• Journal of Digital Convergence
• /
• v.9 no.6
• /
• pp.1-11
• /
• 2011

It is time to review the direction of R&D investment which is the source of change in knowledge information ages. The DEA(Data Envelopment Analysis) is a efficient method by using the ratio of input and output elements. In this paper, we analyzed industry relationship and efficiency by DEA in order to analyze ripple effect of the regional industry technology development project. According to these results, we found the primary affected factor in performance of this project was human resource, and the turnover of participated company was not on the rise yet. On types of the project, we could find the efficiency quotient of critical technique development project was higher than of common technique development project because project period or budget scale infected to project performance. We expect the enhancement of technique developer, tenn and budget, and it is necessary the project results should lead performance such as sales force and employee growth.

• Journal of Digital Convergence
• /
• v.10 no.11
• /
• pp.315-321
• /
• 2012

Since technological innovation is such an important factor that it can determine a company's economic growth and competitive enhancement, all the companies make lots of investments and efforts for technological innovation. As outcomes of technological innovation, there are patents, trademark and copyrights, etc. and they are mostly approved as a legal right called 'Intellectual Property Right'. To activate such an intellectual property right, financing techniques are needed for enterprises to raise funds through collaterals, such as technological and intellectual patents. In reality, however, any IP-related financial system is not really activated due to the lack of surety-related regulations in Korea. Thus, on the premise that it is important to carry out an objective and reliable valuation on IP as a collateral for the activation of IP finance, this study intends to investigate various different methods of patent valuation needed for IP finance.

• Journal of Korean Medicine for Obesity Research
• /
• v.4 no.1
• /
• pp.161-183
• /
• 2004

Context : Oriental medicine deals with mind cardinally and effectiveness of CBT on weight control is well-known. but there is no well-structured psychotherapy for weight control like CBT in Oriental medicine so far. Therefore It is necessary to develop new cognitive program based on the theory of Oriental medical. Objective: This study examined whether Yangsung program based on new cognitive weight regulation model is effective on weight loss, self esteem and self control. Design and setting: 44 women were assigned randomly to 2 groups; experimental group(n=24) and control group(n=10). experimental group had 11 sessions consisted of cognitive therapy, meditation, general diet and exercise education. Control group had personal interview with general diet and exercise education and ear acupuncture once a week for two months. All subjects were weighed and evaluated with Rosenberg self esteem scale, and three factor eating questionnaires at the beginning of the program and at the end of the program. Result: Experimental group reported significant changes of weight, self esteem, restraint eating, disinhibition and hunger(p<0.01). Compared with control group, more significant(p<0.05) Weight reduction and self-esteem enhancement were reported in experimental group than control group. There is no significant difference between two groups in changes of restraint eating, disinhibition and hunger.

• Journal of Korean Society on Water Environment
• /
• v.30 no.2
• /
• pp.212-219
• /
• 2014

In this study, a land pollutant load calculation method in TMDLs was improved to consider climate change scenarios. In order to evaluate the new method, future change in rainfall patterns was predicted by using SRES A1B climate change scenarios and then post-processing methods such as change factor (CF) and quantile mapping (QM) were applied to correct the bias between the predicted and the observed rainfall patterns. Also, future land pollutant loads were estimated by using both the bias corrected rainfall patterns and the enhanced method. For the results of bias correction, both methods (CF and QM) predicted the temporal trend of the past rainfall patterns and QM method showed future daily average precipitation in the range of 1.1~7.5 mm and CF showed it in the range of 1.3~6.8 mm from 2014 to 2100. Also, in the result of the estimation of future land pollutant loads using the enhanced method (2020, 2040, 2100), TN loads were in the range of 4316.6~6138.6 kg/day and TP loads were in the range of 457.0~716.5 kg/day. However, each result of TN and TP loads in 2020, 2040, 2100 was the same with the original method. The enhanced method in this study will be useful to predict land pollutant loads under the influence of climate change because it can reflect future change in rainfall patterns. Also, it is expected that the results of this study are used as a base data of TMDLs in case of applying for climate change scenarios.

• Journal of Microbiology and Biotechnology
• /
• v.19 no.6
• /
• pp.596-603
• /
• 2009

This study aimed to examine the influence of adding an oxygen vector, n-dodecane, on hyaluronic acid (HA) production by batch culture of Streptococcus zooepidemicus. Owing to the high viscosity of culture broth, microbial HA production during 8-16 h was limited by the oxygen transfer coefficient $K_La$, which could be enhanced by adding n-dodecane. With the addition of n-dodecane to the culture medium to a final concentration of 5% (v/v), the average value of $K_La$ during 8-16 h was increased to $36{\pm}2h^{-1}$, which was 3.6 times that of the control without n-dodecane addition. With the increased $K_La$ and dissolved oxygen (DO) by adding 5% (v/v) of n-dodecane, a 30% increase of HA production was observed compared with the control. Furthermore, the comparison of the oxygen mass transfer in the absence and presence of n-dodecane was conducted with two proposed mathematical models. The use of n-dodecane as an oxygen vector, as described in this paper, provides an efficient alternative for the optimization of other aerobic biopolymer productions, where $K_La$ is usually a limiting factor.

• Journal of Korean Society for Geospatial Information Science
• /
• v.10 no.3 s.21
• /
• pp.99-105
• /
• 2002

In 1995 of May, the Ministry of Construction and Transportation (NOCT) developed the First Nation-wide Master Plan of GIS. It is set up in response to an increasing and various demands on spatial informations. Until now, a set of diverse projects related to spatial information have been proposed and executed. However, cost-benefit analysis of investment and decision making for alternatives have not been carried out appropriately because scientific evaluations for obtaining efficiency and economical validity of investment have been deficient. Optimum decision making for projects based on itemized priority order using effect or cost of proposed alternative plan is a fundamental expedient for demonstration of propriety of projects and enhancement of efficiency of investment. From such understanding, this paper applied the analytic hierarchy process (AHP) technique to the cost required to construct a GIS so that analyze the weight of each cost factor.

• Journal of Ginseng Research
• /
• v.40 no.1
• /
• pp.55-61
• /
• 2016

Background: A number of neurological and neurodegenerative diseases share impaired cognition as a common symptom. Therefore, the development of clinically applicable therapies to enhance cognition has yielded significant interest. Previously, we have shown that activation of lysophosphatidic acid receptors (LPARs) via gintonin application potentiates synaptic transmission by the blockade of $K^+$ channels in the mature hippocampus. However, whether gintonin may exert any beneficial impact directly on cognition at the neural circuitry level and the behavioral level has not been investigated. Methods: In the current study, we took advantage of gintonin, a novel LPAR agonist, to investigate the effect of gintonin-mediated LPAR activation on cognitive performances. Hippocampus-dependent fear memory test, synaptic plasticity in the hippocampal brain slices, and quantitative analysis on synaptic plasticity-related proteins were used. Results: Daily oral administration of gintonin for 1 wk significantly improved fear memory retention in the contextual fear-conditioning test in mice.We also found that oral administration of gintonin for 1 wk increased the expression of learning and memory-related proteins such as phosphorylated cyclic adenosine monophosphate-response element binding (CREB) protein and brain-derived neurotrophic factor (BDNF). In addition, prolonged gintonin administration enhanced long-term potentiation in the hippocampus. Conclusion: Our observations suggest that the systemic gintonin administration could successfully improve contextual memory formation at the molecular and synaptic levels as well as the behavioral level. Therefore, oral administration of gintonin may serve as an effective noninvasive, nonsurgical method of enhancing cognitive functions.

• YAKHAK HOEJI
• /
• v.49 no.6
• /
• pp.459-464
• /
• 2005

The immune reinforcement of the probiotic lactic acid bacteria Lactobacillus acidophilus, Streptococcus thermophilus and Bifidobacterium bifidum was studied in RAW 264.7 cell line treated with diluted solution (dilution to $2^{5}$) of the supernatnats of lactic acid bacteria. RAW 264.7 cell line was used as a macrophage model to assess the effects of lactic acid bacteria on the production of nitric oxide (NO) and cytokine tumor necrosis factor (TNF)-$\alpha$ and cell morphological changes. The production of NO and TNF-$\alpha$ were largely affected by lactic acid bacteria in dose-dependent manner in 24 or 48 hr cultures and cell morphological changes were also largely affected by lactic acid bacteria. Especially Bifidobacterium bifidum differentially stimulated the production of NO and TNF-$\alpha$. NO production was increased by Bifidobacterium bifidum 25 $\mu$l/ml more than LPS (20 ng/ml) control, and TW-$\alpha$ by Bifidobacterium bifidum 6.25 $\mu$l/ml more than LPS (10 ng/ml) control. The in vitro approaches employed here should be useful in further characterization of the effects of lactic acid bacteria on systemic immunity.

• Journal of Digital Convergence
• /
• v.18 no.1
• /
• pp.159-168
• /
• 2020

The purpose of this study is to verify the effects of nurses' turnover intention, Nunchi, and job stress on organizational socialization. Data were collected from 180 nurses working in hospitals in G-do. Analysis was done using t-test, ANOVA, Pearson correlation coefficient, and Multiple regression with IBM SPSS WIN/21.0. Organizational socialization was inversely correlated to turnover intention (r=-.52, p<.001), job stress (r=-.31, p<.001), and was positively correlated to Nunchi (r=.33, p<.001). The most influential factor on the subjects' organizational socialization was turnover intention (β=-.37, p<.001), Nunchi (β=.26, p<.001), job stress (β=-.24, p<.001), deployment to the desired department (β =.19, p=.001), Age 30 years or younger (β=-.14, p=.012), and Working department-OR (β=.11, p=.050). The explanatory power was 47.0% (F=25.59, p<.001). Therefore, a organizational socialization enhancement program is needed to reduce turnover intention and job stress. Also, age and desired depertment need to be taken into account when assigning departments.

• Journal of Acupuncture Research
• /
• v.23 no.2
• /
• pp.139-157
• /
• 2006

In the present study, I have investigated the bee venom (BV) and melittin (a major component of BV) -mediated anti-proliferative effects, and defined its mechanisms of action in cultured rat aortic vascular smooth muscle cells (VSMCs). BV and melittin $(0.4{\sim}0.8\;{\mu}g/ml)$ effectively inhibited 50 ng/ml platelet derived growth factor BB (PDGF-BB)-induced VSMCs proliferations. The regulation of apoptosis has attracted much attention as a possible means of eliminating excessively proliferating VSMCs. In the present study, the treatment of BV and melittin strongly induced apoptosis of VSMCs. I examined the effects on $NF-{\kappa}B$ activation to investigate a possible mechanism for anti-proliferative effects of BV and melittin, the PDGF-BB-induced $I{\kappa}B{\alpha}$ phosphorylation and its degradation were potently inhibited by melittin, and DNA binding activity and nuclear translocation of $NF-{\kappa}B$ p50 subunit in response to the action of PDGF-BB were potently attenuated by melittin. In further investigations, melittin markedly inhibited the PDGF-BB-induced phosphorylation of Akt but not ERK1/2, upstream signals of $NF-{\kappa}B$. Treatment of melittin also potently induced pro-apoptotic protein p53, Bax, and caspase-3 expression, but decreased anti-apoptotic protein Bcl-2 expression. These results suggest that the anti-proliferative effects of BV and melittin in VSMCs through induction of apoptosis via suppressions of $NF-{\kappa}B$ and Akt activation, and enhancement of apoptotic signal pathway. Based on these results, BV acupuncture can be a candidate as a therapeutic method for restenosis and atherosclerosis.