• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1419-1426
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• 2008

Fulminant hepatic failure is a clinical syndrome associated with a high mortality rate. Orthotopic liver transplantation is the only clinically proven effective treatment for patients with end-stage liver disease who do not respond to medical management. A major limitation of this treatment modality is the scarcity of donor organs available, resulting in patients dying while waiting for a donor liver. An extracorporeal bioartificial liver (BAL) device containing viable hepatocytes has the potential to provide temporary hepatic support to liver failure patients, serving as a bridge to transplantation while awaiting a suitable donor. In some patients, providing temporary hepatic support may be sufficient to allow adequate regeneration of the host liver, thereby eliminating the need for a liver transplant. Although the BAL device is a promising technology for the treatment of liver failure, there are several technical challenges that must be overcome in order to develop systems with sufficient processing capacity and of manageable size. In this overview, the authors describe the critical issues involved in developing a BAL device. They also discuss their experiences in hepatocyte culture optimization within the context of a microchannel flat-plate BAL device.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.05a
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• pp.413-416
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• 2012

The information technology such as personal computers and the internet has become a critical factor in forming a common and popular culture over the last few decades. Those technical inventions have transformed the educational environment. In the past, the only way to get an education was for students to attend schools or private institutions by themselves. In contrast, the internet enables people to learn from a distance by using cyber-education courses and many e-learning contents are provided. Based on those infrastructures, students can be educated in a convenient and flexible way without totally depending on attending school. The purpose of this paper is to examine what the effect of cyber-learning at home is, and to analyse what the problem is? Lastly, this paper also suggests measures to alleviate the adverse effects of it.

• Journal of Microbiology and Biotechnology
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• v.12 no.6
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• pp.878-881
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• 2002

The goal of the current research was to assess the influence of the growth rate of Nocardia amarae on its overall metal binding capacity. Batch sorption isotherms for cadmium (Cd), copper (Cu), and nickel (Ni) showed that Nocardia cells harvested from chemostat cultures at a dilution rate of $0.33d^-1$ had a significantly higher metal sorption capacity than cells grown at 0.5 and $1d^-1$. The cell surface area estimated using a dye technique indicated that pure N. amarae cells grown at a lower growth rate had a significantly more specific surface area than cells harvested from a higher growth rate operation. Accordingly, this difference in the specific surface area seemed to indicate that the higher metal sorption capacity of the slowly growing Nocardia cells was due to their higher specific surface area.

• Journal of the Korean Institute of Gas
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• v.10 no.2 s.31
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• pp.47-54
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• 2006

The immediate causes of accidents are often identified as human error or technical failure but the investigation and analysis of the circumstances surrounding major industrial accidents such as Three Mile Island, Chemobyl and Kings Cross have revealed issues beyond the immediate causes. These issues relate to wider considerations of the safety culture. The safety culture of an organization is very complex and hard to study, but it is possible to examine norms that make up the culture. This paper focuses on environmental attitudes and actions among managerial and non-managerial workers in high risk industry such as chemical industries. The main purpose is to get a better understanding of safety culture and to develop measuring tool by examining their nature and strength and by analysing underlying factors that offer explanations for attitudinal differences.

• Environmental and Resource Economics Review
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• v.26 no.2
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• pp.139-172
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• 2017

Nuclear safety measures such as safety technology, culture, and regulation affects nuclear performances. This paper analyzes the change of nuclear performance by considering nuclear safety measures. Nuclear performance and technical data ranging 1970 to 2015 are collected from the Power Reactor Information System (PRIS) of IAEA. The result of panel regression analysis shows that overall engineering level, maintenance engineering and productivity decrease the forced loss rate (FLR). FLR structurally increase after Chernobyl accident in 1986 whereas after TMI and Fukushima accidents FLR didn't show any significant changes. The structural increase of FLR after Chernobyl are likely to result from the efforts of international communities for nuclear safety culture which makes nuclear operating company pay more opportunity cost to achieve nuclear safety.

• International Journal of Advanced Culture Technology
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• v.3 no.1
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• pp.145-152
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• 2015

The article aims to apply a friction stir spot welding for producing the lap joint between AA5052 aluminum alloy and C11000 copper alloy. The dimension of the materials was 100 mm in length, 30 mm in width and 1.0 mm in thickness. The copper plate was set overlap the aluminum plate by 30 mm. The welding parameter was the rotating speed of 2500-4000 rpm, the pin inserting rate of 2-8 mm/min and the holding time of 6 sec. The mechanical properties test and the microstructure investigation were performed to evaluate the lap joint quality. The summarized results are as follows. The friction stir spot welding could produce effectively the lap joint between AA5052 and C11000 copper. Increase of the rotating speed and holding time directly affected to decrease the tensile shear strength of the lap joint. The optimized welding parameters in this study that indicated the tensile shear strength of 864 N was the rotating speed of 3500 rpm, the pin inserting rate of 6 mm/min and the holding time of 4sec. The experimental results also showed that the hardness of the weld metal was lower than that of the base materials.

• Biotechnology and Bioprocess Engineering:BBE
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• v.6 no.1
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• pp.25-30
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• 2001

Viral safety is a prerequisite for manufacturing clinical albumin and immunoglobulins from human plasma pools. This study was designed to evaluate the efficacy of cold ethanol fractionation and pasteurization (60$\^{C}$ heat treatment for 10h) for the removal/inactivation of human immunodeficiency virus type 1 (HIV-1) during the manufacturing of albumin and immunoglobulins. Samples from the relevant stages of the production process were spiked with HIV-1, and the amount of virus in each fraction was quantified by the 50% tissue culture infectious dose(TCID(sub)50). Both fraction IV fractionation and pasteurization steps during albumin processing were robust and effective in inactivating HIV-1, titers of which were reduced from an initial 8.5 log(sub)10 TCID(sub)50 to undetectable levels. The log reduction factors achieved were $\geq$ 4.5 and $\geq$ 6.5, respectively. In addition, fraction III fractionation and pasteurization during immunoglobulins processing were robust and effective in eliminating HIV-1. HIV-1 titers were reduced from an initial 7.3 log(sub)10 TCID(sub)50 to undetectable levels. The log reduction factors achieved in this case were $\geq$ 4.9 and $\geq$ 5.3, respectively. These results indicate that the process investigated for the production of albumin and immunoglobulins have sufficient HIV-1 reducing capacity to achieve a high margin of safety.

• Korean Journal of Food Science and Technology
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• v.20 no.4
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• pp.518-525
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• 1988

Lactobacillus casei IFO 3012 and Kluyveromyces fragilis(KFCC 35458) were cultured together in Soymilk to investigate the growth characteristics and the conditions suitable for acid Production. L. casei produced more amount of acid rapidly when cultured with K. fragilis in soymilk than when cultured singly. The optimum conditions for acid production by the mixed cultures of L. casei and K. fragilis were achieved with a temperature of $35-37^{\circ}C$, a 1:5-1:9(O.D 660) ratio of L. casei to K. fragilis at inoculum, a 1.0 level of sucrose fortification or a 2.0% level of skim milk powder fortification and a culture time of 24hr. Under these conditions the amounts of acid produced by the single culture of L. casei and the mixed cultures with K. fragilis were 0.31% and 0.44% in soymilk, 0.43% and 0.97%, respectively, in soymilk fortified with 1.0% level of sucrose. These indicate that the amount of acid produced by mixed cultures is about 1.42 fold greater in soymilk and about 2.26 fold greater in soymilk fortified with 1.0% level of sucrose than that produced by the single culture of L. casei. The amount of acid produced in soymilk fortified with 2.0% level of skim milk powder was 1.0 level for both of the single culture of L. casei and the mixed cultures of L. casei and K. fragilis after 24hr incubation. In soymilk fortified with skim milk power less than 1.5 the mixed culture with K. fragilis showed higher content of acid than the single culture of L. casei only.

• The Journal of the Convergence on Culture Technology
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• v.8 no.5
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• pp.631-639
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• 2022

Recently, the government is trying to change the paradigm of occupational safety by enforcing the entire revision of the Industrial Safety and Health Act and the Punishment of Serious Accidents Act with the goal of reducing the occupational accident and death rate by half. In particular, small-scale workplaces with less than 50 employees or less than 100 million won have difficulties in establishing a safety and health management system due to lack of safety and health management competency and lack of will of business owners. Therefore, this study attempted to identify problems and suggest improvement measures through an expert survey on the overall business area of the small business safety and health technology support project, which is one of the government's policies.

• International conference on construction engineering and project management
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• 2022.06a
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• pp.170-178
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• 2022

A high-performing Earned Value Management System (EVMS) can influence project success and help stakeholders meet project objectives. Although EVMS processes are well-supported by technical guidelines and standards, project managers often face challenges related to the project culture, team, resources, and business practices that make up the project environment within which an EVMS is being used. A comprehensive literature review revealed a lack of a data-driven and consistent assessment frameworks that can gauge the environment surrounding EVMS implementation. This paper will discuss the EVMS environment of construction and environmental projects, and examine its impact on cost performance. The authors used a multi-method approach to identify 27 environment factors that make up the EVMS environment, assessing them on 18 construction and environmental projects worth over $2 billion of total cost. Research methods employed include: (1) a literature review of more than 300 references; (2) a survey of 294 respondents; and (3) remote research charrettes with more than 60 participating expert practitioners. Culture (one of the identified environment categories) was found to be relatively more important in terms of its impact on the EVMS environment, followed by people, practices, and resources. These exploratory results show statistically significant differences in cost performance between completed projects with either a good or poor environment, for the sample projects. Key environment factors are outlined, and guidance is provided to practitioners around how to set up an effective EVMS environment in a construction or environmental project to inform decision-making and support achieving the project cost objectives successfully.