• Title/Summary/Keyword: exits

Search Result 239, Processing Time 0.023 seconds

Current Status and Future Perspective of Nuclear Cardiology (심장핵의학의 현황과 전망)

  • Chung, June-Key
    • Nuclear Medicine and Molecular Imaging
    • /
    • v.43 no.3
    • /
    • pp.159-164
    • /
    • 2009
  • Coronary artery disease is on the rise over the world. Myocardial perfusion SPECT is a well established technique to detect coronary artery disease and to assess left ventricular function. In addition, it has the unique ability to predict the prognosis of the patients. Moreover, the application of ECC-gated images provided the quantitatve data and improved the accuracy. This approach has been proved to be cost-effective and suitable for the emerging economies as well as developed countries. However, the utilization of nuclear cardiology procedures vary widely considering the different countries and region of the world. Korea exits 2-3 times less utilization than Japan, and 20 times than the United States. Recently, with the emerging of new technology, namely cardiac CT, cardiac MR and stress echocardiography, the clinical usefulness of nuclear cardiology has been called in question and its role has been redefined. For the proper promotion of nuclear cardiology, special educations should be conducted since the nuclear cardiology has the contact points between nuclear medicine and cardiology. Several innovations are in horizon which will impact the diagnostic accuracy as well as imaging time and cost savings. Development of new tracers, gamma camera technology and hybrid systems will open the new avenue in cardiac imaging. The future of nuclear cardiology based on molecular imaging is very exciting. The newly defined biologic targets involving atherosclerosis and vascular vulnerability will allow the answers for the key clinical questions. Hybrid techniques including SPECT/CT indicate the direction in which clinical nuclear cardiology may be headed in the immediate future. To what extent nuclear cardiology will be passively absorbed by other modalities, or will actively incorporate other modalities, is up to the present and next generation of nuclear cardiologists.

CFD Analysis on Base Region of Small Scaled 4 Nozzle Clustered Engine Configuration (CFD를 이용한 축소형 공기 클러스터드 노즐의 저부 유동 분석)

  • Kim, Seong-Lyong;Kim, In-Sun
    • Aerospace Engineering and Technology
    • /
    • v.11 no.1
    • /
    • pp.68-77
    • /
    • 2012
  • Flow characteristics of base region of small scaled 4 nozzle clustered engine has been analyzed with CFD approach along with the tests of numerical methods. The numerical test shows that Spalart-Allmaras turbulence model is appropriate for the present research. Plumes expanded from nozzles exits collide with each other and make high pressure stagnation region. Some of collided plumes expand again reversely into the base region with supersonic speeds. The reversed plume in the base region goes out to the outer region through the minimum vent area formed by the nearest nozzle exterior surfaces. But different from the empirical theory, the minimum vent area does not play a role of throat. Additionally the temperature of the nozzle inner surface strongly affects the temperature of the reversed plumes.

Stabilization of the primary sigma factor of Staphylococcus aureus by core RNA polymerase

  • Mondal, Rajkrishna;Ganguly, Tridib;Chanda, Palas K.;Bandhu, Amitava;Jana, Biswanath;Sau, Keya;Lee, Chia-Y.;Sau, Subrata
    • BMB Reports
    • /
    • v.43 no.3
    • /
    • pp.176-181
    • /
    • 2010
  • The primary sigma factor ($\sigma^{A}$) of Staphylococcus aureus, a potential drug target, was little investigated at the structural level. Using an N-terminal histidine-tagged $\sigma^{A}$ (His-$\sigma^{A}$), here we have demonstrated that it exits as a monomer in solution, possesses multiple domains, harbors primarily $\alpha$-helix and efficiently binds to a S. aureus promoter DNA in the presence of core RNA polymerase. While both N- and C-terminal ends of His-$\sigma^{A}$ are flexible in nature, two Trp residues in its DNA binding region are buried. Upon increasing the incubation temperature from 25$^{\circ}$ to 40$^{\circ}C$, $\sim$60% of the input His-$\sigma^{A}$ was cleaved by thermolysin. Aggregation of His-$\sigma^{A}$ was also initiated rapidly at 45$^{\circ}C$. From the equilibrium unfolding experiment, the Gibbs free energy of stabilization of His-$\sigma^{A}$ was estimated to be +0.70 kcal $mol^{-1}$. The data together suggest that primary sigma factor of S. aureus is an unstable protein. Core RNA polymerase however stabilized $\sigma^{A}$ appreciably.

A study on the Comparison of High-rise building Egress Safety Rule in Countries for improvement of High-rise evacuation safety design criteria (초고층 피난안전설계 기준 개선을 위한 국내외 피난관계법령 비교에 관한 연구)

  • Hwang, EunKyung;Park, SuRoh
    • Journal of the Society of Disaster Information
    • /
    • v.9 no.4
    • /
    • pp.429-438
    • /
    • 2013
  • In this study, compare and analyze for high-rise evacuation safety design criteria improvement about internal high-rise building egress safety rule. To the result, high-rise evacuation safety design criteria improvement data can be summarized as follows. First, should compute the evacuation capacity about the number of persons and when more than 2 exits are requested, over 50% of evacuation capacity must be satisfied even approaching to 1 exit is unable. Second, 2 ways of evacuation can be made smoothly by the stair or exit separation-distance standard regulation. Third, regulate the length limitation of dead-end corridor or passageway and it should give grades in limitation of whether the spring-cooler has been installed. Fourth, must secure the evacuation way and do the evacuee guidance when it's safety area and elevator or stair. Also needs to provide extra safety area to secure horizontal direction Escape Safety except fire escaping floor.

Air Curtain Nozzle Design for Uniform Jet Expulsion (균일한 제트 분출을 위한 에어커튼 노즐 설계)

  • Park, Won-Hee;Chang, Hee-Chul
    • Fire Science and Engineering
    • /
    • v.30 no.4
    • /
    • pp.39-45
    • /
    • 2016
  • The optimal design of an air curtain nozzle installed at exits, such as fire doors, was determined in order to block the flow of smoke into safe zones. Smoke is the greatest cause of loss of life during the fire. To block the flow of smoke, the airflow must be expelled uniformly without eccentricity from the slits in the air curtain nozzle installed on the upper part of the opening. In order to accomplish this, factors such as air inflow volume, shape of the internal slits, and thickness of the external slits were considered as variables in this study, and a numerical analysis was performed under various conditions. This led to the selection of a final shape which led to the finalization of a design shape. The final shape was manufactured as a prototype and the results were compared and verified with the results of the numerical analysis. The relative error of the numerical analysis results was less than 1%, and the average speed of all the slits was tested, exhibiting a highly consistent tendency.

A Study on Estimation of Added Resistance in Waves Using Modified Radiated Energy Method and Short Wave Correction Method (수정된 방사 에너지법과 단파장 영역 보정법을 이용한 파랑 중 부가저항 추정에 관한 연구)

  • Oh, Seunghoon;Yang, Jinho
    • Journal of the Society of Naval Architects of Korea
    • /
    • v.53 no.1
    • /
    • pp.62-68
    • /
    • 2016
  • A simple calculation tool for added resistance in waves is developed to utilize for initial design or embedded module for navigation support system. In order to select an appropriate calculation method for added resistance in waves, three methods (drift method, integrated pressure method, radiated energy method) based on strip method are applied to Wigley I and KVLCC2. The methods for added resistance in waves give the underestimated results because it is difficult to consider nonlinear effects due to reflected wave. We apply asymptotic (Faltinsen's method) and empirical formula (NMRI's method) to improve the accuracy for short wave length region. In comparison with experimental results, the combination of radiated energy method and short wave correction method of NMRI is the most reasonable. However, a simple sum of results calculated by two methods gives rise to the overestimation of added resistance for short wave length region because added resistance of radiated energy method exits in total reflection region. To overcome this problem, modified radiated energy method is proposed using correction coefficient defined by reflection coefficient of NMRI's method. Finally, added resistance in regular waves is composed of added resistance of modified radiated energy method and that of short wave correction method of NMRI. Estimated added resistance in regular waves is validated by comparison with experimental results of other research groups.

Descriptive hydrography of shelikof Strait, Gulf of Alaska, during the Spring Spawning Time of Walleye Pollock, Theragra chalcogramma, in the Early 1980's (명태(Theragra chalcogramma)의 산란장, 알라스카만 쉘리코프 해협의 1980년대 초반의 해황에 관한 연구)

  • KIM, SUAM
    • 한국해양학회지
    • /
    • v.28 no.1
    • /
    • pp.35-46
    • /
    • 1993
  • To delineate water properties and current patterns in the spawning area of walleye pollock, hydrographic cast and current meter data collected in Strait, Gulf of alaska, were analysed, three water masses are identified in Shelikof Strait. A small amount of cold and dilute water ($<{\;}3^{\circ}C{\;}and{\;}<{\;}31.5\textperthousand$) originates from the lower Cook Inlet and flows southwestward close to the Alaska Peninsula coast. One branch of alaska coastal Current which enters the strait from the northeast comprises the main body of the upper and middle layers of the strait, and flows toward the southwest. Estimation of geostrophic baroclinic currents reveals that comparatively fast flow exists in the surface over the deepest portion of the strait, and most water exits through the southwestern entrance between Semidi and chirikof Is. On the other hand, a relatively slow-moving warm and saline ($>{\;}5^{circ}C{\;}and{\;}>{\;}32\textperthousand$) of the southwestern entrance flows northeasterly, and occupies the bottom layer in Shelikof Strait.

  • PDF

Improving the Performance of AODV(-PGB) based on Position-based Routing Repair Algorithm in VANET

  • Jung, Sung-Dae;Lee, Sang-Sun;Oh, Hyun-Seo
    • KSII Transactions on Internet and Information Systems (TIIS)
    • /
    • v.4 no.6
    • /
    • pp.1063-1079
    • /
    • 2010
  • Vehicle ad hoc networks (VANET) are one of the most important technologies to provide various ITS services. While VANET requires rapid and reliable transmission, packet transmission in VANET is unstable because of high mobility. Many routing protocols have been proposed and assessed to improve the efficiency of VANET. However, topology-based routing protocols generate heavy overhead and long delay, and position-based routing protocols have frequent packet loss due to inaccurate node position. In this paper, we propose a position-based routing repair algorithm to improve the efficiency of VANET. This algorithm is proposed based on the premise that AODV (-PGB) can be used effectively in VANET, if the discovery, maintenance and repair mechanism of AODV is optimized for the features of VANET. The main focus of this algorithm is that the relay node can determine whether its alternative node exits and judge whether the routing path is disconnected. If the relay node is about to swerve from the routing path in a multi-hop network, the node recognizes the possibility of path loss based on a defined critical domain. The node then transmits a handover packet to the next hop node, alternative nodes and previous node. The next node repairs the alternative path before path loss occurs to maintain connectivity and provide seamless service. We simulated protocols using both the ideal traffic model and the realistic traffic model to assess the proposed algorithm. The result shows that the protocols that include the proposed algorithm have fewer path losses, lower overhead, shorter delay and higher data throughput compared with other protocols in VANET.

Analysis of the Causes of Casualties of Jecheon Sports Center Fire - Focus on an Initial Response and Management - (제천 스포츠센터 화재의 다수 사상자 발생원인 분석 -초기대응과 관리적인 측면을 중심으로-)

  • Lee, Eui-Pyeong
    • Fire Science and Engineering
    • /
    • v.32 no.5
    • /
    • pp.57-66
    • /
    • 2018
  • A sports center fire in Jecheon that caused 29 deaths and 40 injuries was analyzed based on initial response and management in order to investigate the causes of the casualties. The aspects of initial response included delay of reporting 119, not being guided to the exit for the body scrubber on the $2^{nd}$ floor for escape, opening the fire doors of the exits on the $1^{st}$ floor and $3^{rd}$ floor, not closing the fire door of the main stairs on the $3^{rd}$ floor, and not doing an emergency broadcast. The management aspects included closing the alarm valve of the sprinkler system on the $1^{st}$ floor, starting-stop of the fire pump controller, neglecting leakage of water and electricity between the false ceiling and ceiling in the parking lot, hiding the exit light in the ladies bathroom lounge on the $2^{nd}$ floor and piling up things in the exit, neglecting the button of an automatic door on the $2^{nd}$ floor, conventional fire safety management, insufficient inspection of fire equipment, and not working fire shutters and smoke exhaust windows.

The Effects of Mycoplasma Infection on Semen Parameters (in Normal Human Semen) (남성에서 Mycoplasma 감염이 정액검사소견에 미치는 영향에 관한 연구)

  • Kim, Sun-Haeng;Kim, Young-Ho;Kim, Tak;Hur, Jun-Yong;Park, Yong-Kyun;Ku, Pyung-Sham
    • Clinical and Experimental Reproductive Medicine
    • /
    • v.23 no.3
    • /
    • pp.311-318
    • /
    • 1996
  • Mycoplasmas have long been suspected of contributing to involuntary infertility in couples. However considerable disagreement exits concerning the role of genital mycoplasma infection in human infertility. Several investigators have noted abnormalities in the semen analysis of men with positive mycoplasma cultures, and early epidemiologic studies indicated that Ureaplasma urealyticum was linked to human reproductive failure on the basis of higher frequencies of isolation from infertile versus fertile couples and successful pregnancies in infertile couples after doxycycline therapy. However, subsequent investigators have questioned these findings because there are many studies in which treatment for mycoplasma in the male or female did not demonstrate an improved pregnancy rate, and semen samples from unexplained infertile men containing ureaplasmas have not revealed poorer motility, fewer spermatozoa and more aberrant forms. The objective of this study were to investigate the incidence rate of mycoplasma in semen and to investigate whether the presence of mycoplasma in semen makes significant difference to the semen volume, sperm motility and sperm counts. The results were that the rate of isolation of mycoplasma species was 70.3%. Semen volume is $2.84{\pm}1.01ml$ for culture negative and $3.15{\pm}1.42ml$ for culture positive group. Sperm motility is $46.23{\pm}15.80%$ for culture negative and $50.09{\pm}15.69%$ for culture positive group, and sperm count is $95.47{\pm}47.14({\times}(P)10^6/ml)$ for culture negative and $86.73{\pm}47.59({\times}10^6/ml)$ for culture positive group. In conclusion, we suggest that the presence of mycoplasma in semen makes no significant differences to the sperm parameters.

  • PDF