• Journal of Acupuncture Research
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• 제25권4호
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• pp.105-116
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• 2008

Objectives : The aim of this study was to compare the effect of acpuncture and electroacupuncture of low(EA(L)) and high(EA(H)) frequencies at San Yin Jiu($SP_6$) and sham point in rats. We made suppressed state of intestinal motility with loperamide in rat and carried out needle retention acupuncture, low frequency electro-acupuncture and high frequency electro-acupuncture at ($SP_6$) in rat devided into pre-treatment group and post-treatment group. We fed charcoal to them after the treatment and measured the travel rate of charcoal in the gastrointestine track to analyze which treatment affected more in intestinal hypermotility Results : 1. Examining intestinal motility of normal rat treated with electro-acupuncture at $SP_6$, high frequency electro-acupuncture significantly increased intestinal motility. 2. Pre-treated with acupuncture at $SP_6$ significantly suppressed intestinal motility. 3. Post treatment with acupunture and low frequency electro-acupuncture at $SP_6$ showed significant increase of intestinal motility. Conclusions : As folowing study there were 21 groups to find out which treatment showed significant increase of intestinal motility and pre-treated acupuncture, post-treated with acupunture and low frequency electro-acupuncture at $SP_6$ was highly significant with control at the figure than any other groups.

• Journal of Acupuncture Research
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• 제20권3호
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• pp.86-103
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• 2003

Objective : Recently, many studies have showed the evidences of the effect of the acupunture treatment through scientific methods. One of these methods is functional MRI. We performed electro-acupunture on Sp6 and observed the changes of brain activation using fMRI. Methods : To see the effect of electro-acupunture stimulation on Sp6, the experiment was carried out on 12 healthy volunteers, using the gradient echo sequence with the 3.0T whole-body MRI system(ISOL). After the needle insertion on right Sp6, 2Hz of electric stimulation was given for 30 seconds, repeated five times, with 30 seconds' intervals. The Image analysis including motion correction, talairach transformation, and smoothing was done with SPM99. Results : 1. Group averaged brain activation induced by bilateral eletro-acupunture stimulation on Sp6 activates Brodman Area 3, 7, 13. 2. Group averaged brain deactivation induced by bilateral eletro-acupunture stimulation on Sp6 activates Brodman Area 6, 38, 47. 3. Group averaged brain activation induced by unilateral(right side) eletro-acupunture stimulation on Sp6 activates Brodman Area 5, 6, 13, 17, 18, 19, 31, 38, 40 ptoms, back pain(32.5%) was the 4. Group averaged brain deactivation induced by unilateral(right side) eletro-acupunture stimulation on Sp6 activates Brodman Area 3, 4, 18, 21, 36, 38, 39. 5. Brain region activated by motor stimulation activates Brodman Area 3, 4, 6, 18, 19.

• Journal of Acupuncture Research
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• 제25권5호
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• pp.139-149
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• 2008

Objectives : The aim of this study was to compare the effect of needle retention(NR) and electro-acupuncture of low(EA(L)) and high(EA(H)) frequencies at $SP_6$ and Sham point in rats. Methods : Intestinal hypermotility was induced by feeding carbachol and experimental groups divided mainly into 7 groups which were normal, holder, control, acupuncture in normal state of rats, pre-treatment of acupuncture(NR, EA) in hypermotility, post-treatment of acupuncture(NR, EA) in hypermotility. We fed charcoal to them after the treatment and measured the travel rate of charcoal in the gastrointestinal track so that which treatment affected more in intestinal hypermotility. Results : As the following study, each acupuncture ways of EA(L) had significant effect of decreasing travel rate on intestinal hypermotility than EA(H) and NR. The comparison between pre-treatment and post-treatment, pre-treatment had slight more effect than post-treatment but not significantly. There was more affected at $SP_6$ than Sham point on this study. Conclusions : There were 21 groups to find out which treatment was best to slow down the intestinal motility and $SP_6$-EA(L)-C had significant effect compared with control group at the figure than any other groups. That meant $SP_6$ had effect on gastric disorder such as intestinal hypermotility and its' effect had more prevention than cure. Further study was needed to have more precise effect of EA and $SP_6$.

• Korean Journal of Acupuncture
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• 제27권1호
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• pp.87-106
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• 2010

Objective & Methods: The purpose of this study is to investigate the anti-oxidative and immuneregulative effects of electro-acupouncture(EA) at SP6(Sameumgyo) in aged rats. The author performed several experimental items including blood cell counts, blood chemistry, measurement of various oxidants and antioxidants in liver and spleen, analysis of various cytokines in spleen. The results are as follows. Results: 1. EA at SP6 significantly reduced the number of platelets in blood. 2. EA at SP6 significantly reduced NO concentration and significantly increased catalase activity in liver. 3. EA at SP6 significantly reduced NO concentration and significantly increased SOD activity, catalase activity and glutathione concentration in spleen. 4. EA at SP6 restored the increase of IL-4, IL-6 and the decrease of IFN-$\gamma$ in aged rat spleen. Conclusion: According to these results, it is postulated that EA at SP6 has an antioxidative effect through increasing the activities of antioxidative enzymes and inhibiting production of oxidized substances, as well as an immune regulative effect in aging process. In consequence, it is presumed that EA at SP6 may have an anti-aging effect.

• 셀메드
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• 제2권1호
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• pp.10.1-10.6
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• 2012

Acupuncture works by stimulating peripheral sensory nerves and their endings causing an increase in cutaneous blood flow and microcirculation, as well as release of neurotransmitters, neuropeptides, and hormones. SP6 Patch is a nanoscale nontransdermal device that mildly stimulates Stomach 36 (zusanli) and other acupuncture points. As stimulation of these points has been indicated to have an effect on hypothalamic function, it is of great research interest to investigate the effect of SP6 Patch on the physiology of organs that are affected by hypothalamic regulation. Bioelectrical tissue impedance data indicative of cellular physiologic organ function, using an Electro Interstitial Scan (EIS) system, were acquired from hypothalamus, pancreas, liver, intestines, kidneys, thyroid and adrenal glands in 10 (1 male, 9 females) volunteers while wearing the SP6 Patch daily for 1 week. EIS testing was performed at baseline with no patch, 30 min after wearing the patch, and after wearing the patch 12 h/day for 1 week. Subjects were instructed to keep well hydrated during the study period. All subjects served as their own control. The hypothesis was: The SP6 Patch worn 12 h/day on the Stomach 36 acupuncture point for 1 week, may significantly improve cellular physiologic functional status of different organs measured by EIS. All tested organs achieved significant improvement in their functional physiologic status after wearing the SP6 Pach 12 h/day for 1 week compared to baseline with an overall average statistical power > 89%. Based upon these results the hypothesis was accepted as true.

• Korean Journal of Acupuncture
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• 제20권3호
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• pp.9-27
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• 2003

Objectives : The aim of this study was to examine the effects of electro-acupuncture(EA) at the SP6(Sameumgyo)-GB39(Hyeonjong) on normal human EEG using power spectral analysis. Methods : EEG power spectrum exhibit site-specific and state-related differences in specific frequency bands. In this study, power spectrum was used as a measure of complexity(LAXTHA Co., KOREA). 30 channel EEG study was carried out in 20 subjects $(20\;males;\;age=21.4{\pm}0.5\;years)$. Results : In $\alpha$(alpha) band, the power values at F4 channels(p<0.05) during the SP6-GB39 acupoints treatment was significantly increased. But, the power values at Fz channel during the non-acupoint treatment was significantly decreased . In $\beta$(beta) band, the power values at Fz, FTC1, T3 channels(p<0.05) was significantly increased during the SP6-GB39 acupoints treatment. In $\delta$(delta) band, the power values at F4, C3, Cz, CP1, Pz channels(p<0.05) during SP6-GB39 acupoints treatment were significantly decreased.

• 대한한방부인과학회지
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• 제37권2호
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• pp.75-108
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• 2024

Objectives: The purpose of this study is to review the acupuncture treatment for Polycystic ovary syndrome (PCOS) in women. Methods: We searched articles in 3 search engines with keywords related to 'Polycystic ovary syndrome', 'PCOS', and 'Stein-leventhal' in February 2024. Clinical researches and case reports that used acupuncture on PCOS were included. Animal studies and non clinical data were excluded. Data on acupuncture treatment such as methods, site, duration, frequency, and period were analyzed. Results: Of 60 selected articles, there were 51 randomized controlled trials, 5 clinical trials and 4 case reports. Studies were conducted using manual acupuncture, electro acupuncture, auricular acupuncture, thread embedding acupuncture, warm needling and laser acupuncture. Most studies used more than one acupoint, and there were 78 acupoints selected for acupuncture treatment for PCOS. The most commonly used acupoint was 三陰交 (SP6)(n=50). By analyzing the network of acupoints, 關元 (CV4), 氣海 (CV6), 中脘 (CV12), 三陰交 (SP6), 血海 (SP10), 天樞 (ST25), 足三里 (ST36) were located in center of the network. The mean treatment time, number of treatments, and duration were 28.63±4.48 minutes, 34.52±29.26 times, and 98.18±38.25 days. Conclusions: The results of this study could be useful in establishing the evidence for performing standardized acupuncture treatment for Polycystic ovary syndrome.

• 대한한방부인과학회지
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• 제32권4호
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• pp.102-115
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• 2019

Objectives: This study aimed to review randomized controlled trials (RCTs) on the effects of interventions of Korean medicine for chronic pelvic pain (CPP). Methods: We searched eleven electronic databases from inception up to Apr 2018. RCTs evaluating the effects of Korean medicine interventions for CPP were retrieved. Results: 11 RCTs were included and total number of experimental group was 390 cases. A total of 4 types of interventions were used, of which acupuncture (45.5%), electro-acupuncture (18.2%), electro-acupuncture + auricular acupuncture + moxibustion (18.2%) were the most frequently utilized. 關元 (CV4) (100.0%), 會陰 (CV1) (80.0%), 三陰交 (SP6) (80.0%), 陰陵泉 (SP9) (80.0%) were most frequently used acupoint in acupuncture treatment. Conclusions: For evidence-based treatment of korean medicine intervention for CPP, high quality RCTs must be conducted.

• 대한한의학회지
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• 제37권1호
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• pp.1-9
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• 2016

Objectives: Objectives : This study is aimed to develop a Clinical Practice Guideline (CPG) on acupuncture treatment for the patients with Post-stroke Urinary Retention; PSUR. Methods: Experts committee, consisting of stroke or methodology specialists, searched Medline, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and 19 Korean medicine journals. The search terms were selected to screen the randomized controlled trials (RCTs) or systematic reviews for the effectiveness of acupuncture on PSUR compared with placebo or conventional group. Levels of evidence and grades of recommendations were appraised based on Recommendations for Development of Clinical Practice Guideline in Korean Medicine. Results & Conclusions: 4 RCT were included to build the CPG. There was a strong evidence to support the effectiveness of acupuncture treatment for PSUR. The moderate evidence was presented that over 3 times a week of the acupuncture should be performed over 4 weeks on the acupoints, such as SP6, CV3, CV6, CV4, SP9, BL28, BL23, BL22, KI3 or BL67, for 15-30 minutes. 20-140Hz frequency and 10-20 minutes of treatment is suggested if electro-acupuncture treatment is performed with. It was also suggested that the procedure should begin at the acute stage just after the vital signs of the patients are stabilized. Finally, there was a moderate evidence to support safety of acupuncture treatment for PSUR.

• Korean Journal of Acupuncture
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• 제30권3호
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• pp.145-150
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• 2013

목적 : 본 연구는 코카인 연구에 사용된 경혈을 고찰하고 그 효능을 경락학설의 관점에서 해석하기 위해 수행되었다. 방법 : 논문 검색 사이트 PubMed에서 50 개의 논문, KISS에서 16 개의 논문, OASIS에서 9 개의 논문, NDSL에서 40 개의 논문, DBPIA에서 19 개의 논문을 '코카인' 또는 '침'을 검색어로 하여 조사하였다. 영문로 작성된 코카인(남용, 의존, 민감화, 섭취, 금단 증상, 재발, 탐닉)에 관한 논문을 조사하였고 수기침이나 전침만을 대상으로 하였으며 이침은 제외하였다. 결과 : 가장 많이 이용된 경혈은 신문(HT7)이었고 합곡(LI4), 태연(LU9), 족삼리(ST36), 삼음교(SP6) 등은 한 번씩 사용되었다. 신문은 수소음심경이 뇌의 기능과 깊이 관련되어 있다는 것 및 혈명이 가지는 뜻으로부터 충분히 이해될 수 있으며 태연은 신문의 효능을 증강시키는 것으로 생각된다. 합곡은 머리 꼭대기로 흐르는 궐음경을 조절하는 것으로 생각되고 족삼리는 궐음과 관련된 스트레스 반응을 조절하는 것으로 보이며 삼음교는 정신질환에 효능이 있으므로 뇌 기능을 조절하기 위해 사용된 것으로 생각된다. 결론 : 코카인 연구에 사용된 경혈은 다양한 경로를 통해 뇌 기능에 영향을 주는 것으로 사료되며 장부상통 이론이 일정 부분 관련되어 있는 것으로 생각된다.