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ANTI-INFLAMMATORY EFFECTS OF PPARγ ON HUMAN DENTAL PULP CELLS (치수세포에서 PPARγ의 항 염증작용에 관한 연구)

  • Kim, Jeong-Hee
    • Restorative Dentistry and Endodontics
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    • v.31 no.3
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    • pp.203-214
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    • 2006
  • Dental pulp is a loose, mesenchymal tissue almost entirely enclosed in the dentin. It consists of cells, ground substance, and neural and vascular supplies. Damage to the dental pulp by mechanical, chemical, thermal, and microbial irritants can provoke various types of inflammatory response. Pulpal inflammation leads to the tissue degradation, which is mediated in part by Matrix metalloproteinase leads to accelerate extracellular matrix degradation with pathological pathway We have now investigated the induction of MMPs and inflammatory cytokines by Lipopolysaccharide (LPS) control of inflammatory mediators by peroxisome proliferator-activated receptors (PPARs). Human dental pulp cells exposed to various concentrations of LPS ($1-10{\mu}g/ml$) revealed elevated levels of MMP-2 and MMP-9 at 24 hrs of culture. LPS also stimulated the production of ICAM-1, VCAM-1, $IL-1{\beta},\;and\;TNF-{\alpha}$. Adenovirus $PPAR{\gamma}\;(Ad/PPAR{\gamma})\;and\;PPAR{\gamma}$ agonist rosiglitazone reduced the synthesis of MMPs, adhesion molecules and pro-inflammatory cytokines. The inhibitory effect of $Ad/PPAR{\gamma}$ was higher than that of $PPAR{\gamma}$ agonist. These result offer new insights in regard to the anti-inflammatory potential of $PPAR{\gamma}$ in human dental pulp cell.

Risk Perception and Correlates of Tobacco Use among Young People Outside of Formal School Settings in Lagos State, Nigeria

  • Odukoya, OO;Dada, MR;Olubodun, T;Igwilo, UA;Ayo-Yusuf, OA
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.6
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    • pp.2833-2839
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    • 2016
  • Background: Tobacco use among youth is a major public health problem. Youth outside of formal school settings are often understudied but may be at increased risk. Materials and Methods: A descriptive cross-sectional study was carried out among 326 young people aged 15-24 years in four randomly selected motor parks in Lagos state. Interviewer-administered questionnaires were used to collect data. Results: The mean age of the respondents was $21.0{\pm}2.3yrs$. Many 252 (77.3%) dropped out before the end of the third year of secondary schooling. The majority were aware that active (78.2%), and passive smoking (77.3%) are harmful to health. Nearly two-thirds of the respondents disagreed with an outright ban of cigarettes (63.2%) and restriction of cigarette sales to persons below 18 years (67.9%) while 254 (66.8%) supported a ban on tobacco smoking in enclosed public places. One hundred and fifty (46.0%) respondents had experimented with smoking of which 106 (32.5%) had progressed to become current smokers. Half of the current smokers, 54 (50.9%), felt the need for a cigarette first thing in the morning. A multivariate analysis for smoking initiation, showed that for every increasing year of age, respondents were 1.08 times more likely to have initiated cigarette smoking; males and respondents who lived alone or with peers were 2.34 times and 1.77 times more likely to have initiated smoking respectively; those who consume alcohol and marijuana were 7.27 and 1.89 times respectively more likely to have initiated smoking while those who consumed alcohol were 6.17 times more likely to be current smokers.

Measurement and Analysis of X-ray Absorbed Dose in Water Phantom using TLD (TLD를 이용한 X-선 수중 흡수선량 측정 및 해석)

  • Oh, Jang-Jin;Jun, Jae-Shik;Hah, Suck-Ho;Kim, Wuon-Shik;Hwang, Sun-Tae
    • Journal of Radiation Protection and Research
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    • v.13 no.2
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    • pp.21-28
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    • 1988
  • Absorbed dose in water was analyzed by Burlin's general cavity theory for medium X-ray energy region (HVL : 0.29, 0.84, 1.60, 2.62mm Cu) using LiF : PTFE TL dosimeter(0.4 mm ${\times}\;{\phi}$ 12.5mm, hot-pressed LiF TLD-700) which was enclosed in lucite capsule. The absorbed dose rate at 5cm depth in water phantom was determined with measurement error of ${\pm}5%$. This result was compared to that of the ionization method, indirectly absolute measurement method, of which measurement error of ${\pm}2%$. The difference between these two results lies within measurement error of LiF : PTFE method. Therefore, the absorbed dose in water obtained by LiF: PTFE is reliable, and this result suggests the base to estimate dose-equivalent for medium X-rays.

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Injury Symptoms of Orchids by Sulfur dioxide Gases in Greenhouse (시설내 아황산가스에 의한 난의 피해 증상)

  • Lee, Young-Ran;Choi, Seong-Youl;Kwon, Oh-Keun;Huh, Eun-Joo
    • FLOWER RESEARCH JOURNAL
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    • v.17 no.4
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    • pp.237-241
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    • 2009
  • This study was conducted to determine injury symptoms of orchids by sulfur dioxide gases, three orchid plants (Phalaenopsis, Cymbidium, Oncidium) were exposed to sulfur dioxide gas in an enclosed growth chambers. Sulfur dioxide gases treatments consist of five different concentrations (0, 5, 10 25, and 50 ppm) and plant exposure of 18 hours with $25{\pm}5^{\circ}C$ air temperature and $50{\pm}5%$ relative humidity. SPAD values for chlorophyll content and percent leaf injury as well as leaf ion exudation were measured before and after the gas treatments. Phalaenopsis leaves showed 23.3% leaf injury at 10 ppm sulfur dioxide gas, whereas Cymbidium and Oncidium showed 4.0 and 4.4% leaf injury under 25 ppm or less, respectively. Major leaf injury symptoms appeared as initial water-soaking under side of the leaf, followed by rapidly progressed complete leaf discolorization or chlorosis. As the gas concentration increased, the SPAD value decreased while ion exudation increased. Cymbidium and Oncidium were resistant to sulfur dioxide gas than Phalaenopsis.

Optimal wind-induced load combinations for structural design of tall buildings

  • Chan, C.M.;Ding, F.;Tse, K.T.;Huang, M.F.;Shum, K.M.;Kwok, K.C.S.
    • Wind and Structures
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    • v.29 no.5
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    • pp.323-337
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    • 2019
  • Wind tunnel testing technique has been established as a powerful experimental method for predicting wind-induced loads on high-rise buildings. Accurate assessment of the design wind load combinations for tall buildings on the basis of wind tunnel tests is an extremely important and complicated issue. The traditional design practice for determining wind load combinations relies partly on subjective judgments and lacks a systematic and reliable method of evaluating critical load cases. This paper presents a novel optimization-based framework for determining wind tunnel derived load cases for the structural design of wind sensitive tall buildings. The peak factor is used to predict the expected maximum resultant responses from the correlated three-dimensional wind loads measured at each wind angle. An optimized convex hull is further developed to serve as the design envelope in which the peak values of the resultant responses at any azimuth angle are enclosed to represent the critical wind load cases. Furthermore, the appropriate number of load cases used for design purposes can be predicted based on a set of Pareto solutions. One 30-story building example is used to illustrate the effectiveness and practical application of the proposed optimization-based technique for the evaluation of peak resultant wind-induced load cases.

Chromosome Configurations of Human Oocytes Matured in vitro following Cryopreservation at the Germinal Vesicle Stage (인간 미성숙난자의 동결.융해후 체외 배양된 난자에 대한 염색체 분석)

  • Park, S.E.;Chung, C.J.;Son, W.Y.;Chung, H.M.;Lee, S.H.;Lee, W.S.;Ko, J.J.;Yoon, T.K.;Cha, K.Y.
    • Clinical and Experimental Reproductive Medicine
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    • v.24 no.2
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    • pp.253-259
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    • 1997
  • Objective: To investigate effects of cryoprotectant and cryopreservation on the chromosome of the human immature oocytes. Design: Intact cumulus-enclosed immature oocytes were collected from unstimulated ovaries and divided into three groups, such as no treatment as control (group 1), only 1,2-propanediol (PROH)-treated (group 2), and cryopreserved oocytes (group 3). Oocytes in group 1, 2, and survived oocytes after cryopreservation in group 3 were cultured for 48 hours. Setting: Infertility Medical Center at the CHA General Hospital, Seoul, Korea. Patients: Oocytes were obtained from Patients undergoing gynecological surgery. Main Outcome Measures: Maturation rate, abnormality in chromosomes by fluorescence in situ hybridization (FISH). Results: There was no effect of PROH only treatment on the chromosomal abnormalities in group 2 compared to control oocytes (41.4% and 31.8%, respectively). Whereas significantly increased abnormalities in chromosome (77.8%) were found in group 3. Conclusions: Human oocytes matured in vitro after cryopreservation at the germinal vesicle (GV) stage showed increased incidence of chromosomal abnormalities. These abnormalities may impair the capacity for further development of the embryos derived from frozen-thawed oocytes.

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Effect of Vibration during Distribution Process on Compression Strength of Corrugated Fiberboard Boxes for Agricultural Products Packaging (농산물 포장용 골판지상자의 수송 중 진동에 의한 압축강도 변화)

  • Shin, Joon Sub;Kim, Jongkyoung
    • KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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    • v.27 no.2
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    • pp.91-100
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    • 2021
  • Agricultural corrugated fiberboard packaging boxes frequently experience damage due to loading and unloading, vibration during transport, and shock by dynamic distribution condition change. This study was carried out to estimate effect of vibration during distribution process on compression strength of corrugated fiberboard boxes for agricultural products. In order to identify the degradation caused by vibration, after box packaging the agricultural products(tangerine or cucumber), the natural frequencies of the packaging boxes were measured by varying the relative humidity(50, 70 and 90%) at 25℃ temperature. Various types of corrugated fiberboard boxes were packed with tangerines and cucumbers, and the PSD plot vibration tests were conducted by utilizing the actual vibration recording results of the Gyeongbu Expressway section between Seoul and Gimcheon. As a result of the experiment, the decrease in compression strength of the box was relatively low in DW-AB, and the decrease in compression strength of the SW-A 0201(RSC) type box was the highest at 20.49%. In particular, both SW-A and DW-AB showed low compression strength degradation rates for open folder type boxes. The moisture content varies depending on the type of the box or agricultural products, and the enclosed 0201(RSC) type box was generally higher than the open folder or bliss type box, which is believed to be the reason for the decrease in compression strength of RSC type box due to humidity. By the agricultural product, the percentage of decrease in compression strength of box packed with cucumbers was especially high.

Indoor distribution characteristics of airborne bacteria in pig buildings as influenced by season and housing type

  • Kim, Ki Youn;Ko, Han Jong
    • Asian-Australasian Journal of Animal Sciences
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    • v.32 no.5
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    • pp.742-747
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    • 2019
  • Objective: A concentration of airborne bacteria generated from swine houses is recognized to be relatively higher than other work places and it is essential to optimally manage it to prevent farmers' respiratory diseases. This study was conducted to assess the distribution characteristics of airborne bacteria in swine houses located at South Korea. Methods: A total 27 pig buildings of the enclosed type operated with mechanical ventilation system by a side wall fan and deep-pit manure system with slats were surveyed. Air samples were collected at 1.0 m above the middle floor in pig housing room. A six-stage viable particulate cascade impactor was used to identify the distribution of the sizes of particles in diameter. Results: Seasonal mean levels of airborne bacteria in the housing rooms of gestation/farrowing pigs, nursery pigs and growing/fattening pigs were 3,428(${\pm}1,244$) colony forming unit $(cfu)/m^3$, $8,325({\pm}3,209)cfu/m$, and $13,254({\pm}6,108)cfu/m^3$ for spring; $9,824({\pm}2,157)cfu/m^3$, $18,254({\pm}5,166)cfu/m^3$, and $24,088({\pm}9,274)cfu/m^3$ for summer; $1,707({\pm}957)cfu/m^3$, $4,258({\pm}1,438)cfu/m^3$, and $8,254({\pm}2,416)cfu/m^3$ for autumn; and $2,322({\pm}1,352)cfu/m^3$, $6,124({\pm}1,527)cfu/m^3$ and $12,470({\pm}4,869)cfu/m^3$ for winter, respectively. Conclusion: Concentrations of airborne bacteria according to pig housing type were highest in growing/fattening housing room followed by nursery housing room and gestation/farrowing housing room. In terms of seasonal aspect, the pig building showed the highest levels of airborne bacteria in summer followed by spring, winter and autumn. The respirable airborne bacteria which are ranged between 0.6 and $4.7{\mu}m$ accounted for approximately 60% compared to total airborne bacteria regardless of pig housing type.

Design of Integrated Safery System for Sealed Places (밀폐된 공간을 위한 통합안전시스템의 설계)

  • Jeong, Min-Seung;Lee, Chang-Shin;Cho, Woo-Hyeon
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.23 no.1
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    • pp.97-102
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    • 2019
  • Disaster accidents at industrial sites have been increasing every year. In shipyards there are countless enclosed spaces causing issues like harmful-toxic gases stuck in those sealed areas. And due to such special and complicated structures of the working places with many layers of walls separating each other, there exist more issues of communication with workers trapped inside when accidents happen. Under this circumstance there must be a huge difficulty to evacuate or rescue the workers in case of any disaster. Therefore, in this paper, We would like to introduce the "integrated safety system" to more effectively deal with the problems and prevent such disasters in tough working environments. The suggested integrated safety system can prevent accidents in advance because it can control the data on the location of the workers in real time and the numerical values such as gas, oxygen, and carbon dioxide generated in the workplace in real time.

A Study on the Sensor Module System for Real-Time Risk Environment Management (실시간 위험환경 관리를 위한 센서 모듈시스템 연구)

  • Cho, Young Chang;Kwon, Ki Jin;Jeong, Jong Hyeong;Kim, Min Soo
    • Journal of IKEEE
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    • v.22 no.4
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    • pp.953-958
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    • 2018
  • In this study, a portable detection system was developed that can detect harmful gas and signals simultaneously in an enclosed space of industrial sites and underground facilities. The developed system is a sensor module for gas detection, a patch type 1 channel small ECG sensor, a module for three-axial acceleration detection sensor, and a system for statistics. In order to verify the performance of the system modules, the digital resolution, signal frequency, output voltage, and ultra-small modules were evaluated. As a result of the performance of the developed system, the digital resolution was 300 (rps) and the signal amplification gain was 500 dB or more, and the ECG module was manufactured with $50mm{\times}10mm{\times}10mm$ to increase patch utilization. It is believed that the product of this research will be valuable if it is used as an IoT-based management system for real-time monitoring of industrial workers.