• 한국철도학회논문집
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• 제19권3호
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• pp.388-396
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• 2016

서울 수도권 지하철 망은 과거 수십 년 동안 도심지의 인구 분산, 교통 정체 해소 그리고 인접 도시의 활성화 등 다수의 목적을 위하여 여러 번의 진화 과정을 거쳐 왔다. 본 연구에서는 서울 수도권 망의 동적인 진화에 따라 지하철 망의 특성과 망의 효율이 어떻게 변화해 왔는지를 분석하였다. 아울러 본 연구에서는 지하철 망의 효율을 보다 현실적으로 나타낼 수 있는 새로운 척도를 제안하였다. 서울 지하철 망의 효율성은 74%로 외국의 값들보다 높게 나타났으며 승객의 실질적인 흐름을 고려하면 효율성은 85% 이상으로 더 높게 나타났다. 9호선과 신분당선, 의정부선과 에버라인 노선들은 2013년 9월 이후로 수송 실적 관련 자료를 공개하지 않기 때문에 본 연구에서는 분석 범위를 데이터가 존재하는 2008년 9월부터 2013년 9월로 국한하였다.

• 한국융합학회논문지
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• 제9권8호
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• pp.365-377
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• 2018

본 연구는 한국 암 생존자의 삶에서 경험하는 행복감을 진화론적 개념분석 방법을 통해서 확인하고자 하였다. 분석 자료는 2000년 1월부터 2017년 9월까지 본 연구의 목적에 부합되는 11개의 논문을 분석하였다. 그 결과 한국 암 생존자의 행복감에서 나타나는 속성은 마음의 평정을 이루는 주관적 경험, 삶의 만족감과 안녕감을 위한 긍정적 마음, 작은 것의 소중함과 고마움을 깨닫게 되는 삶의 의미, 타인을 이해하고 도우며 더불어 살아가는 삶을 위한 관계형성이었다. 선행요인으로는 삶의 위기를 수용하고 현실에 대처하며 자기성찰과 환경적 지지가 이루어지는 것이며, 결과요인은 내면의 힘이 증가하고, 사랑을 느끼며, 새로운 삶을 추구하고, 자기실현을 이루게 된다. 본 연구는 한국 암 생존자의 행복감을 증진시킬 수 있는 단계적 사정을 위한 기본틀을 제시하였다는데 의의가 있으며, 다학제적 융합프로그램을 통한 암 생존자 관리가 이루어져야 할 것이다.

• Asian-Australasian Journal of Animal Sciences
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• 제28권6호
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• pp.876-887
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• 2015

Dicer, an ribonuclease type III type endonuclease, is the key enzyme involved in biogenesis of microRNAs (miRNAs) and small interfering RNAs (siRNAs), and thus plays a critical role in RNA interference through post transcriptional regulation of gene expression. This enzyme has not been well studied in the Indian water buffalo, an important species known for disease resistance and high milk production. In this study, the primary coding sequence (5,778 bp) of bubaline dicer (GenBank: AB969677.1) was determined and the bubaline Dicer1 biocomputationally characterized to determine the phylogenetic signature among higher eukaryotes. The evolutionary tree revealed that all the transcript variants of Dicer1 belonging to a specific species were within the same node and the sequences belonging to primates, rodents and lagomorphs, avians and reptiles formed independent clusters. The bubaline dicer1 is closely related to that of cattle and other ruminants and significantly divergent from dicer of lower species such as tapeworm, sea urchin and fruit fly. Evolutionary divergence analysis conducted using MEGA6 software indicated that dicer has undergone purifying selection over the time. Seventeen divergent sequences, representing each of the families/taxa were selected to study the specific regions of positive vis-$\grave{a}$-vis negative selection using different models like single likelihood ancestor counting, fixed effects likelihood, and random effects likelihood of Datamonkey server. Comparative analysis of the domain structure revealed that Dicer1 is conserved across mammalian species while variation both in terms of length of Dicer enzyme and presence or absence of domain is evident in the lower organisms.

• Steel and Composite Structures
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• 제24권2호
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• pp.227-237
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• 2017

This paper presents optimization of a long-span portal steel frame under dynamic wind loads using a surrogate-assisted evolutionary algorithm. Long-span portal steel frames are often used in low-rise industrial and commercial buildings. The structure needs be able to resist the wind loads, and at the same time it should be as light as possible in order to be cost-effective. In this work, numerical model of a portal steel frame is constructed using structural analysis program (SAP2000), with the web-heights at five locations of I-sections of the columns and rafters as the decision variables. In order to evaluate the performance of a given design under dynamic wind loading, the equivalent static wind load (ESWL) is obtained from a database of wind pressures measured in wind tunnel tests. A modified formulation of the problem compared to the one available in the literature is also presented, considering additional design constraints for practicality. Evolutionary algorithms (EA) are often used to solve such non-linear, black-box problems, but when each design evaluation is computationally expensive (e.g., in this case a SAP2000 simulation), the time taken for optimization using EAs becomes untenable. To overcome this challenge, we employ a surrogate-assisted evolutionary algorithm (SAEA) to expedite the convergence towards the optimum design. The presented SAEA uses multiple spatially distributed surrogate models to approximate the simulations more accurately in lieu of commonly used single global surrogate models. Through rigorous numerical experiments, improvements in results and time savings obtained using SAEA over EA are demonstrated.

• Structural Engineering and Mechanics
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• 제20권5호
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• pp.527-542
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• 2005

The main objective of this study is to examine the accuracy of the complete quadratic combination (CQC) rule with the modal responses defined by the ordinates of the uniform hazard spectra (UHS) to evaluate the peak responses of the multi-degree-of-freedom (MDOF) systems subjected to nonstationary seismic excitations. For the probabilistic analysis of the peak responses, it is considered that the seismic excitations can be modeled using evolutionary power spectra density functions with uncertain model parameters. More specifically, a seismological model and the Kanai-Tajimi model with the boxcar or the exponential modulating functions were used to define the evolutionary power spectral density functions in this study. A set of UHS was obtained based on the probabilistic analysis of transient responses of single-degree-of-freedom systems subjected to the seismic excitations. The results of probabilistic analysis of the peak responses of MDOF systems were obtained, and compared with the peak responses calculated by using the CQC rule with the modal responses given by the UHS. The comparison seemed to indicate that the use of the CQC rule with the commonly employed correlation coefficient and the peak modal responses from the UHS could lead to significant under- or over-estimation when contributions from each of the modes are similarly significant.

• 한국간호교육학회지
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• 제19권4호
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• pp.558-570
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• 2013

Purpose: In these days, the concept of health literacy becomes important because it is essential to have a clear grasp of patients' basic ability to understand health-care information. Therefore, we intended to discover attributes, antecedents and consequences of health literacy through contextual analysis. Method: Following Rodgers' evolutionary concept analysis, we did a literary review. The databases KMBase, KoreaMed, Kstudy, NDSL, and RISS were searched for articles. Among published literature about health literacy, twenty articles which satisfied the inclusion criteria were chosen. Results: Health literacy consists of three attributes: information seeking, information understanding, and information utilizing. Furthermore antecedents are as follows: health status, health belief, socioeconomic status, and information quality. Finally, we were able to explain the consequences of health literacy by showing improvement of self-care and interaction, and a decrease of social costs. Conclusion: We expect this study to guide the direction of future studies, and as a concept analysis that examines the conceptual attributes in the context of health literacy. Based on the result of this study, the design of a standardized tool and the program of health literacy promotion education need to be developed.

• Journal of Plant Biotechnology
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• 제49권1호
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• pp.15-29
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• 2022

Cyclophilins (CYPs) are highly conserved ubiquitous proteins belong to the peptidyl prolyl cis/trans isomerase (PPIase) superfamily. These proteins are present in a wide range of organisms; they contain a highly conserved peptidyl-prolyl cis/trans isomerase domain. A comprehensive database survey identified a total of 35 genes localized in all cellular compartments of Solanum lycopersicum L., but largely in the cytosol. Sequence alignment and conserved motif analyses of the SlCYP proteins revealed a highly conserved CLD motif. Evolutionary analysis predicted the clustering of a large number of gene pairs with high sequence similarity. Expression analysis using the RNA-Seq data showed that the majority of the SlCYP genes were highly expressed in mature leaves and blooming flowers, compared with their expression in other organs. This study provides a basis for the functional characterization of individual CYP genes in the future to elucidate their role(s) in protein refolding and long-distance signaling in tomatoes and in plant biology, in general.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2022년도 추계학술대회
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• pp.216-216
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• 2022

The starch-branching enzymes (BEs) are responsible for synthesizing the amylopectin, which plays an important role in determining the structural and physical properties of starch granules. BE has two differently functioning isoforms (BEI and BEIIa/b) based on their difference in the chain-length pattern by the degree of polymerization (DP), which mainly contributes to the amylopectin chain length distribution in starch biosynthesis. In this study, we investigated functional haplotypes and evolutionary analyses of SBE1 in 374 rice accessions (320 Korean bred and 54 wild). The analyses were performed based on the classified subpopulations. Haplotype analysis generates a total of 8 haplotypes, of which only four haplotypes were functional carrying four functional SNPs in four different exons of SBE1 on chromosome 6. Nucleotide diversity analysis showed a highest pi-value in aromatic group (0.0029), while the lowest diversity value was in temperate japonica (0.0002), indicating the signal of this gene evolution origin. Different directional selections could be estimated by negative Tajima's D value of temperate japonica (-1.1285) and positive Tajima's D value of tropical japonica (0.9456), where the selective sweeps were undergone by both positive purifying and balancing selections. Phylogenetic analysis indicates a closer relationship of the wild with most of the cultivated subgroups indicating a common ancestor for SBE1 gene. FST-values indicate distant genetic relationships of temperate japonica from all other classified groups. PCA and population structure analysis show an admixed structure of wild and cultivated subpopulations in some proportions.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제18권5호
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• pp.1238-1259
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• 2024

Previous studies on joint optimization of computation offloading and service caching policies in Mobile Edge Computing (MEC) have often neglected the impact of dependency-aware subtasks, edge server resource constraints, and multiple users on policy formulation. To remedy this deficiency, this paper proposes a many-objective joint optimization dependency-aware task offloading and service caching model (MaJDTOSC). MaJDTOSC considers the impact of dependencies between subtasks on the joint optimization problem of task offloading and service caching in multi-user, resource-constrained MEC scenarios, and takes the task completion time, energy consumption, subtask hit rate, load variability, and storage resource utilization as optimization objectives. Meanwhile, in order to better solve MaJDTOSC, a many-objective evolutionary algorithm TSMSNSGAIII based on a three-stage mating selection strategy is proposed. Simulation results show that TSMSNSGAIII exhibits an excellent and stable performance in solving MaJDTOSC with different number of users setting and can converge faster. Therefore, it is believed that TSMSNSGAIII can provide appropriate sub-task offloading and service caching strategies in multi-user and resource-constrained MEC scenarios, which can greatly improve the system offloading efficiency and enhance the user experience.

• Wind and Structures
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• 제17권2호
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• pp.227-244
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• 2013

Non-stationary extreme winds such as thunderstorm downbursts are responsible for many structural damages. This research presents a time domain approach for estimating along-wind load effects on tall buildings using multiple wind speed time history samples, which are simulated from evolutionary power spectra density (EPSD) functions of non-stationary wind fluctuations using the method developed by the authors' earlier research. The influence of transient wind loads on various responses including time-varying mean, root-mean-square value and peak factor is also studied. Furthermore, a simplified model is proposed to describe the non-stationary wind fluctuation as a uniformly modulated process with a modulation function following the time-varying mean. Finally, the probabilistic extreme response and peak factor are quantified based on the up-crossing theory of non-stationary process. As compared to the time domain response analysis using limited samples of wind record, usually one sample, the analysis using multiple samples presented in this study will provide more statistical information of responses. The time domain simulation also facilitates consideration of nonlinearities of structural and wind load characteristics over previous frequency domain analysis.