• Journal of Information Processing Systems
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• v.11 no.4
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• pp.601-615
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• 2015

Region of interest (ROI) is the most informative part of a medical image and mostly has been used as a major part of watermark. Various shapes ROIs selection have been reported in region-based watermarking techniques. In region-based watermarking schemes an image region of non-interest (RONI) is the second important part of the image and is used mostly for watermark encapsulation. In online healthcare systems the ROI wrong selection by missing some important portions of the image to be part of ROI can create problem at the destination. This paper discusses the complete medical image availability in original at destination using the whole image as a watermark for authentication, tamper localization and lossless recovery (WITALLOR). The WITALLOR watermarking scheme ensures the complete image security without of ROI selection at the source point as compared to the other region-based watermarking techniques. The complete image is compressed using the Lempel-Ziv-Welch (LZW) lossless compression technique to get the watermark in reduced number of bits. Bits reduction occurs to a number that can be completely encapsulated into image. The watermark is randomly encapsulated at the least significant bits (LSBs) of the image without caring of the ROI and RONI to keep the image perceptual degradation negligible. After communication, the watermark is retrieved, decompressed and used for authentication of the whole image, tamper detection, localization and lossless recovery. WITALLOR scheme is capable of any number of tampers detection and recovery at any part of the image. The complete authentic image gives the opportunity to conduct an image based analysis of medical problem without restriction to a fixed ROI.

• Biomaterials and Biomechanics in Bioengineering
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• v.2 no.2
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• pp.97-109
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• 2015

A series of amphiphilic graft copolymers were synthesized by varying the number of graft chains and graft chain lengths. The polarity of the hydrophobic graft chain on the copolymers was varied their solution properties. The glass transition temperature of the copolymers was in the low-temperature region, because of the amorphous nature of poly (trimethylene carbonate) (PTMC). The surface morphology of the lyophilized colloid gel had a bundle structure, which was derived from the combination of poly(N-hydroxyethylacrylamide)( poly(HEAA)) and PTMC. The solution properties were evaluated using dynamic light scattering and fluorescence measurements. The particle size of the graft copolymers was about 30-300 nm. The graft copolymers with a higher number of repeating units attributed to the TMC (trimethylene carbonate) component and with a lower macromonomer ratio showed high thermal stability. The critical association concentration was estimated to be between $2.2{\times}10^{-3}$ and $8.9{\times}10^{-2}mg/mL$, using the pyrene-based fluorescence probe technique. These results showed that the hydrophobic chain of the graft copolymer having a long PTMC segment had a low polarity, dependent on the number of repeating units of TMC and the macromonomer composition ratio. These results demonstrated that a higher number of repeating units of TMC, with a lower macromonomer composition, was preferable for molecular encapsulation.

• The KIPS Transactions:PartD
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• v.8D no.1
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• pp.71-80
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• 2001

Object-Oriented (OO) methodology to use the concept like encapsulation, inheritance, polymorphism, and message passing demands metrics that are different from structured methodology. There are many studies for OO software metrics such as program complexity or design metrics. But the metrics for the analysis class need to decrease the complexity in the analysis phase so that greatly reduce the effort and the cost of system development. In this paper, we propose new metrics to measure the complexity of analysis classes which draw out in the analysis phase based on Unified Process. By the collaboration complexity, is denoted by CC, we mean the maximum number of the collaborations can be achieved with each of the collaborator and detennine the potential complexity. And the interface complexity, is denoted by IC, shows the difficulty related to understand the interface of collaborators each other. We prove mathematically that the suggested metrics satisfy OO characteristics such as class size and inheritance. And we verify it theoretically for Weyuker' s nine properties. Moreover, we show the computation results for analysis classes of the system which automatically respond to questions of the it's user using the text mining technique. As we compared CC and IC to CBO and WMC, the complexity can be represented by CC and IC more than CBO and WMC. We expect to develop the cost-effective OO software by reviewing the complexity of analysis classes in the first stage of SDLC (Software Development Life Cycle).

• Journal of KIISE:Software and Applications
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• v.28 no.10
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• pp.720-731
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• 2001

Complexity metrics have been developed for the structured paradigm of software development are not suitable for use with the object-oriented(OO) paradigm, because they do not support key object-oriented concepts such as inheritance, polymorphism. message passing and encapsulation. There are many researches on OO software metrics such as program complexity or design metrics. But metrics measuring the complexity of classes at the OO analysis phase are needed because they provide earlier feedback to the development project. and earlier feedback means more effective developing and less costly maintenance. In this paper, we propose the new metrics to measure the complexity of analysis classes which draw out in the analysis based on RUP(Rational Unified Process). By the collaboration complexity, is denoted by CC, we mean the maximum number of the collaborations can be achieved with each of the collaborator and determine the potential complexity. And the interface complexity, is denoted by IC, shows the difficulty related to understand the interface of collaborators each other. We verify theoretically the suggested metrics for Weyuker's nine properties. Moreover, we show the computation results for analysis classes of the system which automatically respond to questions of the user using the text mining technique. As a result of the comparison of CC and CBO and WMC suggested by Chidamber and Kemerer, the class that have highly the proposed metric value maintain the high complexity at the design phase too. And the complexity can be represented by CC and IC more than CBO and WMC. We can expect that our metrics may provide us the earlier feedback and hence possible to predict the efforts, costs and time required to remainder processes. As a result, we expect to develop the cost-effective OO software by reviewing the complexity of analysis classes in the first stage of SDLC(Software Development Life Cycle).

• Applied Biological Chemistry
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• v.37 no.5
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• pp.343-348
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• 1994

Ti plasmid of A. tumefaciens was labeled with $^3H-thymidine$, purified and encapsulated into phosphatidylserine (PS) and PS-cholesterol (Chol; 1 : 1 molar ratio) liposomes by lyophilization-rehydration method. PS was supplemented with 1 mole percent octadecyl rhodamine B for fluorometric measurement of PS. Liposomes entrapping $^3H-Ti plasmid$ were fused with Nicotiana sanderae protoplasts by treating with 5 mM $CaCl_2$ and 10% PEG. The fusion was evidenced by fluorescence microscopic technique. The amounts of Ti plasmid and PS associated with protoplasts were assayed by the radioactivity of $^3H-Ti plasmid$ and by the fluorescence of rhodamine B. About 7.9% of the PS liposome and 7.2% of PS-Chol liposome were fused with protoplasts. During the fusion process, about 30% of the liposomal contents of PS-Chol liposome was leaked, in contrast to about 60% leakage of its contents in PS liposome. Accounting the number of liposomes fused with protoplasts together with the encapsulation efficiency and the leakage of liposomal contents, it was calculated that ca. 1,700 Ti plasmid was transfered into one protoplast by the present method. This result may indicates that the present method transfers enough Ti plasmid into plant protoplast to elicit genetic transformation of plants.

• KIPS Transactions on Software and Data Engineering
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• v.2 no.10
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• pp.651-660
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• 2013

Object oriented design brought up improvement of productivity and software quality by adopting some concepts such as inheritance and encapsulation. However, both the number of software's classes and object couplings are increasing as the software volume is becoming larger. The object coupling between classes is closely related with software complexity, and high complexity causes decreasing software quality. In order to solve the object coupling issue, IT-field researchers adopt a component based development and software quality metrics. The component based development requires explicit representation of dependencies between classes and the software quality metrics evaluates quality of software. As part of the research, we intend to gain a basic data that will be used on decomposing software. We focused on properties of the linkage between classes rather than previous studies evaluated and accumulated the qualities of individual classes. Our method exploits machine learning technique to analyze the properties of linkage and predict the strength of dependency between classes, as a new perspective on analyzing software property.

• Bulletin of the Korean Chemical Society
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• v.16 no.10
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• pp.923-929
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• 1995

Four crystal structures of M3-A (M3Na9-xHx-A, M=Rb or K and x=1 or 0), Rb3Na8H-A(a=12.228(1) Å and R1=0.046), Rb3Na9-A (a=12.258(3) Å and R1=0.058), K3Na8H-A (a=12.257(3) Å and R1=0.048) and K3Na9-A (a=12.257(3) Å and R1=0.052), have been determined by single crystal x-ray diffraction technique in the cubic space group Pm3^m at 21 ℃. In all structures, each unit cell contained three M+ ions all located at one crystallographically distinct position on 8-rings. Rb+ ions are 3.12 and 3.21 Å away respectively from O(1) and O(2) oxygens, about 0.40 Å away from the centers of the 8-rings, and K+ ions are 2.87 and 2.81 Å apart from the corresponding oxygens. These distances are the shortest ones among those previously found for the corresoponding ones. Eight 6-rings per unit cell are occupied by eight Na+ ions, each with a distance of 2.31 Å to three O(3) oxygens. The twelfth cation per unit cell is found as Na+ opposite 4-ring in the large cavities of M3Na9-A and assumed to be H+ for M3Na8H-A. With these noble non-framework cationic arrangements, larger M+ ions preferably on all larger 8-rings and the compact Na+ ions on all 6-rings, the bond angles in the 8-rings of M3-A, 145.1 and 161.0 respectively for (Si,Al)-O(1)-(Si,Al) and (Si,Al)-O(2)-(Si,Al), turned out to be remarkably stable and smaller, by more than 12 to 17°, than the corresponding angles found in the crystal structures of zeolites A with high concentration of M+ ions. It is to achieve these remarkably relaxed 8-rings, the main windows for the passage of gas molecules, with simultaneously maximized cavity volumes that M3-A have been selected as one of the efficient zeolite A systems for gas encapsulation.