• 대한의용생체공학회:의공학회지
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• 제45권1호
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• pp.26-36
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• 2024

Functional brain imaging techniques have been used to diagnose psychiatric disorders such as dementia, depression, and autism. Recently, these techniques have also been actively used to study hearing loss. The present study reviewed the application of the functional brain imaging techniques in auditory research, especially those focusing on hearing loss, over the past decade. EEG, fMRI, fNIRS, MEG, and PET have been utilized in auditory research, and the number of research studies using these techniques has been increasing. In particular, fMRI and EEG were the most frequently used technique in auditory research. EEG studies mostly used event-related designs to analyze the direct relationship between stimulus and the related response, and in fMRI studies, resting-state functional connectivity and block designs were utilized to analyze alterations in brain functionality in hearing-related areas. In terms of age, while studies involving children mainly focused on congenital and pre- and post-lingual hearing loss to analyze developmental characteristics with and without hearing loss, those involving adults focused on age-related hearing loss to investigate changes in the characteristics of the brain based on the presence of hearing loss and the use of a hearing device. Overall, ranging from EEG to PET, various functional brain imaging techniques have been used in auditory research, but it is difficult to perform a comprehensive analysis due to the lack of consistency in experimental designs, analysis methods, and participant characteristics. Thus, it is necessary to develop standardized research protocols to obtain high-quality clinical and research evidence.

• 대한한방내과학회지
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• 제44권6호
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• pp.1118-1138
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• 2023

Objectives: Sarcopenia is an age-associated skeletal muscle disorder that can profoundly impact the health of elderly people. However, the efficacy of herbal medicine in sarcopenia is uncertain. This review aims to investigate evidence of the effect of herbal medicine on sarcopenia. Methods: We systematically searched 12 electronic databases for relevant randomized controlled trials (RCTs). Only trials that met the inclusion criteria were selected, and the characteristics of the included studies were extracted and synthesized in a narrative manner. The quality of the included studies was assessed using Cochrane's Risk of Bias (RoB) 2.0 tool. Results: 7 RCTs involving 672 participants with sarcopenia met the inclusion criteria. The intervention combining herbal medicine and conventional treatment (i.e., exercise, nutritional support) had a significant therapeutic effect compared with the conventional treatment, showing improvement in muscle strength (i.e., grip strength), muscle mass (i.e., appendicular skeletal muscle mass index), and physical function (i.e., gait speed, short physical performance battery, and timed up and go test). However, the methodological quality of the included RCTs was relatively low due to their high RoB, making it difficult to evaluate the efficacy of herbal medicine in sarcopenia. In terms of safety, several adverse events were reported. Conclusion: This review suggests that herbal medicine has a positive effect on muscle strength, muscle mass, and physical performance in elderly patients with sarcopenia, but there is a clear need for further research in this area.

• 한국임상약학회지
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• 제34권1호
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• pp.39-61
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• 2024

Background: The Food and Drug Administration (FDA), the European Medicines Agency (EMA), and the Ministry of Food and Drug Safety (MFDS) have been implementing the expedited programs that promote the innovative approval of new medications to be used for serious diseases. The authors comprehensively investigated, analyzed, and compared the regulations and guidelines associated with the expedited programs. Methods: The expedited programs for innovative drug development and approval were searched from the homepages of FDA, EMA and MFDS. The detailed information on the regulations and guidelines associated with the programs was comprehensively extracted from various electronic repositories of each regulatory authority. The information on each program was analyzed, categorized, and compared from the points of benefits, applicability with scientific rationale, application procedure, and maintenance. Results: FDA's programs include Fast Track Designation, Breakthrough Therapy Designation, Priority Review Designation, and Accelerated Approval. EMA's regulation implements PRIority MEdicines (PRIME), Accelerated Assessment, Marketing Authorization under Exceptional Circumstances (MAEC), and Conditional Marketing Authorization (CMA). MFDS has a single Expedited Program. These programs are broadly categorized into those that 1) facilitate early and proactive communication with regulatory authorities, 2) shorten the review time after submitting a marketing application, and 3) temporarily approve a marketing authorization under certain conditions. Conclusion: Each expedited program requires a different level and amount of safety and efficacy evidence to be submitted to each regulatory authority. This article will likely provide the comprehensive information on which program provides scientific and regulatory advantages to be taken for innovative medication development.

• Clinics in Shoulder and Elbow
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• 제26권3호
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• pp.296-301
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• 2023

Background: A supervised physiotherapy program (SPP) is a standard regimen after surgical rotator cuff repair (RCR); however, the effect of a home-based exercise program (HEP), as an alternative, on postoperative functional recovery remains unclear. Therefore, the purpose of this meta-analysis was to compare the functional effects of SPP and HEP after RCR. Methods: We searched electronic databases including Central, Medline, and Embase in April 2022. The primary outcomes included the Constant score, American Shoulder and Elbow Surgeons score, University of California Los Angeles shoulder score, and pain score. Secondary outcomes included range of motion, muscle strength, retear rate, and patient satisfaction rate. A meta-analysis using random-effects models was performed on the pooled results to determine the significance. Results: The initial database search yielded 848 records, five of which met our criteria. Variables at 3 months after surgery were successfully analyzed, including the Constant score (mean difference, -8.51 points; 95% confidence interval [CI], -32.72 to 15.69; P=0.49) and pain score (mean difference, 0.02 cm; 95% CI, -2.29 to 2.33; P=0.99). There were no significant differences between the SPP and HEP. Other variables were not analyzed owing to the lack of data. Conclusions: Our data showed no significant differences between SSP and HEP with regard to the Constant and pain scores at 3 months after RCR. These results suggest that HEP may be an alternative regimen after RCR. Level of evidence: I.

• 한방재활의학과학회지
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• 제34권1호
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• pp.83-95
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• 2024

Objectives This review was conducted to evaluate the therapeutic effects of manual acupuncture (MA) for shoulder impingement syndrome (SIS). Methods We searched 12 electronic databases (DBpia, Korean studies Information Service System [KISS], Oriental Medicine Advanced Searching Integrated System [OASIS], Research Information Sharing Service [RISS], China National Knowledge Infrastructure [CNKI], CINAHL, Clinical Key, Cochrane Library, Embase, JAMA, PubMed, Web of Science) to find randomized-controlled clinical trials (RCTs) investigating therapeutic effects of MA for treating SIS. Shoulder Pain and Disability Index scores and numeric pain rating scale or visual analogue scale were analyzed as the main evaluation criteria. Results Among 181 studies, 169 were screened and only 12 RCTs were eligible in our review. Finally, 11 RCTs could be statistically analyzed. MA was more effective than sham treatment and physical therapy in terms of reducing pain (p=0.003, p=0.0007 each). Electroacupuncture (EA) showed more significant effect than physical therapy (PT) for improving shoulder pain (p<0.00001) and shoulder functionality (p<0.00001). Conclusions These results suggest that MA and EA could be superior option for treating SIS than sham treatment or PT. However this review has its limitations due to the small sample size and lack of well-designed RCTs that were included in the study. Further well-designed RCTs are necessary to provide high-level evidence.

• Journal of Preventive Medicine and Public Health
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• 제57권3호
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• pp.252-259
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• 2024

Objectives: This study investigated factors associated with the retention of people living with human immunodeficiency virus (HIV) on antiretroviral therapy (ART) during the first 3 years of treatment. Methods: A retrospective study using electronic health records was conducted at a tertiary hospital in Jakarta, Indonesia. Adult HIV-positive patients who started ART from 2010 until 2020 were included. A binary logistic regression model was used to identify factors associated with ART retention in the first 3 years. Results: In total, 535 respondents were included in the analysis. The ART retention rates for the first, second, and third years were 83.7%, 79.1%, and 77.2%, respectively. The multivariate analysis revealed a negative association between CD4 count when starting ART and retention. Patients with CD4 counts >200 cells/mL were 0.65 times less likely to have good retention than those with CD4 counts ≤200 cells/mL. The year of starting ART was also significantly associated with retention. Patients who started ART in 2010-2013 or 2014-2016 were less likely to have good retention than those who started ART in 2017-2020, with adjusted odds ratios of 0.52 and 0.40, respectively. Patients who received efavirenz-based therapy were 1.69 times more likely to have good retention than those who received nevirapine (95% confidence interval, 1.05 to 2.72). Conclusions: Our study revealed a decline in ART retention in the third year. The CD4 count, year of enrollment, and an efavirenz-based regimen were significantly associated with retention. Patient engagement has long been a priority in HIV programs, with interventions being implemented to address this issue.

• Asia pacific journal of information systems
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• 제23권1호
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• pp.45-63
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• 2013

The purpose of this research is on the identification of the effects of perceived interactivity formed by the electronic collaborative referral system on the organizational loyalty. Two channels through which the effects proceeded were investigated. One is the "system channel" which consists of "interactivity of the inter-organizational system ${\rightarrow}$ intention of using the system ${\rightarrow}$ organization loyalty" (hypothesis 1, 2), that is the channel which anticipates that a better understanding on the interactivity of the inter-organizational system makes the intention of the using the system strong, and this strong intention results the higher organization loyalty. The other is "organization channel" which consists of "interactivity of the inter-organizational system ${\rightarrow}$ perceived interactivity on the counterpart ${\rightarrow}$ perceived relation benefits with the counterpart ${\rightarrow}$ organization loyalty" (hypothesis 3, 4, 5). The channel means that as the perceived interactivity of users on the inter-organizational system becomes greater, the perceived interactivity with the counterpart is increasing. And this makes the users feel that more benefits can be obtained by the relationship with system providing organization, and finally makes the organization loyalty that is the intention to maintain the relationship greater. The corroborative evidence data confirm the two channels are obtained by questing on the electronic referral system of Samsung Medical Center to the doctors of the first and second collaborated hospitals or clinics, and by analyzing statistically. The verification result for the "system channel" showed that as the perception on the interactivity of inter-organizational system was increasing, the intention for consistent using increased(support hypothesis 1), and then the organization loyalty that is the relationship maintaining indication by using the referral system also increased(support hypothesis 2). And the confirmation result for the "organization channel" indicated that the perceptive interactivity on the counterpart increased as the understanding on the interactivity of inter-organizational system increased(support hypothesis 3), consecutively, with the intuitive relation benefits increase with the counterpart(support hypothesis 4) the organization loyalty means the intention to maintain the relationship was confirmed to increase(support hypothesis 5). These results demonstrate that when the perceived interactivity in using many systems at the collaboration between organizations is increasing, the positive image on the systems creates the consistent system using intention, and the positive image increases the wants for preserving the relationship with counter organization. In addition, the perceived interactivity of inter-organizational system users affects directly on the perceived interactivity of the counter organization, so the important role of inter-organizational system in promoting the interactivity between cooperative counterparts was recognized. And the perceived interactivity on the counter organization become greater, the influence on the perceived benefits from cooperation is positive. Therefore, the perceived interactivity by using inter-organizational system was confirmed as a prerequisite for the continuous relationship.

• 전자공학회논문지 IE
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• 제49권2호
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• pp.1-8
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• 2012

단사정 구조의 순수 $ZrO_2$ 또는 5.35wt%의 $Y_2O_3$를 첨가한 정방정 구조의 $Y_2O_3(Y-TZP)$를 $Al_2O_3$에 첨가하여 그 기계적 특성 및 열충격 저항성을 연구하였다. $ZrO_2(m)$와 Y-TZP의 첨가량이 커짐에 따라 $Al_2O_3$의 소결 밀도가 증가하였다. 또한 Y-TZP의 첨가량이 증가함에 따라 비커스 경도도 증가하였고 첨가량 20wt%에서 최고값을 나타내었다. 시편의 경도는 소결 밀도에 의존함을 알 수 있었다. $ZrO_2(m)$나 Y-TZP 첨가량의 증가는 파괴인성을 향상시키는 결과를 얻을 수 있었다. 이러한 결과로 $Al_2O_3$의 경도는 $ZrO_2$의 transformation toughening 뿐 아니라 미세균열 강화에서도 얻어짐을 알 수 있었다. 단사정 구조의 순수 $ZrO_2$의 첨가는 $Al_2O_3-ZrO_2$의 열 충격 저항성을 향상시켰다. 결정입도는 $ZrO_2$의 첨가량이 증가함에 따라 커진다.

• 한국산학기술학회논문지
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• 제20권7호
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• pp.242-248
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• 2019

본 연구는 Electronic Control Unit (EC)기술이 적용된 스마트 홈이 휠체어를 사용하는 장애인의 일상생활활동 수행도와 만족도에 미치는 영향을 알아보고자 하였다. 본 연구의 참여자는 국립재활원 재활병원에 입원한 환자 중에서 지역 사회 복귀와 집으로 퇴원을 계획하는 대상자 중에서 스마트 홈을 경험하기를 원하는 사람을 연구에 포함하였다. 15명의 참여자 중 척수손상장애인은 10명, 나머지 5명은 뇌병변 장애인이었다. 스마트 홈은 ECU기술이 적용된 것으로 가구 및 기반 제품들의 전동화, 기반 시설들의 자동화 그리고 제품과 시설들을 통합하여 스마트 디바이스와 음성으로 제어할 수 있도록 구성하였다. 휠체어 사용자의 일상생활 수행도와 만족도는 캐나다 작업수행평가에 의해 평가되었다. 스마트 홈에서 거주해본 결과 거실과 현관, 침실, 기타(환경적요소) 부분에서 일상생활의 수행도가 3점 이상의 평균값 차이를 보였다. 공간별 수행도 비교 결과, 현재 주거 공간에 비해 스마트 홈 주거 공간별 수행도가 모두 유의미한 차이(p<0.05)로 향상되었다. 만족도 역시, 거실과 현관, 침실, 주방 영역에서 4점 이상의 차이를 보였고 주거 공간별 만족도 비교 결과 모두 유의미한 차이(p<0.05)로 향상되었다. 본 연구는 하이테크 기반의 스마트 홈 적용 가능성의 기초적인 근거를 제공했다는 점에서 임상적 의의를 가진다. 추후에는 근거 수준의 질 향상을 위해 다수의 연구 참여자를 확보한 연구가 진행되어야 할 것이다.

• 기록학연구
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• 제42호
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• pp.3-35
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• 2014

최근의 전자기록 환경은 기록의 의미와 기록관리의 역할 변화란 관점에서 볼 때 거대한 패러다임 전환기임이 분명하다. 하지만 근대 시민혁명 과정에서 연유하여 산업사회를 거치면서 정립된 기록의 의미와 기록관리의 역할은 아직도 완고하다. 실증주의 사조에 기반을 둔 문자화된 종이기록 중심의 관리이론 및 방식은 아직도 지배적으로 통용되고 있으며, 주로 공기록과 같은 대규모 조직에서 생성된 기록들을 대상으로 관리하며 과거의 사실에 대한 보고로서 인식되고 있다. 이러한 상황에서 기억 담론은 문자화된 공기록 중심의 기록관리를 탈피하고, 다원화된 사회 속에 기록의 의미 및 기록관리의 역할을 모색할 수 있는 단초를 제공해 줄 수 있다. 그동안 국내외 기록학계에서는 기록은 행위에 대한 객관적, 중립적 증거라는 점에서, 기록은 곧 기억이라는 단순한 인식이 만연되어왔다. 하지만 최근 포스트모더니즘의 영향 속에 기록이 지닌 객관성, 중립성에 회의를 품게 되었고, 사회의 다원화 속에 공기록 중심의 기록관리에 대한 반성의 움직임이 일고 있다. 이에 본고에서는 기록과 기억의 관계 정립을 위한 기반 연구로, 사회적 기억 구축을 위한 기록관리의 역할 및 방향성을 모색해 보고자 한다. 이를 위해 우선기록과 기억 간의 관계 정립을 위한 단초로 기억 담론에 대한 학계의 논의를 고찰한 다음, 그동안 기록학 영역에서 진행되어 온 기억을 둘러싼 제반 연구들을 검토하였다. 이를 발판으로 사회적 기억 형성을 위해 기록학 영역에서 수행해야 할 역할 및 향후 방향성을 논의코자 하였다.