• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 추계학술대회
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• pp.23-23
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• 2018

Taiwan, formerly known as Formosa, located on tropical and subtropical climate zones with abundant biological resources. According to the latest version of the Flora of Taiwan, there are 4339 species of vascular plants including 1054 endemic species. First, Taiwania (Taiwania cryptomerioides), named after its native island of Taiwan, have been isolated more than 500 secondary metabolites, including lignans, terpenoids, steroids, and flavonoids. Several of the metabolites are reported to have antibacterial, antifungal, antimite, antitermite and antitumor activities. In order to investigate plant secondary metabolic diversity toward industrial applications, we established deep transcriptome resources for non-model plants and fungi to produce terpenoid metabolites of economic importance. Second, many plants of Lauraceae have been utilized in folk medicine for their exciting bioactivities. The twigs and leaves from 27 tree species of Lauraceae grown in Taiwan were performed to evaluate potential bioactivity. The leaves of Cinnamomum osmophloeum are traditionally used in folk medicines, and many biological activities have been identified, such as antibacterial, antifungal, antitermite, antidiabetic, antihyperuricemia, antiinflammatory, and antioxidant activities. However, C. osmophloeum has nine chemotypes with various secondary metabolite profiles. In order to efficiently produce active compounds, we established the genetic markers to identify the chemotype plants. Finally, Cinnamomum kanehirae is the host of the medicinal mushroom Antrodia cinnamomea. Several in vivo and in vitro studies indicated that A. cinnamomea possesses a diverse range of biological activities. Because of the potential pharmacological application, we established the transformation system to enhance the triterpenoid contents production.

• The Plant Pathology Journal
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• 제24권3호
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• pp.245-268
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• 2008

The outcome of plant-pathogen interactions is influenced significantly by endogenous small molecules that coordinate plant defence responses. There is currently tremendous scientific and commercial interest in identifying chemicals whose exogenous application activates plant defences and affords protection from pathogen infection. In this review, we provide a survey of compounds known to induce disease resistance in plants, with particular emphasis on how each compound was originally identified, its putative or demonstrated mechanism of defence induction, and the known biological target(s) of each chemical. Larger polymeric structures and peptides/proteins are also discussed in this context. The quest for novel defence-inducing molecules would be aided by the capability for high-throughput analysis of candidate compounds, and we describe some issues associated with the development of these types of screens. Subsequent characterization of hits can be a formidable challenge, especially in terms of identifying chemical targets in plant cells. A variety of powerful molecular tools are available for this characterization, not only to provide insight into methods of plant defence activation, but also to probe fundamental biological processes. Furthermore, these investigations can reveal molecules with significant commercial potential as crop protectants, although a number of factors must be considered for this potential to be realized. By highlighting recent progress in the application of chemical biology techniques for the modulation of plant-pathogen interactions, we provide some perspective on the exciting opportunities for future progress in this field of research.

• 생약학회지
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• 제29권4호
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• pp.331-337
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• 1998

Most Annonaceous acetogenins are potently bioactive and offer exciting potential as new antitumor, pesticidal and other bioactivites. The major mode of action of the acetogenin is inhibition of electron transport in the mitochodria. Two known cytotoxic ketolactone Annonaceous acetogenins, (2,4-cis)-isoannonacin (compound 1) and (2,4-trans)-isoannonacin (compound 2), have been isolated from Asimina triloba (Annonaceae) by bioactivity directed fractionation. The structures were characterized on the basis of chemical and spectral data. Compounds 1 and 2, which are known but are first isolated from the seeds of this species, were ob-tained. In brine shrimp lethality test (BST), 1 and 2 exhibited cytotoxicity.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2001년도 춘계학술대회논문집
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• pp.368-373
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• 2001

A major concern on high-energy centrifugal pump is the potential for interaction of two-phase flow phenomena with mechanical response of the pumping elements. The other concern is the pressure pulsations created from trailing edge of the impeller blade and flow separation and recirculation at partial load in centrifugal pumps. These interactions generating between rotor and casing cause dynamic pulsation on pump and exciting pipeline vibration. The higher severity responses, the more lead to failure of pump and system components. Finally, it cause severe axial vibration of single stage pump due to the hydraulic instability in flow condition below BEP.

• 한국응용곤충학회지
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• 제34권1호
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• pp.9-14
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• 1995

From a chemist's perspective, Scarabaeidae is one of the most exciting group of insects to work on the isolation, identification, and synthesis of sex pheromones because-as opposed to Lepidoptera, which by and large utilizes straight chain alcohols, aldehydes, and acetates-the pheromonal chemistry of scarab beetles is remarkably diverse. While species in the subfamily Rutelinae utilize pheromone constituents, which are presumably fatty acid derivatives, the more primitive species in the subfamily Melolonthinae use phenolic, amino acid derivative, and terpenoid compounds. Here, I discuss the recent advances we have accomplished in the identification of scarab sex pheromones with especial emphasis on their chemical diversity. Also, I discuss the potential role of these sex pheromones in insect pest management. Field tests revealed that, in contrast to what has been frequently observed in the Lepidoptera, the higher the dosage of sex pheromone loaded in the traps the greater the capture of scarab beetles. These data suggest that mass trapping is more likely to be useful for scarab pest management than mating distruption.

• 한국해양공학회지
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• 제2권2호
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• pp.27-36
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• 1988

For the purposes of drilling oil field and extracting oil deep water in more rough weather, the size of drilling rigs must be estimated. In this paper, the three dimensional source distribution method is used and we assume 10 deg. heeling and trimming condition of the drilling rig(SR-192). Also, the effects of the hydrodynamic forces which include the drift forces for field method, and the motion responses are studied with changing the incident wave direction in the assumed inclining condition. The theory and numerical codes used in this thesis appeared to be very useful for the preliminary design of drilling rigs.

• 대한조선학회지
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• 제18권3호
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• pp.29-38
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• 1981

In general the drift result in ship heeling, thus it seems to be necessary to analyze the ship motion by considering both the drifting and heeling phenomena. In this paper, a drift velocity and a heeling angle are given as prior conditions, and then within the linear potential theory the hydrodynamic coefficients and wave exciting forces and moments are derived for a ship advancing and drifting with constant speeds. And numerical calculations are preformed for a cylindrical body of shiplike cross section at zerp forward velocity. The 2-D hydrodynamic forces and moments of a heeled cylinder are calculated by using the Frank Close-Fit method. These numerical results for the oscillating cylinder without drift velocity have shown better agreements with experimental data than the numerical results of Kobayashi[2]. The motion responses for a drifting cylinder are calculated ignoring the drift velocity effect in the free surface condition. The accuracy of these calculations can not be verified, because the experimental data are not available. Through these numerical calculations to so concluded that drift velocity effects on the body motion are signiffcant.

• Carbon letters
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• 제8권3호
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• pp.214-224
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• 2007

The field of photocatalysis is one of the fastest growing areas both in research and commercial fields. Titanium dioxide is the most investigated semi-conductor material for the photocatalysis applications. Research to achieve $TiO_2$ visible light activation has drawn enormous attentions because of its potential to use solar light. This paper reviews the attempts made to extend its visible photocatalytic activity by carbon doping. Various approaches adopted to incorporate carbon to $TiO_2$ are summarized highlighting the major developments in this active research field. Theoretical features on carbon doping are also presented. Future scenario in the rapidly developing and exciting area is outlined for practical applications with solar light.

• Journal of Information Processing Systems
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• 제14권1호
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• pp.101-128
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• 2018

Thanks to its potential in many applications, Blockchain has recently been nominated as one of the technologies exciting intense attention. Blockchain has solved the problem of changing the original low-trust centralized ledger held by a single third-party, to a high-trust decentralized form held by different entities, or in other words, verifying nodes. The key contribution of the work of Blockchain is the consensus algorithm, which decides how agreement is made to append a new block between all nodes in the verifying network. Blockchain algorithms can be categorized into two main groups. The first group is proof-based consensus, which requires the nodes joining the verifying network to show that they are more qualified than the others to do the appending work. The second group is voting-based consensus, which requires nodes in the network to exchange their results of verifying a new block or transaction, before making the final decision. In this paper, we present a review of the Blockchain consensus algorithms that have been researched and that are being applied in some well-known applications at this time.

• Molecules and Cells
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• 제42권9호
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• pp.617-627
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• 2019

Brain organoids are an exciting new technology with the potential to significantly change our understanding of the development and disorders of the human brain. With step-by-step differentiation protocols, three-dimensional neural tissues are self-organized from pluripotent stem cells, and recapitulate the major millstones of human brain development in vitro. Recent studies have shown that brain organoids can mimic the spatiotemporal dynamicity of neurogenesis, the formation of regional neural circuitry, and the integration of glial cells into a neural network. This suggests that brain organoids could serve as a representative model system to study the human brain. In this review, we will overview the development of brain organoid technology, its current progress and applications, and future prospects of this technology.