• Korean Journal of Child Studies
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• v.31 no.5
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• pp.79-99
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• 2010

This study inquired into the life and experiences of two elder sisters who have different individual and familial risk factors and their younger brothers from the mixed-age preschool class through ethnographic research method using participant observation. The results showed that an elder sister from low-income multi-children family played her role very actively through caring for, learning and playing with younger brother during almost of the play situations. On the other hand, the other elder sister who has experience of depression, showed strong possessiveness and neglect of younger brother. As for psychological aspects of sibling relationship, the elder sisters were suffering psychological stresses resulted from excessive role expectation in family or from self-recognition on elder sister role, respectively.

• Clinical and Experimental Pediatrics
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• v.48 no.7
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• pp.701-705
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• 2005

Purpose : Parents' genetic information plays an important role in their children's genetic expression. Human chromosome has 23-paternal chromosomes and 23-maternal chromosomes. Parental chromosomal translocation can induce clinical problems in their children because of imbalance in genetic information. We intent to analyze the cytogenentic and clinical features about children with maternal balanced translocation between chromosome 15 and 18. Methods : We detected by one family's FISH study of chromosome 15. We have evaluated children born to clinically normal parents about peripheral bood analysis, endocrine, metabolic, radiologic study, electroencephalogram and social & intelligence scale. and We analysis their clinical manifestation by hospital records. Results : Patient's father and elder sister are normal clinically and genetically. Her mother's chromosome show balanced translocation, 46, XX, t(15;18)(p11.2;p11.3). One child has 46, XX, der(18) t(15;18)(p11.2;p11.3), mental retardation, growth retardation, speech & social developmental delay, recurrent infection and mild mitochondria dysfunction. Her young brother has 46, XY, der(15) t(15;18) (p11.2;p11.3), mental retardation, aggressive behavior, obesity and speech developmental delay. Conclusion : In this study we observed the children with developmental delay, dysmorphic facial features, mental retardation, growth retardation associated with growth hormone deficiency and aggressive behavior due to unbalanced translocation between chromosome 15 and 18.