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Prevention of UV-induced Skin Damage by Activation of Tumor Suppressor Genes p53 and $p14^{ARF}$

  • Petersen, R.;John, S.;Lueder, M.;Borchert, S.
    • Proceedings of the SCSK Conference
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    • 2003.09a
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    • pp.338-351
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    • 2003
  • UV radiation is the most dangerous stress factor among permanent environmental impacts on human skin. Consequences of UV exposure are aberrant tissue architecture, alterations in skin cells including functional changes. Nowadays new kinds of outdoor leisure-time activities and changing environmental conditions make the question of sun protection more important than ever. It is necessary to recognize that self-confident consumers do not consider to change their way of life, they demand modern solutions on the basis of new scientific developments. In the past one fundamental principle of cosmetics was the use of physical and organic filter systems against damaging UV-rays. Today new research results demonstrate that natural protecting cell mechanisms can be activated. Suitable biological actives strongly support the protection function not from the surface but from the inside of the cell. A soy seed preparation (SSP) was proven to stimulate natural skin protective functions. The major functions are an increased energy level and the prevention of DNA damage. These functions can I be defined as biological UV protection. The tumor suppressor protein p53 plays a key role in the regulation of DNA repair. p53 must be transferred into the phosphorylated form to work as transcription factor for genes which are regulating the cell cycle or organizing DNA repair. A pretreatment with SSP increases the phosphorylation rate of p53 of chronically UV-irradiated human keratinocytes significantly. According to the same test procedure SSP induces a dramatic increase in the expression of the tumor suppressor protein p14$^{ARF}$ that is supporting the p53 activity by blocking the antagonist of p53, the oncoprotein Mdm2. Mdm2, a ubiquitin E3-ligase, downregulates p53 and at the same time it prevents phosphorylation of p53. The positive influence of the tumor suppressor proteins explains the stimulation of DNA repair and prevention of sunburn cell formation by SSP, which was proven in cell culture experiments. In vivo the increased skin tolerance against UV irradiation by SSP could be confirmed too. We have assumed, that an increased repair potential provides full cell functionality.y.

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Durability and Characteristics of Ag-Pd Rod Heater for Bidet Fabricated by Screen Printing Process (스크린 프린팅 공정에 의해 제조된 비데용 Ag-Pd 봉형 발열체의 내구성 및 물성 평가 )

  • Tae-Ung Park;Da-Eun Hyun;Ik-Soo Kim;Sung-Chul Lee;Yeon-Sook Lee;Yong-Nam Kim;Dong-Won Lee;Jong-Min Oh
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.36 no.1
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    • pp.81-87
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    • 2023
  • Heaters using the resistance heating principle are used in various industrial fields that require heat and are also essentially used in bidet among small home appliances. A planar heater and a coil-inserted heater mounted on a conventional commercially used bidet have disadvantages and limitations of complicated manufacturing process and local heating. In this study, silver-palladium (Ag-Pd) powder material was used for a screen-printing process that is more advantageous in achieving simplification than the existing process, and a rod-type heater for bidet was manufactured. The on-off cycle test under actual conditions was conducted to confirm the durability and the capability of the fabricated heater, and the fabricated heater operated more than 2,600 on-off cycles, which means it could be applied for a commercial product. In addition, through the on-off cycles under harsh conditions, the cause of failure was identified after the test that the durability limit temperature of the heater was 850℃. Through Ag-Pd rod heater in this study, it is expected to contribute to the efficient development of electrode materials for heaters and the improvement of the durability of heaters in the future.

A study on the implementing the Movement of <Life Nurturing Method and Conduction Exercise(養生方導引法)> of 《Pathogenesis and Manifestations of Food Stagnation and Indigestion(宿食不消病諸候)》 in 『Treatise on the Pathogenesis and Manifestations of All Diseases(諸病源候論)』 (『제병원후론(諸病源候論)』 《숙식불소병제후(宿食不消病諸候)》에서 <양생방도인법(養生方導引法)>의 동작(動作) 구현(具顯)에 관한 고찰)

  • Kyung-Hoon, Song;Gyeong-Cheol, Kim;Hai-Woong, Lee
    • Journal of Society of Preventive Korean Medicine
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    • v.26 no.3
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    • pp.87-96
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    • 2022
  • Objective : We examined the literature of <Life Nurturing Method and Conduction Exercise(養生方導引法)> of 《Pathogenesis and Manifestations of Food Stagnation and Indigestion(宿食不消病諸候)》 in 『Treatise on the Pathogenesis and Manifestations of All Diseases(諸病源候論)』 and actually implement its movement to present conduction exercise based on the principle of Korean medicine treatment. Method : We used web services for traditional Eastern Asian medical classics and some literature on 『Treatise on the Pathogenesis and Manifestations of All Diseases(諸病源候論)』 and its <Life Nurturing Method and Conduction Exercise(養生方導引法)〉. The original text was interpreted and the movements of <Life Nurturing Method and Conduction Exercise> were implemented according to the literature. A qi-gong(氣功) expert demonstrated the movements and we took pictures. Results : <Life Nurturing Method and Conduction Exercise(養生方導引法)> was written in the symptom of Food Stagnation and Indigestion(宿食不消候) and the symptom of food damage and excessive eating(食傷飽候) among the chapters of 《Pathogenesis and Manifestations of Food Stagnation and Indigestion(宿食不消病諸候)》. With respect to the movements and breathing, stretching your back allows qi(氣) energy to enter the lower cinnabar field(下丹田) immediately, and when the lower stomach is full of qi it can be transported upper body, leading to better communication of qi around the body. Conclusion : The practical implementation of the movements and postures will contribute to understanding the characteristics, pathology, and contents of diseases related to indigestion, and furthermore it can be widely used clinically for prevention and treatment of digestive disorders.

Formulation and evaluation a finite element model for free vibration and buckling behaviours of functionally graded porous (FGP) beams

  • Abdelhak Mesbah;Zakaria Belabed;Khaled Amara;Abdelouahed Tounsi;Abdelmoumen A. Bousahla;Fouad Bourada
    • Structural Engineering and Mechanics
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    • v.86 no.3
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    • pp.291-309
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    • 2023
  • This paper addresses the finite element modeling of functionally graded porous (FGP) beams for free vibration and buckling behaviour cases. The formulated finite element is based on simple and efficient higher order shear deformation theory. The key feature of this formulation is that it deals with Euler-Bernoulli beam theory with only three unknowns without requiring any shear correction factor. In fact, the presented two-noded beam element has three degrees of freedom per node, and the discrete model guarantees the interelement continuity by using both C0 and C1 continuities for the displacement field and its first derivative shape functions, respectively. The weak form of the governing equations is obtained from the Hamilton principle of FGP beams to generate the elementary stiffness, geometric, and mass matrices. By deploying the isoparametric coordinate system, the derived elementary matrices are computed using the Gauss quadrature rule. To overcome the shear-locking phenomenon, the reduced integration technique is used for the shear strain energy. Furthermore, the effect of porosity distribution patterns on the free vibration and buckling behaviours of porous functionally graded beams in various parameters is investigated. The obtained results extend and improve those predicted previously by alternative existing theories, in which significant parameters such as material distribution, geometrical configuration, boundary conditions, and porosity distributions are considered and discussed in detailed numerical comparisons. Determining the impacts of these parameters on natural frequencies and critical buckling loads play an essential role in the manufacturing process of such materials and their related mechanical modeling in aerospace, nuclear, civil, and other structures.

Resonance analysis of cantilever porous graphene platelet reinforced pipe under external load

  • Huang, Qinghua;Yu, Xinping;Lv, Jun;Zhou, Jilie;Elvenia, Marischa Ray
    • Steel and Composite Structures
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    • v.45 no.3
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    • pp.409-423
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    • 2022
  • Nowadays, there is a high demand for great structural implementation and multifunctionality with excellent mechanical properties. The porous structures reinforced by graphene platelets (GPLs) having valuable properties, such as heat resistance, lightweight, and excellent energy absorption, have been considerably used in different engineering implementations. However, stiffness of porous structures reduces significantly, due to the internal cavities, by adding GPLs into porous medium, effective mechanical properties of the porous structure considerably enhance. This paper is relating to vibration analysis of fluidconveying cantilever porous graphene platelet reinforced (GPLR) pipe with fractional viscoelastic model resting on foundations. A dynamical model of cantilever porous GPLR pipes conveying fluid and resting on a foundation is proposed, and the vibration, natural frequencies and primary resonant of such a system are explored. The pipe body is considered to be composed of GPLR viscoelastic polymeric pipe with porosity in which Halpin-Tsai scheme in conjunction with the fractional viscoelastic model is used to govern the construction relation of nanocomposite pipe. Three different porosity distributions through the pipe thickness are introduced. The harmonic concentrated force is also applied to the pipe and the excitation frequency is close to the first natural frequency. The governing equation for transverse motions of the pipe is derived by the Hamilton principle and then discretized by the Galerkin procedure. In order to obtain the frequency-response equation, the differential equation is solved with the assumption of small displacement, damping coefficient, and excitation amplitude by the multiple scale method. A parametric sensitivity analysis is carried out to reveal the influence of different parameters, such as nanocomposite pipe properties, fluid velocity and nonlinear viscoelastic foundation coefficients, on the primary resonance and linear natural frequency. Results indicate that the GPLs weight fraction porosity coefficient, fractional derivative order and the retardation time have substantial influences on the dynamic response of the system.

On the effect of porosity on the shear correction factors of functionally graded porous beams

  • Ben Abdallah Medjdoubi;Mohammed Sid Ahmed Houari;Mohamed Sadoun;Aicha Bessaim;Ahmed Amine Daikh;Mohamed-Ouejdi Belarbi;Abdelhak Khechai;Aman Garg;Mofareh Hassan Ghazwani
    • Coupled systems mechanics
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    • v.12 no.3
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    • pp.199-220
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    • 2023
  • This article presents a new analytical model to study the effect of porosity on the shear correction factors (SCFs) of functionally graded porous beams (FGPB). For this analysis, uneven and logarithmic-uneven porosity functions are adopted to be distributed through the thickness of the FGP beams. Critical to the application of this theory is a determination of the correction factor, which appears as a coefficient in the expression for the transverse shear stress resultant; to compensate for the assumption that the shear strain is uniform through the depth of the cross-section. Using the energy equivalence principle, a general expression is derived from the static SCFs in FGPB. The resulting expression is consistent with the variationally derived results of Reissner's analysis when the latter are reduced from the two-dimensional case (plate) to the one-dimensional one (beam). A convenient algebraic form of the solution is presented and new study cases are given to illustrate the applicability of the present formulation. Numerical results are presented to illustrate the effect of the porosity distribution on the (SCFs) for various FGPBs. Further, the law of changing the mechanical properties of FG beams without porosity and the SCFare numerically validated by comparison with some available results.

Mechanical and thermal stability investigation of functionally graded plates resting on visco-Pasternak foundation

  • Samira Hassiba Tagrara;Mohamed Mehdi hamri;Mahmoud Mohamed Selim Saleh;Mofareh Hassan Ghazwani;Abdelbaki Chikh;Abdelmoumen Anis Bousahla;Abdelhakim Kaci;Fouad Bourada;Abdelouahed Tounsi
    • Steel and Composite Structures
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    • v.46 no.6
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    • pp.839-856
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    • 2023
  • This work presents a simple four-unknown refined integral plate theory for mechanical and thermal buckling behaviors of functionally graded (FG) plates resting on Visco-Pasternak foundations. The proposed refined high order shear deformation theory has a new displacement field which includes indeterminate integral variables and contains only four unknowns in which any shear correction factor not used, with even less than the conventional theory of first shear strain (FSDT). Governing equations are deduced from the principle of minimum total potential energy and a Navier type analytical solution is adopted for simply supported FG plates. The Visco-Pasternak foundations is considered by adding the impact of damping to the usual foundation model which characterized by the linear Winkler's modulus and Pasternak's foundation modulus. The accuracy of the present model is demonstrated by comparing the computed results with those available in the literature. Some numerical results are presented to show the impact of material index, elastic foundation type, and damping coefficient of the foundation, on the mechanical and thermal buckling behaviors of FG plates.

An integral quasi-3D computational model for the hygro-thermal wave propagation of imperfect FGM sandwich plates

  • Abdelouahed Tounsi;Saeed I. Tahir;Mohammed A. Al-Osta;Trinh Do-Van;Fouad Bourada;Abdelmoumen Anis Bousahla;Abdeldjebbar Tounsi
    • Computers and Concrete
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    • v.32 no.1
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    • pp.61-74
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    • 2023
  • This article investigates the wave propagation analysis of the imperfect functionally graded (FG) sandwich plates based on a novel simple four-variable integral quasi-3D higher-order shear deformation theory (HSDT). The thickness stretching effect is considered in the transverse displacement component. The presented formulation ensures a parabolic variation of the transverse shear stresses with zero-stresses at the top and the bottom surfaces without requiring any shear correction factors. The studied sandwich plates can be used in several sectors as areas of aircraft, construction, naval/marine, aerospace and wind energy systems, the sandwich structure is composed from three layers (two FG face sheets and isotropic core). The material properties in the FG faces sheet are computed according to a modified power law function with considering the porosity which may appear during the manufacturing process in the form of micro-voids in the layer body. The Hamilton principle is utilized to determine the four governing differential equations for wave propagation in FG plates which is reduced in terms of computation time and cost compared to the other conventional quasi-3D models. An eigenvalue equation is formulated for the analytical solution using a generalized displacements' solution form for wave propagation. The effects of porosity, temperature, moisture concentration, core thickness, and the material exponent on the plates' dispersion relations are examined by considering the thickness stretching influence.

Enhancement of High-Temperature Catalytic Reactions Using Membranes (분리막을 이용한 고온 촉매 반응 효율 향상)

  • Eun-Young Kim;Myeong-Hun Hyeon;Su-Young Moon
    • Membrane Journal
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    • v.33 no.6
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    • pp.305-314
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    • 2023
  • Various methods for removing by-products from chemical reactions are being studied to improve yield of catalytic reaction. Since the water is predominantly generated as a by-product in industrially significant reactions, it is necessary to develop the technology that can reliably remove water over a wide range of temperatures. Although several strategies using absorbents and additional dehydration reactions, have been proposed, they have limitations due to the issues such as additional energy and time consuming steps and sustainability of conversion. Membrane technology, which offers advantages such as easy operation, installation, and low maintenance costs, proves to be a promising approach for enhancing the efficiency of catalysts in various catalytic reactions. Therefore, this review discusses the removal of by-products using membranes and the associated benefits in this context.

Free and forced vibration analysis of FG-CNTRC viscoelastic plate using high shear deformation theory

  • Mehmet Bugra Ozbey;Yavuz Cetin Cuma;Ibrahim Ozgur Deneme;Faruk Firat Calim
    • Advances in nano research
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    • v.16 no.4
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    • pp.413-426
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    • 2024
  • This paper investigates the dynamic behavior of a simply supported viscoelastic plate made of functionally graded carbon nanotube reinforced composite under dynamic loading. Carbon nanotubes are distributed in 5 different shapes: U, V, A, O and X, depending on the shape they form through the thickness of the plate. The displacement fields are derived in the Laplace domain using a higher-order shear deformation theory. Equations of motion are obtained through the application of the energy method and Hamilton's principle. The resulting equations of motion are solved using Navier's method. Transforming the Laplace domain displacements into the time domain involves Durbin's modified inverse Laplace transform. To validate the accuracy of the developed algorithm, a free vibration analysis is conducted for simply supported plate made of functionally graded carbon nanotube reinforced composite and compared against existing literature. Subsequently, a parametric forced vibration analysis considers the influence of various parameters: volume fractions of carbon nanotubes, their distributions, and ratios of instantaneous value to retardation time in the relaxation function, using a linear standard viscoelastic model. In the forced vibration analysis, the dynamic distributed load applied to functionally graded carbon nanotube reinforced composite viscoelastic plate is obtained in terms of double trigonometric series. The study culminates in an examination of maximum displacement, exploring the effects of different carbon nanotube distributions, volume fractions, and ratios of instantaneous value to retardation times in the relaxation function on the amplitudes of maximum displacements.