• Title/Summary/Keyword: excessive

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Effects of Indomethacin on the Production of Cytokines in Mice Exposed to Excessive Zinc (과량의 아연에 노출된 생쥐의 사이토카인 생산에 미치는 인도메타신의 영향)

  • 채병숙;신태용
    • YAKHAK HOEJI
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    • v.46 no.4
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    • pp.258-264
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    • 2002
  • Zinc plays an important role in immunobiological responses, while excessive zinc attenuates immune functions in a dose-dependent manner. Zinc excess has been reported to increase levels of plasma prostaglandin E$_2$ (PGE$_2$), which is known to inhibit production of Th (helper T) 1-associated cytokines and to induce inflammatory responses. Thus, this study was investigated the effects of indomethacin, a potent inhibitor of PGE$_2$ synthesis, on the proinflammatory cytokine and lymphokine production in ICR mice exposed to excessive zinc. Indomethacin at doses of 5 mg/kg was administered i.p. 30 minutes before zinc chloride (Zn) 30 mg/kg orally daily for 10 days. Excessive Zn remarkedly increased tumor necrosis factor (TNF)-$\alpha$ and interleukin (IL)-1$\beta$ levels in both serum and splenic supernatants compared with those in controls, while indomethacin significantly reduced the excessive Zn-induced levels of IL-1$\beta$. In serum, excessive Zn significantly decreased the levels of IL-2 and interferon (IFN)-${\gamma}$ compared with those in controls, whereas indomethacin significantly enhanced the excessive Zn-decreased levels of IFN-${\gamma}$ but did not affect the Zn-decreased levels of serum IL-2. In splenic supernatants, All of excessive Zn, indomethacin, and combination of Zn and indomethacin significantly enhanced IL-2 levels compared with those in controls, but indomethacin didn't affect the Zn-induced production of IL-2. These data, therefore, suggest that indomethacin significantly attenuated the in vivo and ex vivo IL-1$\beta$ production increased by excessive zinc and remarkedly enhanced the in vivo excessive zinc-suppressed production of IFN-${\gamma}$ but not IL-2.

The Sleepy Child (졸린 소아에 대한 평가와 치료)

  • Kang, Seung-Gul;Kim, Leen
    • Sleep Medicine and Psychophysiology
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    • v.16 no.2
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    • pp.56-60
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    • 2009
  • Excessive daytime sleepiness in childhood might be abnormal phenomenon and often related to the sleep disorders or insufficient sleep duration. The most common cause of excessive daytime sleepiness would be insufficient sleep. However, narcolepsy, idiopathic hypersomnia, circadian rhythm sleep disorders, medication, medical illness and other sleep disorders that could cause insomnia and poor quality of sleep also result in excessive daytime sleepiness. The misdiagnosed and untreated excessive daytime sleepiness in childhood can lead to serious developmental and educational problem.

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A Study on The Excessive Liver-Symptoms(肝實證) in The Analysis of Five Visceral Symptoms By The Five Pathogenic Factors(五邪) (오장변증중(五臟辨證中) 간실증(肝實證)의 오사(五邪)에 의한 연구)

  • Kim, Jae-Hong;Kim, Tae-Hee
    • The Journal of Internal Korean Medicine
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    • v.15 no.1
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    • pp.176-209
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    • 1994
  • 1. The Jung-Sa(正邪) of the Excessive Liver-Symptoms belongs to the eleven symptoms, there are blue face, blue thin fingernail, anger, fancy of larg body, dizziness, eye flame, Bell's palsy, hard swelling pain at braest, side pain going on the belly from the side, side pain and movement at the left side. 2. The Mi-Sa(微邪) of the Excessive Liver-Symptoms belongs to the four symptoms, there are meat in eye, edema in cheek, lack of appetite and diarrhea. 3. The Juk-Sa(賊邪) of the Excessive Liver-Symptoms belongs to the only one symptom, this is nosebleeding. 4. The Hu-Sa(虛邪) of the Excessive Liver-Symptoms belongs to the three symptoms, there are scrotum constraction, strain in belly and constipation. 5. The Sil-Sa(實邪) of the Excessive Liver-Symptoms belongs to the twenty eight symptoms, there are red eye, raised eyes(兩眼上?), spitting blood, sternocostal turgid pain, turgidity in belly, drooping testis, vomiting water acid, sickening, belching, confusion, impatience, frequent forgetfulness, headache, giddness, eye pain, deaf, ringing in the ear, feeling inverse, drying mouth, stuffiness sensation in the chest, chest pain, stuffiness sensation in the belly, bellyache, quadriplegia, spasm of extremities, tremor, alternate spells of fever and chills, high fever and strain in muscle. 6. Those symptoms, Red corner of the eye, red face, swelling on the forehead, stiff-neck and back strong, opisthotonos, constracture of the limbs, vomiting yellow bitter water, speech impediment, epilepsy, depression, strong tongue, different thing in throat, fullness and distention of the gastric region, feeling sick and tenesmus, have no connected with the Excessive Liver-Symptoms(肝實證) 7. The Excessive Liver-Symptoms(肝實證) is connected with the ganjabyoung(肝自病) and Hwa(火) which the pathology is, than because Mock(木) is excessive and Mock-Saeng-Hwa(木生火), the ganjabyoung(肝自病) and Sil-Sa(實邪) are many. 8. There are the sixteen symptoms with the exception of The Excessive Liver-Symptoms(肝實證), because supposed that the scholars in medicine included the union syndroms(合病), the combine syndroms(兼病) and the analysis of symptoms(辨證) in The Analysis of Five Visceral Symptoms. 9. During consideration of the symptoms at the above statements, where are many causes by Gan-Pung(肝風), there is difficult of distinction between the excessive Liver-Symptoms(肝實證) and C.V.A(Cerebral Vascular Attack). Because than NaeKyung(內經) distinguished between the excessive Liver-Symptoms(肝實證) and C.V.A., the future medical specialists connected with the excessive Liver-Symptoms(肝實證) and C.V.A.. 10. An appearance of Sang-Hwa(相火) that the liver possessed is divided into an appearance of Hwa(火), there will be making a study att the more necessary. 11. The cuases of each syndroms are consist of the origins of syndroms, its pathology and the positions where the syndroms appeared, I consider that is the various ways how judge the syndroms except the Five Pathogenic Factors(五邪). 12. If more than study will be achieved in all, the new definition will be standed about the Excessive and Deficient Five Visceral Syndroms(五臟虛實證), I consider this will be the foundation data that study the Oriental Medicine and the important data that is a judgement standard of clininc.

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Association of Health Indicators with Excessive Television Viewing among Elementary School Students in Seoul, Korea (서울시 초등학생의 과잉 텔레비전 시청과 관련된 건강지표)

  • Shin, Sun-Mi
    • Journal of the Korean Society of School Health
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    • v.26 no.2
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    • pp.104-113
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    • 2013
  • Purpose: The aim of this study was to investigate prevalence and ecological characteristics of excessive television viewing among elementary school students in Seoul. Methods: Secondary data, representative sample of 11,082 subjects in Seoul was used. After prevalence of the excessive television viewing was identified by using factor analysis, 6 main factors explaining the ecological indicators was founded. After identifying prevalence of the excessive television viewing, by using factor analysis, we found 6 main factors explaining the ecological indicators. After categorizing factors into socio-psychological and lifestyle characteristics, we were investigated the odds ratio of excessive television viewing per characteristics by using multiple logistic regression. Results: The prevalence of excessive television viewing was 29.7% among the elementary school student in Seoul. The prevalence were higher in male, higher grade, and non-South of the Han River. Socio-psychological indicators which expressed excessive television viewing were annoying or bullying, scolding from teacher, depressed mode, thought for a runaway from home, an experience of diet, and negative body image. Life style indicators were a lower intake of fruit and vegetables, a higher intake of Ramyun and soft drink, a worse life style of hand washing, and wearing safety equipment. Conclusion: Lifestyle of television viewing was the comprehensive results from family, school, and society rather than a personal preference. Therefore, it is necessary to educate the hazard of excessive television viewing, to reenforce the students' health competence, to activate a safe leisure program as an alternate of television viewing, and to develop a recommendation.

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The Mediating Roles of Preschoolers' Self-regulation in the Relationship Between Maternal Parenting Behaviors and Preschoolers' Excessive Immersion in Smartphones (어머니의 양육행동과 유아의 스마트폰 과몰입 간의 관계에서 유아의 자기조절능력의 매개적 역할)

  • Park, Bokyung;Park, Nam-Shim
    • Korean Journal of Childcare and Education
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    • v.14 no.5
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    • pp.117-136
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    • 2018
  • Objective: This study examined the mediating roles of preschoolers' self-regulation in the relationship between maternal parenting behaviors and preschoolers' excessive immersion in smartphones. Methods: A total of 268 mothers of preschoolers responded to questionnaires on three research variables. Data were analyzed by correlation analyses and regression analyses. Results: First, maternal warmth/encouragement was negatively related to preschoolers' excessive immersion in smartphones, while maternal overprotectiveness/permission and rejection/neglect were positively related to preschoolers' excessive immersion in smartphones. Second, maternal warmth/encouragement and limit setting were positively linked to preschoolers' self-regulation, but maternal overprotectiveness/permission and rejection/neglect were negatively linked to preschoolers' self-regulation. Third, preschoolers' self-regulation was negatively associated with their excessive immersion in smartphones. Finally, preschoolers' self-regulation fully mediated the relationship between maternal warmth/encouragement and preschoolers' excessive immersion in smartphones, and preschoolers' self-regulation partially mediated the relationship between maternal overprotectiveness/permission, rejection/neglect and preschoolers' excessive immersion in smartphones. Conclusion/Implications: The results of this study suggest that positive maternal parenting behaviors and preschoolers' effective self-regulation are important in order to decrease preschoolers' smartphone overuse. These findings provide empirical evidence to develop programs for prevention and intervention of preschoolers' smartphone addiction.

An Exploratory Study on Undergraduates' SNS Addiction Tendencies and Learning Attitudes (대학생의 SNS 중독경향성과 학습태도에 관한 탐색연구)

  • Baek, Yumi
    • Journal of Korea Society of Digital Industry and Information Management
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    • v.13 no.4
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    • pp.231-245
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    • 2017
  • The purpose of this study is to analyze the trend line through scatter diagram analysis on correlation between SNS addiction tendencies and learning attitudes, figure out the knee point influencing learning attitudes negatively in detail, and examine influence among subareas. To address the goal, study questions are formulated as follows. First, this author did screening on the data of variables measured and analyzed descriptive statistics. Second, this researcher produced the trend line by drawing a scatter diagram in order to analyze correlation between SNS addiction tendencies, withdrawal symptoms, excessive communication, and excessive time wasting, and learning attitudes exploratorily. Third, to explore correlation between self-evaluation, learning participation, and developmental attitudes, the subfactors of learning attitudes related to SNS addiction tendencies, this author drew a scatter diagram and analyzed the threshold of positive and negative correlation. To verify the study questions, the SNS addiction tendency scale and learning attitude scale were applied to 301 university students in Chungcheong area. According to the study results, first, their learning attitudes are influenced by SNS addiction tendencies, excessive communication and excessive time wasting, and they are not influenced by withdrawal symptoms that much. Second, excessive communication, a factor of SNS addiction tendencies, and self-evaluation and developmental attitudes, factors of learning attitudes, show positive correlation to some extent and indicate negative correlation after the threshold. However, excessive communication and learning participation are found to show no correlation. Third, according to the results of examining correlation with learning attitudes by dividing them into excessive communication and excessive time wasting groups with the knee point of 1.40, as the symptom of excessive communication is found more, it influences self-evaluation, learning participation, developmental attitudes, and learning attitudes more negatively in general. The result of this study is expected to provide foundational material necessary to develop educational programs to prevent undergraduates' excessive SNS use and SNS addiction which can be used in the scenes of counseling or education.

Excessive crying: behavioral and emotional regulation disorder in infancy

  • Kim, Joon-Sik
    • Clinical and Experimental Pediatrics
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    • v.54 no.6
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    • pp.229-233
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    • 2011
  • In the pediatric literature, excessive crying has been reported solely in association with 3-month colic and is described, if at all, as unexplained crying and fussing during the first 3 months of life. The bouts of crying are generally thought to be triggered by abdominal colic (over-inflation of the still immature gastrointestinal tract), and treatment is prescribed accordingly. According to this line of reasoning, excessive crying is harmless and resolves by the end of the third month without long-term consequences. However, there is evidence that it may cause tremendous distress in the mother-infant relationship, and can lead to disorders of behavioral and emotional regulation at the toddler stage (such as sleep and feeding disorders, chronic fussiness, excessive clinginess, and temper tantrums). Early treatment of excessive crying focuses on parent-infant communication, and parent-infant interaction in the context of soothing and settling the infant to sleep is a promising approach that may prevent later behavioral and emotional disorders in infancy.

Evaluation of the Degree of Consolidation using Settlement and Excessive Pore Water Pressure (침하량과 간극수압에 의한 압밀도의 평가(지반공학))

  • 이달원;임성훈;윤제식;김지문
    • Proceedings of the Korean Society of Agricultural Engineers Conference
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    • 2000.10a
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    • pp.444-450
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    • 2000
  • This study was performed to analyze the degree of consolidation by the dissipation of excessive pore water pressure and final settlement prediction methods of the very soft clay. Hyperbolic method, Asaoka method and curve fitting method were used to compute the degree of consolidation. The degree of consolidation with excessive pore water pressure were used to compute, which considered the dissipation time with embankment construction. The degree of consolidation that was obtained by the peak excessive pore water pressure was less than in the case of the dissipation excessive pore water pressure. And, the degree of consolidation by the total settlement was nearly the same value that of layer settlement. The degree of consolidation that was obtained by excessive pore water pressure was larger than in the case of the settlement.

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Adequate Excessive Air Ratio for The Various Blended Coal at a USC Boiler (USC 보일러에서 혼합연료별 적정과잉공기비)

  • Park, Jin-Chul;Lee, Jae-Heon;Moon, Seung-Jae
    • Plant Journal
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    • v.7 no.2
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    • pp.44-51
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    • 2011
  • Given the fact that the entire bituminous coal used for a boiler is imported, the supply of coal is often affected by the rise of international coal price. Moreover, coal suppliers have been diversified due to the competition among power generation companies for reducing costs and inexpensive sub-bituminous coal is used. As a result, boilers combustion conditions have been deviated from the initial boiler design. This requires the selection of adequate excessive air ratio for different combustion conditions to enhance the efficiency of boiler operation. The boiler efficiency has been identified through an examination on the change of excessive air ratio by mixed fuel in unit 8 of Dangjin power plant complex. In addition, an excessive air ratio was calculated based on the examination result. According to the study result, the adequate excessive air ratio was 13% when Macquarie and Powder river were mixed at a ratio of 5:5 and when Sonoma and Megaprima persada were mixed at a ratio of 5:5. When BHP Billiton and Powder river were mixed at a ratio of 4:6 and Centennial and Batubara were mixed at a ratio of 3:7, the adequate excessive air ratio was 11%.

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The Moderated Effects of Self-control on the Relationship between Excessive Use of the Internet and the Stress Levels of Elementary School Children (초등학생의 인터넷 과다 사용과 스트레스와의 관계에 대한 자아통제력의 중재효과)

  • Cho, Song-Yon
    • Korean Journal of Child Studies
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    • v.31 no.5
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    • pp.47-61
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    • 2010
  • This study examined the moderated effects of self-control on the relationship between elementary school children's excessive use of the Internet and their stress levels. The participants were 403 elementary school children from Chungnam-do. The instruments used were the 'Internet Addiction Autodiagnosis Scale (K-Scale)', the 'Stress Scale' and the 'Self-control Rating Scale'. The collected data were analyzed by t test, F test and the Scheffe test for a post hoc test, Pearson's partial correlation and stepwise multiple regression, and Cronbach's ${\alpha}$ for reliability by SPSS program (17.0 version). The results were as follows : First, it was found that there were significant differences in terms of excessive use of the Internet, stress levels, and self-control by gender, grade, academic achievement, the beginning year of first Internet access and the number of hours of Internet usage hours per day. Second, there were significant positive correlations between excessive use of the Internet (r = .40, p < .001) and stress levels (r = .44, p < .001) and the immediate satisfaction of self-control. Finally, the immediate satisfaction of self control was seen to moderate the relationships between the total scores for the excessive use of the Internet and stress levels and between withdrawal of excessive use of the Internet and the accompanying stress levels.