• 제목/요약/키워드: endocrine

검색결과 1,567건 처리시간 0.039초

Clinicopathological characteristics of extrahepatic biliary neuroendocrine neoplasms in the gallbladder, extrahepatic biliary tract, and ampulla of Vater: A single-center cross-sectional study

  • Young Mok Park;Hyung Il Seo;Byeong Gwan Noh;Suk Kim;Seung Baek Hong;Nam Kyung Lee;Dong Uk Kim;Sung Yong Han
    • 한국간담췌외과학회지
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    • 제27권4호
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    • pp.380-387
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    • 2023

  • Backgrounds/Aims: In 2019, the grading and staging system for neuroendocrine neoplasms (NENs) was significantly changed. In this study, we report the clinicopathological characteristics and surgical outcomes of patients with extrahepatic biliary NENs who underwent curative resection with or without adjuvant treatment. Methods: We retrospectively reviewed a database of 16 patients who developed NENs, neuroendocrine carcinoma (NEC), and mixed endocrine non-endocrine neoplasms (MiNENs) after curative resection. Among them, eight patients had ampulla of Vater (AoV) tumors, and eight patients had non-AoV tumors. Results: G1 and G2 were more frequently observed in the AoV group than in the non-AoV group (12.5% and 62.5%, respectively). In contrast, NEC and MiNEN were more common in the non-AoV group (50.0%). High Ki-67 index (> 20%) and perineural invasion (PNI) were more frequently observed in the non-AoV group. Advanced age (> 65 years), mitotic count > 20 per 2 mm2, and Ki-67 index > 20% were strongly correlated with patient survival (p = 0.018, 0.009, and 0.044, respectively). Advanced age (> 65 years) and mitotic count > 20 per 2 mm2 were significantly correlated with disease recurrence (p = 0.033 and 0.010, respectively). Conclusions: AoV and non-AoV tumors had significant differences in the histologic grade, Ki67, and PNI. Patients with non-AoV tumors had an increased risk for survival and recurrence than those in the AoV group. For extrahepatic biliary NENs, early detection of tumors, adequate surgery, and aggressive adjuvant treatment for high-risk patients are important to achieve long-term survival and prevent disease recurrence.

  • https://doi.org/10.14701/ahbps.23-045 인용 PDF

Endocrine Disrupters

  • Lee Jung Ran;Choi Jeongeun;Jin Chang Bae;Choi Myung Ja
    • 한국식품위생안전성학회:학술대회논문집
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    • 한국식품위생안전성학회 2001년도 The Asia-Pacific Conference on Reproductive Biology and Environmental Sciences
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    • pp.155-155
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    • 2001

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Studies of the Endocrine Disruption in Wildlife Fish

  • Jamin Koo;Jisung Ryu;Kuhyuck Chung;Lee, Chulwoo;Park, Kwangsik
    • 한국환경독성학회:학술대회논문집
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    • 한국환경독성학회 2001년도 추계심포지움 및 학술발표회:환경오염의 생체지표를 이용한 위해성 평가의 최근 기법
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    • pp.106-106
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    • 2001

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