0-fold cutoff of arbitrary criteria, the expression levels of 168 out of 41,174 genes were significantly modulated in the adrenal cortex by stress when comparing the control and experimental groups. These genes were related to apoptosis, cell cycle, immune response, inflammatory responses, and signal transduction, and thus may be used as potential targets for the development of therapeutics for chronic stress or depression. Six significant genes among these were selected for real time polymerase chain reaction analysis to confirm the change of their expression levels. The gene for phospho 1 was also further investigated because its expression showed the greatest fold-change.

• 소성∙가공
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• 제12권4호
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• pp.302-307
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• 2003

Hot rolled strip is cooled by air and water in Run-Out-Table. In this process, phase transformation and shape deformation occurs due to temperature drop. Because of un-ideal cooling condition of ROT, irregular shape deformation and phase transformation arise in the strip. which affect the strip property and lead to the residual stress of strip. And these exert effects on the following processes, coiling process, coil cooling process, and re-coiling process. Through these processes, the residual stress becomes higher and severe. For the prediction of residual stress distribution and shape deformation of final product, Finite element(FE) based model was used. It consists of non-steady state heat transfer analysis, elasto-plastic analysis. thermodynamic analysis and phase transformation kinetics. Successive FEM simulation were applied from ROT process to coil cooling process. In each process simulation, previous process simulation results were used for the next process simulation. The simulation results were matched well with the experimental results.

• 임상간호연구
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• 제20권2호
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• pp.211-222
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• 2014

Purpose: This study was done to identify the effects of Laughter therapy on recovery status from facial paralysis, pain, and stress in Bell's palsy patients. Methods: This research was a nonequivalent control group non-synchronized pre-posttest quasi-experimental research design. Data were collected from August 8, to October 15, 2013 at D university Oriental Medical Center in B city. Participants were 60 patients with Bell's palsy who were assigned to one of two groups: an experimental group of 30 patients and a control group of 30 patients. t-test, $x^2-test$, Fisher's exact test and Welth-Aspin test were used to test the homogeneity between the two groups and t-test, Welth-Aspin test and ANCOVA were used to test the research hypotheses. SPSS program was used for statistical analysis. Results: There were significant increases in recovery status from facial paralysis and decreases in stress after Laughter therapy in the experimental group. Conclusion: The results indicate that Laughter therapy is effective in facilitating recovery status from facial paralysis and decreasing stress. Therefore, Laughter therapy can be used as an effective nursing intervention for patients with facial paralysis and to relieve stress in these patients.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제45권2호
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• pp.91-96
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• 2019

Objectives: This study aimed to investigate the effects of chronic restraint stress on the osseointegration of titanium implants. Materials and Methods: Twenty adult male Wistar albino rats were used in the study. After surgical insertion of titanium implants into the metaphyseal part of the tibial bone, rats were randomly divided into two groups: a control group (CNT group) and an experimental restraint stress group (RS group). In the CNT group, titanium implants were inserted surgically, and rats received no further treatment during the 47-day experimental period. In the RS group, restraint stress was applied for 3 hours per day for 45 days, beginning 2 days after implant surgery. Weight of the rats was measured prior to surgery and at the end of the study to analyze the effects of stress. At the end of the experimental period, rats were euthanized, and implants and surrounding bone tissues were used for undecalcified histological analysis. Serum cortisol levels were assessed in cardiac blood samples from the rats following centrifugation. Results: Average weight of rats in the RS group was lower than that of rats in the CNT group after the experimental protocol had been completed (P<0.05). Further, serum cortisol levels were higher in the RS group than in the CNT group (P<0.05). There were no significant differences in boneimplant connection levels between the two groups (P>0.05). Conclusion: The data analyzed in this study suggest that chronic restraint stress did not adversely affect rats during a 45-day osseointegration period.

• Composites Research
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• 제28권1호
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• pp.6-14
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• 2015

치아의 수복에 사용되는 재료인 Methacrylate 기질 복합레진(Clearfil AP-X)과 Silorane 기질 복합레진(Filtek P90)을 대상으로 스트레인게이지법과 FEM 분석법으로 중합수축응력거동을 분석하였다. 또한 복합레진의 탄성계수와 수축변형률을 중합수축응력과 관계시켜 이론식을 제시하고 이 식의 계산결과와 FEM 분석법의 결과를 비교하였다. 스트레인 게이지법으로 측정한 결과, 중합수축응력의 최대값은 Clearfil AP-X가 Filtek P90 보다 약 2.8배 높게 나타났다. FEM 분석 결과, Von-Mises 응력은 복합레진 수복재와 PMMA 링사이의 계면부에서 최대로 되었으며 시편표면의 계면부가 내부보다 응력집중이 더 컸음을 알았다. 예측식을 통한 반경 방향의 수축응력은 평면응력상태의 FEM 분석법을 통한 값과 비교하여 오차 5% 이내로 정확했음을 확인하였다.

• 대한간호학회지
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• 제26권4호
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• pp.963-975
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• 1996

The purpose of this study was to call attention to the mental, physical and occupational hazards of the anticancer-drug-handling nurses by examining the possible urinary mutagenicity and measuring physical symptoms and stress level of the nurses exposed to anticancer drugs. The experimental group of the urinary mutagenicity assay was 14 nurses handling anticancer drugs at the medical wards of a hospital located in J city ; the control group was 12 psychiatric nurses of the same hospital. The test material was the nurses' 24hrs urine, which was concentrated by XAD-2 column chromatography. Tester strains were TA98(±S9 mix), TA100(±S9 mix), TA1535(±S9 mix) and TA1537(±S9 mix) ; Salmonella mammalian-microsomal test(Ames test) was employed for the urinary mutagenicity assay. The physical symptoms of which the nurses experienced were investigated through self-reports on open-questionnaires. The stress levels of the experimental group were measured by a stress measuring instrument developed by this author. Reliability of this instrument was found to be adequate (Cronbach's Alpha=0.9079). To ascertain the urinary mutagenicity of the experimental group, the mean and the standard deviation of the colonies of Tester strains appearing on the minimal plates were taken and compared differences between two groups. T-test was employed for the significance test of two groups. The physical symptoms were compared between the two groups through the analysis of the nurse' self-reports. The mean and standard deviation of the stress levels of the experimental group were also calculated and were examined through t-test. The results were summarized as follows : 1. The experimental group revealed significantly higher urinary mutagenicity both in the activation method test and the non-activation method test of the tester strains TA98, TA100 and TA1535. In the case of TA1537, two groups showed no difference in the non-activation method test, but the activation method revealed difference. 2. The physical symptoms were also much more frequently reported in the experimental group. 79.3% of the experimental group reported more than 1 kind of physical symptoms. On the other hand, 33.2% of the control group complained of 1 kind of physical symptom. The items with high symptom frequency were 'headache', 'itching sensation', 'corneal congestion', 'skin allergy' 3. The mean score of stress in the experimental group was 2.41(range 1-4). The experimental group showed the stress level above 2.0 in the 14 of 15 items in all. The highest stress level were recorded in the following items in the order quoted, 'I fear that anticancer drug may touch any part of body while handling it.', 'I feel concerned there is no protective countermeasure against anticancer drug handling.', 'I am afraid the anticancer drug handling may produce a fetal loss in the future'.

• 대한기계학회논문집A
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• 제28권9호
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• pp.1328-1336
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• 2004

According to our fatigue tests carried out at 20 Hz, R=0.1 on transversely butt-welded joints, fatigue strengths of as-welded specimens, that is, specimens having residual stress are higher than those of annealed specimens in short life range, but vice verse in long life range. This behavior seems to be concerned mainly with residual stress relaxation by applied loading. After analyzing the welding process, we conducted finite element analysis to quantify the degree of residual stress relaxation. By taking into account residual stress relaxation, modified Goodman diagram, and nominal stress, we evaluated the fatigue life of the welded joint from the S-N curve for the parent material. The estimated results are in a good agreement with the experimental results.

• 한국생산제조학회지
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• 제8권1호
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• pp.21-27
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• 1999

In this study, stress intensity factors KI, KII, KIII are existing at the same time to a hollow cylindrical bar of three dimension inclination crack. In order to investigate by experimentally the effect of the inclination angle $\psi$ of crack, artificial inclination cracks in the circumferential direction are put in the surface of a hollow cylindrical bar made by the epoxy-resin. Experimentally, stress analysis methods of stress intensity factors were proposed. But, suitable method are the caustic method and the photoelastic stress freezing method. The mixed mode of KI, and KII, were determined by the photoelastic method of the classical approach method and the FORTRAN language program of the used smallest square method.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 춘계학술대회
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• pp.108-113
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• 2004

According to our fatigue tests carried out at 20 Hz, R=0.1 on transversely butt~welded joints, fatigue strengths of as-welded specimens, that is, specimens having residual stress are higher than those of annealed specimens in short life range, but vice verse in long life range. This behavior seems to be concerned mainly with residual stress relaxation by applied loading. After analyzing the welding process, we conducted finite element analysis to quantify the degree of residual stress relaxation. By taking into account residual stress relaxation, modified Goodman diagram, and nominal stress, we evaluated the fatigue life of the welded joint from the S-N curve for the parent material. The estimated results are in a good agreement with the experimental results.

• Nuclear Engineering and Technology
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• 제55권4호
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• pp.1250-1264
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• 2023

This paper presents approximate in-depth residual stress and plastic strain profiles for laser-peened alloy 600 surface via FE analysis. In approximations, effects of the initial welding residual stress and the number of shots are quantified. Based on FE analysis results, residual stress profiles are quantified by two variables; the maximum difference in stress before and after LSP, and the depth up to which the compressive residual stress exists. Plastic strain profiles are quantified by one variable, the maximum equivalent plastic strain at the surface. The proposed profiles are validated by comparing with published LSP experimental results for welded plates. Effects of the initial welding residual stress and the number of shots on these variables are discussed. The proposed profile can be directly applied to predict the mitigation effect of LSP on PWSCC and to efficiently perform structural integrity assessment of laser peened nuclear components.