• Title/Summary/Keyword: exclusive volume effect

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Stabilization of Enzyme in "Solvophobically" Controlled Polymer Microcapsules ("솔보포빅"한 고분자 마이크로 캡슐을 이용한 효소 안정화에 관한 연구)

  • Kim, Yong-Jin;Kim, Jin-Woong;Kim, Jin-Oh;Kim, Jin-Woo;Chang, Ih-Seop
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.32 no.1 s.55
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    • pp.29-33
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    • 2006
  • This article describes an enzyme stabilization method that allows the use of enzymes irrespective of environmental factors, especially heat, while maintaining their activity for a long time. We have designed enzyme microcapsules that consist of papain enzyme cores, poly(propylene glycol) interlayers, and poly(${\epsilon}-caprolactone$) walls. By confocal laser scanning microscopy measurements and the thermal stability of papain-loaded microcapsules, it is demonstrated that the papain is surrounded by a hydrophobic polyol layer and stabilized by the exclusive volume effect. In our study, improved thermal stability can be obtained by using more hydrophobic long-chained polyols, which is understood to be attributed to the effective formation of a hydrophobic polyol layer between the papain and the polymer wall by means of conformational anchoring in the interface.

Effectiveness Analysis of Exclusive Median Bus Lane that Uses Microsimulation (미시적 시뮬레이션을 이용한 중앙버스전용차로 효과분석)

  • Kim, Myung Soo
    • International Journal of Highway Engineering
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    • v.15 no.2
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    • pp.159-167
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    • 2013
  • PURPOSES : In this study, the effects of when median exclusive bus lanes were applied to Daejeon trunk road (Wolpyeng crossway~Seodaejeon crossway, 6.3km) and (Daeduck Bridge 4~Kyeryong 4, 2.6km) by Microscopic Simulation VISSIM (5.0) was studied. The median exclusive bus lanes are one of the measures of transportation system manage techniques that can especially improve the efficiency of public transportation facilities. METHODS : According to the analysis of VISSIM on the Gyerong mainroad and Daedeok mainroad, when the median exclusive bus lanes were applied unlike when the roadside bus-only lanes were applied, the average travel speed of vehicles decreased but the average delay time and travel time increased. This arised from the changes in the geometric structure of the road which occurred the reduction of vehicle lane in the center of the road. RESULTS : In the case of bus, on the other hand, the average travel speed increased but the average delay time and travel time decreased. This is because the problems such as illegal parking and stopping, secondary road in out vehicle, and conflict of intersection right turn that roadside bus-only lanes occurred was solved. CONCLUSIONS : Although the introduction of median exclusive bus lanes will have a negative effect on general traffic flow due to the aggravation of travel, decrease of passenger car usage will lead to decrease of traffic volume. Therefore, smooth vehicle travel is expected.

Dynamic Analysis of the Effect of Network Externality in Vertically Differentiated Market (수직적으로 차별화된 시장 하에서 망외부성이 미치는 영향에 대한 동태적 분석)

  • Cho, Hyung-Rae;Rhee, Minho
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.42 no.2
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    • pp.1-8
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    • 2019
  • Network externalities are essentially dynamic in that the value consumers feel about a product is affected by the size of the existing customer base that uses that product. However, existing studies on network externalities analyzed the effects of network externalities in a static way, not dynamic. In this study, unlike previous studies, the impact of network externalities on price competition in a vertically differentiated market is dynamically analyzed. To this end, a two-period duopoly game model was used to reflect the dynamic aspects of network externalities. Based on the game model, the Nash equilibria for price, sales volume, and revenue were derived and numerically analyzed. The results can be summarized as follows. First, if high-end product has strong market power, the high-end product vendor takes almost all benefits of the network externality. Second, when high-end product has strong market power, the low-end product will take over most of the initial sales volume increase. Third, when market power of high-end product is not strong, it can be seen that the effects of network externalities on the high and low-end products are generally proportional to the difference in quality. Lastly, if there exists a strong network externality, it is shown that the presence of low-end product can be more profitable for high-end product vendor. In other words, high-end product vendor has incentive to disclose some technologies for the market entrance of low-end product, even if it has exclusive rights to the technologies. In that case, however, it is shown that the difference in quality should be maintained significantly.

On the Effect of Sea Borne Cargo Movement to Urban Transportation in the Pusan Port -Container Transport Oriented- (부산 항만물동량이 도시교통에 미치는 영향에 관한 연구 - 컨테이너 화물 운송을 중심으로 -)

  • Yang, Won;Lee, Cheol-Yeong
    • Journal of Korean Port Research
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    • v.4 no.1
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    • pp.3-20
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    • 1990
  • The Port of Pusan, the largest port in Korea, handled 23% of total sea borne cargo movement, 14% of imported cargo, 58% of exported cargo and 95% of container cargo in 1989. Also the port of Pusan has been played a key role in handing container cargo throughout the last 10 years. The paper is aimed to survey the effect of sea borne cargo movement to urban transportation, that is, to find traffic volume arising by general/bulk cargoes through the port and to estimate vehicle rated of container tractor tailer on the roads between terminal including conventional piers and ODCY, and finally the following results are obtained. (1) AADV of truck to transport general/bulk cargoes are 6,322 units in 1989,and routes penetrate into the center of city and pass through the most of urban arterials. (2) In the container transport, if HVEF is adopted to 3 of tractor trailer, AVR in each transport freeway 13.7%. (3) IF HVEF is adopted to 6 of tractor trailer. AVR are as follows: BooDoo-Ro 44.1%, WooAm-Ro 39.3%, SooYoung-Ro 17.8%, Urban freeway 20.3%. Based upon these results, the following suggestions were drawn : o ODCY scattered around the city should be unified in a few groups to raise port productivity. o Rail service for inland container transportation should be escalated to relieve urban traffic congestion. o Coastal feeder service between terminal and hinterland should be studied to restrict the penetration of container tractor trailer into the central parts in the urban areas. o Exclusive freeway system for effective container transportation should be implemented to reduce urban traffic delay.

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The Exploitation of World Fishery Resources for 10 Years under the New Regime in the Sea (신해양질서 10년후 세계어업자원 이용동향)

  • 이장욱;허영희
    • The Journal of Fisheries Business Administration
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    • v.23 no.1
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    • pp.43-87
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    • 1992
  • In this paper, state of exploitation of world fishery resources after 10 years under the new regime in the sea, called the era of exclusive economic zone (EEZ) expending up to a 200 nautical miles from coastal line, was reviewed to determine effect from establishing EEZ in the world fishery production and its export/import volume based on the fishery statistics annually published by the Food and Agriculture Organization (FAO) of United Nation. The world total production from marine living resources had a trend showing a waned increase during 1970's when most of coastal states were translated into the reality of EEZ. From mid-1980's onwards, it increased rapidly, reaching about 85 million tons . Such increase in production was basically from the Pacific Ocean, accounting for more than 60% of the world total production. Fishing areas where showed increase in the production after the new regime in the sea were the southwestern Atlantic (FAO area 41) , the eastern Indian (FAO area 57) and the whole fishing areas in the Pacific except the eastern central Pacific (FAO area 77). Increase in the production from distant-water fishing countries came from the regions of the southwest Atlantic (FAO area 41) and the southwest Pacific (FAO area 81) . The production from coastal states was up from the regions of the eastern Indian (FAO area 57) , the northwest and northeast Pacific (FAO areas 61 and 67) and the southeast Pacific (FAO area 87) . It was likely that the exploitation of the fishable stocks was well monitored in the areas of the northwest Atlantic (FAO area 21) , the eastern central Atlantic (FAO area 34) and the northeast Pacific (FAO area 67) through appropriate management measures such as annual harvest level, establishment of total allowable catch etc. The marine fisheries resources that have made contribution to the world production, despite expansion of 200 EEZ by coastal states, were sardinellas, Atlantic cod, blue whiting and squids in the Atlantic Ocean : tunas which mainly include skipjack, yellowfin and bigeye tuna, croakers and pony fishes in the Indian Ocean : and sardine, Chilean pilchard, Alaska pollock, tunas (skipjack and yellowfin tuna) , blue grenadier and blue whiting including anchoveta in the Pacific Ocean. It was identified that both fishery production and its export since introduction of the new regime in the sea were dominated by such coastal states as USA, Canada, Indonesia, Thailand, Mexico, South Africa and Newzealand. But difficulties have been experienced in the European countries including Norway, Spain, Japan and Rep. of Korea. Therefore, majority of coastal states are unlikely to have yet undertaken proper utilization as well as rational management of marine living resources in their jurisdiction during the last two decades. The main target species groups which led the world fishery production to go up were Alaska pollock, cods, tunas, sardinellas, chub and jack mackerel and anchoveta. These stocks are largely expected to continue to contribute to the production. The fisheries resources which are unexploited, underexploited and/or lightly exploited at present and which will be contributed to the world production in future are identified with cephalopods, Pacific jack mackerel and Atlantic mackerel, silver hake including anchovies. These resources mainly distribute in the Pacific regions, especially FAO statistical fishing areas 67, 77 and 87. It was likely to premature to conclude that the new regime in the sea was only in favour of coastal states in fishey production.

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Toxic Effect of Azalea Extract on Cardiovascular System (진달래 꽃잎의 추출물이 심혈관계에 미치는 영향)

  • Chun, Jun-Ha;Chung, Sung-Bok;Kang, Seung-Ho;Kim, Yeong-Jo;Shim, Bong-Sub;Lee, Hyun-Woo;Shin, Dong-Gu;Park, Jong-Min
    • Journal of Yeungnam Medical Science
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    • v.8 no.2
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    • pp.52-62
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    • 1991
  • The toxic effect of azalea extract, expecially on cardiovascular system, is relatively unclear. The purpose of this study is to study the possible underlying mechanism and effect of toxic ingredient of azalea on cardiovascular system. The 71 healthy rabbits were divided into 10 groups : In group as preliminary study ; 4cc of normal saline was administered intravenously(N) ; 0.7gm/kg and 1.0gm/kg of azalea extract was administered respectively in the same route, volume(A1, A2) ; atropine was administered intravenously(A) ; after pretreatment with atropine(0.04mg/kg) to block parasympathetic system, azalea extract was injected like the above groups(AA1, AA2) ; normal saline, 0.7gm/kg and 1.0gm/kg of azalea extract were administered respectively with 0.2cc(1 : 1000) epinephrine(E0,E1,E2). We measured the following indices at I minute interval during first 10 minutes and then 10 minute interval during next 30 minutes : RR interval, QTc interval, maximal systolic and diastolic pressure drop with occuring time and presence of significant arrhythmia. The results were as follows : 1. The changes of RR interval, QTc interval were significantly increased in groups by Azalea extract. The blood pressure change was significantly decreased in groups by Azalea extract. There were no significant differences according to dosage of Azalea extract. 2. The changes of RR interval, blood pressure were significant differences between administration of atropine and Azalea extract after pretreatment with atropine, but not in the change of QTc interval. 3. There were no significant differences in the change of RR interval, ATc interval, blood pressure drop according to pretreatment with atropine. 4. The interaction between epineprine and Azalea extract was not noted by the effect of epineprine itself. 5. The ST change by 0.7gm/kg, 1.0gm/kg of Azalea extract was revealed in 1 case(14.0%), 7 case(100%), respectively. 6. Most of all cases with arrhthymia, ventricular tachycardia, ventricular fibrillation, were noted in the group by epineprine, except one case by Azalea extract(1.0gm/kg). It was idioventricular rhythm. In conclusion, azalea extract has negative inotropic and chronotropic effect with arrhythmogenic potential possibly through direct myocardial ischemia or injury but we cann't be absolutely exclusive of actions of autonmic nervous system, especially parasympathetic nervous system.

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