• Journal of Microbiology and Biotechnology
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• 제33권12호
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• pp.1587-1594
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• 2023

Since its first report in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a grave threat to public health. Virus-specific countermeasures, such as vaccines and therapeutics, have been developed and have contributed to the control of the viral pandemic, which has become endemic. Nonetheless, new variants continue to emerge and could cause a new pandemic. Consequently, it is important to comprehensively understand viral evolution and the roles of mutations in viral infectivity and transmission. SARS-CoV-2 beta variant encode mutations (D614G, N501Y, E484K, and K417N) in the spike which are frequently found in other variants as well. While their individual role in viral infectivity has been elucidated against various therapeutic antibodies, it still remains unclear whether those mutations may act additively or synergistically when combined. Here, we report that N501Y mutation shows differential effect on two therapeutic antibodies tested. Interestingly, the relative importance of E484K and K417N mutations in antibody evasion varies depending on the antibody type. Collectively, these findings suggest that continuous efforts to develop effective antibody therapeutics and combinatorial treatment with multiple antibodies are more rational and effective forms of treatment.

• Journal of the Korea Society for Simulation
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• 제33권3호
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• pp.51-63
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• 2024

This study aims to develop a simulator for modeling engagements between fighters and missiles in Beyond Visual Range (BVR) air combat scenarios using DEVS (Discrete Event System specification) formalism. The simulator is modeled to implement sustained formation strategies in 1-versus-many situations, and we applied the model to real scenario two case studies. The two case studies assume a virtual missile neutralization equipment. The first case study analyzes the effectiveness of the missile neutralization equipment based on formations. The second case study analyzes the effectiveness of the missile neutralization equipment in relation to the evasion maneuvering tactic of the formation leader fighter. Through these studies, it is demonstrated that the model can realistically simulate scenarios and be beneficial the development of evasion strategies and tactics.

• Journal of the Korean Professional Engineers Association
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• 제37권5호
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• pp.42-46
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• 2004

Automobile industry with history of more than 100 years is totally influencing all the economic environments and has very important wellbeing role in the World in every country of the world. Korean Automotive industry in production has only about 40 years but ranked remarkably 6th biggist in the world in the year of 2003. Nowadays The auto, industry has changed into buyer's market in competitively global battle fields and also is changing industry paradigm in product, sales, production, colarboration & emerging, etc. BRICs(Especially China)are rapidly emerging as main producers and customers in new big markets. Korea Auto. Industry faces crictical problems such as higher salary, furious labor union's striking lack of raw material, evasion of 3D works with studying engineering by students which are the key pending agenda that should be overcome for prosperous growth and development of achieving US20,000 GNP.

• Tribology and Lubricants
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• 제28권4호
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• pp.184-188
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• 2012

Alcohol components are illegally mixed with petroleum products for tax evasion purposes, but this degrades vehicle performance. The alcohol content in petroleum fuel can be analyzed by gas chromatography. However, this technique requires a long analysis time and is expensive. $CrO_3$, also known as Jones reagent, changes color upon reaction with an alcohol. In this study, therefore, we analyze alcohol contents in vehicle fuel by using $CrO_3$ aqueous solution.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.514-518
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• 2003

In this paper, we investigate three dimensional optimal evasive maneuver patterns for air-to-surface attack missiles against proportionally navigated anti-air defense missiles. Interception error of the defense missile can be generated by evasive maneuver of the attack missile during the time of flight for which the defense missile intercepts the attack missile. Time varying weighted sum of the inverse of these interception errors forms a performance index to be minimized. Direct parameter optimization technique using CFSQP is adopted to get the attack missile's optimal evasive maneuver patterns according to parameter changes of both the attack missile and the defense missile such as maneuver limit and time constant of autopilot approximated by the 1st order lag system. The overall shape of resultant optimal evasive maneuver to enhance the survivability of air-to-surface missiles against proportionally navigated anti-air missiles is a kind of deformed barrel roll.

• Journal of Korean Academy of Nursing Administration
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• 제13권1호
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• pp.74-81
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• 2007

Purpose: This study focuses on doctors' role expectation and patients satisfaction with the referral centers to get necessary basic Method: There were 495 subjects in this study. 245 of them were doctors working in the 397 clinics and hospitals which have made contracts with the referral center in Y General Hospital located in J city, and 250 were patients who had been treated in it. The data were collected from Sep. 25 to Oct. 21, in 2006. Data analysis was processed with SPSS/WIN 14.0 electronically. Results: Concluding cooperative treaties with other clinics and hospitals, doctors expect the following effects: First, the improvement of the treatment quality of patients. The patients satisfaction ranking order for using referral centers is as follows: kindness of the staff, treatment reservation, doctor's satisfying explanation. providing one-stop service, reduction of waiting time for treatment, evasion of repetitive tests. Conclusion: Referral centers should provide various services totally and actively which reflect the role expectation and satisfaction of doctors and patients altogether.

• Journal of Acupuncture Research
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• 제30권5호
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• pp.169-174
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• 2013

Objectives : This study was accomplished to find out clinical features of knee pain of female after menopausal and their recognition of moxibustion treatment. Methods : Before and after 8 times moxibustion treatment(mostly 2 times a weak), survey was done. Moxibustion treatment was done on painful location, 3 times per each point. Results & Conclusions : Other symptom with Knee pain was Click 30.8 %, stiffness 25.6 %, press pain 16.7 %, swelling 14.1 %, fever 5.1 %, none 7.7 %. VAS of moxibustion treatment is significantly increased after treatment. Expectation of moxibustion treatmen is not. "Bad smell" is the first cause of evasion of moxibustion therapy. It should have been considered to reduce bad smell in development of moxibustion.

• Journal of Periodontal and Implant Science
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• 제43권1호
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• pp.3-11
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• 2013

Periodontitis is a chronic inflammation of periodontal tissue caused by subgingival plaque-associated bacteria. Periodontitis has long been understood to be the result of an excessive host response to plaque bacteria. In addition, periodontal pathogens have been regarded as the causative agents that induce a hyperinflammatory response from the host. In this brief review, host-microbe interaction of nonperiodontopathic versus periodontopathic bacteria with innate immune components encountered in the gingival sulcus will be described. In particular, we will describe the susceptibility of these microbes to antimicrobial peptides (AMPs) and phagocytosis by neutrophils, the induction of tissue-destructive mediators from neutrophils, the induction of AMPs and interleukin (IL)-8 from gingival epithelial cells, and the pattern recognition receptors that mediate the regulation of AMPs and IL-8 in gingival epithelial cells. This review indicates that true periodontal pathogens are poor activators/suppressors of a host immune response, and they evade host defense mechanisms.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 한국공작기계학회 2004년도 춘계학술대회 논문집
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• pp.197-202
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• 2004

As a part of environmental pollution prevention and resources recycling, the regeneration of waste tire has been largely contributed to national industry. But, the worker has been evaded this regeneration process by reason of the best mischievous process condition among 3D industries. So, the first, the process condition of regenerating waste tire was analyzed. The second, the equipment or system was developed for the improvement of working strength and environment. The last, researchers intend to solve these problems

• Proceedings of the Korean Information Science Society Conference
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• 한국정보과학회 2008년도 한국컴퓨터종합학술대회논문집 Vol.35 No.1 (B)
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• pp.156-161
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• 2008

자동차 산업이 발달함에 따라 운전자와 탑승자의 편의를 제공하기 위한 연구인 텔레매틱스 사업이 발달하고 있다. 최근 텔레매틱스의 연구는 기존의 사용자에게 편의를 제공하는 것에서 사용자의 안전 및 운전 편의에 초점이 맞추어지고 있다. 본 논문은 RFID를 이용하여 도로와 자동차간의 통신을 통한 교통상황 제공 및 대처 시스템에 대해 기술 한다. 본 논문에서 제안되는 시스템을 통해 운전자는 전방의 도로 상황을 미리 인지하고 대응함으로써, 운전자의 안전 주행을 도와준다.