• Journal of Nutrition and Health
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• 제35권8호
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• pp.825-833
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• 2002

The effects of dietary supplementation of Eleutherococcus senticosus, taurine and carnitine on maximal endurance exercise performance along with other related parameters were evaluated in rats that underwent aerobic exercise training for 6 weeks. Thirty-two male rats (4 weeks old) were randomly divided into 4 groups, and fed experimental diets and/or aerobic exercise trained according to the protocol: SC (sedentary control group), EC (exercise-trained control group), EE (exercise-trained Eleutherococcus senticosus-supplemented group), and EETC (exercise-trained Eleutherococcus senticosus, taurine and carnitine-supplemented group). The food efficiency ratio of EC rats was significantly lower than the value for SC rats (p < 0.01). Exercise-trained control animals (92 $\pm$ 8.8 min) could run significantly longer until exhausted on the treadmill than sedentary control rats (11 $\pm$ 0.8 min) (p < 0.001). Animals fed an Eleutherococcus senticosus-supplemented diet, and an Eleuthherococcus sonticosus, taurine and carnitine- supplemented diet while undergoing aerobic exercise training for 6 weeks exhibited, respectively, 8 and 5 minutes longer running performance until exhausted than the rats fed the control diet. The gastrocnemius muscle glycogen concentration of the rats, measured at 48 hours post maximal exercise performance test, was 43% higher in EC rats than the value for SC rats (p < 0.05), but was not different among EC, EE, and EETC rats. The mitochondrial citrate synthase activity of the soleus muscle was significantly higher in EC rats compared to the value for SC rats (p < 0.01), and showed a tendency to increase, without statistical significance, in EE or EETC rats compared to the value for EC rats. These results indicate that aerobic exercise training for 6 weeks significantly improved maximal exercise performance, muscle glycogen content along with citrate synthase activity, which are important in the energy metabolism of muscle under aerobic exercise. Dietary supplementation of Eleutherococcus senticosus in rats while undergoing aerobic exercise training improved maximal endurance exercise performance without significantly affecting muscle glycogen content and enzyme activities involved in energy metabolism during exercise. Taurine and carnitine supplementation failed to show an additive effect on maximal endurance exercise performance when consumed along with Eleutherococcus senticosus.

• Molecules and Cells
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• 제27권5호
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• pp.557-562
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• 2009

We examined the effects of the NADPH oxidase p22phox C242T polymorphism on endurance exercise performance and oxidative DNA damage in response to acute and chronic exercises. One hundred three subjects were recruited, among which 26 healthy subjects (CC: 12, TC: 12, and TT: 2) were studied during rest, exercise at 85% $VO_2max$, and recovery before and after 8 weeks of treadmill running. Lymphocyte DNA damage increased significantly in response to exercise (p < 0.05). There were no significant differences in plasma MDA, SOD concentrations and lymphocyte DNA damage between CC genotype and T allele group, but significant endurance training differences were observed. Endurance training increased exercise time to exhaustion in both the CC genotype and T allele groups (p < 0.05) but no significant difference was found between groups. The results of the current study with young, healthy, Korean men are interpreted to mean that 1) the majority had the CC genotype of the NADPH oxidase p22phox C242T polymorphism (82.5%: CC, 15.5%: TC, 1.9%: TT), 2) acute exercise increased lymphocyte DNA damage, 3) endurance training significantly increased exercise time to exhaustion, and alleviated lymphocyte DNA damage, and 4) The NADPH oxidase p22phox C242T polymorphism, however, did not alter lymphocyte DNA damage or exercise performance at rest, immediately after exercise, or during recovery.

• The Journal of Korean Physical Therapy
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• 제23권3호
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• pp.57-63
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• 2011

Purpose: The purposes of this study were to investigate the effectiveness of Pilates exercise on Fitness Factors related to motor performance including flexibility, agility, power, balance, and muscle endurance. Methods: Forty subjects were randomly allocated to one of two groups. The Pilates group did Pilates exercises 3 times a week for 8weeks, 60 minutes each time, and submitted to evaluation of protocols to assess sitting and reaching tests, a standing broad jump test, a side step test, a balance test using a Biodex Stability System, and muscle endurance using CSMI. Results: The Pilates group (n=20) participated in Pilates exercises three times in a week for eight weeks. The results show significant post-test differences in the Pilates group in the following areas: flexibility, agility, power, balance and muscle endurance. There was no significant increase in the control group. Post-exercise, there was no significant difference between the Pilates and control group. Conclusion: The Pilates method can offer significant improvement in personal flexibility, agility, power, balance, and muscle endurance. This study suggests that individuals can improve their Fitness Factors related to motor performance using Pilates exercises that do not require equipment or a high degree of skill. Further study is required to quantify the benefits of Pilates exercise.

• 대한임상전기생리학회지
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• 제10권1호
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• pp.39-44
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• 2012

Purpose : This study purposed to analyze how dynamic stabilization exercise on an unstable surface, and static stabilization exercise on muscle strength and endurance. Methods : For this study we sampled 9 people for the unstable surface dynamic stabilization exercise group, 9 for the stable surface static stabilization exercise group, and 9 for the control group. In order to examine muscle strength and endurance, we measured changes in the maximal voluntary isometric contraction (MVIC) using a dynamometer before, 3 weeks after, and 6 weeks after the experiment. Results : First, with regard to change in muscle strength, flexion strength showed a significant change in interaction by time (p<0.05). Extension strength showed a significant change in interaction by time (p<0.05). Second, with regard to change in endurance, flexion endurance showed a significant change in interaction by time (p<0.05). Extension endurance showed a significant change in interaction by time (p<0.05). Conclusion : In conclusion, this study confirmed significant changes in interaction between the groups and by time with regard to changes in muscle strength and endurance. These results suggest the potential of surface dynamic stabilization exercise as a clinical intervention.

• 운동영양학회지
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• 제25권2호
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• pp.15-19
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• 2021

[Purpose] Skeletal muscle glycogen is a determinant of endurance capacity for some athletes. Ginger is well known to possess nutritional effects, such as anti-diabetic effects. We hypothesized that ginger extract (GE) ingestion increases skeletal muscle glycogen by enhancing fat oxidation. Thus, we investigated the effect of GE ingestion on exercise capacity, skeletal muscle glycogen, and certain blood metabolites in exercised rats. [Methods] First, we evaluated the influence of GE ingestion on body weight and elevation of exercise performance in rats fed with different volumes of GE. Next, we measured the skeletal muscle glycogen content and free fatty acid (FFA) levels in GE-fed rats. Finally, we demonstrated that GE ingestion contributes to endurance capacity during intermittent exercise to exhaustion. [Results] We confirmed that GE ingestion increased exercise performance (p<0.05) and elevated the skeletal muscle glycogen content compared to the nonGE-fed (CE, control exercise) group before exercise (Soleus: p<0.01, Plantaris: p<0.01, Gastrocnemius: p<0.05). Blood FFA levels in the GE group were significantly higher than those in the CE group after exercise (p<0.05). Moreover, we demonstrated that exercise capacity was maintained in the CE group during intermittent exercise (p<0.05). [Conclusion] These findings indicate that GE ingestion increases skeletal muscle glycogen content and exercise performance through the upregulation of fat oxidation.

• BMB Reports
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• 제56권6호
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• pp.353-358
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• 2023

In the present study, to determine the efficacy of oral supplementation of ginseng berry extracts in augmenting exercise performance and exercise-associated metabolism, male mice were given orally 200 and 400 mg/kg of body weight (BW) of GBC for nine weeks. Although there are no differences in pre-exercise blood lactate levels among (1) the control group that received neither exercise nor GBC, (2) the group that performed only twice-weekly endurance exercise, and (3) and (4) the groups that combined twice-weekly endurance exercise with either 200 or 400 mg/kg GBC, statistically significant reductions in post-exercise blood lactate levels were observed in the groups that combined twice-weekly endurance exercise with oral administration of either 200 or 400 mg/kg GBC. Histological analysis showed no muscle hypertrophy, but transcriptome analysis revealed changes in gene sets related to lactate metabolism and mitochondrial function. GBC intake increased nicotinamide adenine dinucleotide levels in the gastrocnemius, possibly enhancing the mitochondrial electron transport system and lactate metabolism. Further molecular mechanisms are needed to confirm this hypothesis.

• 대한물리의학회지
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• 제16권2호
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• pp.101-113
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• 2021

PURPOSE: The purpose of this study was to investigate the differences and correlation between body composition, exercise performance, and behavior based on playing football in childhood. METHODS: 16 subjects who played football in childhood participated in the study. Body composition and exercise performance were measured, and problem behavior was assessed for each of them. All subjects were asked to play football 50 min/day, one day/week for 8-weeks. RESULTS: Muscle mass, muscular strength, balance, and cardiopulmonary endurance, anxiety depression, atrophy depression, attention problems, rule violations, DSM somatization problems, DSM rebellious behavior problems, and sociality significantly increased after 8-weeks. There was a negative (-) correlation between anxiety depression and atrophy depression, and DSM somatization problem and muscular strength, attention problem and balance, and rule violation and cardiopulmonary endurance, after playing football. CONCLUSION: These results confirmed that playing football in childhood had a positive effect on body composition, and that exercise performance and problem behavior were related.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2008년도 제49회 학술심포지움 및 국제학술대회
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• pp.37.2-37.2
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• 2008

• 생명과학회지
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• 제27권3호
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• pp.361-369
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• 2017

미토콘드리아의 항상성은 미토콘드리아 생합성과 마이토파지(자가포식에 의한 미토콘드리아 분해)로 불리는 2가지 주요 과정들에 의해 정교하게 조절되고 있다. 지구성 운동 훈련에 반응하여 골격근에서 미토콘드리아 생합성에 관한 기전들은 잘 정립되어 있는 반면 지구성 운동 훈련 후 골격근의 마이토파지 조절 기전과 마이토파지와 미토콘드리아 생합성의 협응을 조절하는 기전은 아직 명확히 밝혀져 있지 않다. 최근 연구들에 의하면 지구성 운동 훈련은 골격근에서 미토콘드리아 생합성, 미토콘드리아 역동성, 미토콘드리아 분해와 관련된 유전인자들의 발현을 증가시킨다고 하였다. 하지만 골격근에서 자가포식이 억제되었을 경우, 지구성 운동 훈련에 의한 미토콘드리아 생합성과 관련된 지표들인 Cox IV와 citrate synthase의 증가는 상쇄되었다. 따라서 자가포식과 마이토파지는 골격근의 미토콘드리아 생합성에 중요한 역할을 하며 정반대되는 이 두 과정(이화 또는 동화작용)의 협응 과정이 지구성 운동 훈련에 반응하여 대사적 기능과 지구력 운동 수행능력을 향상시키는 것과 같은 골격근의 적응에 중요한 듯하다. 지구성 운동은 미토콘드리아의 일정한 숫자를 유지시키기 위해 미토콘드리아 생합성, 미토콘드리아의 융합과 분열, 자가포식/마이토 파지들의 각각의 과정들을 조절하는 것으로 여겨진다. 지구성 운동 훈련은 골격근에서 마이토파지를 활성화시켜 미토콘드리아 양과 질을 조절하여 늙고 건강하지 않은 미토콘드리아를 젊고 건강한 미토콘드리아로 교체시킬 수 있다. 이 총론에서 미토콘드리아 생합성과 마이토파지의 분자학적 기전과 서로 상반되는 이 두 과정간의 협응이 골격근의 지구성 훈련에 대한 세포적 적응에 관련한다는 내용이 논의될 것이다.

• Journal of Nutrition and Health
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• 제36권7호
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• pp.711-719
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• 2003

본 연구에서는 운동선수에 버금하는 VO$_2$max를 지닌 남자대학생을 대상으로 타우린 (4 g/day), 카르니틴 (4 g/day), 글루타민 (4 g/day), 또는 위약을 2주간 복용시킨 후 지구력운동 수행능력 및 혈중 피로요소와 관련하여 다음과 같은 결론을 얻었다. 1) VO$_2$max의 75% 강도에서 탈진 시까지의 운동지속시간은 타우린복용군의 경우 85.2$\pm$4.3분으로 복용 전에 비해 6.9분 증가하였으며, 카르니틴복용군의 경우 92.5 $\pm$ 21.1분으로 복용 전에 비해 9.0분 증가하였다. 한편, 글루타민복용군에서는 복용 전에 비해 운동지속시간이 오히려 2.7분 단축된 것으로 나타났다. 2) 운동수행 1시간 후, 그리고 탈진상태에서 채취된 혈액의 젖산농도는 타우린, 카르니틴 또는 글루타민 복용시 복용 전에 비해 감소하는 경향을 보였으며, 특히 카르니틴 복용은 탈진상태의 혈중 젖산농도를 복용 전에 비해 43% 유의하게 감소시켰다 (p < 0.05) 3) 타우린, 카르니틴 또는 글루타민을 복용시킨 결과 안정 시, 운동수행 1시간 후, 탈진 시 및 회복기 혈청 무기인산염 농도가 복용 전에 비해 더 낮은 경향을 보였다. 특히 타우린 복용군의 경우 탈진상태의 혈청 무기인산염 농도가 복용 전에 비해 14% 유의하게 감소하였고 (p < 0.05), 카르니틴 복용군의 경우 안정 시 혈청 무기인산염 농도가 복용 전에 비해 20% 유의하게 감소하였다 (p < 0.05). 4) 타우린 복용군 또는 카르니틴 복용군의 경우 탈진상태에서 측정된 혈청 암모니아농도가 복용 전에 비해 각기 32% 및 23% 유의적으로 감소하였으나 (p <0.05), 글루타민 복용군의 경우에는 복용 전에 비해 혈청 암모니아 농도가 오히려 다소 증가하는 경향을 보였다. 이상의 결과로부터 타우린 또는 카르니틴 복용은 지구력운동 수행능력을 향상시키고, 혈 중 피로요소 농도를 개선하는 효과가 있음을 알 수 있다.