• Journal of Gastric Cancer
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• 제1권3호
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• pp.174-179
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• 2001

Purpose: For curative resection of recurrent gastric cancer, it is imperative that there be no unrecognized foci of tumoral disease outside the operation field. PET (positron emission tomography) with FDG (18 fluoro-2 deoxy-D-glucose) is a whole-body imaging technique that exploits the increased rate of glycolysis in tumor cells to detect disease. The authors evaluated the usefulness of FDG-PET in assessing resectability of recurrent gastric cancer. Materials and Methods: Seven patients with recurrent gastric cancer were studied with FDG-PET from December 1998 to October 2000. All FDG-PET images were interpreted in conjunction with conventional diagnostic methods. All imaging results were correlated with the pathological diagnosis and clinical outcome. Results: A final diagnosis of recurrence was obtained at 14 sites in all 7 patients by histology or clinical follow up. Locoregional recurrence, including distant metastasis, developed in 6 of 7 patients and distant recurrence in only one. FDG-PET detected all recurrent sites (5 locoregional and 5 distant) in 5 patients without peritoneal recurrence, but did not detect peritoneal seeding in 2 patients with peritoneal recurrence. The accuracy of FDG-PET in estimating resectability was $71.4\%$ (5/7), and that of CT and PET together was $85.7\%$ (6/7). A curative resection could be performed in three of the recurrent patients (2 locoregional and 1 distant recurrence). Conclusion: Our results suggest that FDG-PET may be useful for detecting locoregional and distant recurrence of gastric cancer and for selecting appropriate treatment. However, considering that FDG-PET was limited in detecting peritoneal seeding and determining the exact anatomical extension of tumor, it should be used in conjunction with other anatomical images.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7689-7694
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• 2015

Background: Bone tumors are neoplasias with a high overall mortality; one of the main factors that reduce survival is their high capacity to develop metastases. It has been reported that finding lung metastases at diagnosis of osteosarcoma (OS), chondrosarcoma (CS) and giant cell tumor of bone (GCTb) is quite common. In this study, we inquire the relationship of metastases caused by these tumors with different clinical and pathological aspects, in order to guide medical personnel in the diagnosis and opportune treatment of metastases or micro metastases. Materials and Methods: We collected data of 384 patients with clinical, radiological and histopathological diagnosis of OS, GCTb and CS that attended the National Rehabilitation Institute (INR) during 2006 to 2014. Chi-square and Fisher's exact tests were performed for data analysis. Results: In the three tumor types, the presence of metastases at diagnosis was variable (p=0.0001). Frequency of metastases was 36.7%, 31.7% and 13.2% for OS, CS and GCTb respectively. The average age had no significant difference (p>0.05) in relation to metastases, even so, patients with OS and GCTb and metastases, were older while patients with CS and metastases were younger, in comparison to patients without metastases. Males had a higher frequency of metastases (68.2%, p = 0.09) in contrast to CS and GCTb, in which the metastases was more frequent in women with 51.9% (p = 0.44) and 57.9% (p = 0.56) respectively. Broadly, metastasis was associated with primary tumors located in the femur (44.4%), followed by the tibia (15.6%); metastases was more frequent when primary tumor of GCTb and OS were in the same bones, but were located in the hip (26.3%) for CS. Conclusions: The frequency of metastases in OS, GCTb and CS is high in our population and is determined by different clinicopathological variables related to the kind of tumor. Further studies are needed in order to evaluate metastases subsequent to diagnosis and associations with survival and clinicopathological factors, as well as to determine the sensitivity and specificity of current methods of detection.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5171-5174
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• 2014

Background: The increase in breast cancer awareness and widespread use of mammographic screening has led to an increased detection of (non-palpable) breast cancers that cannot be discovered through physical examination. One of the methods used in the diagnosis of these cancers is vacuum-assisted core biopsy, which prevents a considerable number of patients from undergoing surgical procedures. The aim of this study was to present the results of stereotactic vacuum-assisted core biopsy for suspicious breast lesions. Materials and Methods: Files were retrospectively scanned and data on demographic, radiological and pathological findings were recorded for patients who underwent stereotactic vacuum-assisted core biopsy due to suspicious mammographic findings at the Interventional Radiology Centre of the Florence Nightingale Hospital between January 2010, and April 2013. Statistical analysis was carried out using Pearson's Chi-square, continuity correction, and Fisher's exact tests. Results: The mean age of the patients was 47 years (range: 36-70). Biopsies were performed due to BIRADS 3 lesions in 8 patients, BIRADS 4 lesions in 77 patients, and BIRADS 5 lesions in 3 patients. Mammography elucidated clusters of microcalcifications in 73 patients (83%) and focal lesions (asymmetrical density, distortion) in 15 patients (17%). In terms of complications, 1 patient had a hematoma, and 2 patients had ecchymoses (3/88; 3.3%). The histopathologic results revealed benign lesions in 63 patients (71.6%) and malignant lesions in 25 patients (28.4%). The mean duration of the procedure was 37 minutes (range: 18-55). Although all of the BIRADS 3 lesions were benign, 22 (28.6%) of the BIRADS 4 lesions and all of the BIRADS 5 lesions were malignant. Among the malignant cases, 80% were in situ, and 20% were invasive carcinomas. These patients underwent surgery. Conclusions: In cases where non-palpable breast lesions are considered to be suspicious in mammography scans, the vacuum-assisted core biopsy method provides an accurate histopathologic diagnosis thus preventing a significant number of patients undergoing unnecessary surgical procedures.

• 성인간호학회지
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• 제12권4호
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• pp.619-628
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• 2000

The purpose of this study was to evaluate the knowledge level of pressure ulcer among hospital nurses through a cross-sectional survey by using the pressure ulcer knowledge assessment tool of Beitz et al.(1998). The total of subjects was 160 voluntary participants (60 were from Hospital A and 100 were from Hospital B) working at adult patients' units in two university hospitals located in the same city. None of the hospitals had expert nurses of pressure ulcer nor provided a regular pressure ulcer education program during the past one year. The survey tool consisted of 32 true-false items which were grouped into the risk factors knowledge category(13 items), the wound assessment knowledge category(4 items), and the treatment methods knowledge category(15 items). An internal consistency reliability test of the tool yielded an overall coefficient of 0.72; the coefficient for the risk factors knowledge category was 0.40, that for the wound assessment knowledge category was 0.33; that for the treatment knowledge category was 0.54. The main findings of the study are as follows. 1) Demographic characteristics of the two hospital nurses were similar except for the educational level(p=0.029) and the work units(p=0.001). These observations were maintained even if Hospital A and B were separately compared. 2) The knowledge level of the subjects about pressure ulcer in general was low as indicated by 53.3 points(of 100 possible points) on average. The knowledge level about treatment methods of pressure ulcer was the lowest as indicated by 47.0 points on average. 3) No correlation between the knowledge level of the pressure ulcer and the demographic characteristics of nurses was found except that the knowledge level of I.C.U. nurses was significantly higher(p=0.0003) than that of nurses in other units(p=0.2926) in the case of Hospital A. 4) The knowledge level of nurses in Hospital B was higher than for nurses in Hospital A. The reason was not identified, but it seems that it is related to the role of the I.C.U. or some other factors. The study results confirmed the existing literature that knowledge level of nurses about pressure ulcer is low regardless of age, educational level, or work experience. However, the working place(unit) affected the knowledge level. Further research on the exact reason for the differences in the knowledge level is needed in the future.

• 한국통신학회논문지
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• 제40권8호
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• pp.1551-1559
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• 2015

최근 스마트 기기가 PC와 유사한 성능을 보이면서, 사용자들은 메신저, SNS(Social Network Service), 은행 업무 등 PC에서 수행했던 업무들을 모바일 기기에서도 수행할 수 있게 되었다. 이 같은 긍정적인 변화와 함께 스마트 기기를 대상으로 하는 공격으로, 보안 위협이 증가하는 부정적인 변화도 나타났다. 대표적으로 사용자의 개인정보 유출, 부당한 과금을 비롯하여 최근에는 DDoS(Distributed Denial of Service) 공격을 발생시키는 봇(Bot)으로 스마트 기기가 활용되면서 모바일 보안에 대한 위협이 증가하는 실정이다. 특히, 스마트 기기의 80% 이상을 차지하는 안드로이드 플랫폼에서의 악성코드를 통한 피해건수가 증가하고 있다. 본 논문에서는 안드로이드의 악성코드를 탐지하기 위해 통계 기반 분석법 중 하나인 시계열 분석법을 제안한다. 시계열 모델 중 기존의 데이터를 기반으로 정확한 예측값을 도출할 수 있는 자기회귀 이동평균 모델을 이용하였으며, Z-Score를 이용한 비정상 데이터 후보군 추출을 통해서 전체 데이터와의 비교 없이 추출된 후보군과의 데이터 비교를 통해서 빠르게 악성코드를 탐지하는 방법을 이용한다. 악성코드 탐지 실험 결과를 통해 제안하는 방법의 타당성을 검증하고자 한다.

• 한국통신학회논문지
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• 제37권7A호
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• pp.586-599
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• 2012

본 논문에서는 RGB영상과 깊이영상을 사용하여 얼굴검출 및 추적을 고속으로 수행할 수 있는 방법을 제안한다. 이 방법은 얼굴검출 과정과 얼굴추적 과정으로 구성되며, 얼굴검출 과정은 기본적으로 기존의 Adaboost 방법을 사용하나, 깊이영상을 사용하여 탐색영역을 축소한다. 얼굴추적은 템플릿 매칭방법을 사용하며, 조기종료 기법을 사용하여 수행시간을 줄였다. 이 방법들을 구현하여 실험한 결과, 얼굴검출 방법은 기존의 방법에 비해 약 39%의 수행시간을 보였으며, 얼굴추적 방법은 $640{\times}480$ 해상도의 프레임 당 2.48ms의 추적시간을 보였다. 또한 검출율에 있어서도 제안한 얼굴검출 방법은 기존의 방법에 비해 약간 낮은 검출률을 보였으나, 얼굴로 인식하였지만 실제로는 얼굴이 아닌 경우의 오검출률에 있어서는 기존방법의 약 38% 향상된 성능을 보였다. 또한 얼굴추적 방법은 추적시간과 추적 정확도에 있어서 상보적인 관계를 가지며, 특별한 경우를 제외한 모든 경우에서 약 1%의 낮은 추적오차율을 보였다. 따라서 제안한 얼굴검출 및 추적방법은 각각 또는 결합하여 고속 동작과 높은 정확도를 필요로 하는 응용분야에 사용될 수 있을 것으로 기대된다.

• 한국의료질향상학회지
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• 제10권1호
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• pp.58-76
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• 2003

Background : Aim of this study is focused on the analysis of the needed abilities of medical representatives resulting in building up the market and increasing sales. It is to propose methods to increase this ability ensuring continuous growth in market share and profit. Methods : A survey was conducted between January 6 and May 31, 2003. Using SPSS(Version 10.0), the collected data was analyzed by Hotelling T2, factor analysis. Some hypotheses were selected to include the conclusion. Some questionnaires for physicians working in hospitals or clinics and the medical representatives working in a pharmaceutical company were created and asked to them to either prove or reject those hypotheses. The results were analyzed to find the primary factors that effect the interactions between physician and the medical representatives. These factors were also studied along with the theoretical research based on published references. Results : The results were as follows. The main reasons for the physician to meet with a medical representatives were collection of product informations needed for patient treatment and collection of informations on current medical issue and as well as personal interests. The main parameters by which physicians evaluate the medical representatives are human relationship including sincerity and manners and supply of accurate and unbiased information on products. Overall, the medical representatives' perception on the importance of medical knowledge and ability to deliver it are lower than that expected by physicians. Conclusion : Medical and pharmaceutical companies' environment are changed rapidly. And those changes forced medical representatives to set new roles and competency. In order to drive away from the past 'rule of thumb' and 'adaptation to circumstance', optimal method and systemic development to train and support the medical representatives should be quipped. They will help medical representatives to be specialists in medical knowledge and to understand the exact need of health care professions. Product competitiveness will be increased and eventually successful business can be achieved through it.

• Journal of Trauma and Injury
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• 제25권4호
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• pp.247-253
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• 2012

Purpose: Hemorrhage is a main cause of death in trauma patients. The goal of this study is to describe the characteristics of trauma patients with massive bleeding and to evaluate the prognostic factors concerning their survival. Methods: This study was performed retrospectively and included trauma patients with massive bleeding who had been treated from March 2007 to August 2012. The inclusion criterion was patients who received more than 10 U of packed red blood cells within the first 24 hours after visiting the emergency department. Based on their medical records, we collected data in terms of demographic findings, mechanisms of injury, initial clinical and laboratory findings, methods for hemostasis (emergency surgery and/or angioembolization), transfusion, injury severity score (ISS), revised trauma score (RTS) and trauma and injury severity score (TRISS). We used the Mann-Whitney U test and Fisher's exact test to compare the variables between the patients that survived and those that did not. We performed a logistic regression analysis with the significant variables from the univariate test. Results: Thirty-two(32) patients were enrolled. The main mechanisms of injury were falls and motor vehicle accidents. The mean transfusion amount of packed red blood cells (PRBC) was 17.4 U. The mean elapsed time for the first hemostasis (surgery or embolization) was 3.5 hours. The initial technical success rates were 83.3%(15/18) in angioembolization and 66.7%(8/12) in surgery. The overall mortality rate was 34.4%(11/32). The causes of death were bleeding, brain swelling and multiple organ failure. The ISS(25.5 vs 46.3, p=0.000), TRISS(73.6 vs 45.1, p=0.034) and base excess(<-12 mmol/L, p=0.020) were significantly different between the patients who survived and those who did not. Conclusion: The ISS was a prognostic factor for trauma patients with massive bleeding.

• 대한수의학회지
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• 제33권2호
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• pp.269-275
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• 1993

토끼의 바이러스성 간염, 소위 토끼 출혈병의 원인체에 대한 각종 세포주들에 바이러스증식을 유도하고 한편 실험적 감염예에 대한 면역형광항체법과 immunoperoxidase 방법에 의한 원인체의 조직내에 분포상황을 조사하기 위하여 감염된 토끼를 폐사직후 부검하여 간장, 비장, 신장, 폐 및 뇌조직을 절제하여 동결절편하거나 또는 포르말린고정 파라핀 포매 절편을 $5{\sim}7{\mu}m$로 작제하여 면역반응에 공시하였다. 공시된 각종 세포주에 대한 원인체의 세포배양성은 인정되지 않았으며 면역조직화학적방법을 이용한 면역반응에서는 간장에서 강한 양성반응을 보였으며, 비장과 신장에서는 소수예에서 백색수주변 대식세포와 신사구체에서 양성반응을 각각 나타내었다. 그러나 기타 장기에서는 특이한 양성반응이 인정되지 않았다. ABC immunoperoxidase 방법을 이용한 간장의 포르말린고정 파라핀포매 절편에서 portal triad를 중심으로한 소엽주변부 간세포에서 강한 양성반응을 나타내었으며, 이들 양성반응은 간세포 및 동양혈관세포의 세포질내에 미세과립상으로 미만성 및 세포질주변성으로 관찰되었다. 그리고 감염세포와 비감염세포와의 구별이 명확히 인정되었고 양성반응을 보이는 부위는 H-E 염색상 변성괴사된 간세포에 일치되었다. 이상의 결과에서 본 질병의 표적기관은 간장이며 포르말린고정 파라핀포매 간조직의 immunoperoxidase 방법에 의한 면역조직화학적방법이 본병 진단에 크게 활용되리라 본다.

• 에너지공학
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• 제17권4호
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• pp.182-188
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• 2008

본 연구에서는 탄소 균형 및 1차식에 의한 공연비 산정방법을 대체연료에 적용하여 그 결과를 비교하였다. 이전의 연구에서는 Eltinge 차트의 확장, 미연탄화수소의 보상 및 다양한 방법으로부터 계산한 결과를 비교하였다. 또한 Eltinge 방법은 현재 공연비를 산정하는 방법 중 가장 일반적인 식이라는 것을 확인하였다. 그러나 최근 지구온난화 방지를 포함하여 환경 보호와 에너지보존에 대한 요구가 증가하면서 내연기관에 대체연료를 사용이 도입되기 시작하면서 이러한 대체연료들에 대한 공연비의 정확한 산정이 필요하게 되었다. 특히, 산소를 포함하는 연료에서는 Eltigne방법을 제외하고 모든 공연비 산정법들이 다시 유도되어야한다. 이 연구에서는 이미 그 정확성이 확인된 탄소균형식을 이용하여 대체연료의 공연비를 산정하기 위해 다시 유도하였고, 각 대체 연료에 실제로 적용이 가능한 1차식을 새로이 제시하였다. 평가 결과, 탄소균형식으로 계산한 공연비는 가솔린 연료와 비교하여 다소 오차가 증가하였지만, 그 정확도는 다양한 대체 연료들에 적용하기에 충분하다는 결론을 얻었다. 또한, 제시된 1차식은 $\lambda=1.2$이하에서는 그 정확도가 매우 높았다.