• 한방안이비인후피부과학회지
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• 제24권2호
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• pp.104-110
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• 2011

Objectives : We report a case of Erythema Nodosum on lower extremities which was by acupuncture and herbal medicine treatment. Methods : We treated a female patient who has erythema nodosom, edema at lower extremities and arthralgia with acupuncture and Moktongdaean-tang.. To evaluate the results of this treatment, we observed shape and number of Erythema Nodosum. We measured circumference of left ankle. We used visual analogue scale(VAS) of arthralgia. Results : Erythema Nodosum on lower extremities, Edema of both ankle were subsided. Arthralgia was gradually disappered. Conclusions : Acupuncture and Moktongdaean-tang have improved the signs and symptoms of Erythema Nodosum case. It is concluded that acupuncture, herbal medicine treatment is considerably effective on Erythema Nodosum.

• 한방안이비인후피부과학회지
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• 제14권2호
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• pp.271-277
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• 2001

Erythema nodosum is a nodular erythematous eruption predominently limited to the pretibial area but occasionally involving the arms or other areas. That is clinical entity defined easily but there are many different opinions about histopathologic findings, Recently erythema nodosum is characterized histopathologically by a septal panniculitis in which the fibrous septa of subcutaneous fat become inflamed. Erythema nodosum has been known to be frequently associated with some kinds of drugs, infections with streptococci, mycobacteria but in $60\%$, no cause is found, Treatment of erythema nodosum consists of supportive care and elimination of underlying causes. Because spontaneous resolution of the lesions can occur in 3 to 6 weeks. Although there are trial treatments are applied to erythema nodosum, ego corticosteroids, NSAIDs, potassium iodine, there isn't any definite. So We report a case of erythema nodosum which was not relieved by NSAIDS but by experimental acupuncture treatment.

• 한방안이비인후피부과학회지
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• 제10권1호
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• pp.39-49
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• 1997

Erythema nodosum is a nodular erythematous eruption usually limited to the low extremities. Erythema nodosum seems to be Gwadungjun(瓜藤纏) and Damp-heat flow(濕毒流注) in oriental medicine. The symptom of erythema nodosum is similar to that of Gwadungjun, so we investigated the literatures of oriental medicine and recet medicine. The results were summarized as follows; 1. In Oriental medicine, erythema nodosum regarded as Damp-heat flow and Gwadungjun. 2. Inflammatory nodus of lower extremity, ie, similar to Gwadungjun, Damp-heat flow, Bichonbal(비천發), Samnibal(三里發), Ududok(魚두毒), etc. 3. Erythema nodosum results from inner damp-heat(內有濕熱), affection due to pathogenic wind(外感風邪). 4. Treatment is to clear away heat(淸熱), remove dampness(利濕), heat from blood(凉血), cold-damp(祛寒), and promote blood flood(活血通絡). 5. We can use Bangpungtongsungsan(防風通聖散), Sopunghwa1hyultang(疏風活血湯), and Danguijumtongtang(當歸拈通湯), etc.

• 한방안이비인후피부과학회지
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• 제25권2호
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• pp.83-91
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• 2012

Background and Objective : Erythema nodosum-like lesions in patients with Behcet's disease is a reactive dermatosis that occurs in response to various stimuli, such as bacterial, fungal and viral infections, drugs and malignancies. We observed and treated a case of erythema nodosum-like lesions with Behcet's disease. We present this case because there were no former reports of erythema nodosum-like lesions with Behcet's disease treated by herbal medicine. Methods : The patient was a 28-year-old. The chief complains were erythema, nodose, edema, burning sensation, tenderness on both legs, forearms and feet, arthralgia and genital ulcers. She was treated with Wolbi-Tang for eleven days. We diagnosed the medication according to the results of manual abdominal examination of the patient. We used the Visual Analogue Scale(VAS). Results : After the treatment the grade of VAS was decreased and clinical symptoms were improved. Conclusions : Wolbi-Tang can be used on the treatment of erythema nodosum-like lesions with Behcet's disease.

• Tuberculosis and Respiratory Diseases
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• 제71권3호
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• pp.221-224
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• 2011

Poncet's disease is an aseptic polyarthritis developing in the presence of active Tuberculosis occurring elsewhere, and is not due to direct involvement of joints but to an immunological reaction to tuberculoprotein. We experienced a case of Poncet's disease accompanying erythema nodosum in a 55-year-old female patient with pulmonary tuberculosis. She had multiple tender erythematous nodules on both lower limbs for 3 months and a cough and sputum from one month ago. She felt severe pain in both knees and ankles with swelling one week before admission. Her chest X-ray, computed tomography (CT) scan and positive sputum AFB stain results revealed that she had active pulmonary tuberculosis accompanying erythema nodosum and aseptic polyarthritis. Her arthritis and erythema nodosum were dramatically improved within four weeks after anti-tuberculosis therapy. We report a case of Poncet's disease in pulmonary tuberculosis accompanying erythema nodosum.

• 대한간호
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• 제8권2호통권40호
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• pp.30-31
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• 1969

• Clinical and Experimental Pediatrics
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• 제57권2호
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• pp.91-95
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• 2014

Griscelli syndrome type 2 (GS2) is a rare autosomal recessive disease caused by mutations in the RAB27A gene. It is characterized by cutaneous hypopigmentation, immunodeficiency, and hemophagocytic lymphohistiocytosis. We describe 2 brothers who had GS2 with clinically diverse manifestations. The elder brother presented with a purely neurological picture, whereas the younger one presented with fever, pancytopenia, hepatosplenomegaly, and erythema nodosum. Considering that cutaneous hypopigmentation was a common feature between the brothers, genetic analysis for Griscelli syndrome was performed. As the elder sibling had died, mutation analysis was only performed on the younger sibling, which revealed a novel homozygous mutation in the RAB27A gene on chromosome 15 showing a single-base substitution (c.136T>A p.F46I). Both parents were heterozygous for the same mutation. This confirmed the diagnosis of GS2 in the accelerated phase in both siblings. The atypical features of GS2 in these cases are a novel mutation, isolated neurological involvement in one sibling, association with erythema nodosum, and 2 distinct clinical presentations in siblings with the same genetic mutation.

• 한방안이비인후피부과학회지
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• 제5권1호
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• pp.151-152
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• 1992

• Pediatric Infection and Vaccine
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• 제23권1호
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• pp.67-71
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• 2016

결절성 홍반은 소아에서 가장 흔한 피하지방층의 염증으로 하지의 압통을 동반한 결절을 특징으로 한다. 이 질환은 다양한 원인에 의해 발생되지만 공통된 조직소견을 보여준다. 저자들은 임상적 소견 및 혈청학적 방법으로 마이코플라즈마 폐렴균에 의한 결절성 홍반을 진단하였고 조직병리적인 접근을 통해 결절성 홍반의 면역병인에 대해 고찰해 보았다. 조직병리소견은 제 4형 면역반응 염증을 보였으며 이는 다양한 원인에 의한 결절성 홍반의 발생 기전을 이해하는데 도움을 줄 것이다.

• IMMUNE NETWORK
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• 제2권4호
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• pp.223-226
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• 2002

Background: The type 2 deviated immunological state is predominant in lepromatous leprosy. Erythema nodosum leprosum (ENL) is an immune-complex mediated reaction that typically occurs in lepromatous leprosy. To date, the serum levels of tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-2 receptor, IL-10, IL-$1{\beta}$, IL-1 receptor antagonist and monocyte chemoattractant protein-1 (MCP-1) were reported to be higher in lepromatous leprosy. TNF-${\alpha}$ is also known to be higher in ENL, which is reduced after thalidomide treatment. However the serum type 2 chemokine levels in lepromatous leprosy patients have not been reported. Methods: The serum levels of the type 2 chemokines such as thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and eotaxin together with IL-12 and IL-10 in the sera from leprosy patients were detected using an enzyme-linked solvent assay (ELISA) method. Results: The Serum TARC, MDC, eotaxin, IL-10 and IL-12 levels in lepromatous leprosy patients were not significantly different from the normal control levels. The serum levels were not significantly different between the paucibacillary group and multibacillary group. The serum TARC or MDC levels in the ENL patients were more reduced after a treatment containing thalidomide. Conclusion: The type 2 chemokines are not related to the severity of lepromatous leprosy. The larger reducing effect of the TARC or MDC levels in ENL patients by a treatment containing thalidomide suggests the potential role of these chemokines in the development of ENL and the therapeutic mechanism of thalidomide.