• Title/Summary/Keyword: equilibrium state

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Cardioprotective Potency of the Antioxidante Amifostine in the Ischemic and Reperfused Isolated Rat Heart (항산화제 Amifostine의 허혈 및 재관류시 흰쥐 적출심장의 심근 보호기능)

  • 허강배;천수봉;김송명
    • Journal of Chest Surgery
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    • v.31 no.9
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    • pp.845-854
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    • 1998
  • Background: S-2-(3 aminoprophlamino) ethylphosphorothioic acid(WR-2721) is one of the radical scavenging thiols. We tested its protective effects in the reperfused heart. Material and Method: The experimental setup was the constant pressure Langendorffs perfusion system. We investigated the radical scavenging properties of this compound in isolated rat hearts which were exposed to 20 minutes ischemia and 20 minutes reperfusion. Four experimental groups were used:group I, control, Amifostine 50 mg(1 mL) peritoneal injection 30 minutes before ischemia(group II), Amifostine 10 mg(0.2 mL) injection during ischemia through coronary artery(group III),and Amifostine 50 mg(1 mL) peritoneal injection 2 hrs before ischemia(group IV). The experimental parameters were the levels of latate, CK-MB, and adenosine deaminase(ADA) in frozen myocardium, the quantity of coronary flow,and left ventricular developed pressure, and it's dp/dt. Statistical analysis was performed using repeated measured analysis of variance and student t-test. Result: The coronary flow of group II and IV were less than group I and III at equilibrium state but recovery of coronary flow at reperfusion state of group II, III, and IV were more increased compared with group I. The change of systolic left ventricular devoloping pressure of group II and IV were less than control group at equilibrium state, which seemed to be the influence of the pharmacological hypotensive effect of amifostine. But it was higher compared with group I at reperfusion state. The lactic acid contents of group II were less than control group in frozen myocardium.(Group I was 0.20 0.29 mM/g vs Group II, which was 0.10 0.11 mM/g). The quantity of CK-MB in myocardial tissue was highest in group IV (P=0.026 I: 120.0 97.8 U/L vs IV: 242.2 79.15 U/L). The adenosine deaminase contents in the coronary flow and frozen myocardium were not significantly different among each group. Conclusion: Amifostine seemed to have significant cardioprotective effect during ischemia and reperfusion injuries of myocardium.

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A New Aluminium Container for $\gamma$-Ray Spectrometry Analysis of Radium and Radon (라듐 및 라돈의 감마선 분광 분석을 위한 알루미늄 용기의 제작 및 특성 조사)

  • Lee, Kil Yong;Yoon, Yoon Yeol;Seo, Bum Kyoung
    • Analytical Science and Technology
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    • v.13 no.6
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    • pp.743-750
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    • 2000
  • For the ${\gamma}$-ray spectrometry analysis of radium and radon in environmental samples, plastic Marinelli beakers have been usually used. But, there are two problems; one is the increment of background by adsorption of airborne radon daughters on the plastic beaker, and other is the incompleteness of radioactive equilibrium by the loss of gaseous radon produced during the radioactive equilibrium process. In order to solve these problems, we made aluminium counting container, and investigated its characteristics. We investigated radioactive equilibrium process using the aluminium container. We found that both solid and liquid samples reached at radioactive equilibrium state in the aluminium container without loss of gaseous radon. By the use of the aluminium container, we established radon and radium analysis method of solid and liquid samples using gamma-ray spectrometry.

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A Comparison of the Crack Plane Equilibrium Model for Elastic-Plastic Fracture Analysis with the Irwin's Plastic Zone Corrected LEFM (탄소성 파괴해석을 위한 크랙 평면 평형모형과 항복 선형 파괴역학과의 비교에 관한 연구)

  • Lee, Kyu-Yong;Smith, F.W.
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.20 no.1
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    • pp.30-36
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    • 1984
  • It is well known that the application of linear elastic fracture mechanics is inadequate to solve the large deformation fracture failures which occurr in ductile manner because of the large scale yielding due to the severe stress concentration in the region adjacent to the crack tip. The authors have been evolved a fracture model, the crack plane equilibrium model, for this kinds of elastic-plastic fracture problems in the previous report. In this report, the crack plane equilibrium model was compared with the Irwin's plastic zone corrected linear elastic fracture mechanics through theoretical comparisons and experimental results to examine the validity of the crack plane equilibrium model as an available tool for nonlinear fracture analysis. Through this study, the main results were reached as follows; Irwin's plastic zone corrected linear elastic fracture mechanics could be applicable only for small scale yielding problems as expected while the crack plane equilibrium model valid as a fracture model for large deformation fracture failure. However, the followings should be considered for the more precise evaluations of CPE model; 1) It is necessary to test more specimens which contain small cracks in the range of 2a/W<0.1. 2) It is important to detect the crack initiation point during the fracture test for determining an accurate fracture load. 3) Effects of specimen thickness in the fracture process zone should be examined.

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A Missile Guidance Law Based on Sontag's Formula to Intercept Maneuvering Targets

  • Ryoo, Chang-Kyung;Kim, Yoon-Hwan;Tahk, Min-Jea;Choi, Kee-Young
    • International Journal of Control, Automation, and Systems
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    • v.5 no.4
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    • pp.397-409
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    • 2007
  • In this paper, we propose a nonlinear guidance law for missiles against maneuvering targets. First, we derive the equations of motion described in the line-of-sight reference frame and then we define the equilibrium subspace of the nonlinear system to guarantee target interception within a finite time. Using Sontag's formula, we derive a nonlinear guidance law that always delivers the state to the equilibrium subspace. If the speed of the missile is greater than that of the target, the proposed law has global capturability in that, under any initial launch conditions, the missile can intercept the maneuvering target. The proposed law also minimizes the integral cost of the control energy and the weighted square of the state. The performance of the proposed law is compared with the augmented proportional navigation guidance law by means of numerical simulations of various initial conditions and target maneuvers.

Determination of an Optimum Initial Cable Tension Force for Cable-Stayed Bridges using the Least Square Method (최소자승법을 이용한 사장교의 적정 케이블 장력 결정)

  • Park, Yong Myung;Cho, Hyun Jun
    • Journal of Korean Society of Steel Construction
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    • v.17 no.6 s.79
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    • pp.727-736
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    • 2005
  • This study presents a method of determining the optimum cable tension forces for the proper initial equilibrium state of a cable-stayed bridge using the least square method. The proposed method minimizes the errors, i.e., the differences, such as the deflection and the moments of the girder and the tower, between the target values from a continuous beam by considering the cable anchor point as supports of the girder and the responses obtained from the analysis of the entire cable-stayed bridge system. Especially, the proposed method can selectively control the adjustment of the tower moment, the girder moment, and the deflections by introducing the weighing matrix. Through numerical analysis and comparisons with existing studies, the usefulness and validity of the proposed method was verified.

A Study on Maximum and Mean Velocity Relationships with Varied Channel Slopes and Sediment (유사가 있는 경우와 수로경사가 변화하는 경우의 최대유속과 평균유속과의 관계에 관한 연구)

  • Choo, Tai-Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.9 no.1
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    • pp.154-159
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    • 2008
  • This study proposes how to decide mean velocity which is one of the very important and efficient discharge measurement in water resources area. In order to achieve this goal, Chiu's velocity distribution equation recently developed from the probability and entropy concepts is used to establish, analyze and compare a linkage between the mean velocity obtained from the Manning's equation which is well known in the world. Besides, it becomes clear that a channel cross section also has a propensity to establish and maintain an equilibrium state that can be measured and classified by a function of entropy M, ratio of mean and maximum velocities irrespective of including sediment or varied channel slope. Therefore, The linkage to be established in this study can be used to compute the cross sectional velocity distribution with the maximum velocity.

Flow Characteristics of Refrigerant Mixtures with R32 in a Capillary Tube (R32를 포함한 R22 대체 혼합냉매의 모세관 유동 특성)

  • Chang, S.D.;Ro, S.T.
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.8 no.2
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    • pp.177-186
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    • 1996
  • The characteristics of the flow of pure HFC refrigerants(R32, R125, and R134a) and their mixtures through capillary tubes were investigated experimentally. Two capillary tubes with 1.2mm and 1.6mm inner diameter and 1.5m length were adopted as test sections. Mass flow rates and temperatures and pressures were measured for several condensing temperatures and degrees of subcooling at capillary tube inlet. The effects of the condensing temperature, inner diameter of capillary tube, and subcooling on the mass flow rate of refrigerants were discussed, and the mass flow rates of HFC refrigerants were compared with that of R22. The pressure and temperature distributions along the capillary tube compared with that of R22. The pressure and temperature distributions along the capillary tube show that there is a metastable equilibrium state in the flow through the tube. Underpressure for vaporization increases as refrigerant mass flux increases and inlet subcooling decreases. Empirical correlation was suggested to predict underpressure for vaporization of the HFC refrigerants.

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SELECTIVE REDUCTION OF ACTIVE METAL CHLORIDES FROM MOLTEN LiCl-KCl USING LITHIUM DRAWDOWN

  • Simpson, Michael F.;Yoo, Tae-Sic;Labrier, Daniel;Lineberry, Michael;Shaltry, Michael;Phongikaroon, Supathorn
    • Nuclear Engineering and Technology
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    • v.44 no.7
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    • pp.767-772
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    • 2012
  • In support of optimizing electrorefining technology for treating spent nuclear fuel, lithium drawdown has been investigated for separating actinides from molten salt electrolyte. Drawdown reaction selectivity is a major issue that requires investigation, since the goal is to remove actinides while leaving the fission products and other components in the salt. A series of lithium drawdown tests with surrogate fission product chlorides was run to obtain selectivity data with non-radioactive salts, develop a predictive model, and draw conclusions about the viability of using this process with actinide-loaded salt. Results of tests with CsCl, $LaCl_3$, $CeCl_3$, and $NdCl_3$ are reported here. Equilibrium was typically achieved in less than 10 hours of contact between lithium metal and molten salt under well-stirred conditions. Maintaining low oxygen and water impurity concentrations (<10 ppm) in the atmosphere was observed to be critical to minimize side reactions and maintain stable salt compositions. An equilibrium model has been formulated and fit to the experimental data. Good fits to the data were achieved. Based on analysis and results obtained to date, it is concluded that clean separation between minor actinides and lanthanides will be difficult to achieve using lithium drawdown.

The Relationship Between Monetary and Macroprudential Policies

  • KANG, JONG KU
    • KDI Journal of Economic Policy
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    • v.39 no.1
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    • pp.19-40
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    • 2017
  • This paper analyzes the interaction between monetary and macroprudential policies mainly in the context of the non-cooperation among policy authorities. Each policy authority's optimal response is to tighten its policy measures when other authorities' policy measures are loosened. This indicates that the two policies are substitutes for each other. This result still holds when an additional financial stability mandate is assigned to the central bank. The condition for the response functions to converge to a Nash equilibrium state is analyzed along with the speed of convergence, showing that they depend on the authorities' preferences and the number of mandates assigned to policy authorities. If the financial supervisory authority (FSA) assigns greater importance to the output gap or a stronger financial stability mandate is assigned to the central bank (CB), the probability of non-convergence increases and the speed of convergence declines even when the condition of convergence is satisfied. Meanwhile, if the CB considers output stability as an important task, the probability of convergence and the speed of converging to a state of equilibrium are high. Finally, when a single mandate or small number of mandates is/are assigned to each authority, stability is more quickly restored as compared to when many mandates are assigned.

Geomechanical analysis of elastic parameters of the solid core of the Earth

  • Guliyev, Hatam H.
    • Geomechanics and Engineering
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    • v.14 no.1
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    • pp.19-27
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    • 2018
  • It follows from the basic principles of mechanics of deformable solids relating to the strength, stability and propagation of elastic waves that the Earth's inner core cannot exist in the form of a spherical structure in the assumed thermobaric conditions and calculation values of physico-mechanical parameters. Pressure level reaches a value that is significantly greater than the theoretical limit of medium strength in the model approximations at the surface of the sphere of the inner core. On the other hand, equilibrium state of the sphere is unstable on the geometric forming at much lower loads under the influence of the "dead" surface loads. In case of the action of "follower" loads, the assumed pressure value on the surface of the sphere is comparable with the value of the critical load of "internal" instability. In these cases, due to the instability of the equilibrium state, propagation of homogeneous deformations becomes uneven in the sphere. Moreover, the elastic waves with actual velocity cannot propagate in such conditions in solid medium. Violation of these fundamental conditions of mechanics required in determining the physical and mechanical properties of the medium should be taken into account in the integrated interpretations of seismic and laboratory (experimental) data. In this case, application of the linear theory of elasticity and elastic waves does not ensure the reliability of results on the structure and composition of the Earth's core despite compliance with the required integral conditions on the mass, moment of inertia and natural oscillations of the Earth.