• 제목/요약/키워드: environmental toxicology

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극소수성 물질들에 대한 Slow-Stirring방법에 의한 옥탄올/물 분배계수 측정 (Slow-Stirring Methods for Determining the n-Octanol/Water Partition Coefficient(Pow) of Highly Hydrophobic Chemicals)

  • 장희라;이봉재;김균;김용화
    • Environmental Analysis Health and Toxicology
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    • 제20권4호통권51호
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    • pp.351-358
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    • 2005

  • The n -octanol/water partition coefficient (Pow) is one of the most important parameters employed for estimating a chemiral's environmental fate and toxicity. The shake-flask method, one direct experimental method, i.1 prone to experimental artifacts for highly hydrophobic compounds. Thus, a valid method for direct determination of the Pow of highly hydrophobic compounds is needed. The slow -stirring method has been demonstrated to provide reliable log Pow data to log Pow greater than 5. This study was performed to evaluate the accuracy of slow- stirring experiment for determination of log Pow, particularly for highly hydrophobic compounds. 1, 2, 3, 4-tetrachlorobenzene, hexachlorobezene, 2, 2', 3, 3', 5, 5', 6, 6'-octachlorobiphenyl, decachlorobiphenyl, and p, p'-DDT (4.5$\times$0.02, 5.41$\times$0.06, 7.26$\times$0.04, 7.87$\times$0.10, and 6.03$\times$0.06, respectively. The octanol/water partition coefficient by the slow-stirring method were very similar to the literature values. These results indicate that the slow- stirring method allows for reliable determination of log Pow of highly hydrophobic chemicals.

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