• BMB Reports
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• v.50 no.5
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• pp.233-234
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• 2017

Aberrant expression of the polypeptide N-acetyl-galactosaminyltransferase (GALNTs) has been associated with cancer, but their function(s) in metastasis remains elusive. We have recently identified GALNT14, one of the O-GalNAc glycosylation-initiating enzymes, as a prognostic marker for pulmonary relapse in breast cancer patients. Furthermore, we showed that GALNT14 promotes lung metastasis by the following novel mechanisms: 1) enhancing metastasis initiation by inhibiting the anti-metastatic effect of BMP produced from the lung stroma, 2) exploiting growth signals (e.g. FGF) supplied by macrophages, for their growth into macrometastases in the lung environment. These multi-faceted roles of GALNT14 in lung metastasis are achieved by GALNT14-mediated inhibition and activation of the BMP and FGF signaling pathways, respectively. The link among GALNT14, its downstream pathways and lung metastasis, provides us with an opportunity to develop effective therapeutic intervention for breast cancer.

• 한국전산유체공학회:학술대회논문집
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• 2002.05a
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• pp.79-87
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• 2002

The present work analyzed the effect of mixing vane shape on the flow structure and heat transfer downstream of mixing vane in a subchannel of fuel assembly, by obtaining velocity and pressure fields, turbulent intensity, flow-mixing factors, heat transfer coefficient and friction factor using three-dimensional RANS analysis. NJl5, NJ25, NJ35, NJ45, which were designed by the authors, were tested to evaluate the performances in enhancing the heat transfer. Standard $\kappa-\epsilon$ model is used as a turbulence closure model, and, periodic and symmetry conditions are set as boundary conditions. The flow blockage ratio is kept constant, but the twist angle of mixing vane is changed. The results with three turbulence models( $\kappa-\epsilon$, $\kappa-\omega$, RSM) were compared with experimental data.

• Proceedings of the KSME Conference
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• 2004.04a
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• pp.1819-1824
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• 2004

The common method to improve heat transfer in Nuclear fuel rod bundle is install a mixing vane in space grid. The previous split mixing vane is guides cooling water to swirl flow in sub-channel of fuel assembly. But, this swirl flow decade rapidly after mixing vane and the effect of enhancing the heat transfer vanish behind this short region. The large scale secondary vortex flow was generated by rearranging the inclined angle direction of mixing vanes to the coordinated directions. This LSVF mixing vanes generate the most strong secondary flow vortices which maintain about 35 $D_H$ after the spacer grid and the streamwise vorticity in subchannel with LSVF mixing vane sustain two times more than that in subchannel with split mixing vane. The turbulent kinetic energy and the Reynolds stresses generated by the mixing vanes have nearly same scales but maintain twice more than previous type.

• Journal of the Ergonomics Society of Korea
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• v.32 no.5
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• pp.429-435
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• 2013

Objective: This study aims to analyze job satisfaction and accident prevention according to job rotation system types in a motor company. Background: The study of a motor company's job rotation system has come to attention with enhancing productivity, preventing musculoskeletal disorders, and improving quality. Method: In this study, a survey was conducted to show job satisfaction rates according to job rotation systems. Also an investigation was done regarding industrial accidents and previous workers who are receiving treatment for musculoskeletal disorder over the last five years. Results: The job rotation system in this study has been carried out by voluntary decision of workers. Out of the job rotation types, the medium rotation complexity type had high job satisfaction whereas in a high or low rotation complexity type, which many workers prefer, led to less number of accidents and days of sick leave. Application: The results of this study are expected to be a fundamental data to job design.

• Advances in Energy Research
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• v.3 no.1
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• pp.1-10
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• 2015

In the past sidetracking was the means to bypass a damaged zone or to correct the direction of a wellbore. Nowadays, this method is very common and useful in relocating the bottom of a wellbore in a more productive zone and consequently enhancing the production of a reservoir by saving a significant amount of time and money. In this paper, the stability of the bend area is assessed considering varied conditions of stress regime and sidetrack orientation. In general, the stress regime and the orientation of the principal stresses have negligible effect on the stability of the sidetrack compared to sidetrack inclination. On the other hand, the sidetrack deviation angle from the vertical main well plays the major role in the stability of the bend area.

• Journal of the Korean Society of Food Science and Nutrition
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• v.24 no.6
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• pp.978-983
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• 1995

The effect of sulfur-containing amino acids on lipid metabolism was studied in rats fed casein as a protein source. Plasma cholesterol, HDL-cholesterol and atherosclerotic index decreased in the cysteine group compared to the methionine group. Plasma triglyceride and phospholipid level were not affected by the supplementation of the sulfur-containing amino acids. The levels of cholesterol and triglyceride in liver decreased by both methionine and cysteine. Cysteine increased the fecal excretion of coprostanol, total neutral steroid and bile acid. The results suggest that plasma cholesterol level is affected by dietary ratio of cysteine/methionine and that the hypocholesterolemic effects of cysteine is, at least in part, through reducing cholesterol absorption from small intestine and through enhancing fecal excretion of bile acids.

• Microbiology and Biotechnology Letters
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• v.25 no.3
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• pp.248-252
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• 1997

Wild strains of bifidobacteria isolated from Korean feces were tested for their growth and acid production abilities in 10% skim milk. Growth of bifidobacteria was markedly decreased from the second transfer in the skim milk culture. When two strains, BF5 and BF33, were grown in skim milk with various supplements, the growth was enhanced by supplementation of 0.5% yeast extract, and 0.05% cysteine but not by short chain fatty acids. There was no enhancing effect of CO$_{2}$, substitution in the fermentor on growth. The viable cell counts of bifidobacteria, BF5 and BF33, were 9.76 and 9.98 logCFU/ml, respectively, after 30 hr cultivation and were diminished by 3 and 6 logs during storage at 5$\circ$C for 12 days.

• Journal of Information Processing Systems
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• v.14 no.4
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• pp.1033-1048
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• 2018

This paper proposes an integrated lighting enabler system (ILES) based on standard machine-to-machine (M2M) platforms. This system provides common services of end-to-and M2M communication for smart lighting system. It is divided into two sub-systems, namely end-device system and server system. On the server side, the M2M platform OpenMTC is used to receive data from the sensors and send response for activating actuators. At the end-device system, a programmable smart lighting device is connected to the actuators and sensors for communicating their data to the server. Some experiments have been done to prove the system concept. The experiment results show that the proposed integrated lighting enabler system is effective to reduce the power consumption by 25.22% (in average). The proving of significance effect in reducing power consumption is measured by the Wilcoxon method.

• Journal of the Korean institute of surface engineering
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• v.37 no.1
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• pp.64-70
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• 2004

Cryogenic characteristics of austenitic stainless steel based on 304 steel with nickel and nitrogen were investigated at room temperature and $-196^{\circ}C$. The alloys were fabricated by vacuum arc furnace and cold working after homogenization treatment. The addition of nickel and nitrogen decreased the stability of $\delta$-ferrite and induced the stability against the formation of martensite to result significantly in enhancing ductility at $-196^{\circ}C$. Nitrogen reduced Md temperature, which was beneficial to the tensile strength and elongation at $25^{\circ}C$ and -196$^{\circ}C$.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.30 no.8
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• pp.491-495
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• 2017

We investigated solution-processed indium-zinc oxide (IZO) thin-film transistors (TFTs) by inserting a 2-(4-biphenylyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole (PBD) buffer layer. This buffer layer efficiently tuned the energy level between the semiconducting oxide channel and metal electrode by increasing charge extraction, thereby enhancing the overall device performance: the IZO TFT with embedded PBD layer (thickness: 5 nm; width: $2,000{\mu}m$; length: $200{\mu}m$) exhibited a field-effect mobility of $1.31cm^2V^{-1}s^{-1}$, threshold voltage of 0.12 V, subthreshold swing of $0.87V\;decade^{-1}$, and on/off current ratio of $9.28{\times}10^5$.