• Fisheries and Aquatic Sciences
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• 제11권3호
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• pp.177-181
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• 2008

Glyceraldehyde 3-phosphate dehydrogenase(GAPDH) is a key enzyme for carbohydrate metabolism in most living organisms. Recent reports and our own searches of teleost species in publicly available genomic databases have identified at least two distinct GAPDH genes in a given species. The two GAPDH genes are located on the same chromosome in teleosts, whereas they are located on the different chromosomes in mammals. Thus, we reconstructed a phylogenetic tree to better understand the evolutionary history of the GAPDH genes in the vertebrate lineage. Our phylogenetic analysis revealed unambiguously that the two GAPDH genes of teleosts are phylogenetically closely affiliated to one of the cytosolic GAPDH and spermatogenic GAPDH-S of mammals. This indicates that the two paralogous GAPDH genes shared a common ancestor and subsequently underwent a gene duplication event during early vertebrate evolution. However, GAPDH-S of teleosts showed significant differences in the polypeptide residues and tissue distribution of its mRNA transcripts from that of mammals, implying they have undergone a different history of functionalization.

• 한국전산구조공학회논문집
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• 제24권3호
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• pp.319-328
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• 2011

이 논문은 ESO 기법을 기초로 한 Strut-Tie 모델의 구성을 제안하고 있다. 평면응력 요소를 사용한 기존의 ESO방법과 달리, ESO기법에 의해 최적화된 구조가 트러스와 비슷한 형태를 가지는 사실에 기인하여, Strut-Tie 모델을 통한 전단설계에 트러스 요소를 사용한 ESO기법을 새롭게 적용하였다. 예제들을 통해 제안된 방법이 가장 좋은 Strut-Tie 모델을 찾을 수 있음을 입증하였으며, 앞서 2차원 평면응력 요소와 Strut-Tie 모델의 연관성에 대한 연구를 통해 ESO방법이 효과적으로 사용될 수 있음은 물론 경험하지 못한 특히 복잡한 철근 콘크리트 구조물의 전단설계에 효과적으로 사용이 가능한 대안이 될 수 있을 것으로 판단된다.

• International Journal of Fluid Machinery and Systems
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• 제9권3호
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• pp.265-276
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• 2016

Energy systems working coherently in different conditions may not have a specific design which can provide optimal performance. A system working for a longer period at lower efficiency implies higher energy consumption. In this effort, a methodology demonstrated by a jet pump design and optimization via numerical modeling for fluid dynamics and implementation of an evolutionary algorithm for the optimization shows a reduction in computational costs. The jet pump inherently has a low efficiency because of improper mixing of primary and secondary fluids, and multiple momentum and energy transfer phenomena associated with it. The high fidelity solutions were obtained through a validated numerical model to construct an approximate function through surrogate analysis. Pareto-optimal solutions for two objective functions, i.e., secondary fluid pressure head and primary fluid pressure-drop, were generated through a multi-objective genetic algorithm. For the jet pump geometry, a design space of several design variables was discretized using the Latin hypercube sampling method for the optimization. The performance analysis of the surrogate models shows that the combined surrogates perform better than a single surrogate and the optimized jet pump shows a higher performance. The approach can be implemented in other energy systems to find a better design.

• Composites Research
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• 제27권6호
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• pp.207-212
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• 2014

The shape optimization of composite flexbeam sections of a bearingless helicopter rotor is studied using a finite element (FE) sectional analysis integrated with an efficient evolutionary optimization algorithm called particle swarm assisted genetic algorithm (PSGA). The sectional optimization framework is developed by automating the processes for geometry and mesh generation, and the sectional analysis to compute the elastic and inertial properties. Several section shapes are explored, modeled using quadratic B-splines with control points as design variables, through a multiobjective design optimization aiming minimum torsional stiffness, lag bending stiffness, and sectional mass while maximizing the critical strength ratio. The constraints are imposed on the mass, stiffnesses, and critical strength ratio corresponding to multiple design load cases. The optimal results reveal a simpler and better feasible section with double-H shape compared to the triple-H shape of the baseline where reductions of 9.46%, 67.44% and 30% each are reported in torsional stiffness, lag bending stiffness, and sectional mass, respectively, with critical strength ratio greater than 1.5.

• 한국유전체학회:학술대회논문집
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• 한국유전체학회 2005년도 The 14th Korea Genome Conference
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• pp.74-74
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• 2005

• 기술혁신연구
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• 제22권4호
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• pp.117-143
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• 2014

기존의 기술 진화 경로 연구는 주로 거시적 동향 분석 수준에서 이루어져 왔으며 포괄적인 기술정책 방향 수립에는 시사점이 있었으나, 기업 기술 및 특허전략에는 활용가치가 낮았다. 2000년대부터 논문 및 특허 등의 데이터를 활용해 미시적인 기술의 진화 경로를 분석하고, 기업 기술전략에 적용하려는 연구가 증가하고 있다. 그러나 대부분 과거 진화 경로의 서술에 그치고 있으며 기술의 진화 또는 파생-융합 등의 변화에 대한 분석은 전문가의 정성적 판단에 상당부분 의존하고 있다. 본 연구에서는 특허 인용 네트워크를 구축해 미시적 기술의 진화 경로를 도출하고, 기술의 진화와 파생을 동적 기술트리를 통해 분석하는 방법론을 제시한다. 동적 기술트리 분석은 기술의 핵심요소를 체계화하고, 신기술 요소의 신규성과 확장성을 평가해 차세대 기술진화와 파생에 대한 정량적 판단을 가능하게 한다. 이를 통해 차세대 신기술과 파생기술에 대하여 파악, 평가, 비교하고 나아가 예측의 토대를 구축한 것이 본 연구의 의의이다. 본 연구의 결과는 기술 및 특허전략과 포트폴리오 구축의 신뢰성을 높일 수 있는 좋은 도구가 될 것이다. 본 연구에서 제안한 방법론을 이용하여 최근 전력산업에서 기존 교류 송전의 대안으로 주목을 받고 있는 초고압 직류송전 시스템 기술을 대상으로 실증분석을 수행하였다.

• Genomics & Informatics
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• 제8권4호
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• pp.170-176
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• 2010

The Ribonucleotide reductases (RNR) are essential enzymes that catalyze the conversion of nucleotides to deoxynucleotides in DNA replication and repair in all living organisms. The RNRs operate by a free radical mechanism but differ in the composition of subunit, cofactor required and regulation by allostery. Based on these differences the RNRs are classified into three classesclass I, class II and class III which depend on oxygen, adenosylcobalamin and S-adenosylmethionine with an iron sulfur cluster respectively for radical generation. In this article thirty seven sequences belonging to each of the three classes of RNR were analyzed by using various tools of bioinformatics. Phylogenetic analysis, dot-plot comparisons and motif analysis was done to identify a number of differences in the three classes of RNRs. In this research article, we have attempted to decipher evolutionary relationship between the three classes of RNR by using bioinformatics approach.

• Parasites, Hosts and Diseases
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• 제37권4호
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• pp.197-213
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• 1999

Phylogeny is the evolutionary history of a group or the lineage of organisms and is reconstructed based on morphological, molecular and other characteristics. The genealogical relationship of a group of taxa is often expressed as a phylogenetic tree. The difficulty in categorizing the phylogeny is mainly due to the existence of frequent homoplasies that deceive observers. At the present time, cladistic analysis is believed to be one of the most effective methods of reconstructing a phylogenetic tree. Excellent computer program software for phylogenetic analysis is available. As an example, cladistic analysis was applied for nematode genera of the family Acuariidae, and the phylogenetic tree formed was compared with the system used currently. Nematodes in the genera Nippostrongylus and Heligmonoides were also analyzed, and the validity of the reconstructed phylogenetic trees was observed from a zoogeographical point of view. Some of the theories of parasite evolution were briefly reviewed as well. Coevolution of parasites and humans was discussed with special reference to the evolutionary relationship between Enterobius and primates.

• 한국경영과학회지
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• 제25권4호
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• pp.67-80
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• 2000

Symbiotic evolutionary algorithms, also called cooperative coevolutionary algorithms, are stochastic search algorithms that imitate the biological coevolution process through symbiotic interactions. In the algorithms, the fitness evaluation of an individual required first selecting symbiotic partners of the individual. Several partner selection strategies are provided. The goal of this study is to analyze how much partnering strategies can influence the performance of the algorithms. With two types of test-bed problems: the NKC model and the binary string covering problem, extensive experiments are carried out to compare the performance of partnering strategies, using the analysis of variance. The experimental results indicate that there does not exist statistically significant difference in their performance.

• Asian-Australasian Journal of Animal Sciences
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• 제16권2호
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• pp.266-268
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• 2003

This paper makes an analysis of the ecological behaviours of 3 categories of quails, namely wild Japanese quails from the Weishan Lake Area, medium-sized domestic quails and pint-sized domestic quails. The study indicates as follows: (1) There is difference in morphological and biological habits between domestic quails and wild Japanese ones. (2) The cross-breeding between the wild and domestic quails is a cross from exclusion to affinity. (3) The behaviours of quails such as pursuit,paw and mating are selective. (4) The wild Japanese quails and domestic ones can succeed in mating and in reproducing fertilized eggs but with a low rate. (5) Evolutionary differentiation has been formed in varying degrees between the domestic quails and their wild ancestors in morphological and ecological characteristics.