• 대한화장품학회지
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• 제37권1호
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• pp.61-66
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• 2011

본 연구는 이질풀 추출물의 항산화 효능에 관한 연구로, 항산화 및 항노화의 기능성 화장품 소재로서의 개발 가능성을 확인하고자 하였다. 이질풀의 주요 성분으로는 tannin, (-)epicatechin, kaempferitin, kaepferol-7-rhamnoside, brevifolin, corilagin, pyrogallol, ellagitannin, geraniin, gallic acid, succinic acid, quercetin, protocatechuic acid 등이 보고되어 있다. DPPH 라디칼 소거능 평가를 통한 이질풀 추출물의 항산화 효능을 측정한 결과, 대조군인 quercetin과 비교하여 우수한 소거 활성을 확인할 수 있었다. 동일 농도($50\;{\mu}g/mL$)를 처리하였을 때 이질풀 추출물의 DPPH 라디칼 소거능은 약 98.33 %로 측정되었으며, quercetin의 경우 78.05 %로 측정되었다. Human keratinocyte (HaCaT)에 이질풀 추출물을 처리하여 세포내 Reactive Oxygen Species (ROS) 생성 저해능을 측정한 결과, $IC_{50}$값은 이질풀 추출물과 quercetin에서 각각 43.22, $102.35\;{\mu}g/mL$로 측정되어 이질풀 추출물의 우수한 항산화 효능을 확인할 수 있었다. 또한 피부 자극 테스트 및 세포 독성 평가를통하여 이질풀 추출물이 피부에 자극을 유발시키지 않는 안전한 소재임을 확인하였다.

• Journal of the Korean Wood Science and Technology
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• 제44권4호
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• pp.559-570
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• 2016

The EtOAc and $H_2O$ soluble fractions of Katsura tree (Cercidiphyllum japonicum Sieb. Et Zucc) bark extracts were chromatographed on a Sephadex LH-20 column with various aqueous MeOH. Gallic acid (1), methyl galate (2), kurigalin (3), 1,2,3,6-tetra-O-galloyl-${\beta}$-D-glucose (4) and 1,2,3,4,6-penta-O-galloyl-${\beta}$-D-glucose (5) were isolated from EtOAc fraction. Isocorilagin (6) and methyl galate (2) were separated from $H_2O$ fraction. The structure determination was done by $^1H$ and $^{13}C$ NMR. Of these isolated compounds, methyl galate (2), kurigalin (3) and isocorilagin (6) were isolated, for the first time, from the bark extracts of Cercidiphyllum japonicum.

• Archives of Pharmacal Research
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• 제26권12호
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• pp.1024-1028
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• 2003

A prolyl endopeptidase inhibitor was isolated from the ethyl acetate soluble fraction of Phyllanthus ussurensis. The active compound was identified as an ellagitannin, corilagin. It was shown to non-competitively inhibit prolyl endopeptidase (PEP) with the $IC_{50}$ value of $1.17 \times $10^{-6}\mu$M. The Ki value was $6.70 \times 10^{-7}$ M. Corilagin was less inhibitory to other serine proteases such as chymotrypsin, trypsin, and elastase, indicating that it was relatively a specific inhibitor of PEP. Corilagin also effectively inhibited reactive oxygen species such as hydroxide and superoxide anion radical, hydrogen peroxide, and DPPH. Especially, corilagin showed potent scavel1ging activity on the superoxide anion radical in the ESR method ($IC_{50} =3.79 \times 10^{-6}$M) as well as xanthine oxidase system.

• 생약학회지
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• 제50권3호
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• pp.155-158
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• 2019

Cornus alba (CA) geographically distributes in Korea, Japan, Northeast China and Russia. The cornus species have been used traditionally as anti-inflammatory, hemostatic and diuretic in Korea. Previously, it was reported CA and its separated components have excellent antioxidant, anti-inflammatory and anti-prostate cancer efficacy. Present work, the validation and content determination was tried on the ellagitannin, cornusiin B which were isolated from the CA by using high-performance liquid chromatography (HPLC). As a result, the content of cornusiin B were 3.07% in ethanolic extract of CA.

• 한국식품영양학회지
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• 제30권2호
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• pp.181-190
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• 2017

Functional foods are of great significance since our society is accelerating into aging. An aging society has many physiological metabolic diseases such as hypertension, diabetes, heart disease, cancer, dementia and geriatric diseases. Fundamental treatments for the elderly are almost impossible and the social burden is heavy. If these diseases can be prevented or alleviated by improving dietary habits using functional foods, the significance would be very large. Pomegranate has been found to have 124 different kinds of phytochemicals. Polyphenols have a wide range of protective effects including various physiological metabolic diseases and cancers. It is necessary to develop functional foods such as preservatives and food extenders which can contribute to food safety, required in the food industry, by using such bioactive substances. Pomegranates have been reported to decrease the impact of many serious illnesses. There is a considerable amount of bioactive substances in the peel of a pomegranate, which has potent anticancer, antioxidant, antimicrobial and anti-apoptotic properties. Unfortunately, the peel is typically discarded after processing. Despite knowledge regarding the bioactive substances in the pomegranate peel and peel extracts, including their functionality and diversity, the knowledge is not well known by consumers in general. The aim of this study was to review up to date research trends for processing and developing new functional foods by utilizing nutritional functional substances, favourite food materials, and materials for processing food contained in pomegranate peels and pomegranate peel extracts. This study will summarize the data found in pomegranate peel and pomegranate peel extract literature mainly recently published in Science Direct. There are polyphenolic compounds (ellagitannins, punicalagin, proanthocyanidin, flavonoids, polysaccharides, etc.) in the fruit peel, making up about 50% of the pomegranate's weight. The polyphenol content of a pomegranate fruit peel is 149.91 mg/g, which is about 100 times higher than the juice. Paying attention to the fact that the ellagitannin content (14.22 mg/g) in the fruit peel is also twice as high as that of the fruit juice and seeds, that confirms the possibility of utilizing the peel as a food ingredient capable of developing new, functional bioactive foods.