• Asian Pacific Journal of Cancer Prevention
• /
• 제15권22호
• /
• pp.10021-10025
• /
• 2014

Background: The study aimed to describe the age distribution of breast cancer diagnosis among Chinese females for comparison with the United States and the European Union, and provide evidence for the screening target population in China. Materials and Methods: Median age was estimated from hospital databases from 7 tertiary hospitals in China. Population-based data in China, United States and European Union was extracted from the National Central Cancer Registry, SEER program and GLOBOCAN 2008, respectively. Age-standardized distribution of breast cancer at diagnosis in the 3 areas was estimated based on the World Standard Population 2000. Results: The median age of breast cancer at diagnosis was around 50 in China, nearly 10 years earlier than United States and European Union. The diagnosis age in China did not vary between subgroups of calendar year, region and pathological characteristics. With adjustment for population structure, median age of breast cancer at diagnosis was 50~54 in China, but 55~59 in United States and European Union. Conclusions: The median diagnosis age of female breast cancer is much earlier in China than in the United States and the European Union pointing to racial differences in genetics and lifestyle. Screening programs should start at an earlier age for Chinese women and age disparities between Chinese and Western women warrant further studies.

• 인문언어
• /
• 제8집
• /
• pp.151-173
• /
• 2006

Even in this current high-tech industrial age, mythological imagination is considered important. Although each mythology scattered all across the world may have an insignificant origin, to understand that particular society fully, one must not mistakenly assume that the mythology itself is a production of a primitive mind. Ultramodern physics and futurology professor Freeman Dyson has also acknowledged this opinion. He insists that in order for human kind to survive into the far future it most keep in touch with its far past. Levi-Strauss also observes that mythology and science aren't a entirely separate domains. The scientific mind is regarded as a source of understanding the intrinsic qualities of mythology. Taking mythology and science as a binomial opposition, and only weighing their prospects, should be put to the past as we should recognize the need for mythology and science's qualitative unification. In this new point of view, regarding mythology as a meaningless irrationality should cease, while finding out why the inevitably related world of mythology needs metaphoric, ideological consideration. By utilizing 'Whale Rider' by Witi Ihimaera(2004) we will discover why our lives require an 'image' that is borrowed from our experience. The author, Witi Ihimaera, is originally from the Maori tribe, who approaches the world with a mythological imagination, which is not easy to understand with scientific thinking nor in modern civilization. When looking into the mythology of the ocean which still lives in modern civilization, while noting that the world is one, the author indicates that reality and unreality, nature and the super-natural, present and the past, science and fantasy, were not divided from the beginning. However, overtime humans have divided the borders. To do this, the author interprets the ancient emotions of the Maori tribe which have been traditionally accumulated in the group identity in a new literary way by introducing the Maori tribe's ancestral god, Paikia, who can converse with the ocean and the whales. This piece, which has been made into a movie and won awards in 5 international film festivals, including the Toronto International Film Festival, regards primitive emotions as a rational concept instead of an instrumental concept. Also these primative emotions are continuing their attempts to communicate with nature. Furthermore, it advises contemporary human beings who seek for eternal life to not exploit the cultural differences that have been formed naturally, and it is vital for human beings to transcend the ethnic boundaries and to think rationally. In the story, we can find "the dissimilar us" that philosopher E. Levinas mentioned in his sayings, which refers to responsible human beings who devote their lives for the sake of other people instead of fulfilling their own needs.

• 생명과학회지
• /
• 제30권6호
• /
• pp.563-569
• /
• 2020

유방암의 수술적 치료에 있어서 종양성형학적 수술이란 종양학적 안정성과 성형적 만족도를 모두 충족시키는 수술을 일컫는 용어이다. 처음 시작한 서양에서는 적은 절개나 절제, 미세침습수술을 지향하기 보다 유방축소술을 기본으로 제거될 조직에 병변을 포함하도록 계획한다. 충분한 절제가 가능하기 때문에 수술 전 검사, 절제연에 대한 고민, 수술 중 병리 검사의 필요성 등도 줄면서 종양학적 안전성에도 도움이 된다고 알려져 왔다. 개개인의 체형에 대한 병변의 종양학적 안정성을 충족시키는 최소 절제 비율에 따라 전위 또는 보충으로 나뉘게 된다. 환자의 기본 체형은 인종적인 영향을 받는 유방암의 특징으로, 유럽, 미국이나 영국의 경우 평균 크기가 대개 36D(600 ㎤) 이상으로, 유방고정술이나 유방축소술이 주로 사용되고, 성형 측면의 최대 목표인 대칭을 위해서는 반대측 유방의 축소도 흔히 이루어지고 있다. 부산대학교병원 유방암 환자 671명의 평균 분포를 분석해 본 결과, 평균은 33A (75%, <35B)로, 대략 체적은 300 ㎤ (75%, <400 ㎤)라고 생각할 수 있다. 따라서 서양과는 다른 수술법이 선택될 수 밖에 없다. 수술 전 MRI를 이용한 범위의 확인을 통한 대상 선정과 함께 초음파와 피부 표식을 이용한 정확한 절제 범위의 계획도 중요하다. 병리적 판독 기준도 절제연 음성이면 종양학적 안정성에 충분하다는 것으로 관점이 바뀐 것은 보존 수술에 유리한 측면이 된다. 동결절편검사는 여전히 고급 전문 인력, 시간이 지나치게 소요되고 있어 편리하고 안전한 병변의 절제에 도움이 될 만한 새로운 방법들이 필요하여 연구되고 있다. 대표적인 최근 연구로는 무선주파수를 이용하는 margin probe, 형광 색소를 결합한 Aqueous Quantum-Dot-Molecular Probes 등을 들 수 있다. 합병증 측면에서 박리 면적이 늘어나는 종양성형학적 수술의 단점을 보강할 수 있는 최근 기술로 초음파 에너지 기구들이 유용하고, 수술 범위가 늘어남에 따라 생길 수 있는 혈종이나 장액 저류의 감소에 도움이 될 수 있다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권17호
• /
• pp.7523-7527
• /
• 2015

Background: Pediatric acute lymphoblastic leukemia (pALL) patients at King Abdulaziz Medical City represent a pure Saudi Arabian population. ETV6-RUNX1 positive pALL patients have good prognosis as compared to ETV6-RUNX1 negative counterparts. Therefore, frequencies of these two patient groups have a huge consideration in treatment strategies of pALL in a given population. Different geographical locations have been reported to have different frequencies of ETV6-RUNX1 ranging from 10% in Southeast Asia to 30% in Australia. Aim: Therefore, the objective of this study was to establish the ETV6-RUNX1 status of Saudi Arabian pALL patients and its association with clinical parameters and early remission. Materials and Methods: Clinical parameters and ETV6-RUNX1 status (using FISH technique) of pALL patients attending the Pediatric Oncology Clinic, King Abdulaziz Medical City, Riyadh from 2006 to 2011 were studied. Comparisons between ETV6-RUNX1 positive and negative groups were accomplished using chi-square test or Fisher's exact test. All statistical analyses were performed using SAS version 9.2 (SAS Institute, Inc., Cary, NC). Results: Out of 54 patients, 33 were male and 21 were females (ratio 1.57:1). B- and T-cell lineages were found in 47 (87%) and 7 (13%) patients respectively. Only 5 (9.3%) patients were ETV6-RUNX1 positive while 49(80.7%) were ETV6-RUNX1 negative. All ETV6-RUNX1 patients (100%) were of B-cell lineage and 80% (4/5) were in the 3-7 year age group. None of the ETV6-RUNX11 patients had ${\geq}5%$ blasts (no remission) at day 14 as compared with 9% in the ETV6-RUNX1 negative group (Figure 1). Conclusions: Frequency of ETV6-RUNX1 positive patients (less than 10%) in our pALL patients is much lower than reported for most European countries, North America, Australia and Japan while it is in accordance with ETV6-RUNX1 frequencies from Egypt (11.6%), Pakistan (10%), Spain (2%) and India (5-7%). This shows ethnic differences in genetics of pALL as well as higher frequencies of ETV6-RUNX1 positive pALL mostly in more industrialized countries, probably due to some industrial pollutants or westernized lifestyle.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권17호
• /
• pp.7213-7218
• /
• 2014

Background: Egypt has one of the highest prevalences of hepatitis C virus (HCV) infection worldwide. Although the IL28B gene polymorphism has been shown to modify the course of chronic HCV infection, this has not been properly assessed in the Egyptian population. Materials and Methods: The IL28B rs12979860 single nucleotide polymorphism (SNP) was therefore examined in 256 HCV-infected Egyptian patients (group II) at different stages of disease progression and in 48 healthy volunteers (group I). Group II was subdivided into GII-A (chronic hepatitis patients, n=119), GII-B (post hepatitis cirrhosis, n=66) and GII-C (HCC on top of cirrhosis, n=71). Results: The C/T genotype was the commonest in all groups. It was more frequent in GI (52%) than in GII (48%). There was no significant difference in the frequency of C/T and C/C or T/T genotypes between groups and subgroups (p=0.82). Within the subgroups; the C/C genotype was more common in GII-B while C/T and T/T genotypes were more common in GII-C, though with no significant difference (p=0.59 and p=0.80). There was no significant association between IL28B rs12979860 SNP and viral load, ALT, AFP level, METAVIR scores for necro-inflammation and fibrosis, and Child-Pugh classification. Conclusions: 1) IL28Brs12979860 C/T genotype is the commonest genotype in HCV-associated CH and HCC in Egypt. 2) IL28Brs12979860 polymorphisms are not associated with disease progression or aggression (histological staging, severity of fibrosis in CH or the incidence of post-HCV HCC). 3) Differences in IL28Brs12979860 genotypes could be a consequence of environmental or ethnic variation.

• 한국인구학
• /
• 제24권2호
• /
• pp.255-286
• /
• 2001

해외로 이주한 이민자들의 언어능력 계발은 이민국 내에서 경제적으로 적응하는데 있어 중요한데, 이는 현지사회에서의 언어 소통능력이 이민국의 노동시장에 얼마나 적합한지 나타내는 이민자의 기술 수준 중에서 중요한 부분을 차지하기 때문이다. 게다가 언어는 이민자가 사회에 적응하고, 다양한 인종과 민족집단으로 구성된 미국과 같은 사회에서 사회적, 정치적 응집력을 나타내는 이민자의 기술 수준 중에서 중요한 부분을 차지하기 때문이다. 게다가 언어는 이민자가 사회에 적응하고, 다양한 인종과 민족 집단으로 구성된 미국과 같은 사회에서 사회적, 정치적 응집력을 나타내는 데 매우 중요한 역할을 담당한다. 이 연구의 주 목적은 미국 내의 한국인과 다른 아시아 이주자들의 영어능력에 대한 결정요인을 분석하는 것이다. 본 연구의 분석을 위해서 질적, 양적인 측면에서 가장 대표성을 담보하고 있는 미국의 센서스 자료(PUMS, A, 5%)를 이용하였다. 서열화된 범주를 가지고 있는 영어사용능력의 질적 격차를 분석하기 위해서 본 연구에서 사용된 통계기법은 Ordered Probit이다. 분석 결과는 미국에 오래 거주한 경우, 가족 중에 자녀가 있는 경우, 모국어가 보다 적게 사용되는 지역에 거주하는 경우, 이주를 할 때의 연령이 보다 낮은 경우, 학력이 보다 높은 경우에 영어를 보다 유창하게 사용한다는 사실을 알 수 있었다. 하지만, 아시아 이민자들의 영어사용능력의 수준은 출신국별 이민역사와 모국어의 차이별로 두드러진 차이가 존재하였다.

• 한국사회복지학
• /
• 제67권4호
• /
• pp.227-249
• /
• 2015

본 연구의 목적은 미국에 거주하고 있는 정신장애를 가진 아시아계 미국인과 미국계 백인의 직업의 의미와 중요성, 직장에서 받는 메시지 및 차별에 대한 차이를 알아보는 것을 목적으로 한다. 고용은 단기적으로나 장기적으로 정신장애인의 회복에 긍정적인 영향을 미친다. 비록 정신장애인의 회복과 고용관련 서비스와 직업의 의미에 대한 연구가 진행 되고 있지만 다른 인종에 비해 서비스의 참여율이 낮고 중도포기율이 높은 정신장애를 가진 아시아계 미국인을 대상으로 시행된 연구는 전무하다. 그렇기 때문에 정신장애를 가진 아시아계 미국인이 생각하는 직업의 의미와 사회나 직장에서 경험하는 차별에 대한 연구가 필요하다. 본 연구는 양적 연구와 질적 연구를 혼합하는 방식을 적용하였다. 설문지 개발을 위해 Millner(2015)가 실시한 정신장애인의 직업과 장애에 대한 연구결과와 9명의 정신장애인들이 인지인터뷰와 파일럿 테스트에 참여하여 개방형/폐쇄형 질문을 포함한 설문지가 개발되었다. 설문은 5월부터 8월까지 실시되어 총 91명의 정신장애인이 성공적으로 설문을 완료하였다. 양적 분석을 위해 t-test가 사용되었으며 개방형 질문은 연구자가 함께 분석하였다. 정신장애를 가진 아시아계 미국인은 미국계 백인보다 직업에 대한 높은 열망을 가지고 있으며 직장 내에서 소수인종과 정신장애라는 이중장벽을 경험하는 것으로 나타났다. 가족 혹은 서비스 제공자에게 고용과 관련하여 인종과 장애로 인한 사회적 차별을 경험하고 부정적인 메시지를 받은 것으로 나타났다. 직업 서비스 제공자들은 다문화 정신장애인의 특성과 직업의 의미, 이들이 실제로 경험하고 있는 이중장벽과 사회적 차별을 이해하고 이를 줄이기 위해 노력해야 할 것이다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권7호
• /
• pp.3163-3167
• /
• 2014

Background: Breast-conserving surgery (BCS) plus radiotherapy is equivalent to modified radical mastectomy (MRM) in terms of outcome. However there is wide variation in mastectomy rates dependent both on tumour and patient characteristics. Objective: This study aimed to assess the determinants of surgery choice in Asian patients with early breast cancer in a middle-income country. Materials and Methods: 184 patients with early breast cancer treated between Jan 2008 and Dec 2010 were recruited to complete a questionnaire. Chi-square test was used to analyze the association between surgery choice and demographic and tumour factors, surgeon recommendation, family member and partner opinions, fear of recurrence, avoidance of second surgery, fear of disfigurement, interference with sex life, fear of radiation and loss of femininity. Results: 85 (46%) had BCS while 99 (54%) had mastectomy. Age >60, Chinese ethnicity, lower education level, and larger tumour size were significantly associated with mastectomy. Surgeon recommendation was important in surgery choice. Although both groups did not place much importance on interference with sex life, 14.1% of the BCS group felt it was very important compared to 5.1% in the mastectomy group and this was statistically significant. There was no statistical difference between the two groups in terms of the other factors. When analyzed by ethnicity, significantly more Malay and Indian women considered partner and family member opinions very important and were more concerned about loss of femininity compared to Chinese women. There were no statistical differences between the three ethnic groups in terms of the other factors. Conclusions: When counseling on surgical options, the surgeon has to take into account the ethnicity, social background and education level, age and reliance on partner and family members. Decision-making is usually a collective effort rather than just between the patient and surgeon, and involving the whole family into the process early is important.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권5호
• /
• pp.1887-1893
• /
• 2012

The aim of this study was to detail characteristics of mammary Paget's disease (PD) representing the whole population in China. A total of 4211 female breast cancer inpatients at seven tertiary hospitals from seven representative geographical regions of China were collected randomly during 1999 to 2008. Data for demography, risk factors, diagnostic imaging test, physical examination and pathologic characters were surveyed and biomarker status was tested by immunohistochemistry. The differences of demography and risk factors between PD with breast cancer and other lesions were compared using Chi-square test or t-test, with attention to physical examination and pathological characters. The percentage of PD was 1.6% (68/4211) in all breast cancers. The mean age at diagnosis was 48.1, and 63.2% (43/68) patients were premenopausal. There is no difference in demography and risk factors between PD with breast cancer and other breast cancer (P > 0.05). The main pattern of PD in physical exam and pathologic pattern were patients presenting with a palpable mass in breast (65/68, 95.6%) and PD with underlying invasive cancer (82.4%, 56/68) respectively. The rate of multifocal disease was 7.4% (5/68). PD with invasive breast cancer showed larger tumor size, more multifocal disease, lower ER and PR expression and higher HER2 overexpression than those in other invasive breast cancer (P < 0.05). These results suggested that PD in China is a concomitant disease of breast cancer, and that PD with underlying invasive cancer has more multiple foci and more aggressive behavior compared with other breast invasive cancer. We address the urgent needs for establishing diagnostic and therapeutic guidelines for mammary PD in China.

• Clinical and Experimental Pediatrics
• /
• 제57권3호
• /
• pp.125-134
• /
• 2014

Purpose: The aim of this study was to characterize Korean patients with Fanconi anemia (FA), which is a rare but very challenging genetic disease. Methods: The medical records of 12 FA patients diagnosed at Chonnam National University Hospital from 1991 to 2012 were retrospectively reviewed. Results: The median age at diagnosis was 6.2 years. All patients showed evidence of marrow failure and one or more physical stigmata. Chromosome breakage tests were positive in 9 out of 11 available patients. The median follow-up duration was 69.5 months. The Kaplan-Meier (KM) survival of all patients was 83.3% at 10 years and 34.7% at 20 years, respectively. Seven patients underwent 9 stem cell transplantations (SCTs). Among them, 5 were alive by the end of the study. Ten-year KM survival after SCT was 71.4% with a median follow-up of 3.4 years. All 5 patients treated with supportive treatment alone died of infection or progression at the median age of 13.5 years, except for one with short followup duration. Acute leukemia developed in 2 patients at 15.4 and 18.1 years of age. Among 6 patients who are still alive, 3 had short stature and 1 developed insulin-dependent diabetes mellitus. Conclusion: We provide information on the long-term outcomes of FA patients in Korea. A nation-wide FA registry that includes information of the genotypes of Korean patients is required to further characterize ethnic differences and provide the best standard of care for FA patients.