• Wind and Structures
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• v.25 no.5
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• pp.493-506
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• 2017

Wind-induced response behavior of long-span roof structures is very complicated, showing significant contributions of multiple vibration modes. The largest load effects in a huge number of members should be considered for the sake of the equivalent static wind loads (ESWLs). Studies on essential matters and necessary conditions of the universal ESWLs are discussed. An efficient method for universal ESWLs on long-span roof structures is proposed. The generalized resuming forces including both the external wind loads and inertial forces are defined. Then, the universal ESWLs are given by a combination of eigenmodes calculated by proper orthogonal decomposition (POD) analysis. Firstly, the least squares method is applied to a matrix of eigenmodes by using the influence function. Then, the universal ESWLs distribution is obtained which reproduces the largest load effects simultaneously. Secondly, by choosing the eigenmodes of generalized resuming forces as the basic loading distribution vectors, this method becomes efficient. Meanwhile, by using the constraint equations, the universal ESWLs becomes reasonable. Finally, reproduced largest load effects by load-response-correlation (LRC) ESWLs and universal ESWLs are compared with the actual largest load effects obtained by the time domain response analysis for a long-span roof structure. The results demonstrate the feasibility and usefulness of the proposed universal ESWLs method.

• Steel and Composite Structures
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• v.25 no.3
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• pp.315-326
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• 2017

In this work, thermoelastic dynamic behavior of functionally graded carbon nanotube reinforced composite (FG-CNTRC) cylinders subjected to mechanical pressure loads, uniform temperature environment or thermal gradient loads is investigated by a mesh-free method. The material properties and thermal stress wave propagation of the nanocomposite cylinders are derived after solving of the transient thermal equation and obtaining of the time history of temperature field of the cylinders. The nanocomposite cylinders are made of a polymer matrix and wavy single-walled carbon nanotubes (SWCNTs). The volume fraction of carbon nanotubes (CNTs) are assumed variable along the radial direction of the axisymmetric cylinder. Also, material properties of the polymer and CNT are assumed temperature-dependent and mechanical properties of the nanocomposite are estimated by a micro mechanical model in volume fraction form. In the mesh-free analysis, moving least squares shape functions are used to approximate temperature and displacement fields in the weak form of motion equation and transient thermal equation, respectively. Also, transformation method is used to impose their essential boundary conditions. Effects of waviness, volume fraction and distribution pattern of CNT, temperature of environment and direction of thermal gradient loads are investigated on the thermoelastic dynamic behavior of FG-CNTRC cylinders.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.6
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• pp.3208-3229
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• 2017

Rectification is an essential procedure for simplifying the disparity extraction of stereo matching algorithms by removing vertical mismatches between left and right images. To support real-time stereo matching, studies have introduced several look-up table (LUT)- and computational logic (CL)-based rectification approaches. However, to support high-resolution images, the LUT-based approach requires considerable memory resources, and the CL-based approach requires numerous hardware resources for its circuit implementation. Thus, this paper proposes a multi-level accumulation-based rectification method as a simple CL-based method and its circuit implementation. The proposed method, which includes distortion correction, reduces addition operations by 29%, and removes multiplication operations by replacing the complex matrix computations and high-degree polynomial calculations of the conventional rectification with simple multi-level accumulations. The proposed rectification circuit can rectify $1,280{\times}720$ stereo images at a frame rate of 135 fps at a clock frequency of 125 MHz. Because the circuit is fully pipelined, it continuously generates a pair of left and right rectified pixels every cycle after 13-cycle latency plus initial image buffering time. Experimental results show that the proposed method requires significantly fewer hardware resources than the conventional method while the differences between the results of the proposed and conventional full rectifications are negligible.

• Journal of Navigation and Port Research
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• v.40 no.5
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• pp.311-316
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• 2016

Vietnam is one of Asia's fastest developing economies. A long coastline of nearly 3,500 km provides a comparative advantage for Vietnam in developing a seaport system. Despite accounting for only about 30% of Vietnam's traffic volume, the Northern seaports have rapidly developed over the years. However, the location of the container terminals close to the common hinterland are a cause of fierce competition among container terminals. To outperform rivals and improve competitiveness, it is essential to identify the competitive positions of container terminals. This study analyzes the competitive positioning of container terminals in the northern region of Vietnam between 2005 and 2014 by applying the Boston Consulting Group (BCG) matrix in order to assist terminal operators and policy makers to generate strategic planning as well as to improve priorities for development. Otherwise, the period from 2005-2014 aims to clarify the static and dynamic positioning of container terminals. The results demonstrate that the Hai Phong terminal dominates the market, but the Nam Hai Dinh Vu and Dinh Vu terminals are considered as "star" performers. Quang Ninh, Doan Xa, and Transvina are losing their competitive positions in Northern Vietnam.

• KSBB Journal
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• v.19 no.5
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• pp.335-340
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• 2004

Mesangial expansion caused by cell proliferation and glomerular extracellular matrix accumulation is one of the earliest renal abnormalties observed at the onset of hyperglycemia in diabetes mellitus. Transcription factor Sp1 is implicated in the transcriptional regulation of a wide range of genes participating in cell proliferation, and is assumed to play an essential role in mesangial expansion, transforming growth factor (TGF)-$\beta$1, plasminogen activator inhibitor (PAI)-1. We have generated a phosphorothioated double-stranded Sp1-decoy oligodeoxynucleotide that effectively blocks Sp1 binding to the promoter region for transcriptional regulation of TGF-$\beta$1 and PAI-1. The Sp1 decoy oligodeoxynucleotide suppressed transcription of these cytokines and proliferation of primary rat mesangial cells in response to serum stimulation. These results suggest that the Sp1 decoy oligodeoxynucleotide could bea powerful tool in preventing the pathogenesis of renal hypertrophy.

• The Journal of Korean Academy of Prosthodontics
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• v.38 no.5
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• pp.631-639
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• 2000

Root-form endosseous implants which are in use today have a variety of materials, designs and surface characteristics. Among them, pure titanium surface implants and titanium matrix coated with HA are popular as well as are available in many studies. Rate of clinical success is obviously lower in jaw with cancellous bone than dense bone. In order to increase the rate of success in poor bone quality. More advanced techniques of implant surgery and surface treatment of implant fixture body have been developed. As a successful result, the installation of HA coated implant in bone quality type III or IV became highly successful. Since most clinical studies were performed without knowing the characteristics of HA coated implants, it has been impossible to come up with proper clinical data. Therefore the characterization of HA coated implants is essential to understand long term clinical performance and the predictability of HA coated implant system Our results showed that HA coated implants had the success rate at 93.7% in bone quality type III, IV for 3.8 years, and the fixture of Steri-Oss showed more stability with time.

• Journal of Environmental Impact Assessment
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• v.17 no.3
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• pp.153-165
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• 2008

Recently the use demand for national parks has been rapidly increased due to the change of leisure patterns in Korea. The intensive use of national parks, however, can cause serious management problems both in resource conservation and in visitor satisfaction. In order to prepare the effective management plan for the sustainable use of national parks, it is essential to evaluate the visitor satisfaction. The purpose of this study is to provide important information for the management strategies for Namsan and Tohamsan national parks in Kyongju. Importance-performance analysis (IPA) was adopted to analyze the visitor expectation and satisfaction. The questionnaire survey was performed to the 420 visitors of the three sites (Namsan Sam-reung, Namsam Yong-jang, and Tohamsan) that are the most popular areas in Kyongju national park. The IPA for the 18 satisfaction items shows that all the values for importance are higher than those for performance in the three sites. This results indicates that visitors' satisfactions for the 18 items are lower than their expectations. The IP matrix reveals that the management effort should be concentrated on the educational opportunities for nature and culture in Yong-jang, on the convenient access to park in Sam-reung. and on the availability of cool drinking water in Tohamsan. Based on the results, several suggestions for the management strategies were summarized for the three sites in conclusion.

• The Korean Journal of Cytopathology
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• v.12 no.2
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• pp.111-115
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• 2001

Solitary fibrous tumor on the pleura is rare but should be included in the differential diagnosis on a peripheral pulmonary nodule. Cytologic features of solitary fibrous tumor of the pleura is not familar to the pathologist and may be misdiagnosed as malignancy. We report fine needle aspiration cytologic(FNAC) findings of a case of solitary fibrous tumor misdiagnosed as adenocarcinoma in a 48-year-old woman. The FNAC displayed a mixture of bland-looking spindle cells and clusters of epithelioid cells, which have hyperchromatic nuclei with prominent nucleoli. The helpful finding to distinguish It from other circumscribed benign and malignant lesions is the presence of fibromyxoid matrix admixed with blood vessels and thin collagen fibers. Familiarity with these features is essential to avoid misdiagnosis and overtreatment.

• Bulletin of the Korean Chemical Society
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• v.32 no.6
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• pp.1975-1979
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• 2011

The modification of a gas diffusion layer (GDL), a vital component in polymer electrolyte fuel cells, is described here for use in the electrochemical detection of antibody-antigen biosensors. Compared to other substrates (gold foil and graphite), mouse anti-rHBsAg monoclonal antibody immobilized on gold-coated GDL (G-GDL) detected analytes of goat anti-mouse IgG antibody-ALP using a relatively low potential (-0.0021 V vs. Ag/AgCl 3 M NaCl), indicating that undesired by-reactions during electrochemical sensing should be avoided with G-GDL. The dependency of the signal against the concentration of analytes was observed, demonstrating the possibility of quantitative electrochemical biosensors based on G-GDL substrates. When a sandwich method was employed, target antigens of rHBsAg with a concentration as low as 500 ng/mL were clearly measured. The detection limit of rHBsAg was significantly improved to 10 ng/mL when higher concentrations of the 4-aminophenylphosphate monosodium salt (APP) acting on substrates were used for generating a redox-active product. Additionally, it was shown that a BSA blocking layer was essential in improving the detection limit in the G-GDL biosensor.

• Environmental Mutagens and Carcinogens
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• v.22 no.4
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• pp.236-242
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• 2002

Using agarose-coupled methotrexate, we have successfully isolated two proteins, which have strong interactions with methotrexate. The two proteins were analyzed by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry and identified as carbamoyl-phosphate synthetase 2 and phosphoribosylglycinamide formyltransferase, respectively. Interestingly, both of these two proteins are essential key enzymes in nucleotide biosynthetic pathways, like dihydrofolate reductase, a well-known methotrexate target. We confirmed the specificity of their interactions between methotrexate and two target proteins by the methods of competition binding assay, which were followed by western blotting using antibody against carbamoyl-phosphate synthetase 2 and phosphoribosylglycinamide formyltransferase, respectively. Moreover, we could observe that carbamoyl-phosphate synthetase 2 is overexpressed in methotrexate-resistant MOLT-3 cells comparing with control MOLT-3 cells. This result indicates that carbamoyl-phosphate synthetase 2 may be a novel target of methotrexate in cancer therapy. We propose that chemical proteomics can be a powerful technique to identify target proteins of a chemical.